She had a history of splenectomy, severe bone disease, and renal involvement, all of which were related to GD and considered as relative contraindications for a lung transplantation
[ncbi.nlm.nih.gov]
In nonneuronopathic type 1, two of the following manifestations must be present for initiation of treatment: hepatic, splenic, cardiac, pulmonary or renal involvement, anemia
[oatext.com]
Renal failure, heart and cerebrovascular involvement reduce survival. A Cochrane review provided little evidence on the use of ERT.
[aetna.com]