Create issue ticket

29 Possible Causes for Refractory Insomnia

  • Fatal Familial Insomnia

    Fatal familial insomnia (FFI) is a rare, hereditary prion-protein disease. Methionine-valine polymorphism at codon 129 of the prion-protein gene (PRNP) determines the phenotype in other hereditary prion-protein diseases, but association with the clinical phenotype in FFI remains uncertain. Early clinical findings in FFI[…][ncbi.nlm.nih.gov]

  • Insomnia

    Our patient did not show refractory insomnia early in the disease course, nor demonstrate typical MRI and EEG alterations.[ncbi.nlm.nih.gov] Abstract We report a case with bipolar II disorder having mixed features, in which refractory insomnia persisted.[ncbi.nlm.nih.gov] These findings suggest the efficacy of cognitive behavioral therapy for insomnia for patients with chronic insomnia who are refractory to pharmacotherapy.[ci.nii.ac.jp]

  • Restless Legs Syndrome

    RLS Benzodiazepines Daytime sleepiness; increased risk of falls at night; potential for abuse Can be useful in intermittent RLS, particularly when insomnia is significant[aafp.org] ; may be used with dopamine agonist in patients with refractory RLS Clonazepam (Klonopin) 0.5 mg Zolpidem (Ambien) 5 mg Ergotamine dopamine agonists Same as for non-ergotamine[aafp.org] […] potential for abuse Limited studies of effectiveness, but a reasonable choice in individuals with RLS associated with pain; may be used with dopamine agonist in patients with refractory[aafp.org]

  • Bronchiolitis obliterans with Obstructive Pulmonary Disease

    […] the liver cytochrome P450 oxidase system, significant risk for drug interactions (e.g. ciprofloxacin, cimetidine ) and variable serum concentrations Side effects Severe, refractory[amboss.com] […] nausea and vomiting with abdominal pain Tachycardia ; that may degenerate into arrhythmias with severe intoxication Central nervous system involvement ( tremor ;, agitation, insomnia[amboss.com]

  • Paraneoplastic Syndrome

    […] grimacing”; myoclonic and ballistic movements with limbs; rhythmic contractions of abdominal wall; dystonic movements of the trunk and limbs; opisthotonos-like posture; insomnia[ncbi.nlm.nih.gov] […] hyperthermia Acute personality change, aggressive behavior (seen at a psychiatric center); progressive confusion, decreased level of consciousness; general and partial seizures, refractory[ncbi.nlm.nih.gov]

  • Pulmonary Bullous Emphysema

    […] the liver cytochrome P450 oxidase system, significant risk for drug interactions (e.g. ciprofloxacin, cimetidine ) and variable serum concentrations Side effects Severe, refractory[amboss.com] […] nausea and vomiting with abdominal pain Tachycardia ; that may degenerate into arrhythmias with severe intoxication Central nervous system involvement ( tremor ;, agitation, insomnia[amboss.com]

  • Cluster Headache

    The headache attacks occurred daily while sleeping, thus the patient suffered from insomnia.[ncbi.nlm.nih.gov] We herein report a case of a patient with a cluster headache in which the symptoms were refractory to conventional preventive treatments except for high-dose glucocorticoids[ncbi.nlm.nih.gov]

  • Hypersomnia

    refractoriness.[doi.org] ., REM sleep behavior disorder); in cases of insomnia that do not respond to usual behavioral or pharmacological approaches; and finally, for atypical symptoms or treatment[doi.org]

  • Anti-NMDA Receptor Encephalitis

    Twenty days later, he developed refractory convulsive status epilepticus with admission to Intensive Care Unit.[ncbi.nlm.nih.gov] […] grimacing”; myoclonic and ballistic movements with limbs; rhythmic contractions of abdominal wall; dystonic movements of the trunk and limbs; opisthotonos-like posture; insomnia[ncbi.nlm.nih.gov] We report the case of a 30 year-old male patient who presented with total insomnia followed by episodes of psychomotor restlessness resembling anxiety attacks.[ncbi.nlm.nih.gov]

  • Tic Disorder

    Clonazepam is helpful for light to moderate night-time RLS associated with insomnia.[ncbi.nlm.nih.gov] Gabapentin has shown some effectiveness and opiates are effective for refractory patients (see Vignatelli et al, 2006 for treatment guidelines).[ncbi.nlm.nih.gov]

Further symptoms