Retinal Lipid Deposits: Causes & Reasons

Possible Causes for Retinal Lipid Deposits

Atherosclerosis. 2007, 193 (2): 235-240. 10.1016/j.atherosclerosis.2006.08.060 View Article PubMed Google Scholar Crispin S: Ocular lipid deposition and hyperlipoproteinaemia [doi.org]

Prog Retin Eye Res. 2002, 21 (2): 169-224. 10.1016/S1350-9462(02)00004-6 View Article PubMed Google Scholar Goldstein JL, Hobbs HH, Brown MS: Familial Hypercholesterolemia [doi.org]

Diabetic Retinopathy

deposits) Cotton-wool spots (ischemic retina leading to accumulations of axoplasmic debris within adjacent bundles of ganglion cell axons) Retinal neovascularisation. [futurelearn.com]

Haemorrhages Venous beading (venous caliber changes consisting of alternating areas of venous dilation and constriction) Intraretinal microvascular abnormalities Hard exudates (lipid [futurelearn.com]

Retinopathy

With progression to moderate NPDR, fluid that contains lipids seeps from leaky damaged capillaries to eventually form lipid-rich deposits known as hard exudates. [uspharmacist.com]

Accumulation of fluid in retinal tissues results in edema. As capillary damage intensifies, blood escapes into retinal tissues (retinal hemorrhages). [uspharmacist.com]

Clinical Findings The earliest clinical stage of DR, mild NPDR, is characterized by the presence of tiny swellings or microaneurysms in the retinal capillary walls. [uspharmacist.com]

Familial Hypercholesterolemia Type 1

Familial hypercholesterolemia (FCH) is a rather common genetic disorder characterized by prominent hypercholesterolemia due to the selective elevation of low-density lipoproteins (LDL), triglyceride levels within reference ranges, and a tendency to develop xanthomas and coronary heart disease. It is also referred to[…] [symptoma.com]

Minimal Change Nephropathy

From Wikidata Jump to navigation Jump to search Human disease Minimal Change Glomerulonephritis Minimal change disease (disorder) Nephrotic syndrome with Lesion of Minimal Change Glomerulonephritis Nephrotic syndrome with lesion of minimal change glomerulonephritis Nephrotic syndrome with lesion of minimal change[…] [wikidata.org]

Nephrotic Syndrome

The differences between nephrotic and nephritic syndrome are easily forgotten. At the most basic level, remember that nephrotic syndrome involves the loss of a lot of protein, whereas nephritic syndrome involves the loss of a lot of blood. Nephrotic syndrome Proteinuria ( >3.5g in 24hrs ) ++++ Protein Urine looks[…] [geekymedics.com]

Familial Hypercholesterolemia

PLoS One. 2017 Dec 11;12(12):e0189316. doi: 10.1371/journal.pone.0189316. eCollection 2017. Author information 1 Department of Endocrinology, The Affiliated Hospital of Qingdao University, Qingdao University, Qingdao, China. 2 Department of Endocrinology, Linzi District People's Hospital, Zibo, China. 3 Department of Gerontology,[…] [ncbi.nlm.nih.gov]

Familial Combined Hyperlipidemia

OBJECTIVE: Genetic studies implicated upstream stimulatory factor 1 (USF1) in familial combined hyperlipidemia because the rs2073658 minor allele was associated with reduced risk of familial combined hyperlipidemia and related disorders. The molecular mechanisms whereby rs2073658 influences trait expression have[…] [ncbi.nlm.nih.gov]

Familial Hyperlipidemia

BACKGROUND: The benefits of physical activity in children have been studied extensively; however, its role in children with familial hyperlipidemia (FH) is unknown. OBJECTIVE: To determine associations between physical activity, adiposity, and lipid profiles in children with FH. DESIGN: A physical activity questionnaire was[…] [ncbi.nlm.nih.gov]

Radiation Retinopathy

A 30-year-old woman diagnosed with choroidal melanoma and treated with plaque radiation and transpupillary thermotherapy 5 years earlier presented with recalcitrant proliferative radiation retinopathy despite multiple intravitreal anti-vascular endothelial growth factor injections. Swept-source and spectral-domain[…] [ncbi.nlm.nih.gov]

Acute Hypertensive Retinopathy

Retinal lipid deposits developed relatively late. Retinal arteriolar changes were a much later phenomenon. [karger.com]

[…] exudates Optic disk edema Yellow hard exudates represent intraretinal lipid deposition from leaking retinal vessels. [msdmanuals.com]

A dilated retinal examination will detect the variable findings of scattered retinal hemorrhages, white patches of poor circulation (cotton-wool spots), macular fatty deposits [eyecenters.com]

Proliferative Retinopathy

Abstract Proliferative diabetic retinopathy is an important cause of visual impairment. We investigated whether the polymorphism of the beta 3-adrenoreceptor (beta 3-AR) gene, which is associated with insulin resistance and an earlier onset of NIDDM, was associated with proliferative diabetic retinopathy (PDR) in 215[…] [ncbi.nlm.nih.gov]

Hyperlipoproteinemia Type 5

Postmortem examination showed hemorrhages in the inner retinal layers and lipid deposits largely in the outer plexiform layer. [ncbi.nlm.nih.gov]

Journal Article Of two patients with type 5 hyperlipoproteinemia, one exhibited lipemia retinalis with multiple retinal hemorrhages and intraretinal lipid extravasations. [scholars.duke.edu]

Lipid within the walls of the retinal vessels was demonstrated by light and electron microscopy. [ncbi.nlm.nih.gov]

Coats Disease

Sub-retinal lipid deposition can lead to fibrovascular tissue formation, resulting in disciform scars in the macular region, as peripheral exudative lesions also tend to track [benthamopen.com]

Extensive retinal hemorrhages and fatty deposits before treatment. The blood, yellow lipid, and fluid have totally resolved following several laser treatments. [eyecenters.com]

The abnormal telangiectatic blood vessels are visible, as are fluid and lipid (fat) deposits or retinal detachment. [medicinenet.com]

Retinal Telangiectasia

Fundus (retinal) findings include lipid deposition at the macula and dilation of arterioles and venules. [lowvision.preventblindness.org]

In these cases, the disease is usually advanced already, with extensive lipid deposition and retinal detachment (see Fig. 120-4 ). [medtextfree.wordpress.com]

In addition to telangiectasis, there may be capillary nonperfusion, aneurysmal formation, and massive lipid deposition. [institut-vision.org]

Hypertensive Retinopathy

[…] exudates Optic disk edema Yellow hard exudates represent intraretinal lipid deposition from leaking retinal vessels. [msdmanuals.com]

If acute disease is severe, the following can develop: Superficial flame-shaped hemorrhages Small, white, superficial foci of retinal ischemia (cotton-wool spots) Yellow hard [msdmanuals.com]

Late-Onset Retinal Degeneration

PURPOSE: To clarify the pathogenesis of late-onset retinal degeneration (L-ORD), an autosomal dominant disorder characterized by thick deposits of lipid-rich material between [ncbi.nlm.nih.gov]

RESULTS: The L-ORD eye had sub-RPE deposits that were positive for lipid, including esterified and unesterified cholesterol. [ncbi.nlm.nih.gov]

[…] the retinal pigment epithelium (RPE) and Bruch's membrane. [ncbi.nlm.nih.gov]

Lattice Degeneration of the Retina

The lesions consist of retinal degeneration leading to an atrophy of the tissues with lipid deposits in the internal retinal layers and they have the same complications and [atlasrleye.com]

Snail-track retinal degeneration is a clinical variation of lattice degeneration, occurring mainly in young myopic eyes, characterized by long circumferential areas of retinal [atlasrleye.com]

Arteriosclerotic Retinopathy

[…] exudates Optic disk edema Yellow hard exudates represent intraretinal lipid deposition from leaking retinal vessels. [msdmanuals.com]

[…] oedema and lipid exudates. 49 The deeper blot haemorrhages appear with progression of hypertension and indicate worsening ischaemia. 49 Deposition of lipid around the fovea [nature.com]

If acute disease is severe, the following can develop: Superficial flame-shaped hemorrhages Small, white, superficial foci of retinal ischemia (cotton-wool spots) Yellow hard [msdmanuals.com]

Cerebral Lipidosis

[…] storage disorders Results for Retinal dystrophy in cerebroretinal lipidosis and additional synonyms E75.6 Lipid storage disorder, unspecified Synonyms: Abnormal lipid deposits [averbis.com]

[…] dystrophy Retinal dystrophy in cerebroretinal lipidosis Clinical Information Conditions characterized by abnormal lipid deposition due to disturbance in lipid metabolism, [icd10data.com]

lipid deposits|Abnormal lipid deposits (disorder)|Cerebral degeneration associated with generalised lipidosis|Cerebral degeneration associated with generalized lipidosis| [averbis.com]

Dupont Sellier Chochillon Syndrome

The retinal exudates can be either “soft” (microinfarcts) or “hard” (deposits of plasma proteins and lipids). [mfa.org.my]

[…] dilations, edema, and, most importantly, thickening of the retinal capillaries (microangiopathy). [mfa.org.my]

Peripheral, symmetric neuro- Macular involvement can cause blindness whereas vitreous hemorrhages can result pathy of the lower extremities from retinal detachment. [mfa.org.my]

Bullous Dystrophy Type Macular

lipid deposits (disorder) 860 83405000 Flat retinoschisis (disorder) 860 86103006 Angioid streaks of choroid (disorder) 860 86923008 Juvenile retinoschisis (disorder) 860 [aspe.hhs.gov]

deposits in the internal retinal layers Many authors consider it to be early stage of lattice degeneration It may lead to development of a retinal break and also RD. [eyewiki.aao.org]

called drusen (buildup of extracellular proteins and lipids), in the macula (a part of the retina), between the retinal pigment epithelium and the underlying choroid. [en.wikipedia.org]

Sorsby's Fundus Dystrophy

The deposit has several unique features when compared with those found in other retinal dystrophies and in aged eyes. [ncbi.nlm.nih.gov]

The most striking finding was a 30-microns thick deposit present within Bruch's membrane that stained positive for lipids. [ncbi.nlm.nih.gov]

Cone Rod Dystrophy Type 16

[…] of age associated with subretinal pigment epithelium lipid-rich deposits[36] and visual field and electroretinogram changes similar to early stage retinitis pigmentosa. [medscape.com]

Late-onset retinal degeneration was only very recently recognized as a clinical entity[36,37] and is characterized by onset of retinal degenerative changes after 50 years [medscape.com]

Cone Rod Dystrophy Type 5

[…] of age associated with subretinal pigment epithelium lipid-rich deposits[36] and visual field and electroretinogram changes similar to early stage retinitis pigmentosa. [medscape.com]

Late-onset retinal degeneration was only very recently recognized as a clinical entity[36,37] and is characterized by onset of retinal degenerative changes after 50 years [medscape.com]

Best Disease

RESULTS: An eye from a Best disease donor with a T6R mutation was found to have deposits containing lipid and glycoconjugates within the central retinal scar. [ncbi.nlm.nih.gov]

These deposits may be remnants of the vitelliform lesion. [ncbi.nlm.nih.gov]

Retinitis Pigmentosa 32

lipid deposition, pigmentary changes in peripheral retina, and loss of vision. [ncbi.nlm.nih.gov]

In patients at advanced stages there’s the possibility of Coats-like disease, which is a form of exudative vasculopathy leading to telangiectatic vessels, lipid deposition [bredagenetics.com]

lipid depositions, and retinal detachment, however it differs from classic Coats disease with age (older age), gender (no sex profile), involvement of eye (generally bilateral [ncbi.nlm.nih.gov]

Snowflake Vitreoretinal Degeneration

deposits in the internal retinal layers Many authors consider it to be early stage of lattice degeneration It may lead to development of a retinal break and also RD. [eyewiki.aao.org]

[…] area of the equator or just in front of it Histologically, this lesion consist of degeneration of the neural elements of retina leading to an atrophy of the tissues with lipid [eyewiki.aao.org]

Bietti Crystalline Dystrophy

Dysfunctional lipid metabolism mayresult in complex lipid retinal or corneal deposits in crystalline form.[5] In patients with BCD, lipid inclusions are found systemically [eyewiki.aao.org]

Bietti crystalline dystrophy (BCD) is a condition in which lipid deposits accumulate in the retinal tissues of the eye leading to progressive loss of vision. [medindia.net]

deposits in the retina and sometimes cornea, degeneration of the retinal pigment epithelium (RPE), and sclerosis of the choroidal vessels. [eyewiki.aao.org]

Aniridia

These have been shown to be intra retinal lipid deposits by histochemical procedures. The implications of this finding are conjectural. [ijo.in]

lipid deposits and the third links congenital aniridia and buphthalmos to present an unusual clinical combination. [ijo.in]

Mention has been made of these deposits as a feature of some cases of sporadic aniridia [7]. [ijo.in]