Responsive to Treatment: Causes & Reasons

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Possible Causes for Responsive to Treatment

Chronic Phase of Chronic Myeloid Leukemia

Despite the remarkable responses to treatment of most patients, a small but significant fraction of them develop clinical resistance to the tyrosine kinase inhibitors (TKIs [ncbi.nlm.nih.gov]

Despite significant advances in CML treatment enabled by the TKIs, a fraction of patients who receive frontline treatment with a TKI demonstrate inadequate response. [ncbi.nlm.nih.gov]

The chronic phase is associated with fewer symptoms and a better response to treatment. [medivizor.com]

Chronic Inflammatory Demyelinating Polyneuropathy

Because of the propensity for relapse, CIDP requires maintenance therapy after the initial response to treatment. [ncbi.nlm.nih.gov]

[…] despite having similar treatment response rates. [journals.plos.org]

Our first aim was to review clinical presentation, course, response to treatment, and prognosis in our childhood patients. [ncbi.nlm.nih.gov]

Chronic Hepatitis C

Lipid profile changes and IR were analyzed at baseline and after the end of treatment, and any effect of these changes on the response to treatment was studied. [ncbi.nlm.nih.gov]

In this report a case of sarcoidosis associated with chronic hepatitis C will be described, with subcutaneous lesions, considered rare, and good response to treatment with [ncbi.nlm.nih.gov]

Figure 1 Virological response to treatment. EOTR, end-of-treatment response; EVR, early virological response; NS, not significant; SVR, sustained virological response. [doi.org]

Classic Paraneoplastic Limbic Encephalitis

Anti-Ma2 encephalitis is outstanding among other PNS associated with classical antibodies in that the response rate to treatment is relatively high. [unboundmedicine.com]

[…] severe neurological deficits or death in a substantial proportion of the patients, approximately one-third show neurological improvement and another 20 - 40% stabilize in response [ncbi.nlm.nih.gov]

While the disorders related to the first category of antibodies associate with cancer (lung, testis and other), prominent brain infiltrates of T-cells, and limited response [jstage.jst.go.jp]

Confluent and Reticulated Papillomatosis

Diagnosis is primarily clinical, based on the appearance of the lesions, the areas affected, and the response to treatment with minocycline. [ncbi.nlm.nih.gov]

Our case showed a satisfactory response to treatment with azithromycin. [ncbi.nlm.nih.gov]

OBJECTIVE/METHODS: To describe the clinical and histopathological findings, as well as response to treatment of all patients diagnosed with CRP at the American University [ncbi.nlm.nih.gov]

Hairy Cell Leukemia

Three patients had a complete remission, and four had a partial remission, according to strict criteria for a response. [ncbi.nlm.nih.gov]

Twelve patients who had previously undergone splenectomy showed a similar response to treatment, with a pre-treatment value of 180.0 mg/dl and a post-treatment value of 219.8 [ncbi.nlm.nih.gov]

Responses were independent of treatment schedule and dose given. 32 Six of 58 patients (5 of 5 treatment failures and 1 of 53 beneficial responses) progressed and required [bloodjournal.hematologylibrary.org]

Bone Lymphoma

[…] clinical response to treatment. [oncology.medicinematters.com]

Medical records of 7 patients with PBL were reviewed and information on age at diagnosis, sex, NHL clinical staging (CS), treatment and response to treatment were retrieved [ncbi.nlm.nih.gov]

[…] to treatment. [ncbi.nlm.nih.gov]

Hairy Cell Leukemia Variant

HCL-V has a poor response to treatment and a shorter survival. [e-immunohistochemistry.info]

However, if the patient is symptomatic and needs intervention, HCL is especially responsive to treatment. [encyclopedia.com]

[…] or treatment failure Variant #2 Note: patients who had complete response before 6 months were given 2 additional cycles of pentostatin, and then treatment was stopped. [hemonc.org]

Autoimmune Hepatitis

OBJECTIVES: The aim of this study is to describe the demographic, clinical and laboratory characteristics of the patients; the treatment and the response to it, the evolution [ncbi.nlm.nih.gov]

RESULTS: Patients were classified into two groups; group A showed a complete response to therapy (n=22; 61%) and group B showed partial response/treatment failure (n=14; 39% [ncbi.nlm.nih.gov]

The heterogeneous nature of this condition means that great variation can be seen in severity, progression of disease and response to treatment within this patient group. [ncbi.nlm.nih.gov]

Multifocal Motor Neuropathy

Genetic variation in the FcRn gene was not associated with ΔIgG levels or response to treatment. [ncbi.nlm.nih.gov]

Multifocal motor demyelinating neuropathy is an acquired immune-mediated neuropathy with distinctive clinical and electrophysiologic manifestations, and response to treatment [ncbi.nlm.nih.gov]

Abstract Multifocal motor neuropathy (MMN) with conduction block is an acquired, autoimmune-mediated neuropathy that is responsive to treatment. [ncbi.nlm.nih.gov]

Primary Central Nervous System Vasculitis

They can be used to document the extent and type of lesions, to gauge response to treatment, and sometimes as surrogates for brain biopsy. [ncbi.nlm.nih.gov]

We analyzed treatments, treatment responses, and factors predictive of outcomes. [ncbi.nlm.nih.gov]

The size of the affected vessels varies and determines outcome and response to treatment. [ard.bmj.com]

Eosinophilic Fasciitis

At a mean follow up of 17.6 months (range 2-94 months), 8 patients had a good response to treatment, 2 patients had no effect, and 2 patients had a poor response to treatment [ncbi.nlm.nih.gov]

MRI is a useful non-invasive tool for establishing the diagnosis, guiding the choice of biopsy site, and monitoring treatment response. [clinicalgate.com]

Bischoff L, Derk CT.Eosinophilic fasciitis: demographics, disease pattern and response to treatment: report of 12 cases and review of the literature.Int J Dermatol. 2008 Jan [malattierare.toscana.it]

Chronic Myeloid Leukemia

[…] to treatment with tyrosine kinase inhibitors in CML patients. [ncbi.nlm.nih.gov]

The patient initiated frontline treatment with dasatinib. A good treatment response was seen initially, with a complete hematologic response by month 2 of treatment. [ncbi.nlm.nih.gov]

CML treatment can be thought of as a series of steps or milestones. » Meet the Milestones that Matter Checkpoints on a Ph+ CML patient’s journey indicate response to treatment [novartisoncology.com]

B-Cell Chronic Lymphocytic Leukemia

[…] and poor response to treatment. [ncbi.nlm.nih.gov]

Response Complete and partial remissions are considered beneficial responses to treatment, whereas stable disease and progressive disease are considered treatment failures [ajmc.com]

During follow-up, aggravation of the kidney disease systematically occurred in the absence of favorable response to hematological treatment. [ncbi.nlm.nih.gov]

Cutaneous Metastasis in Breast Cancer

The prognosis of cancer breast with CM depends primarily on the pathology and biological behavior of the primary tumor and its response to treatment. [ccij-online.org]

CONCLUSION: The response rate of skin metastasis to eribulin treatment was coherent with systemic responses. [ncbi.nlm.nih.gov]

The prognosis of the condition depends on the severity of signs and symptoms, the number of organs systems affected, and the response to treatment. [dovemed.com]

Upper Airway Cough Syndrome

Furthermore, the absence of any of the usual clinical findings does not rule out a response to treatment that is usually effective for PND-induced cough. [ncbi.nlm.nih.gov]

Improvement or resolution of the cough in response to treatment is the pivotal factor in confirming a diagnosis of UACS. [1] Avoidance Establishing the trigger and avoiding [online.epocrates.com]

Aggressive Systemic Mastocytosis

We present a case report of ASM to demonstrate the clinical presentation, laboratory findings, and therapeutic response to treatment. [ncbi.nlm.nih.gov]

In the current article, we propose surrogate markers and treatment response criteria for patients with ASM. [ncbi.nlm.nih.gov]

Standards and standardization in mastocytosis: consensus statements on diagnostics, treatment recommendations and response criteria. [rarediseases.org]

Chronic Active Hepatitis B

RESULTS: Nine patients had a complete response to treatment with interferon alfa (loss of hepatitis B surface antigen), 26 had a partial response (permanently HBV-DNA negative [ncbi.nlm.nih.gov]

[…] of the response to treatment. [ncbi.nlm.nih.gov]

A transient rise in transaminases (seroconversion hepatitis) was seen in responders, but levels returned to within the normal range after response to treatment. [ncbi.nlm.nih.gov]

Trigeminal Autonomic Cephalalgia

Recognition of these clinical differences is paramount because treatment options vary; paroxysmal hemicrania and hemicrania continua demonstrate an absolute response to treatment [journals.lww.com]

METHOD: Hemicrania continua, a continuous, unilateral, side-locked headache, absolutely responsive to preventive treatment with indomethacin, is contrasted with so-called [ncbi.nlm.nih.gov]

The childhood-onset cluster headache was found to be responsive to indomethacin treatment ( Arruda et al 2011 ). [medlink.com]

Chronic Immune Thrombocytopenic Purpura

Response to treatment included ‘Complete Response (CR) and Response (R) categories’. [ghrnet.org]

Out of 30 children, 12 (40%) had a complete response, and 3 (10%) showed response to dapsone, while as 15 children (50%) showed no response to treatment. [jahjournal.org]

Fifteen patients who were non-responsive to Hp eradication treatment, immunosuppressive treatment or danazol treatment are still being monitored without any treatment. [ncbi.nlm.nih.gov]

Philadelphia Chromosome-Positive Chronic Myeloid Leukemia

None of the patients with the deletion had a major cytogenetic response to treatment with interferon. [ncbi.nlm.nih.gov]

This is the first report of a patient attaining deep molecular response for P210 and stable CyR for P195 under treatment with bosutinib. [haematologica.org]

Response to treatment Doctors measure how effective the treatment is based on if there is a major cytogenetic response. [cancer.ca]

Carcinoma in Situ of the Bladder

Results obtained from these metrics were correlated with response to treatment with BCG immunotherapy. [ncbi.nlm.nih.gov]

Complete response to treatment indicated the absence of endoscopic and histological evidence of carcinoma in situ. [ncbi.nlm.nih.gov]

Response to treatment will be determined based on cytology and tissue sample histology findings. [clinicaltrials.gov]

Primary Amyloidosis

Assessment of treatment response Response to treatment is assessed regularly using a number of different tests. [amyloidosis.org.uk]

New agents used in the treatment of multiple myeloma are under investigation and appear to increase hematological response rates. [ncbi.nlm.nih.gov]

Hematologic response to treatment was defined as a 50% or more decrease in serum and urine monoclonal component (MC). [doi.org]

Tropical Sprue

The response to treatment to tetracycline and folic acid has been uniformly successful. [ncbi.nlm.nih.gov]

Treatment of tropical sprue is tetracycline 250 mg po qid for 1 or 2 mo, then bid for up to 6 mo, depending on disease severity and response to treatment. [merck.com]

[…] to treatment with antibiotics Symptoms may appear years after leaving an endemic area and may be relapsing without treatment. [unboundmedicine.com]

Axial Spondyloarthritis

Thus, there is a need for further research to improve the ASAS criteria, based on better knowledge of the natural history, etiopathogenesis, and response to treatment of patients [onlinelibrary.wiley.com]

response rates than placebo. [rheumatologynetwork.com]

“The symptoms are the same, and the response to treatment is the same, but we don’t yet know who will progress to radiographic disease.” [creakyjoints.org]

Folliculotropic Mycosis Fungoides

Multiple different treatment approaches may be needed to achieve a good clinical response and to prevent disease progression. [ncbi.nlm.nih.gov]

Looking at mycosis fungoides patients, best skin response to treatment on mSWAT increased over time. [ascopost.com]

The objective was to assess the clinical features, risk factors for progression, long-term outcome and response to treatment modalities in a large cohort of FMF patients. [ncbi.nlm.nih.gov]

Renal Sarcoidosis

We suggest that the key prognostic factor for renal survival in RS is the early response to treatment. [ncbi.nlm.nih.gov]

[…] mostly rapidly responsive to treatment and remains stable with ongoing treatment [ 10 ]. [academic.oup.com]

As shown in Table 1, most patients had an impressive treatment response, but relapses were frequent. Table 1. [academic.oup.com]

Primary Cutaneous Anaplastic Large-Cell Lymphoma

[…] to treatment in the majority of cases. [ncbi.nlm.nih.gov]

PCALCL was highly responsive to treatment, but the relapse rate was 42%. In all, 3 patients progressed to extracutaneous stage of disease. [ncbi.nlm.nih.gov]

Data collected include initial stage of disease, RT modality (electron/photon), total dose, fractionation, response to treatment, and local recurrence. [ncbi.nlm.nih.gov]

Benign Familial Pemphigus

After active sites of BFP showed good response to treatment, we treated uninvolved skin of the left axilla to assess the efficacy of prophylactic therapy. results Treatment [onlinelibrary.wiley.com]

After active sites of BFP showed good response to treatment, we treated uninvolved skin of the left axilla to assess the efficacy of prophylactic therapy. [ncbi.nlm.nih.gov]

Immune Thrombocytopenic Purpura

Response to treatment was compared using logistic regression. Data were analyzed using SAS V9.2. [ncbi.nlm.nih.gov]

Responses to treatment in immune thrombocytopenic purpura vary among patients. [ncbi.nlm.nih.gov]

No association was encountered between different genotypes and age, hematological parameters, gender, stage of the disease or response to treatment. [ncbi.nlm.nih.gov]