Renal Tubular Cell Atrophy: Causes & Reasons

Possible Causes for Renal Tubular Cell Atrophy

By renal histology the 3 forms of the disease are indistinguishable, all 3 exhibiting a triad of interstitial-cell infiltrates, renal tubular-cell atrophy with cysts arising [ncbi.nlm.nih.gov]

[…] histology (tubular atrophy, interstitial fibrosis, cell infiltration). [sjkdt.org]

[…] from the corticomedullary junction of the kidneys, and renal interstitial fibrosis (Waldherr et al., 1982). [ncbi.nlm.nih.gov]

Nephronophthisis Type 1

[…] histology (tubular atrophy, interstitial fibrosis, cell infiltration). [sjkdt.org]

[…] from the corticomedullary junction of the kidneys, and renal interstitial fibrosis (Waldherr et al., 1982). [ncbi.nlm.nih.gov]

Familial Juvenile Hyperuricemic Nephropathy Type 1

[…] histology (tubular atrophy, interstitial fibrosis, cell infiltration). [sjkdt.org]

[…] membrane disintegration, tubular atrophy with cyst development and interstitial cell infiltration with fibrosis [ 4 ]. [link.springer.com]

On the other hands, medullary cysts have been recently reported in patients with FJHN. [37], [38] Finally, interstitial fibrosis, tubular atrophy, and infiltration of the [sjkdt.org]

Nephronophthisis-Like Nephropathy

[…] histology (tubular atrophy, interstitial fibrosis, cell infiltration). [sjkdt.org]

[…] membrane disintegration, tubular atrophy with cyst development and interstitial cell infiltration with fibrosis [ 4 ]. [bmcmedgenet.biomedcentral.com]

On the other hands, medullary cysts have been recently reported in patients with FJHN. [37], [38] Finally, interstitial fibrosis, tubular atrophy, and infiltration of the [sjkdt.org]

Senior-Boichis Syndrome

[…] histology (tubular atrophy, interstitial fibrosis, cell infiltration). [sjkdt.org]

On the other hands, medullary cysts have been recently reported in patients with FJHN. [37], [38] Finally, interstitial fibrosis, tubular atrophy, and infiltration of the [sjkdt.org]

[…] interstitium by inflammatory cells are characteristic of MCKD and also seen in FJHN. [sjkdt.org]

Focal Segmental Glomerulosclerosis Type 6

1. Peña A, Mendizabal S. Sindrome nefrótico en la edad pediátrica. Asociación Española de Pediatría. Protocolos Diagnóstico Terapeúticos de la AEP: Nefrología Pediátrica. 2008; URL disponible en: https://www.aeped.es/sites/default/files/docu- mentos/14_3.pdf 2. Gordillo R, Spitzer A. The nephrotic syndrome. Pediatr Rev.[…] [revistas.unilibre.edu.co]

Medullary Cystic Kidney Disease Type 1

BIBLIOGRAFÍA 1. Bleyer AJ, Kmoch S. Autosomal dominant tubulointerstitial kidney disease: Of names and genes. Kidney Int. 2014;86:459-61. [ Links ] 2. Hodgkins KS, Schnaper HW. Tubulointerstitial injury and the progression of chronic kidney disease. Pediatr Nephrol. 2012;27:901-9. [ Links ] 3. Bollée G, Dahan K, Flamant M,[…] [scielo.isciii.es]

Arima Syndrome

Masayuki Itoh Masayuki Itoh Correspondence Corresponding author. Tel.: +81 423412712. Affiliations Consortium of Clinical and Basic Research for Arima Syndrome, Japan Department of Mental Retardation and Birth Defect Research, National Center of Neurology and Psychiatry, Kodaira, Japan Yuji Iwasaki Yuji Iwasaki[…] [brainanddevelopment.com]

Nephrotic Syndrome Type 1

Open Access Educational Feature First Online: 30 October 2007 Abstract Congenital nephrotic syndrome (CNS) is a rare kidney disorder characterized by heavy proteinuria, hypoproteinemia, and edema starting soon after birth. The majority of cases are caused by genetic defects in the components of the glomerular[…] [link.springer.com]

Senior-Løken Syndrome Type 7

renal tubular cell atrophy with cyst development, and renal interstitial fibrosis.[15] Primary management depends on delaying the progression of renal failure and the need [iap-kpj.org]

[…] years, although late onset in the third decade has also been reported.[13] The ultrasonographic findings of juvenile nephronophthisis may be normal or may show increased renal [iap-kpj.org]

[…] parenchymal echogenicity, poor corticomedullary differentiation, a small kidney, or medullary cysts.[14] Renal histology is characterized by the triad of interstitial infiltration [iap-kpj.org]

BK Virus Nephropathy

The pathogenesis of BKVN is characterized by high grade BKV replication in renal-tubular epithelial cells of renal allograft. [scielo.isciii.es]

Necrosis of tubular cells let BKV leak into the tissue and blood, and then inflammatory cell infiltration to interstitium occurs. [scielo.isciii.es]

This leads to tubular atrophy, interstitial fibrosis and therefore impaired graft function. [scielo.isciii.es]

Senior-Løken Syndrome Type 4

renal tubular cell atrophy with cyst development, and renal interstitial fibrosis.[15] Primary management depends on delaying the progression of renal failure and the need [iap-kpj.org]

[…] years, although late onset in the third decade has also been reported.[13] The ultrasonographic findings of juvenile nephronophthisis may be normal or may show increased renal [iap-kpj.org]

Senior-Løken Syndrome Type 6

renal tubular cell atrophy with cyst development, and renal interstitial fibrosis.[15] Primary management depends on delaying the progression of renal failure and the need [iap-kpj.org]

[…] years, although late onset in the third decade has also been reported.[13] The ultrasonographic findings of juvenile nephronophthisis may be normal or may show increased renal [iap-kpj.org]

Senior-Løken Syndrome Type 1

renal tubular cell atrophy with cyst development, and renal interstitial fibrosis.[15] Primary management depends on delaying the progression of renal failure and the need [iap-kpj.org]

[…] years, although late onset in the third decade has also been reported.[13] The ultrasonographic findings of juvenile nephronophthisis may be normal or may show increased renal [iap-kpj.org]

Senior-Løken Syndrome Type 3

renal tubular cell atrophy with cyst development, and renal interstitial fibrosis.[15] Primary management depends on delaying the progression of renal failure and the need [iap-kpj.org]

[…] years, although late onset in the third decade has also been reported.[13] The ultrasonographic findings of juvenile nephronophthisis may be normal or may show increased renal [iap-kpj.org]

Senior-Løken Syndrome Type 5

renal tubular cell atrophy with cyst development, and renal interstitial fibrosis.[15] Primary management depends on delaying the progression of renal failure and the need [iap-kpj.org]

[…] years, although late onset in the third decade has also been reported.[13] The ultrasonographic findings of juvenile nephronophthisis may be normal or may show increased renal [iap-kpj.org]

Medullary Cystic Kidney Disease

[…] triad of tubular basement membrane disintegration, tubular atrophy with cyst development, and interstitial cell infiltration with fibrosis. [ncbi.nlm.nih.gov]

The disease variants also have in common a characteristic renal histologic triad of tubular basement membrane disintegration, tubular atrophy with cyst development, and interstitial [ncbi.nlm.nih.gov]

A renal biopsy revealed tubular atrophy, and immunohistochemical staining of the tissue for uromodulin (Tamm Horsfall protein) revealed dense deposits in renal tubular cells [ncbi.nlm.nih.gov]

Nephronophthisis 12

[…] histology (tubular atrophy, interstitial fibrosis, cell infiltration). [sjkdt.org]

[…] from the corticomedullary junction of the kidneys, and renal interstitial fibrosis (Waldherr et al., 1982). [ncbi.nlm.nih.gov]

Nephronophthisis 9

[…] histology (tubular atrophy, interstitial fibrosis, cell infiltration). [sjkdt.org]

[…] from the corticomedullary junction of the kidneys, and renal interstitial fibrosis (Waldherr et al., 1982). [ncbi.nlm.nih.gov]

Nephronophthisis Type 2

[…] histology (tubular atrophy, interstitial fibrosis, cell infiltration). [sjkdt.org]

[…] from the corticomedullary junction of the kidneys, and renal interstitial fibrosis (Waldherr et al., 1982). [ncbi.nlm.nih.gov]

Tubular Aggregate Myopathy

Kidney biopsy revealed chronic tubulointerstitial nephritis (TIN), consisting of focal mononuclear cell infiltration with tubulitis, interstitial fibrosis and tubular atrophy [ci.nii.ac.jp]

Her laboratory data, lip biopsy and muscle biopsy findings were compatible with hypokalemic myopathy due to renal tubular acidosis (RTA) type I associated with primary Sjögren's [ci.nii.ac.jp]

Immunohistochemical analysis of the renal biopsy specimens showed that the infiltrating mononuclear cells were predominantly CD8 + T cells, and CD68 + cells (macrophages), [ci.nii.ac.jp]

Nephronophthisis

[…] from the corticomedullary junction of the kidneys, and renal interstitial fibrosis (Waldherr et al., 1982). [ncbi.nlm.nih.gov]

Hypokalemic Nephropathy

Typical renal biopsy will show interstitial nephritis, fibrosis, tubular atrophy and cyst formation. The pathogenesis of hypokalemic nephropathy is not clear. [renalfellow.blogspot.com]

Histologically:- tubular atrophy, interstitial infiltration of macrophages, and fibrosis Ref: http://www.ncbi.nlm.nih.gov/pubmed/18178802 http://www.ncbi.nlm.nih.gov/pubmed [nephronpower.com]

In other parenchymal areas there is inflammation, interstitial fibrosis and tubular atrophy. [kidneypathology.com]

Nephronophthisis 13

[…] histology (tubular atrophy, interstitial fibrosis, cell infiltration). [sjkdt.org]

[…] from the corticomedullary junction of the kidneys, and renal interstitial fibrosis (Waldherr et al., 1982). [ncbi.nlm.nih.gov]

Radiation Nephritis

Repeated infiltration by inflammatory cells leads to fibrosis, tubular atrophy and loss of renal function. [news-medical.net]

These crystals (arrow 1), varying in size, were surrounded by foreign body giant cells. Note the presence of areas of tubular atrophy and fibrosis (arrow 2). 93. [slideshare.net]

[…] disease Chronic tubulointerstitial nephritis (TIN) is more common than acute TIN Renal Biopsy: small lymphocytes, plasma cells and monocytes in the interstitium with tubular [renalandurologynews.com]

Disorders of Amino-Acid Transport

[…] injury cast formation is relatively minor in some pt. degree of renal failure correlates best with tubular damage & atrophy Reabsorption of filtered light chain into tubular [slideplayer.com]

Dense intratubular casts are shown, with accompanying tubular cell atrophy (H&E, x200). 9. [slideshare.net]

Renal tubules demonstrated more than 50% tubular atrophy. [bmcnephrol.biomedcentral.com]

Senior-Løken Syndrome

renal tubular cell atrophy with cyst development, and renal interstitial fibrosis.[15] Primary management depends on delaying the progression of renal failure and the need [iap-kpj.org]

[…] years, although late onset in the third decade has also been reported.[13] The ultrasonographic findings of juvenile nephronophthisis may be normal or may show increased renal [iap-kpj.org]

Nephronophthisis 4

Histologically, the disease is characterized by disrupted tubular basement membrane structure, renal tubular cell atrophy, interstitial fibrosis and cyst formation. [grantome.com]

[…] histology (tubular atrophy, interstitial fibrosis, cell infiltration). [sjkdt.org]

Nephronophthisis (NPHP), an autosomal-recessive cystic kidney disease, constitutes the most frequent genetic cause of chronic renal failure in the first two decades of life [grantome.com]

Ureteral Obstruction

UUO induced monocyte renal infiltration, tubular cell apoptosis, tubular atrophy, interstitial fibrosis and overexpression of TGFβ, Renin mRNA (RENmRNA), increase of Renin [ncbi.nlm.nih.gov]

Both lisinopril (ACEi) and MSC treatment prevented monocyte infiltration, reduced tubular cell apoptosis, renal fibrosis and TGFβ expression. [ncbi.nlm.nih.gov]

Renal Artery Stenosis

[…] of tubular cells  Fibrosis of the capillary tuft  Intra-renal arterial medial thickening. 6. [slideshare.net]

Structural changes Chronic ischemia in RAS results in structural changes at the tubular level of the kidneys, which include atrophy of tubular cells, fibrosis, inflammation [symptoma.com]

The post-stenotic kidney demonstrates a mixture of vascular sclerosis, tubular atrophy, interstitial fibrosis, cholesterol crystals, inflammatory cells and focal or global [pmj.bmj.com]