Refractory Anemia: Causes & Reasons

Possible Causes for Refractory Anemia

The etiology, clinical features and treatment of 25 cases of idiopathic refractory megaloblastic anemia are described. [bloodjournal.org]

anemia ICD-Morpho 9989/3 Myelodysplastic syndrome, unclassifiable Atlas_Id 1104 Note This disorder is part of the heterogeneous category of myelodysplastic syndrome (MDS) [atlasgeneticsoncology.org]

anemia - Hemoglobin Dysplasia involving erythroid lineage (see below for criteria for dysplasia) Must involve ≥10% of erythroids Ring sideroblasts (see definition below) [surgpathcriteria.stanford.edu]

Idiopathic Refractory Anemia

MDS indicates myelodysplastic syndrome; RA, refractory anemia ; RARS, refractory anemia with ringed sideroblasts; RAEB, refractory anemia with excess of blasts; RAEB-T, RAEB [medical-dictionary.thefreedictionary.com]

Prevention - Refractory anemia Not supplied. Diagnosis - Refractory anemia Not supplied. [checkorphan.org]

PubMed Search : Refractory anemia ringed sideroblasts Page views in 2018: 684 Page views in 2019 to date: 147 Cite this page: Sangle N. [pathologyoutlines.com]

Sideroblastic Anemia

PubMed Search : Refractory anemia ringed sideroblasts Page views in 2018: 684 Page views in 2019 to date: 147 Cite this page: Sangle N. [pathologyoutlines.com]

Gov't MeSH terms 5-Aminolevulinate Synthetase/deficiency 5-Aminolevulinate Synthetase/genetics Anemia, Refractory/blood Anemia, Refractory, with Excess of Blasts/blood Anemia [ncbi.nlm.nih.gov]

The chromosomal pattern of the patient was varied, and was accompanied by the development of refractory anemia with an excess of blasts from refractory anemia with ringed [ncbi.nlm.nih.gov]

Leukoerythroblastic Anemia

Pagina 61 - Refractory anemia (RA) Refractory anemia with ringed sideroblasts (RARS) Refractory anemia with excess blasts (RAEB... ‎ [books.google.it]

[…] pancytopenia + pure red-cell aplasia + Refractory Anemia + sideroblastic anemia + Thrombocytopenia, Anemia, and Myelofibrosis thrombocytosis + WT Limb Blood Syndrome X-Linked [rgd.mcw.edu]

anemia; refractory anemia with ringed sideroblasts; chronic myelomonocytic leukemia; refractory anemia with excess blasts in transformation lab findings severe pancytopenia [memorize.com]

Acute Erythroblastic Leukemia

Refractory anemias: acquired enzymopathies of hematopoietic stem cells. Nouv Rev Fr Hematol 1969; 9 :65–86. 8. Kiossoglou KA, Mitus WJ, Dameshek W. [doi.org]

anemia with excess blasts and preceding or concurrent history of erythropoietin therapy for anemia (n=16). [ncbi.nlm.nih.gov]

anemia with increase in blasts, chronic myelomonocytic leukemia, and preleukemia). [web.archive.org]

Paroxysmal Nocturnal Hemoglobinuria

The presence of a subclinical PNH population in myelodysplastic bone marrow disorders, such as aplastic anemia or refractory anemia, may correlate with a positive immunotherapeutic [ltd.aruplab.com]

How to diagnose PNH Patients with a Coombs-negative hemolytic anemia, AA, refractory anemia, and unexplained thrombosis in conjunction with cytopenias or hemolysis should [bloodjournal.org]

MDS patients reported to possess PNH cells tend to be classified as refractory anemia and often have the following characteristics: a hypocellular marrow, human leukocyte [bloodjournal.org]

Aplastic Anemia

Winkler T, Fan X, Cooper J, et al: Treatment optimization and genomic outcomes in refractory severe aplastic anemia treated with eltrombopag. [merckmanuals.com]

[…] effective in improving blood counts in refractory aplastic anemia. [rarediseases.org]

DeZern AE, Zahurak M, Symons H, et al: Alternative donor transplantation with high-dose post-transplantation cyclophosphamide for refractory severe aplastic anemia. [merckmanuals.com]

Acute Myeloid Leukemia

Cytogenetic investigation of the bone marrow cells of an 88-year-old woman with refractory anemia with an excess of blasts in transformation with progression to acute myelocytic [ncbi.nlm.nih.gov]

anemia with excess blasts in transformation [RAEB T] Type 1 Excludes acute exacerbation of chronic myeloid leukemia ( C92.10 ) refractory anemia with excess of blasts not [icd10data.com]

This category includes the entities of refractory anemia (RA) for those with anemia and only dyserythropoiesis (but in whom ring sideroblasts account for less than 15% of [doi.org]

Anemia of Chronic Disease

We noted that patients with large hepatic adenomas had severe iron refractory anemia similar to that observed in anemia of chronic disease. [ncbi.nlm.nih.gov]

To review the effect of 6 weeks of subcutaneous recombinant human erythropoietin 75 IU/kg administered 3 times weekly to resolve refractory anemia of chronic disease and heal [ncbi.nlm.nih.gov]

Furthermore, effective treatment of the underlying disease results in improvement or resolution of the anemia. [hematology.org]

Primary Myelofibrosis

[…] frequency of leukemic blast cells (its degree of leukemicness) and, therefore, its course, than to clonal sideroblastic anemia (‘refractory sideroblastic anemia in the WHO [doi.org]

anemia with excess of blasts (RAEB) or refractory anemia with excess of blasts in transformation (RAEB-t) with an IPSS score of >1.5 (appendix C) Note: Subjects with a secondary [vademecumhematologie.nl]

anemia with ringed sideroblasts associated with marked thrombocytosis (RARS-t) Myelodysplastic syndrome (MDS) Diagnosis of MPN For diagnosis of MPN the criteria include: [news-medical.net]

Acute Monocytic Leukemia

Two had acute monocytic leukemia (AMoL), one had chronic myelomonocytic leukemia, one had refractory anemia, and the other had juvenile chronic myelogenous leukemia. [ncbi.nlm.nih.gov]

(PRCA)赤芽球ろう purpura紫斑 r refractory anemia with excess of blasts (RAEB)移行型芽球増加型不応性貧血 remission induction寛解導入 retrovirus レトロウイルス rouleaux formation連銭形成 s severe combined immunodeficiency [tokyo-med.ac.jp]

Anemia Completed NCT00046930 Phase 3 cytarabine;daunorubicin hydrochloride;zosuquidar trihydrochloride;Placebo 19 Cyproheptadine in Preventing Weight Loss in Children Receiving [malacards.org]

Pancytopenia

Bone marrow aspiration revealed refractory anemia with ringed sideroblasts of myelodysplastic syndrome (MDS). [jstage.jst.go.jp]

[…] and some refractory anemia patients. [cancertherapyadvisor.com]

It has been suggested that some of these cases may just simply be cases of refractory anemia. [mjmsr.net]

Leukemia

anemia with ring sideroblasts associated with marked thrombocytosis 9982/3 Myelodysplastic syndromes Refractory anemia 9980/3 Refractory neutropenia 9991/3 Refractory thrombocytopemia [atlasgeneticsoncology.org]

anemia”). [doi.org]

This category includes the entities of refractory anemia (RA) for those with anemia and only dyserythropoiesis (but in whom ring sideroblasts account for less than 15% of [dx.doi.org]

Chronic Myeloid Leukemia

anemia with excess blasts in transformation [RAEB T] Type 1 Excludes acute exacerbation of chronic myeloid leukemia ( C92.10 ) refractory anemia with excess of blasts not [icd10data.com]

anemia”). [doi.org]

anemia (RA), refractory anemia with ringed sideroblasts (RARS), and refractory anemia with excess blasts (RAEB). 18 Poor-risk cytogenetic abnormalities, including abnormalities [doi.org]

Bone Marrow Metastasis

He had a history of myelodysplastic syndrome and refractory anemia with ringed sideroblasts diagnosed 5 years earlier. [ncbi.nlm.nih.gov]

Bone Marrow Disease

Anemia (RA), all types Renal Cell Carcinoma Retinoblastoma Rhabdomyosarcoma Severe Aplastic Anemia Severe Combined Immunodeficiency (SCID), all sub-types SCI Sickle Cell [bonemarrow.org]

[…] effective in improving blood counts in refractory aplastic anemia. [rarediseases.org]

Refractory anemia with excess blasts : There are too few red blood cells in the blood and the patient has anemia. [cancer.gov]

Philadelphia Chromosome-Positive Chronic Myeloid Leukemia

Le Beau et al. found that the FMS and GM-CSF genes were both deleted from the chromosome 5q- in BM cells in two patients with refractory anemia and del(5)(q15-q33.3) [ 8 ] [omicsonline.org]

anemia with excess of blasts with basophilia, AML with eosinophilia, and acute eosinophilic leukemia, ACSL6 was identified as a fusion partner to ETV6 (OMIM: 600618) in recurrent [omicsonline.org]

[…] and IRF1 (OMIM: 147575) genes at 5q31.1, CSF1R (OMIM: 164770) and PDGFRB (OMIM: 17341) genes at 5q32, and the RPS14 (OMIM: 130620) gene at 5q33.1.6 In single patients with refractory [omicsonline.org]

Chronic Lymphocytic Leukemia

Refractory: CLL does not respond to standard treatments. [rarediseases.org]

Five patients had refractory cytopenia with multilineage dysplasia, and 3 patients had refractory anemia with excess blasts-2 (RAEB-2). [dx.doi.org]

Refractory: CLL does not respond to standard treatments. Causes The exact cause of chronic lymphocytic leukemia is not known. [rarediseases.org]

Multiple Myeloma

The patient in our case study suffered refractory anemia following surgery and 2 cycles of chemotherapy. [ncbi.nlm.nih.gov]

Therefore, when CRC is associated with refractory anemia, we should not only assume that anemia is a classical symptom of CRC, a result of chronic blood loss, nutritional [ncbi.nlm.nih.gov]

These new symptoms drew our attention, and we considered a diagnosis of synchronous primary CRC and MM, with the anemia as a symptom of MM. [ncbi.nlm.nih.gov]

Non-Hodgkin Lymphoma

[edit] Thalassemia Sickle cell anemia Aplastic anemia Fanconi anemia Malignant infantile osteopetrosis Mucopolysaccharidosis Immune deficiency syndromes Autoimmune diseases [en.wikipedia.org]

Non-Hodgkin lymphoma (NHL) (relapsed, refractory) Neuroblastoma Ewing sarcoma Multiple myeloma Myelodysplastic syndromes Gliomas, other solid tumors Non-malignant (non-cancerous [en.wikipedia.org]

[…] are as follows: Malignant (cancerous)[edit] Acute myeloid leukemia (AML) Chronic myeloid leukemia (CML) Acute lymphoblastic leukemia (ALL) Hodgkin lymphoma (HL) (relapsed, refractory [en.wikipedia.org]

Renal Cell Carcinoma

In refractory patients, this scheme has been modified. [cancertherapyadvisor.com]

In patients with prior therapy, three factors have been identified as associated with poor risk: Low performance status Anemia High corrected serum calcium Median overall [cancertherapyadvisor.com]

Sickle Cell Anemia

Because some of the refractory sickle cell anemia patients require stem cell bone marrow transplant, the effects on fertility must be discussed with this treatment as well [oncofertility.northwestern.edu]

Two of the patients had sickle cell anemia [Hb S (HBB: c.20A > T) (β(S)/β(S))] with refractory leg ulcers that required amputations. [ncbi.nlm.nih.gov]

[…] fertility planning and consultation before administration of hydroxyurea in the event that a malignancy occurs as a side effect of this preventative treatment for sickle cell anemia [oncofertility.northwestern.edu]

Hodgkin Lymphoma

[edit] Thalassemia Sickle cell anemia Aplastic anemia Fanconi anemia Malignant infantile osteopetrosis Mucopolysaccharidosis Pyruvate kinase deficiency Immune deficiency [en.wikipedia.org]

Non-Hodgkin lymphoma (NHL) (relapsed, refractory) Neuroblastoma Ewing sarcoma Multiple myeloma Myelodysplastic syndromes Gliomas, other solid tumors Non-malignant (non-cancerous [en.wikipedia.org]

Chronic Kidney Insufficiency

Chronic kidney insufficiency affects a significant number of individuals in the developed countries, particularly the United States. The progressive nature of the disease and a substantial reduction in the quality of life over the period of time are the primary reasons why an early diagnosis is crucial. Anemia,[…] [symptoma.com]

Gastrointestinal Neoplasm

Tumors or cancer of the GASTROINTESTINAL TRACT, from the MOUTH to the ANAL CANAL. PubMed search builder options Subheadings: analysis anatomy and histology blood blood supply cerebrospinal fluid chemical synthesis chemically induced chemistry classification complications congenital cytology diagnosis diagnostic[…] [ncbi.nlm.nih.gov]

Gastrointestinal Hemorrhage

Upper gastrointestinal bleeding (UGIB) is defined as bleeding proximal to the ligament of Treitz. The incidence of acute upper GI bleeding is ~100 per 100,000 adults per year. Upper GI bleeding is twice as common in men as in women and increases in prevalence with age 5. The demographics of the affected individual will[…] [radiopaedia.org]

Chemotherapy

DIAGNOSES: The patient was diagnosed with MDS refractory anemia with excess of blast II and was classified as very high risk according to the revised international prognostic [ncbi.nlm.nih.gov]

Conclusions: Second-line chemotherapy might have poor efficacy to poor-risk patients with refractory-relapsed small-cell lung cancer. [ncbi.nlm.nih.gov]

The most common grade 3 or worse adverse events were hematologic toxicities, including leukopenia (66%), neutropenia (69%), thrombocytopenia (9%) and anemia (22%). [ncbi.nlm.nih.gov]

Menorrhagia

Abstract Hydrothermablation is a new method which could replace the electrosurgical method of endometrial ablation. Some prospective studies were carried out to assess efficacy, safety and tolerability of hydrothermablation in the treatment of recurrent menorrhagias. Hydrothermablation is an intervention with[…] [ncbi.nlm.nih.gov]

Refractory Anemia with Excess Blasts in Transformation

(Also known as/Synonyms) RAEB (Refractory Anemia with Excess Blasts) What is Refractory Anemia with Excess Blasts? [dovemed.com]

anemia, refractory anemia with ringed sideroblasts, refractory anemia with excess blasts, refractory anemia with excess blasts in transformation, and chronic myelomonocytic [medical-dictionary.thefreedictionary.com]

We next assessed hematologic and clinical relevance between refractory anemia with excess blasts (RAEB) and RAEBt patients with PB blasts of > or =5%. [ncbi.nlm.nih.gov]

Myelodysplasia

Refractory anemia with ring sideroblasts (RARS) is a subtype of myelodysplastic syndrome (MDS) characterized by 15% or more ring sideroblasts in the bone marrow according [ncbi.nlm.nih.gov]

anemia (RA) 1 10-20 30-65 10-40 Refractory anemia with ringed sideroblasts (RARS) 1 10-35 34-83 10-35 Refractory anemia with excess blasts (RAEB) 5-20 >50 8-18 25-30 Refractory [web.archive.org]

Reportable disorder s include: MDS, refractory anemia, refractory anemia with excess blasts in transformation, refractory anemia with ring sideroblast s, refractory anemia [seer.cancer.gov]