Responsive to Treatment: Causes & Reasons

Possible Causes for Responsive to Treatment

Chronic Phase of Chronic Myeloid Leukemia

Despite significant advances in CML treatment enabled by the TKIs, a fraction of patients who receive frontline treatment with a TKI demonstrate inadequate response. [ncbi.nlm.nih.gov]

Despite the remarkable responses to treatment of most patients, a small but significant fraction of them develop clinical resistance to the tyrosine kinase inhibitors (TKIs [ncbi.nlm.nih.gov]

CML patients who received imatinib treatment for at least 3 years and sustained deep molecular response for at least 2 years were eligible. [ncbi.nlm.nih.gov]

Aromatic L-Amino Acid Decarboxylase Deficiency

[…] to Treatment}, author={Majid Alfadhel and Rana F. [semanticscholar.org]

Two groups, one with predominant male sex and favorable response to treatment, and the other with predominant female sex and poor response to treatment, can be discerned. [ncbi.nlm.nih.gov]

Most patients are bed ridden for life, with little response to treatment. [zora.uzh.ch]

Classic Paraneoplastic Limbic Encephalitis

Anti-Ma2 encephalitis is outstanding among other PNS associated with classical antibodies in that the response rate to treatment is relatively high. [unboundmedicine.com]

[…] severe neurological deficits or death in a substantial proportion of the patients, approximately one-third show neurological improvement and another 20 - 40% stabilize in response [ncbi.nlm.nih.gov]

While the disorders related to the first category of antibodies associate with cancer (lung, testis and other), prominent brain infiltrates of T-cells, and limited response [jstage.jst.go.jp]

Chronic Inflammatory Demyelinating Polyneuropathy

Because of the propensity for relapse, CIDP requires maintenance therapy after the initial response to treatment. [ncbi.nlm.nih.gov]

[…] despite having similar treatment response rates. [journals.plos.org]

Although most patients show a gratifying early response to treatment, in many cases the patients relapse. [ncbi.nlm.nih.gov]

Confluent and Reticulated Papillomatosis

Diagnosis is primarily clinical, based on the appearance of the lesions, the areas affected, and the response to treatment with minocycline. [ncbi.nlm.nih.gov]

Our case showed a satisfactory response to treatment with azithromycin. [ncbi.nlm.nih.gov]

OBJECTIVE/METHODS: To describe the clinical and histopathological findings, as well as response to treatment of all patients diagnosed with CRP at the American University [ncbi.nlm.nih.gov]

Eosinophilic Fasciitis

At a mean follow up of 17.6 months (range 2-94 months), 8 patients had a good response to treatment, 2 patients had no effect, and 2 patients had a poor response to treatment [ncbi.nlm.nih.gov]

At a mean follow up of 17.6 months (range 2–94 months), 8 patients had a good response to treatment, 2 patients had no effect, and 2 patients had a poor response to treatment [doi.org]

MRI provides a useful aid for diagnosis and a marker for disease activity and response to treatment. [ncbi.nlm.nih.gov]

Hairy Cell Leukemia

Three patients had a complete remission, and four had a partial remission, according to strict criteria for a response. [ncbi.nlm.nih.gov]

Twelve patients who had previously undergone splenectomy showed a similar response to treatment, with a pre-treatment value of 180.0 mg/dl and a post-treatment value of 219.8 [ncbi.nlm.nih.gov]

Responses were independent of treatment schedule and dose given. 32 Six of 58 patients (5 of 5 treatment failures and 1 of 53 beneficial responses) progressed and required [doi.org]

Hairy Cell Leukemia Variant

HCL-V has a poor response to treatment and a shorter survival. [e-immunohistochemistry.info]

However, if the patient is symptomatic and needs intervention, HCL is especially responsive to treatment. [encyclopedia.com]

[…] or treatment failure Variant #2 Note: patients who had complete response before 6 months were given 2 additional cycles of pentostatin, and then treatment was stopped. [hemonc.org]

Chronic Hepatitis C

PSI-7977: ELECTRON Interferon is not required for Sustained Virologic Response in Treatment-Naïve Patients with HCV GT2 or GT3 Reported by jules Levin AASLD Nov 5-9 2011 SF [natap.org]

AIMS: To investigate lipid and apolipoprotein profile in chronic HCV patients according to treatment response. [ncbi.nlm.nih.gov]

Lipid profile changes and IR were analyzed at baseline and after the end of treatment, and any effect of these changes on the response to treatment was studied. [ncbi.nlm.nih.gov]

Autoimmune Hepatitis

OBJECTIVES: The aim of this study is to describe the demographic, clinical and laboratory characteristics of the patients; the treatment and the response to it, the evolution [ncbi.nlm.nih.gov]

The majority of patients require life-long immunosuppression and incomplete treatment response is associated with a disease progression. [ncbi.nlm.nih.gov]

RESULTS: Patients were classified into two groups; group A showed a complete response to therapy (n=22; 61%) and group B showed partial response/treatment failure (n=14; 39% [ncbi.nlm.nih.gov]

Bone Lymphoma

[…] clinical response to treatment. [oncology.medicinematters.com]

Medical records of 7 patients with PBL were reviewed and information on age at diagnosis, sex, NHL clinical staging (CS), treatment and response to treatment were retrieved [ncbi.nlm.nih.gov]

[…] to treatment. [ncbi.nlm.nih.gov]

Multifocal Motor Neuropathy

[…] to treatment. [thieme-connect.com]

Multifocal motor demyelinating neuropathy is an acquired immune-mediated neuropathy with distinctive clinical and electrophysiologic manifestations, and response to treatment [ncbi.nlm.nih.gov]

Genetic variation in the FcRn gene was not associated with ΔIgG levels or response to treatment. [ncbi.nlm.nih.gov]

Primary Central Nervous System Vasculitis

They can be used to document the extent and type of lesions, to gauge response to treatment, and sometimes as surrogates for brain biopsy. [ncbi.nlm.nih.gov]

We analyzed treatments, treatment responses, and factors predictive of outcomes. [ncbi.nlm.nih.gov]

The size of the affected vessels varies and determines outcome and response to treatment. [ard.bmj.com]

Late Latent Syphilis

[…] a specimen aken on the day that treatment is started as this provides an accurate baseline for monitoring response to treatment. [bashhguidelines.org]

Monitoring response to treatment. [neuroweb.us]

(d) Tests for monitoring the effect of treatment A quantitative RPR/VDRL test is recommended for monitoring the serological response to treatment and should be performed on [bashhguidelines.org]

Episcleritis

Thus, previous exposure to tobacco did not have an effect on treatment response. [doi.org]

Smoking delays the response to treatment in episcleritis and scleritis. [nature.com]

Information about smoking habits was obtained after determining the patient's response to treatment. [doi.org]

Leptomeningeal Metastasis

Cerebrospinal fluid cytology is currently the gold standard for diagnosis of LM and assessment of treatment response, but it has relatively low sensitivity. [ncbi.nlm.nih.gov]

They compared the molecular profiles of 8 control patients without LMM to 8 patients with LMM, including one LMM patient who had an extraordinary response to treatment and [sciencedaily.com]

treatment. [ascopost.com]

Chronic Myeloid Leukemia

OBJECTIVES: The monitoring of response in chronic myeloid leukemia (CML) is of great importance to identify patients failing their treatment in order to adjust TKI choice [ncbi.nlm.nih.gov]

Imatinib dose was increased from 400 to 800 mg with good response. [ncbi.nlm.nih.gov]

Among patients with CML receiving therapy, PCR levels will drop below 0.1%, indicating a strong response to treatment, in approximately one-third. [hematologyandoncology.net]

Chronic Immune Thrombocytopenic Purpura

Fifteen patients who were non-responsive to Hp eradication treatment, immunosuppressive treatment or danazol treatment are still being monitored without any treatment. [ncbi.nlm.nih.gov]

Response to treatment included ‘Complete Response (CR) and Response (R) categories’. [ghrnet.org]

Out of 30 children, 12 (40%) had a complete response, and 3 (10%) showed response to dapsone, while as 15 children (50%) showed no response to treatment. [jahjournal.org]

Penile Intraepithelial Neoplasia

[…] to treatment of BP depends on the integrity of the immune system. [wwww.unboundmedicine.com]

John Paoli, Annika Ternesten Bratel, Gun-Britt Löwhagen, Bo Stenquist, Ola Forslund and Ann-Marie Wennberg DOI: 10.2340/00015555-0130 Failure of response to treatment or recurrent [medicaljournals.se]

[…] to treatment or recurrent disease is often noted in patients with penile intraepithelial neoplasia. [semanticscholar.org]

Lupus Nephritis WHO Class 1

Urine cytokines as predictors of treatment response The relationship between baseline cytokine levels and response to induction treatment at 6 months in proliferative LN [journals.plos.org]

Anti-ds DNA levels should fall in response to treatment. Serum creatinine levels should fall in response to treatment and glomerular filtration rate should rise. [cancertherapyadvisor.com]

The literature outlines LP as a spectrum, from MM to FSGS, with worse response to treatment in patients with FSGS. [1] As demonstrated in our cohort of predominantly ethnic [acrabstracts.org]

Biotin-Responsive Basal Ganglia Disease

TY - JOUR T1 - Teaching NeuroImages: MRI findings of biotin-responsive basal ganglia disease before and after treatment. [wwww.unboundmedicine.com]

Abstract Archives of the RSNA, 2013 SSQ17-05 Biotin-responsive Basal Ganglia Disease (BBGD): Neuroimaging Features before and after Treatment Scientific Formal (Paper) Presentations [archive.rsna.org]

"Teaching NeuroImages: MRI Findings of Biotin-responsive Basal Ganglia Disease Before and After Treatment." Neurology, vol. 86, no. 7, 2016, pp. e71-2. [wwww.unboundmedicine.com]

Chronic Active Hepatitis B

RESULTS: Nine patients had a complete response to treatment with interferon alfa (loss of hepatitis B surface antigen), 26 had a partial response (permanently HBV-DNA negative [ncbi.nlm.nih.gov]

[…] of the response to treatment. [ncbi.nlm.nih.gov]

A transient rise in transaminases (seroconversion hepatitis) was seen in responders, but levels returned to within the normal range after response to treatment. [ncbi.nlm.nih.gov]

Folliculotropic Mycosis Fungoides

Multiple different treatment approaches may be needed to achieve a good clinical response and to prevent disease progression. [ncbi.nlm.nih.gov]

Looking at mycosis fungoides patients, best skin response to treatment on mSWAT increased over time. [ascopost.com]

The objective was to assess the clinical features, risk factors for progression, long-term outcome and response to treatment modalities in a large cohort of FMF patients. [ncbi.nlm.nih.gov]

Aggressive Systemic Mastocytosis

We present a case report of ASM to demonstrate the clinical presentation, laboratory findings, and therapeutic response to treatment. [ncbi.nlm.nih.gov]

In the current article, we propose surrogate markers and treatment response criteria for patients with ASM. [ncbi.nlm.nih.gov]

Standards and standardization in mastocytosis: consensus statements on diagnostics, treatment recommendations and response criteria. [rarediseases.org]

Cutaneous Metastasis in Breast Cancer

The prognosis of cancer breast with CM depends primarily on the pathology and biological behavior of the primary tumor and its response to treatment. [ccij-online.org]

The prognosis of the condition depends on the severity of signs and symptoms, the number of organs systems affected, and the response to treatment. [dovemed.com]

CONCLUSION: The response rate of skin metastasis to eribulin treatment was coherent with systemic responses. [ncbi.nlm.nih.gov]

Philadelphia Chromosome-Positive Chronic Myeloid Leukemia

None of the patients with the deletion had a major cytogenetic response to treatment with interferon. [ncbi.nlm.nih.gov]

This is the first report of a patient attaining deep molecular response for P210 and stable CyR for P195 under treatment with bosutinib. [haematologica.org]

CML treatment can be thought of as a series of steps or milestones. » Meet the Milestones that Matter Checkpoints on a Ph+ CML patient’s journey indicate response to treatment [novartisoncology.com]

Axial Spondyloarthritis

Thus, there is a need for further research to improve the ASAS criteria, based on better knowledge of the natural history, etiopathogenesis, and response to treatment of patients [onlinelibrary.wiley.com]

response rates than placebo. [rheumatologynetwork.com]

“The symptoms are the same, and the response to treatment is the same, but we don’t yet know who will progress to radiographic disease.” [creakyjoints.org]

Primary Cutaneous Anaplastic Large-Cell Lymphoma

[…] to treatment in the majority of cases. [ncbi.nlm.nih.gov]

PCALCL was highly responsive to treatment, but the relapse rate was 42%. In all, 3 patients progressed to extracutaneous stage of disease. [ncbi.nlm.nih.gov]

Data collected include initial stage of disease, RT modality (electron/photon), total dose, fractionation, response to treatment, and local recurrence. [ncbi.nlm.nih.gov]

Renal Sarcoidosis

We suggest that the key prognostic factor for renal survival in RS is the early response to treatment. [ncbi.nlm.nih.gov]

[…] mostly rapidly responsive to treatment and remains stable with ongoing treatment [ 10 ]. [academic.oup.com]

As shown in Table 1, most patients had an impressive treatment response, but relapses were frequent. Table 1. [academic.oup.com]

Primary Amyloidosis

Center, for whom data on response 3 months after treatment initiation were available. [doi.org]

Assessment of treatment response Response to treatment is assessed regularly using a number of different tests. [amyloidosis.org.uk]

To identify and assess the clinical features and treatment response of light chain (AL) amyloidosis diagnosed in patients with previous diagnosis of multiple myeloma (MM). [ncbi.nlm.nih.gov]