Reticulocytes Increased: Causes & Reasons

Possible Causes for Reticulocytes Increased

Reticulocyte count: Increased Treatment: Splenectomy is indicated for moderate to severe cases, but not mild cases. [medical-labs.net]

HS is associated with splenomegaly (commonly), anaemia (variably) with an increased reticulocyte count, and jaundice (occasionally). [bestpractice.bmj.com]

Reticulocyte count As this is a type of haemolytic anaemia reticulocyte count is usually increased. [medicaljoyworks.com]

Acquired Spherocytosis

A complete blood count (CBC) may show increased reticulocytes, a sign of increased red blood cell production, and decreased hemoglobin and hematocrit. [en.wikipedia.org]

If the reticulocyte count is low, the body is not able to keep up with the increased red blood cell production demands. [ihtc.org]

Results We found early acute normochromic normocytic haemolytic anaemia (4–8 weeks) followed by a late macrocytic hypo‐regenerative anaemia with inappropriate low reticulocyte [deepdyve.com]

Toxic Hemolytic Anemia

Reticulocytes are increased from 5 to 20 % (Reticulocytosis). MCV is normal or slightly increased, MCHC is increased. Bone marrow shows erythroid hyperplasia. [labpedia.net]

Hemolysis, in these patients, usually occurs 24 to 48 hours after exposure and is characterized by diminished hemoglobin and hematocrit, increase in reticulocyte count, increase [path.upmc.edu]

[…] of spherocytes on a smear and increased reticulocytes working to compensate for the hemolysis and resultant anemia. [pedclerk.bsd.uchicago.edu]

Pyruvate Kinase Deficiency

Char10C mice also display a reduction in anemia phenotypes associated with the PklrG338D mutation including decreased splenomegaly, decreased circulating reticulocytes, increased [ncbi.nlm.nih.gov]

As a result of splenectomy, reticulocyte counts often increase and transfusion needs are reduced. [orpha.net]

The increased 2,3-DPG levels ameliorate the anemia by lowering the oxygen-affinity of hemoglobin. [orpha.net]

Leukoerythroblastic Anemia

An increased absolute number of reticulocytes indicates increased marrow erythropoiesis. u. Rouleaux: red cells in stacks, as coins. [kerrybrandis.com]

MCHC • reticulocyte count increased Hereditary Spherocytosis pic - round, dense, no central pallor Features of Hereditary Spherocytosis - splenic sequestration - splenomegaly [quizlet.com]

[…] granulocytes from marginal pools PBS- normocytic normochromic initially, polychromasia >5-7 days Reticulocyte count- increased (10-15%) after 5-7 days Platelets- increased [quizlet.com]

Acquired Toxic Hemolytic Anemia

The complete blood count (CBC) serves as the diagnostic cornerstone, providing the anemic level hemoglobin and hematocrit and the increased reticulocyte count indicative of [accessmedicine.mhmedical.com]

[…] in the Erythropoietin Secretion : increases reticulocyte percentage (and absolute reticulocyte count) -> increases RBC production Reticulocytosis is Found in Most Patients [mdnxs.com]

Examination New onset of pallor and anemia Jaundice Gallstones Splenomegaly +/- hepatomegaly INVESTIGATIONS Confirm haemolysis Increased absolute reticulocyte count LDH (elevation [lifeinthefastlane.com]

Congenital Hemolytic Anemia

As a result of splenectomy, reticulocyte counts often increase and transfusion needs are reduced. [orpha.net]

Laboratory studies show evidence not only of many spherocytes but also increased numbers of reticulocytes (young red blood cells), hyperbilirubinemia (increased blood levels [medicinenet.com]

After partial splenectomy, children overall had decreased transfusion requirements, increased hematocrits, decreased bilirubin levels, decreased reticulocyte counts, and elimination [ncbi.nlm.nih.gov]

Anemia due to Glutathione Metabolism Disorder

Polychromasia : immature red cells on peripheral smear Hemolysis leads to increased reticulocytes. [pathophys.org]

[…] count Increases four to seven days after hemolysis Jaundice Peripheral blood smear Heinz bodies Transient splenomegaly Haptoglobin Decreased Hemoglobinuria Liver function [aafp.org]

Complete blood cell count : Anemia of varying degree Reticulocyte count: is increased which indicates increased bone marrow response to anemia. [medcaretips.com]

Autoimmune Hemolytic Anemia

Over the course of the next 5 days, the Hb and Hct decreased to 4.1 g/dL and 12%, respectively, direct bili increased to 12.3 mg/day, reticulocytes slightly increased to 0.9% [ncbi.nlm.nih.gov]

Laboratory data showed low hemoglobin levels and slightly increased reticulocyte counts, while direct and indirect antiglobulin tests were positive. [ncbi.nlm.nih.gov]

[…] of spherocytes on a smear and increased reticulocytes working to compensate for the hemolysis and resultant anemia. [pedclerk.bsd.uchicago.edu]

Hereditary Elliptocytosis

His hemoglobin is now practically normal, but he still has a slight but persistent reticulocyte increase. [pediatrics.aappublications.org]

The patient presented for a general check up when his CBC showed only mild anemia with slightly increased reticulocytes. [ncbi.nlm.nih.gov]

Hematological values showed an increase in reticulocyte counts and mean corpuscular hemoglobin concentration, decreased mean corpuscular volume and hematocrit, and normal [ncbi.nlm.nih.gov]

Sickle Cell - Hemoglobin D

Reticulocyte count was increased (7.3%). Peripheral blood film examination showed many sickled cells (Figure 1). [imagebank.hematology.org]

Markers of hemolysis (increased LDH [ P =0.001], increased absolute reticulocyte count [ P =0.02], and weakly, a lower total Hb [ P =0.07]) were associated with albuminuria [cjasn.asnjournals.org]

Markers of hemolysis include increased LDH, reticulocyte count, and direct bilirubin [1]. [emedicine.medscape.com]

Congenital Dyserythropoietic Anemia

On this treatment, hemoglobin and reticulocytes increased and transfusions became unnecessary. [ncbi.nlm.nih.gov]

a moderate increase in unglycosylated (indirect) bilirubin, a low haptoglobin, and a gradual increase in ferritin level. [accessmedicine.mhmedical.com]

The reticulocyte count was always low, in spite of the increased erythropoietic activity. A beta-thalassemia trait inherited from the mother was demonstrated. [ncbi.nlm.nih.gov]

Sickle Cell - Hemoglobin C

With each course, fetal reticulocytes increased within 48-72 h, peaked in 7-11 d, and fell by 18-21 d. [doi.org]

ASSC is the sudden confiscation of erythrocytes by the spleen leading to a rapid decline in hemoglobin concentration, increased reticulocyte count and splenomegaly. [eposters.net]

In patient I, fetal reticulocytes increased from 16.0 +/- 2.0% to peaks of 37.7 +/- 1.2, 40.0 +/- 2.0, and 32.0 +/- 1.4% in three successive courses. [doi.org]

Sickle Cell Crisis

[…] spleen size — fall in Hb by >20 g/L, thrombocytopenia but normal or increased reticulocytes aplastic crisis — fall in Hb as well as reticulocytes — triggered by parvovirus [lifeinthefastlane.com]

[…] spleen size — fall in Hb by >20 g/L, thrombocytopenia but normal or increased reticulocytes aplastic crisis — fall in Hb as well as reticulocytes <1% — triggered by parvovirus [litfl.com]

[…] spleen size — fall in Hb by >20 g/L, thrombocytopenia but normal or increased reticulocytes aplastic crisis — fall in Hb as well as reticulocyes — triggered by parvovirus [lifeinthefastlane.com]

Hypersplenism

Normocytic, normochromic anemia Reticulocytes increased Increased MCV is due to prominent reticulocytosis Spherocytes Bone marrow Hypercellular with erythroid precursors [5minuteconsult.com]

[…] in red cell production usually is evident by an increase in the reticulocyte count. [medtextfree.wordpress.com]

Immune Hemolytic Anemia White cells May be elevated due to an increased in neutrophils Counts may approach 30 X 10 9 /L Platelets Usually normal Red cells Hb and Hct decreased [5minuteconsult.com]

Cold Agglutinin Disease

[…] breakdown ↑ Indirect/ unconjugated bilirubin ↑ Reticulocytes : loss of erythrocytes → reactive increase in erythropoiesis → increase in reticulocytes in the peripheral blood [amboss.com]

Typical bloodwork results would show: decreased hemoglobin (due to the red cell lysis) increased reticulocyte count (reflecting the marrow kicking red cell production into [transfusion.ca]

[…] count – usually elevated Positive indicators of hemolysis – hyperbilirubinemia, increased lactate dehydrogenase Direct Coombs Establish presence of immunoglobins and complement [arupconsult.com]

Fetal Erythroblastosis

He or she will be anemic, with increased reticulocyte count, anisocytosis, spherocytosis, and young (nucleated, immature) red blood cells released into circulation. [symptoma.com]

reticulocytes. [en.wikipedia.org]

Peripheral blood morphology shows increased reticulocytes. Erythroblasts (also known as nucleated red blood cells) occur in moderate and severe disease. [moondragon.org]

Sickle Cell Anemia

With each course, fetal reticulocytes increased within 48-72 h, peaked in 7-11 d, and fell by 18-21 d. [doi.org]

On her third day of admission, due to hemoglobin (Hb) value of 6.9 g/dL with increase in reticulocytes, the patient was transfused with one unit of compatible leukodepleted [ncbi.nlm.nih.gov]

In patient I, fetal reticulocytes increased from 16.0 +/- 2.0% to peaks of 37.7 +/- 1.2, 40.0 +/- 2.0, and 32.0 +/- 1.4% in three successive courses. [doi.org]

Thalassaemia-Haemoglobin C Disease

Patients present with a moderate to severe microcytic anemia (average MCV 70 fl, Hgb 6 g/dl) and an increased reticulocyte count. [path.upmc.edu]

Markers of hemolysis include increased LDH, reticulocyte count, and direct bilirubin [1]. [emedicine.medscape.com]

Rarely, for obscure reasons, they experience a catastrophic fall in hematocrit, increasing intensity of jaundice, and increasing reticulocyte count. [web2.iadfw.net]

Paroxysmal Cold Hemoglobinuria

Normal reticulocyte percentage is 0.5 to 1.5% b. [errolozdalga.com]

Reticulocytosis may be subtle in the acute phase. Peripheral blood smear may show corresponding polychromasia. [en.wikipedia.org]

Paroxysmal Nocturnal Hemoglobinuria

The blood chemistry revealed the pattern of hemolytic anemia with moderate thrombocytopenia, increased reticulocyte, slightly elevated serum bilirubin (indirect: 0.9mg%, direct [happycampus.com]

Erythrocytes fractionated by centrifugation revealed increased glycolytic enzyme activities of hexokinase, G3PD, PGK, TPI, PK, LDH, G6PD, and 6PGD in the reticulocyte-rich [pediatrics.aappublications.org]

Blockade of terminal complement components presumably prolongs the survival of type III erythrocytes (since there was no simultaneous increase in reticulocytes), which are [nejm.org]

Cerebral Thrombotic Thrombocytopenic Purpura

A number of findings can help to establish the diagnosis of TTP: The reticulocyte count is increased and correlates with the severity of the anemia. [epilepsy.com]

RPI, due to the time that it takes to increase epo synthesis and increase bone marrow RBC production Hemolytic Anemia Reticulocyte Production Index MEDLINE ] Chronic Anemia [mdnxs.com]

Schistocytes, anisopoikilocytosis were seen on peripheral blood smear and megakaryocytes were detected as increased on bone marrow aspiration. [ispub.com]

Thrombotic Thrombocytopenic Purpura

reticulocytes Haemolysis Screen reduced haptoglobins increased LDH (this is the most sensitive marker of severity and disease activity) unconjugated hyperbilirubinaemia increased [lifeinthefastlane.com]

A number of findings can help to establish the diagnosis of TTP: The reticulocyte count is increased and correlates with the severity of the anemia. [epilepsy.com]

However, the reticulocyte count remained at 12% to 15%, with an LDH value of approximately 500 IU/L. [healio.com]

Acute Hemorrhage

[…] the onset of a hemorrhagic anemia by an increase in reticulocyte counts.20 A full level of marrow production as estimated from the absolute reticulocyte count occurs only [medtextfree.wordpress.com]

[…] after 8 to 10 days, at which time the erythroid hyperplasia of the marrow and the absolute reticulocyte count are increased to the same extent.21 The severity of the anemia [medtextfree.wordpress.com]

A surge in erythropoietin also appears to cause premature delivery of marrow reticulocytes to the circulation.18,19,20 The latter event may be detected within 6 to 12 h of [medtextfree.wordpress.com]

Hemolytic Uremic Syndrome

reticulocytes reduced haptoglobins increased LDH unconjugated hyperbilirubinaemia with urinary urobilinogen variable neutrophilia increased urea and creatinine levels (greater [lifeinthefastlane.com]

L-lactate dehydrogenase level Leukocytosis Negative Coombs’ test Proteinuria on urinalysis Reticulocyte count moderately elevated Stool culture positive for Shiga toxin–roducing [aafp.org]

• The peripheral blood smear reveals fragmented RBCs (e.g., schistocytes, spherocytes, segmented RBCs) • Reticulocytosis (proportional to hemolysis) and circulating free [slideshare.net]

HELLP Syndrome

Polychromatic red cells are also seen in blood smears, and increased reticulocyte counts reflect the compensatory release of immature red cells into peripheral blood. [ncbi.nlm.nih.gov]

[…] enzymes, and low platelets) can be deemed as having partial HELLP Laboratory Testing CBC Hemoglobin and hematocrit – evaluate for hemolysis Platelets – low platelet counts increase [arupconsult.com]

Destruction of red blood cells by haemolysis causes increased serum lactate dehydrogenase (LDH) levels and decreased haemoglobin concentrations [ 22, 23 ]. [ncbi.nlm.nih.gov]

Primary Myelofibrosis

The percentage of reticulocytes is mildly increased but may vary widely in a given case. [patient-help.com]

Reticulocytosis and polychromatophilia may be present; teardrop-shaped RBCs (dacryocytes) are characteristic morphologic features. [merck.com]

Thalassemia Minor

[…] count Normal May be slightly increased Slightly increased ( Mildly increased (5 - 10%) Mildly increased Hb electrophoresis Normal pattern Decreased amount of Hb A Variable [labce.com]

[…] weeks' gestation Laboratory features Red blood cell indices: severe macrocytic hypochromic anemia, in the absence of ABO or Rh blood group incompatibility (see Table 1 ) Reticulocytosis [ncbi.nlm.nih.gov]

[…] target cells) Schistocytes Ovalocytes Basophilic stippling Polychromasia Nucleated RBCs Possible hypochromia and microcytosis Codocytes (target cells) Basophilic stippling Reticulocyte [labce.com]

Familial Myelofibrosis

At the same time, the number of immature cells in peripheral blood is increased. [symptoma.com]

Immature granulocytes, reticulocytes, normoblasts, and dacrocytes can be observed under the microscope. [symptoma.com]

Hodgkin Lymphoma

This was manifested by normoblastic hyperplasia of the marrow, a moderate reticulocytosis and increased plasma iron clearance rates. [bloodjournal.org]