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35 Possible Causes for Reduction of Mature B Cells

  • Insulin Resistance

    Reduction of B-cell maturation and Ig production-especially that of IgG2c-by ablation of OcaB prevented age-induced glucose intolerance and insulin resistance and promoted[ncbi.nlm.nih.gov] Here we found that the number of follicular B2 lymphocytes and expression of the B-cell-specific transcriptional coactivator OcaB increase with age in spleen and in intra-abdominal[ncbi.nlm.nih.gov]

  • Chronic Fatigue Syndrome

    […] supports the deregulation of genes involved in B-cell maturation and development identified in gene expression studies [ 74 ].[dx.doi.org] Increased hsa-miR-99b expression regulating mTOR supports the reduction in effector function observed in NK cells in CFS/ME patients seen in the literature [ 11, 13 ] and[dx.doi.org]

  • Lymphedema

    Defect in B cell production driven by GATA2 mutation results in their absolute reduction and mature phenotype in pediatric patients. Blood. 2014;124(21):2746 (abstract).[doi.org] Loss of B cells and their precursors is the most constant feature of GATA-2 deficiency in childhood myelodysplastic syndrome. Haematologica. 2016;101:707–16.[doi.org]

  • Fabry Disease

    To evaluate this possibility, we chose to use the Fabry-Rag model (these mice do not develop mature B or T cells), thereby eliminating any humoral immune response to α-gal[ncbi.nlm.nih.gov] Substrate reduction therapy delays the onset of heat-insensitivity in Fabry mice.[ncbi.nlm.nih.gov]

  • Kostmann Syndrome

    Defect in B cell production driven by GATA2 mutation results in their absolute reduction and mature phenotype in pediatric patients. Blood. 2014;124(21):2746 (abstract).[doi.org] Loss of B cells and their precursors is the most constant feature of GATA-2 deficiency in childhood myelodysplastic syndrome. Haematologica. 2016;101:707–16.[doi.org]

  • Myelodysplasia

    Defect in B cell production driven by GATA2 mutation results in their absolute reduction and mature phenotype in pediatric patients. Blood. 2014;124(21):2746 (abstract).[doi.org] Loss of B cells and their precursors is the most constant feature of GATA-2 deficiency in childhood myelodysplastic syndrome. Haematologica. 2016;101:707–16.[doi.org]

  • X-Linked Hypogammaglobulinemia

    In consequence, most B-cells do not mature past this point in their development and thus there is a total absence or severe reductions in peripheral mature B-cells and Plasma[pathwaymedicine.org] B-cell lymphocytes B-cell development in bone marrow is blocked at pro-B-cell stage to pre-B-cell stage Results in marked reduction in all classes of immunoglobulins (B-cell[arupconsult.com] As a result, there is an absence of mature B-cells in the peripheral circulation with a marked reduction in serum levels of all immunoglobulin subtypes, predisposing patients[jcadonline.com]

  • Systemic Lupus Erythematosus

    […] into plasma cells, even before affinities of antibodies mature sufficiently, leading to the reduction in high-affinity antibody-producing B cells in LMP2A AID mice.[ncbi.nlm.nih.gov] B cells from these mice were functionally normal, immature B cells from the Sle1 z - and Sle1b z -bearing BM exhibited a profound reduction in calcium flux, RAG expression[oadoi.org] This finding is consistent with LMP2A-mediated enhancement of in vitro plasma cell differentiation and suggests that LMP2A may accelerate the differentiation of GC B cells[ncbi.nlm.nih.gov]

  • Sensorineural Hearing Loss

    Defect in B cell production driven by GATA2 mutation results in their absolute reduction and mature phenotype in pediatric patients. Blood. 2014;124(21):2746 (abstract).[doi.org] Loss of B cells and their precursors is the most constant feature of GATA-2 deficiency in childhood myelodysplastic syndrome. Haematologica. 2016;101:707–16.[doi.org]

  • Multiple Sclerosis

    […] into plasma cells, even before affinities of antibodies mature sufficiently, leading to the reduction in high-affinity antibody-producing B cells in LMP2A AID mice.[ncbi.nlm.nih.gov] This finding is consistent with LMP2A-mediated enhancement of in vitro plasma cell differentiation and suggests that LMP2A may accelerate the differentiation of GC B cells[ncbi.nlm.nih.gov]

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