Retinal Degeneration: Causes & Reasons

Possible Causes for Retinal Degeneration

Retinitis Pigmentosa

degeneration (AMD), according to a new report. [sciencedaily.com]

The most common inherited retinal degeneration, RP is currently untreatable. [ncbi.nlm.nih.gov]

rats, a model of retinal degeneration. [ncbi.nlm.nih.gov]

Mucopolysaccharidosis Type 2

Typical signs and symptoms include: Hearing impairment Joint stiffness Coarse face Upper airway disease Carpal tunnel syndrome Communicating hydrocephalus Retinal degeneration [symptoma.com]

Retinal degeneration is seen to a lesser degree in MPS IIB. Patients diagnosed with MPS IIB can live beyond the fifth decade of life. [emedicine.medscape.com]

degeneration Hearing loss Recurrent otitis media Broad chest Ivory-colored papular skin lesions on the upper back and sides of the upper arms Protuberant abdomen Diarrhea [symptoma.com]

Mucolipidosis

Her vision began deteriorating at 12 years of age, due to bilateral corneal opacities and retinal degeneration. [ncbi.nlm.nih.gov]

Ocular findings also include retinal degeneration, myopia, strabismus, and photophobia. Neurological symptoms include hypotonia and pyramidal tract signs. [genedx.com]

degeneration. [ncbi.nlm.nih.gov]

Laurence Moon Syndrome

No treatment is currently known for the retinal degeneration associated with this syndrome Keywords : Article: Download PDF DOI : 10.36106/ijar Cite This Article: A RARE CASE [worldwidejournals.com]

degeneration. (2) Lurie and Levy described two deaf patients as having Bardet-Biedl syndrome without evidence of retinitis pigmentosa. [go.gale.com]

Laurence-Moon-Biedl syndrome A rare genetic disorder featuring mental retardation, extra toes or fingers, and a retinal degeneration, RETINITIS PIGMENTOSA, that may progress [medical-dictionary.thefreedictionary.com]

Leber Congenital Amaurosis

However, retinal degeneration continued to progress unabated. [pnas.org]

We evaluated the consequences of gene therapy on retinal degeneration in patients with RPE65-LCA and its canine model. [ncbi.nlm.nih.gov]

We reported earlier that retinal degeneration 3 (RD3) protein interacts with GC1 and promotes its targeting to the photoreceptor outer segments (POS). [ncbi.nlm.nih.gov]

Mucopolysaccharidosis Type 1

Additional signs and symptoms that may develop include: Enlarged head Chronic nasal discharge Retinal degeneration Splenomegaly Enlarged abdominal organs Skeletal dysplasia [medicinenet.com]

Optic nerve atrophy may also occur with advanced retinal degeneration [14]. Retinal degeneration clinically appears as sensitivity to light or night blindness [15]. [ijponline.biomedcentral.com]

degeneration Hearing impairment – Deafness Musculoskeletal disease – Short stature; joint stiffness; symptoms of peripheral nerve entrapment Findings from examination may [emedicine.medscape.com]

Retinopathy

Autoimmune retinopathy was suspected on the basis of the clinical presentation, electrophysiology, absence of fundus lesions, retinal degenerations or dystrophies, or intraocular [ncbi.nlm.nih.gov]

Degenerations at the Careggi Teaching Hospital of Florence from 2012 to 2017. [ncbi.nlm.nih.gov]

General Information Retinitis pigmentosa, or RP, is a group of inherited eye diseases that cause degeneration of the retina and progressive vision loss. [envisionus.com]

Mucopolysaccharidosis

Additional signs and symptoms that may develop include: Enlarged head Chronic nasal discharge Retinal degeneration Splenomegaly Enlarged abdominal organs Skeletal dysplasia [medicinenet.com]

RPE65-Related Disorder

Spastic paraplegia 43 autosomal recessive, 615043 C1QTNF5 Retinal degeneration, late-onset, autosomal dominant, 605670 C21orf2 No OMIM disease 605670 C21orf2 Retinal dystrophy [qgenomics.com]

Retinitis pigmentosa 9 180104 RPE65 Leber congenital amaurosis 2 204100 RPE65 Retinitis pigmentosa 20 613794 RPGR Cone-rod dystrophy, X-linked, 1 304020 RPGR Macular degeneration [qgenomics.com]

[…] pigmentosa 37 611131 NR2F1 Bosch-Boonstra-Schaaf optic atrophy syndrome, 615722 NRL Retinal degeneration, autosomal recessive, clumped pigment type 615722 NRL Retinitis pigmentosa [qgenomics.com]

Leber Congenital Amaurosis Type 2

RPE65-related Leber congenital amaurosis / early-onset severe retinal dystrophy (RPE65-LCA/EOSRD) is a severe inherited retinal degeneration (IRD) with a typical presentation [ncbi.nlm.nih.gov]

Spastic paraplegia 43 autosomal recessive, 615043 C1QTNF5 Retinal degeneration, late-onset, autosomal dominant, 605670 C21orf2 No OMIM disease 605670 C21orf2 Retinal dystrophy [qgenomics.com]

[…] diseases such as retinitis pigmentosa and age-related macular degeneration (AMD). [fightingblindness.org]

Retinitis Pigmentosa Type 20

Retinal degenerations with truncation mutations in the cone-rod homeobox (CRX) gene. Invest. Ophthalmol. Vis. Sci. 1998;39(12):2417-26 20) Hamel C. Retinitis pigmentosa. [malattierare.regione.veneto.it]

Spastic paraplegia 43 autosomal recessive, 615043 C1QTNF5 Retinal degeneration, late-onset, autosomal dominant, 605670 C21orf2 No OMIM disease 605670 C21orf2 Retinal dystrophy [qgenomics.com]

Glial cell line derived neurotrophic factor delays photoreceptor degeneration in a transgenic rat model of retinitis pigmentosa. Mol. [malattierare.regione.veneto.it]

Vitamin E Deficiency

KEYWORDS: Alpha-tocopherol transfer protein; Ataxia; Macular degeneration; Retinitis pigmentosa; TTPA gene mutation; Vitamin E deficiency [ncbi.nlm.nih.gov]

This includes retinal thinning or degeneration, which causes damage to lining of the eye. [stylecraze.com]

Vitamin E deficiency secondary to abetalipoproteinemia causes such problems as poor transmission of nerve impulses, muscle weakness, and retinal degeneration that leads to [ods.od.nih.gov]

Ataxia-Telangiectasia Syndrome

Björklund, Markus Ringnér, Thomas Perlmann & Johan Holmberg Nature Communications (2018) DZNep inhibits H3K27me3 deposition and delays retinal degeneration in the rd1 mice [doi.org]

Mari Sild & Linda Booij Molecular Psychiatry (2019) Histone Deacetylases Contribute to Excitotoxicity-Triggered Degeneration of Retinal Ganglion Cells In Vivo Annabelle Schlüter [doi.org]

[…] telangiectasia, immunodeficiency, radiosensitivity, infertility, predisposition to malignancies and progressive neuronal degeneration ( Crawford, 1998 ; Kastan et al., 2000 [doi.org]

Tay-Sachs Disease

Some children may have retinitis pigmentosa, a large group of vision disorders that cause progressive degeneration of the retina, the light-sensitive membrane that coats the [rarediseases.org]

Degeneration of the nerve that carries impulses from the eye to the brain to form images (optic atrophy) may occur. [rarediseases.org]

Photic Retinal Injury

Description Retinitis Pigmentosa (RP) refers to a group of inherited retinal degenerations that affect the light sensitive photoreceptor cells of the retina which are important [fightingblindness.ie]

This pathologic condition is a hereditary disease that causes progressive retinal degeneration in both eyes. [tri-stl.com]

To make an appointment in Kellogg’s Inherited Retinal Degeneration Clinic, call 734-232-8080. [healthblog.uofmhealth.org]

Myopic Macular Degeneration

The higher grades of staphylomas were associated with more severe myopic retinal degeneration. [amdsupport.ca]

This stretching of the sclera is thought to lead to retinal degeneration. [strathfieldretina.com.au]

Patients with myopic degeneration have an increased risk of developing peripheral retinal tears and retinal detachment. [retinaconsultants.org]

Non-Syndromic Ocular Stickler Syndrome Type 1

[…] and radial perivascular retinal Lattice degeneration, both of which are present in up to 100% of affected patients [4]. [eyewiki.aao.org]

Fundus photography revealed inferior retinal detachment and peripheral retinal degeneration (Fig. 2A). [spandidos-publications.com]

However, findings of vitreoretinal degeneration, such as early-onset cataract, severe vitreous degeneration, and retinal detachment, were not observed. [clinicalgate.com]

Macular Degeneration

The Argus II has already been tested and approved in the United States and Europe for individuals with Retinitis Pigmentosa (RP) and Outer Retinal Degeneration, respectively [businesswire.com]

Age-related loss of vision in the central portion of the retina (macula), secondary to retinal degeneration. [icd10data.com]

Macular Degeneration Retinal Eye Disease - AMD Macular degeneration, sometimes referred to as Age-related Macular Degeneration (AMD) is damage or breakdown of the macula. [mastereyeassociates.com]

Retinal Perforation

Aplasia retinal arterial tortuosity retinal artery occlusion + retinal degeneration + retinal detachment + Retinal Dysplasia + retinal edema + Retinal Hemorrhage + Retinal [rgd.mcw.edu]

[…] evidence-based Retina/Vitreous Preferred Practice Pattern® (PPP), addressing Posterior Vitreous Detachment, Retinal Breaks, and Lattice Degeneration. [evidence.nhs.uk]

[…] nerve fibers (HP:0007922) ..Intraretinal fluid (HP:0031527) ..Retinal coloboma (HP:0000480) ..Retinal degeneration (HP:0000546) ..Retinal detachment (HP:0000541) ..Retinal [mseqdr.org]

Retinal Detachment

LESSONS: In this case, the retinal degeneration was morphologically different from retinal lattice degeneration, thus suggesting that it might be involved in the onset of [ncbi.nlm.nih.gov]

Asymptomatic retinal breaks and lattice degeneration are visible lesions that are risk factors for later retinal detachment. [ncbi.nlm.nih.gov]

[…] hole associated with lattice degeneration, or retinal break that occurs later at a site of lattice degeneration. [doi.org]

Hallervorden-Spatz Syndrome

The Hallervorden-Spatz syndrome (HSS) is a rare condition characterized by extrapyramidal and pyramidal signs, dystonia, dysarthria, retinal degeneration, dementia and a progressive [ncbi.nlm.nih.gov]

The differential diagnosis of childhood dystonia and retinal pigmentary degeneration associated with neurological conditions is discussed. [ncbi.nlm.nih.gov]

degeneration and brain iron accumulation. [ncbi.nlm.nih.gov]

Olivopontocerebellar Atrophy

[…] which is characterized by dominantly inherited cerebellar ataxia and pigmentary retinal degeneration. [ncbi.nlm.nih.gov]

degeneration (OPCA type III). [ncbi.nlm.nih.gov]

An amorphous debris, presumably degenerated photoreceptors, was noted between the outer nuclear layer and retinal pigment epithelium. [ncbi.nlm.nih.gov]

Disorder of the Vitreous Body

Increased floaters Increased flashes Visual field loss Visual distortion or disturbance Treatment for Retinal Detachment Retinal degenerations or tears can be repaired with [hksh-healthcare.com]

Firm attachment sites: Along blood vessels and at sites of retinal degeneration Space of Martegioni : A funnel shaped space overlying the optic disc with condensed edge Cloquet's [en.wikipedia.org]

Much of this oxygen is consumed by retinal tissue farther from the vessel ( curved red arrows ). ( B ) After the vitreous gel is removed during vitrectomy or degenerates and [iovs.arvojournals.org]

Stickler Syndrome

The ocular findings, frequently bilateral, consisted of radial perivascular retinal degeneration (RPRD) (100%), vitreous syneresis (100%), high myopia (76%), retinal detachment [ncbi.nlm.nih.gov]

Of the eight patients, five did not need any therapy, two children had retinal degeneration in the left eye and retinal detachment in the right eye while one child had retinal [ncbi.nlm.nih.gov]

All patients presented with membranous vitreous anomaly, peripheral retinal degeneration, and/or rhegmatogenous retinal detachment, but no systemic manifestations. [ncbi.nlm.nih.gov]

Boucher-Neuhäuser Syndrome

Familial ataxia, hypogonadism and retinal degeneration. Acta Neurol Scand. 1969. 45:507–510. 2. Neuhäuser G, Opitz JM. [koreamed.org]

Boucher-Neuhäuser syndrome (BNS) is rare autosomal recessive disease, characterised by cerebellar ataxia, hypogonadotropic hypogonadism and chorio-retinal degeneration. [ncbi.nlm.nih.gov]

Abstract Boucher–Neuhäuser syndrome (BNS) is rare autosomal recessive disease, characterised by cerebellar ataxia, hypogonadotropic hypogonadism and chorio-retinal degeneration [insights.ovid.com]

Bonnemann-Meinecke-Reich Syndrome

Peripheral Retinal Degeneration Information on Peripheral Retinal Degeneration Peripheral Retinal Degeneration is a very common disease. [altiusdirectory.com]

- Encephalopathy, intracerebral calcification, retinal degeneration syndrome (disorder) - Encephalopathy, intracerebral calcification, retinal degeneration syndrome - Bonnemann [snomedbrowser.com]

Retinal Degeneration 53 Encephalopathy-Intracerebral Calcification-Retinal Degeneration Syndrome 59 Bonnemann Meinecke Reich Syndrome 53 Bonnemann-Meinecke-Reich Syndrome [malacards.org]

Autosomal Dominant Optic Atrophy

retinal cells and RNFL. [ncbi.nlm.nih.gov]

[…] field (paracentral scotomas), and asymmetric degeneration of the retinal ganglion cells visible as pallor of the optic disk. [egl-eurofins.com]

Degeneration of retinal ganglion cells and their axons; bilateral subacute optic neuropathy, typically with simultaneous or rapidly sequential central or cecocentral visual [unboundmedicine.com]

Choroid Hemangioma

Unfortunately most patients have recurrent problems (retinal detachment, cystoid retinal degeneration) after this treatment and suffer loss of vision. [diagnose-me.com]

The visual defects that are observed are due to retinal degeneration overlying the tumor as well as serous retinal detachments caused by the lesion. [webeye.ophth.uiowa.edu]

Unfortunately, laser results are usually temporary and recurrence of retinal detachment or cystoid retinal degeneration usually results vision loss. [eyecancer.com]

Retinitis

Most forms of retinitis pigmentosa and related retinal degenerations affect only the eye, although in a minority of cases the retinal degeneration is one feature of a syndrome [ommbid.mhmedical.com]

It is the leading cause of inherited retinal degeneration-associated sight impairment[1]. [patient.info]

Some genes causing syndromic forms of retinal degeneration also have been identified. [ommbid.mhmedical.com]

Retinal Telangiectasia

Moreover, there is no retinal degeneration in Atm-/- and Ogg1-/- mice. [theses.fr]

CNTF has been shown to have a neuroprotective effect on photoreceptors, the cells responsible for detecting light in the retina, and animal models of retinal degeneration [neurotechusa.com]

degeneration H35.40 Unspecified peripheral retinal degeneration H35.41 Lattice degeneration of retina Inclusion term(s): Palisade degeneration of retina H35.411 Lattice degeneration [icd10coded.com]