Renal Resistance to PTH: Causes & Reasons

Possible Causes for Renal Resistance to PTH

In PHP, there is renal resistance to PTH at the level of the proximal tubule, which leads to less calcium reabsorption. [symptoma.com]

In some cases, paternal 20q disomies have been found. [2, 7] PHP-2 is associated with renal resistance to PTH action and the absence of AHO phenotype; however, the genetic [emedicine.com]

Pseudohypoparathyroidism (PHP) is a spectrum of endocrine disorders defined by the renal resistance to parathyroid hormone (PTH). [symptoma.com]

Pseudohypoparathyroidism Type 2

Pseudohypoparathyroidism type 1b is a disorder of calcium metabolism resulting from renal resistance to PTH, the genetic basis caused by abnormal imprinting and thus expression [endocrine-abstracts.org]

resistance in the renal proximal tubule, i.e. pseudohypoparathyroidism (PHP). [imprinting-disorders.eu]

In some cases, paternal 20q disomies have been found. [2, 7] PHP-2 is associated with renal resistance to PTH action and the absence of AHO phenotype; however, the genetic [emedicine.medscape.com]

Pseudohypoparathyroidism Type 1A

CONTEXT: The biochemical hallmark of pseudohypoparathyroidism type 1a (PHP1a) is resistance to PTH, but based on tissue-specific imprinting of GNAS, PTH resistance may be [ncbi.nlm.nih.gov]

Overview Practice Essentials Pseudohypoparathyroidism (PHP) is a heterogeneous group of rare endocrine disorders characterized by normal renal function and resistance to the [emedicine.medscape.com]

Pseudohypoparathyroidism Type 1B

Abstract Pseudohypoparathyroid type 1b patients are characterized by renal resistance to PTH in the absence of Albright's hereditary osteodystrophy or other endocrine abnormalities [ncbi.nlm.nih.gov]

resistance to PTH in PHP type 1b. [ncbi.nlm.nih.gov]

Pseudohypoparathyroidism Type 1C

PTH 1-84 is also elevated in these patients, with mild elevations being considered a beneficial compensatory response to end organ PTH resistance, which is observed in renal [mayomedicallaboratories.com]

In PHP, kidney consistently demonstrate resistance to the action of PTH, but the skeletal resistance is variable. [4] Renal resistance to PTH results in biochemical hypoparathyroidism [ijoonline.com]

Pseudopseudohypoparathyroidism

[…] that can be caused by hypoparathyrodism renal osteodystrophy pseudohypoparathyroidism (this topic) pseudopseuodohypoparathyroidism mechanism no PTH resistance normal target [step2.medbullets.com]

Acrodysostosis Type 1

resistance to PTH [analyzedirect.com]

Resistance seems to occur only in the proximal renal tubule, while the action of PTH is unimpaired in other target tissues, such as bone and the renal thick ascending limb [ojrd.biomedcentral.com]

Therefore inactivating GNAS mutations on either the paternal or maternal allele result in Gsα deficiency leading to AHO [7] but resistance of target organs to PTH and other [journals.plos.org]

Hypocalcemia

Pseudohypoparathyroidism refers to end-organ resistance that primarily impairs the renal actions of parathyroid hormone (PTH), a key regulator of calcium homeostasis. [ncbi.nlm.nih.gov]

Vitamin D resistance (rickets) - renal tubular dysfunction (Fanconi's syndrome) or receptor defect. PTH resistance - pseudohypoparathyroidism, hypomagnesaemia. [patient.info]

With high PTH levels (secondary hyperparathyroidism) Vitamin D deficiency - due to nutritional lack, malabsorption, liver disease, receptor defects. [patient.info]

Respiratory Alkalosis

However, in humans, chronic respiratory alkalosis induces some degree of renal PTH resistance, mediated by b-adrenergic receptors, which causes a slight hyperphosphatemia [alpfmedical.info]

In chronic states, hypocalcemia is coupled with hyperphosphatemia and renal PTH-resistance. The diagnosis of RA is heavily based on laboratories studies. [symptoma.com]

Short Stature Type Brussels

The GNAS methylation changes are ultimately responsible for resistance to PTH signalling in the proximal renal tubules. [casereports.bmj.com]

However, there is no PTH resistance in the distal renal tubules nor in bone cells; consequently, patients with PHP1B have reduced urinary calcium excretion and can readily [casereports.bmj.com]

Rare Hyperparathyroidism

Pseudohypoparathyroidism is characterised by similar findings but PTH is elevated due to PTH resistance. [ 1 ] PTH is a key calcium-regulating hormone essential for calcium [patient.info]

Low serum calcium and high PTH levels in a patient with normal renal function suggest resistance to PTH action (pseudohypoparathyroidism type 1a, 1b, 1c, or 2) or, very rarely [mayomedicallaboratories.com]

Neonatal Hypocalcemia

Hypomagnesemia Vitamin D deficiency Maternal vitamin D deficiency Malabsorption Renal insufficiency Hepatobiliary disease PTH resistence -- Transient neonatal pseudohypoparathyroidism [authorstream.com]

High iPTH levels are found in patients with vitamin D deficiency or insensitivity, PTH resistance due to loss-of-function mutations of PTHRl or GNAS, or impaired renal function [clinicaladvisor.com]

Differential Diagnosis The differential diagnosis of transient neonatal hypocalcemia includes PTH resistance, vitamin D deficiency, and DiGeorge syndrome. 5 PTH increases [consultant360.com]

Hyperaldosteronism

Urinary cyclic adenosine monophosphate (cAMP) excretion did not increase in response to parathyroid hormone (PTH) infusion, indicating renal resistance to PTH. [ncbi.nlm.nih.gov]

Renal potassium wasting, suppressed plasma renin activity, and elevated plasma and urinary aldosterone levels accompanied her hypokalemia, suggesting primary hyperaldosteronism [ncbi.nlm.nih.gov]

Hereditary Neonatal Hyperparathyroidism

Any cause of hypomagnesaemia may lead to reduced secretion of PTH, as well as PTH resistance and hence the clinical picture of HPTH. [endobible.com]

[…] to PTH action, usually when serum magnesium concentrations are 1.0 mg/dL [ 0.5 mmol/L]; magnesium repletion increases PTH concentrations and improves renal calcium conservation [merckmanuals.com]

Autosomal Dominant Osteosclerosis Type Worth

resistance to parathyroid hormone (PTH). [mafiadoc.com]

Patients with PHP-Ib usually do not have features of AHO; renal resistance to PTH is the main feature of the condition, occurring with sporadic or autosomal dominant (AD) [mafiadoc.com]

While the renal proximal tubules are resistant to PTH in PHP-Ib, Gsa is derived in osteoblasts from both parental alleles, giving rise to PTH responsiveness at the DOI: 10.1530 [mafiadoc.com]

Osteosclerosis

(PTH). [ncbi.nlm.nih.gov]

Pseudohypoparathyroidism (PHP) is a heterogeneous disorder characterized by hypocalcemia and hyperphosphatemia resulting from selective renal resistance to parathyroid hormone [ncbi.nlm.nih.gov]

Primary Hypomagnesemia with Secondary Hypocalcemia

Hypomagnesemia leads to secondary hypoparathyroidism through a combination of impaired PTH secretion and end-target resistance ( 2 ). [clinchem.aaccjnls.org]

[…] deficiency or resistance Vitamin D deficiency or resistance Patients with burns & renal dysfunction may be at risk for this disorder Systemic Involvement [2] Acute hypocalcemia [physio-pedia.com]

Ca++ absorption and PO43- excretion • Stimulates osteoclastic resorption of bone Hypocalcemia • Decreased PTH – Surgery – Hypomagnesemia – Idiopathic • Resistance to PTH [studyslide.com]

Slipped Capital Femoral Epiphysis

Pseudohypoparathyroidism (PHP) type 1b is a rare childhood disorder characterized by renal resistance to parathyroid hormone (PTH) resulting in biochemical hypoparathyroidism [ncbi.nlm.nih.gov]

Tibia Varum

Subtype Ib: Mainly renal resistance to PTH. Considered as sporadic, although familial cases have been reported. [posterng.netkey.at]

[…] osteodystrophy - hypophosphatemic vitamin d-resistant rickets ; - vitamin-D deficiet rickets: - may see hypophosphatemia, low level of vitamin D, and normal level of PTH [wheelessonline.com]

Subtype Ia: Resistance to PTH and other hormones that stimulate adenyl cyclase in their target tissues, such as TSH. [posterng.netkey.at]

Osteoma

Classically, it presents with pseudohypoparathyroidism (elevated parathyroid hormone [PTH], hypocalcemia, hyperphosphatemia secondary to renal PTH resistance). [emedicine.com]

Hypercalcemic Nephropathy

[…] and skeletal resistance to parathyroid hormone (pth) and designated as "pseudohypoparathyroidism." albright later defined a normocalcemic variant which he termed "pseudopseudohypoparathyroidism [icd9data.com]

[…] associated with short stature, obesity, short metacarpals, and ectopic calcification Originally reported as a hypocalcemic syndrome similar to hypoparathyroidism, but with renal [icd9data.com]

Vitamin D-Dependent Rickets

Hypomagnesemia can cause hypocalcemia through either decreased production of PTH or resistance to PTH action. [endocrinologyadvisor.com]

resistance An abnormal calcium sensing receptor Impaired renal function. [adc.bmj.com]

Secondary Hyperparathyroidism

[…] to PTH with declining renal function.As PTH secretion is stimulated by hyperphosphatemia and vitamin D deficiency, control of secondary hyperparathyroidism begins with the [touchendocrinology.com]

Secondary hyperparathyroidism is due to resistance to the actions of PTH, usually due to gastroinestinal diseases or chronic renal failure. [flexikon.doccheck.com]

[…] hyperparathyroidism Dialysis patients may have discrete, punched out bone lesions with minimal resorption or osteoblast activity ( Am J Surg Pathol 1987;11:205 ) Etiology Renal [pathologyoutlines.com]

Hypoparathyroidism

[…] synthesis, or resistance to PTH in the proximal renal tubule. [hypoparaanswers.com]

Hypomagnesemia causes resistance to PTH. [aacc.org]

It is characterized by insensitivity to the biological activity of PTH (PTH resistance) with resultant low calcium, high phosphate, and high serum PTH. [clinicaladvisor.com]

Osteitis Fibrosa Cystica

We describe a 36-year-old man with sporadic PHP-Ib with renal PTH-resistance, yet severe hyperparathyroid bone disease. [endocrine-abstracts.org]

In addition, patients with normocalcemic hyperparathyroidism may be manifesting bone and renal tubular resistance to the normal actions of PTH. [emedicine.medscape.com]

renal function, contributing to the skeletal resistance to PTH [ 57, 59 ]. [doi.org]

Disorder of Phosphorus Metabolism

Parathyroid failure and resistance to PTH are, therefore, important causes of hyperphosphatemia due to increased renal phosphorus reabsorption. [healio.com]

Pseudohypoparathyroidism is characterised by similar findings but PTH is elevated due to PTH resistance. [ 1 ] PTH is a key calcium-regulating hormone essential for calcium [patient.info]

PTH is usually normal in those with normal renal function but is elevated in those with chronic kidney disease or those with resistance to parathyroid hormone. [renalandurologynews.com]

Tropical Spastic Paraparesis

resistance for external PTH was examined from urinary cAMP excretion in response to 100 units of human recombinant PTH 1–34 (Asahi Chemical Ind., Tokyo, Japan) (E-H test) [dx.doi.org]

Clinical and laboratory findings of the short stature patients with human T-lymphotrophic virus type 1–(HTLV-1–) associated myelopathy/tropical spastic paraparesis The renal [dx.doi.org]

Hypomagnesemia

[…] to cardioversion) ECG Changes similar to hypokalemia Digitalis toxicity Metabolic Resistant hypocalcaemia Resistant hypokalaemia PTH resistance Vit D deficiency INVESTIGATIONS [lifeinthefastlane.com]

[…] to cardioversion) ECG Changes similar to hypokalemia Digitalis toxicity Metabolic Resistant Hypocalcemia Resistant hypokalemia PTH resistance Vit D deficiency INVESTIGATIONS [lifeinthefastlane.com]

Hypomagnesemia leads to secondary hypoparathyroidism through a combination of impaired PTH secretion and end-target resistance ( 2 ). [clinchem.aaccjnls.org]

Macrocephaly

PHP1b is characterized by PTH resistance of the renal cortex due to reduced activity of the stimulatory G protein α subunit (Gsα) of the PTH receptor. [ncbi.nlm.nih.gov]

Pseudohypoparathyroidism (PHP) is a genetic disorder with resistance to parathyroid hormone (PTH) as most important feature. [ncbi.nlm.nih.gov]

In addition to resistance to PTH, PHP1a patients also lack sensitivity for other hormones that signal their actions through G protein-coupled receptors and display physical [ncbi.nlm.nih.gov]

Hyperphosphatemia

Treatment with vitamin D and calcium help to improve resistance of renal tubular cells to PTH (7). [turkjem.org]

[…] to exclude hypoparathyroidism or pseudohypoparathyroidism, which is end-organ resistance to parathyroid hormone (PTH). [merckmanuals.com]

In the case presented here, presence of high serum phosphate on admission can be explained by resistance of renal tubular cells to PTH which is seen in early stages of vitamin [turkjem.org]