Responsiveness Decreasing: Causes & Reasons

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Possible Causes for Responsiveness Decreasing

Anti-NMDA Receptor Encephalitis

A low dosage of risperidone (0.5 mg b.i.d.) was well tolerated, however, and resulted in improvements in the patient's irritability and an apparently decreased response to [dx.doi.org]

Treatment response has been limited at best, with examples of each agent decreasing symptom burden but also potentially worsening dystonia and other abnormalities of movement [dx.doi.org]

Lorazepam, at a maximum dosage of 1 mg t.i.d., decreased the patient's level of agitation and somewhat improved his sleep. [dx.doi.org]

Multiple Mitochondrial Dysfunctions Syndrome Type 1

reduction of apoptosis and mitochondrial dysfunction, slowing of the cerebral excitatory cascade, decrease of local inflammatory response, reduction of free oxygen radicals [annalsofintensivecare.springeropen.com]

This may be in response to improving environmental conditions, although this has yet to be substantiated. [embomolmed.embopress.org]

[…] production, and decrease of vascular and membrane permeability. [annalsofintensivecare.springeropen.com]

Charcot-Marie-Tooth Disease Type 2T

[…] reflex response Decreased reflexes [ more ] 0001265 Impaired distal tactile sensation Decreased touch sensation in extremities 0006937 Impaired distal vibration sensation [rarediseases.info.nih.gov]

0003693 Distal muscle weakness Weakness of outermost muscles 0002460 EMG: chronic denervation signs 0003444 Hammertoe Hammer toe Hammertoes [ more ] 0001765 Hyporeflexia Decreased [rarediseases.info.nih.gov]

Dominant Intermediate Charcot-Marie-Tooth Disease Type E

Cone Rod Dystrophy Type 8

Additionally, full-field ERG showed decreased photopic and scotopic responses, attesting the damage of both cones and rods (Figure 2). [latunisiemedicale.com]

Decreased scotopic (A), photopic (B) and flicker (C) responses Figure 3. Karyotype. monosomy 45,X References 1. Jacobs PA, Browne C, Gregson N, Joyce C, White H. [latunisiemedicale.com]

Charcot-Marie-Tooth Disease Type 2N

[…] reflex response Decreased reflexes [ more ] 0001265 Peripheral axonal atrophy 0003384 Pes cavus High-arched foot 0001761 Pes planus Flat feet Flat foot [ more ] 0001763 Sensory [rarediseases.info.nih.gov]

[…] formation 0001810 Foot dorsiflexor weakness Foot drop 0009027 Foot osteomyelitis Foot bone infection 0001886 Hammertoe Hammer toe Hammertoes [ more ] 0001765 Hyporeflexia Decreased [rarediseases.info.nih.gov]

Cone Rod Dystrophy Type 6

Additionally, full-field ERG showed decreased photopic and scotopic responses, attesting the damage of both cones and rods (Figure 2). [latunisiemedicale.com]

Decreased scotopic (A), photopic (B) and flicker (C) responses Figure 3. Karyotype. monosomy 45,X References 1. Jacobs PA, Browne C, Gregson N, Joyce C, White H. [latunisiemedicale.com]

Adenylate Kinase Deficiency

Interestingly, this study shows that the response to cannabinoid treatment decreases cell viability which does not involve the caspase-3 cascade. [spandidos-publications.com]

For example, the activation of CB receptors can be responsible for the increase in the level of ceramide or the decrease of cAMP level via inhibition of adenilate cyclase. [spandidos-publications.com]

This event seems to be related to the increase in the level of p8 and CHOP, two factors implicated in ER stress response and apoptosis. [spandidos-publications.com]

Orthostatic Syncope

Decreased baroreceptor responsiveness delays cardioacceleration and peripheral vasoconstriction in response to standing. [msdmanuals.com]

The sudden action of standing up might lead to an abnormal vasomotor response by causing sharp decreases in blood pressure and could result in hypoperfusion of tissues (particularly [symptoma.com]

[…] and a decrease in muscle tone, cardiac and vascular compliance. [ncbi.nlm.nih.gov]

Spinocerebellar Ataxia

[…] muscle tone Low muscle tone [ more ] 0001290 Gliosis 0002171 Head titubation 0002599 Hyporeflexia Decreased reflex response Decreased reflexes [ more ] 0001265 Incoordination [rarediseases.info.nih.gov]

[…] reflex response Decreased reflexes [ more ] 0001265 Late onset 0003584 Nystagmus Involuntary, rapid, rhythmic eye movements 0000639 5%-29% of people have these symptoms Hearing [rarediseases.info.nih.gov]

[…] reflex response Decreased reflexes [ more ] 0001265 Impulsivity Impulsive 0100710 Limb ataxia 0002070 Microsaccadic pursuit 0007792 Parkinsonism 0001300 Postural tremor 0002174 [rarediseases.info.nih.gov]

Progesterone Resistance

[…] the progesterone-response compared with that in cells transfected with only PRB. [molpharm.aspetjournals.org]

[…] by altering Pgr methylation, leading to decreased expression and therefore function of PR. [endofound.org]

Similarly, expression of retinaldehyde dehydrogenase 1 A2 (ALDH1A2), the enzyme responsible for conversion of retinol to RA, is also decreased. [obgyn.onlinelibrary.wiley.com]

Granulosis Rubra Nasi

The authors believe that inflammation around sweat ducts are responsible for decreased sweating and hence, vesicle formation- findings in the late stage of GRN. [ncbi.nlm.nih.gov]

Patient was counseled regarding the disease and poor response to treatment. [ncbi.nlm.nih.gov]

On follow up after three weeks, size of the vesicles had decreased and patient stated no increase in size of the vesicles, even on sun exposure. [ncbi.nlm.nih.gov]

Hypertrophy of the Adrenal Cortex

[…] resulting from hypertrophy of the adrenal cortex include hyperglycemia, decreased immunity, decreased allergic response alarm reaction responses resulting from increased [quizlet.com]

Atrophy is a decrease in cell size or decrease in cell number (apoptosis) in response to a decreased level of stress placed on the cells Now that you have finished this video [stomponstep1.com]

IMMUNE SYSTEM: DECREASE MACROPHAGE RESPONSES TO M. I. F. DECREASE RECEPTORS NUMBER TO I gE www.freelivedoctor.com 18. [slideshare.net]

Lycoperdonosis

Lycoperdonosis is generally treated with corticosteroids, which decrease the inflammatory response; these are sometimes given in conjunction with antimicrobials. [translation.babylon.com]

Lycoperdonosis is generally treated with corticosteroids, which decrease the inflammatory response; these are sometimes given in conjunction with antimicrobials.The disease [en.wikipedia.org]

Respiratory Acidosis

Hypoventilation in COPD involves multiple mechanisms, including decreased responsiveness to hypoxia and hypercapnia, increased ventilation-perfusion mismatch leading to increased [en.wikipedia.org]

Hypoventilation in COPD involves multiple mechanisms, including the following: Decreased responsiveness to hypoxia and hypercapnia Increased ventilation-perfusion mismatch [emedicine.com]

[…] dead space ventilation, and decreased diaphragm function secondary to fatigue and hyperinflation. [en.wikipedia.org]

Amelogenesis Imperfecta Type 2A5

[…] defect- decreased antibody response to OVA+ alum immunization T-dependent humoral response defect- decreased antibody response to rSFV T-independent B cell response defect [mutagenetix.utsouthwestern.edu]

FACS naive CD8 T cells in CD8 T cells - decreased FACS T cells - decreased T-dependent humoral response defect- decreased antibody response to rSFV [mutagenetix.utsouthwestern.edu]

[…] defect- decreased antibody response to OVA+ alum immunization T-dependent humoral response defect- decreased antibody response to rSFV 56 Ltbr 0.117 6 125306571-125313885 [mutagenetix.utsouthwestern.edu]

Childhood Absence Seizures

[…] event onset, followed by small fMRI decreases. [ncbi.nlm.nih.gov]

This time course differed markedly from the hemodynamic response function (HRF) model used in conventional fMRI analysis, consisting of large increases beginning after electrical [ncbi.nlm.nih.gov]

In contrast, we observed small early fMRI increases in the orbital/medial frontal and medial/lateral parietal cortex >5 s before seizure onset, followed by profound fMRI decreases [ncbi.nlm.nih.gov]

Cone Dystrophy Type 3

Additionally, full-field ERG showed decreased photopic and scotopic responses, attesting the damage of both cones and rods (Figure 2). [latunisiemedicale.com]

and predominant involvement of photopic (cones) over scotopic (rods) responses 2. [centogene.com]

Decreased scotopic (A), photopic (B) and flicker (C) responses Figure 3. Karyotype. monosomy 45,X References 1. Jacobs PA, Browne C, Gregson N, Joyce C, White H. [latunisiemedicale.com]

Vagal Tone Increased

[…] ventricular response rate. [pharmacologycorner.com]

In response to some stimuli, vagal activity can decrease, allowing the heart to speed up. This may increase the flow of blood, facilitating the flight or fight response. [wisegeek.org]

Others showed a decreased response to local skin inflammation, decreased stress hormones, and fewer colds. [jonlieffmd.com]

Neuroleptic Malignant Syndrome

Reflex responses tend to be decreased. Hyperthermia: Temperature is usually > 38° C and often > 40° C. [msdmanuals.com]

Complement Factor I Deficiency

IgA deficiency in saliva Decreased antibody response to immunizations Decreased neutrophil chemotaxis Nutritional Deficiencies Malabsorption can lead to zinc deficiency Anatomic [pedemmorsels.com]

The percentage of T-lymphocytes was decreased, and lymphocyte response to alloantigen was impaired. [cdc.gov]

[…] or absent -No antibody response to mitogen (antigen stimulation) -Sex linked -Treatment may include gammaglobulins -Primary -Humoral Immune Deficiencies -Absence of serum [quizlet.com]

Respiratory Alkalosis

Increased plasma lactate levels were responsible for 39% of the decrease in plasma [HCO 3 − ]. [academic.oup.com]

[…] ventilatory responses to hypercarbia and hypoxia, muscle weakness, depressed central respiratory drive, and resultant alveolar hypoventilation. [ncbi.nlm.nih.gov]

[…] of the airways causes decreased O2 to come in. remember, exhaling is a passive process but inhalation is not. [usmleforum.com]

X-Linked Lymphoproliferative Disorder

Suggestive findings include Decreased antibody responses to antigens (particularly to EBV nuclear antigen) Impaired T-cell proliferative responses to mitogens Decreased NK-cell [msdmanuals.com]

Chronic Leukemia

Monitoring Response to TKI Therapy Response to TKI therapy is determined by the measurement of hematologic (normalization of peripheral blood counts), cytogenetic (decrease [jnccn.org]

[…] in the number of Ph-positive metaphases using bone marrow cytogenetics), and molecular responses (decrease in the amount of BCR-ABL1 chimeric mRNA using qPCR). [jnccn.org]

The criteria for hematologic, cytogenetic, and molecular response are summarized in CML-D (page 1115). [jnccn.org]

Primary Open-Angle Glaucoma

The frequency of follow-up examinations varies from weeks to months, depending on the patient’s reliability, severity of the glaucoma, and response to treatment. [msdmanuals.com]

Decreasing intraocular pressure (IOP) 20 to 40% Initially, drugs (eg, prostaglandin analogs such as latanoprost or tafluprost, beta-blockers such as timolol) Sometimes surgery [msdmanuals.com]

Pickwickian Syndrome

Body mass index was not related to CO₂ response. Acetazolamide decreased bicarbonate concentration and increased CO₂ response. [ncbi.nlm.nih.gov]

Patients with COPD who hypoventilate have a decreased chemical responsiveness to hypoxia and hypercapnia. [emedicine.medscape.com]

CONCLUSIONS: Patients with obesity-hypoventilation syndrome and higher bicarbonate concentrations had a more blunted CO₂ response. [ncbi.nlm.nih.gov]

ALS2-Related Disorders

As expected, monocular deprivation led to decreased light responses from the deprived eye, whereas responses from the nondeprived eye increased in the binocular, but not the [eurekalert.org]

Occult Macular Dystrophy

Full-field ERG showed normal photopic and scotopic responses both eyes (OU). Multifocal ERG showed absent responses OD and decreased amplitudes OS (Fig. 3 ). [healio.com]

There were, however, decreased local responses in the central area on multifocal ERG (mfERG). Her color vision, implicit time of mfERG, and visual fields were normal. [keio.pure.elsevier.com]

The response densities are highest at the fovea and decrease sharply in the first 5 degrees (See Figure 1). [reviewofophthalmology.com]

Butterfly-Shaped Pigment Dystrophy

However, this is a generalized retinal disorder as revealed by the abnormal mass response (decreased light/dark ratio) of the electrooculogram (EOG). [disorders.eyes.arizona.edu]

[…] light-activated responses in the RPE. [jax.org]

[…] light-activated responses. [ncbi.nlm.nih.gov]

Light Chain Disease

Hematologic responses to BD were rapid and 2 patients achieved a CR, with a normal FLC ratio while the other 2 had >50% decrease of the involved light chain. [doi.org]

At 6 months post-ASCT, all 6 patients showed organ response manifested mainly by decreased proteinuria of greater than 50%. [emedicine.medscape.com]

We conclude that BD appears to be an active combination that results in rapid hematologic responses, rapid decrease of proteinuria and improvement of renal function in patients [doi.org]