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136 Possible Causes for Rimmed Vacuoles (Biopsy

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  • Inclusion Body Myopathy

    METHODS: We have analyzed the SFEMG data in 25 patients (mean age: 63; 16 males) with S-IBM which was diagnosed by the presence of classical rimmed vacuoles in the muscle[ncbi.nlm.nih.gov] Muscle biopsy showed rimmed vacuoles in numerous muscle fibers, and electron microscopy documented accumulation of 15-21 nm filaments.[ncbi.nlm.nih.gov] Histopathology of an HIBM muscle biopsy shows rimmed vacuoles on Gomori's trichrome stain, small fibers in groups and tubulofilaments without evidence of inflammation.[ncbi.nlm.nih.gov]

  • Inclusion Body Myositis

    On muscle biopsy, 9 of 10 (90%) had endomysial inflammation, 7 of 10 (70%) had rimmed vacuoles, and none had perifascicular atrophy.[ncbi.nlm.nih.gov] […] also showed rimmed vacuoles; 2) patients whose biopsies showed no vacuoles but fulfilled clinical criteria for IBM, and 3) patients whose biopsies showed no vacuoles, and[ncbi.nlm.nih.gov] MATERIAL AND METHODS: Here we report on twelve patients: eight with sporadic inclusion body myositis and four with other myopathies with rimmed vacuoles in muscle biopsy.[ncbi.nlm.nih.gov]

  • Limb-Girdle Muscular Dystrophy Type 2G

    Muscle biopsy shows a dystrophic pattern, including rimmed vacuoles.[link.springer.com] vacuoles on muscle biopsy [ 2 – 12 ].[bmcclinpathol.biomedcentral.com] vacuoles in muscle biopsies) that usually are not observed in the analysis of patients with LGMD2A-LGMD2F.[ncbi.nlm.nih.gov]

  • Oculo-Pharyngo-Distal Myopathy

    Muscle biopsies show basophilic-rimmed vacuoles in the sarcoplasm, and other non-specific dystrophic alterations.[jnnp.bmj.com] Muscle biopsy uncovered changes in fiber size and the presence of atrophic fibers with rimmed vacuoles of varying diameter, and core-like structures in type I fibers.[ncbi.nlm.nih.gov] Muscle biopsy was performed on the tibialis anterior muscle in the proband. Muscular dystrophy changes with rimmed vacuoles were the main histopathological changes.[ncbi.nlm.nih.gov]

  • Overlap Syndrome

    A muscle biopsy revealed inflammatory myopathy with rimmed vacuoles (RVs). The diagnosis of scleroderma-polymyositis (SSc-PM) overlap syndrome was made.[ncbi.nlm.nih.gov] None of the muscle biopsies revealed rimmed vacuoles, ruling out inclusion-body myositis [ 21 ].[arthritis-research.biomedcentral.com] RVs on a muscle biopsy in a patient with inflammatory myositis involving axial muscles may be seen either in inclusion body myositis or SSc-PM overlap syndrome.[ncbi.nlm.nih.gov]

  • Oculopharyngeal Muscular Dystrophy

    vacuoles, but a muscle biopsy is not needed for diagnosis.[orpha.net] Figure 4 Rimmed vacuoles at the deltoid muscle biopsy (modified Gomori stain, 350 ).[scielo.br] Muscle biopsy revealed fiber size variations, sporadic rimmed vacuoles, small scattered angulated fibers and a patchy myofibrillar network.[ncbi.nlm.nih.gov]

  • Autosomal Recessive Limb-Girdle Muscular Dystrophy

    vacuoles in muscle biopsies) that usually are not observed in the analysis of patients with LGMD2A-LGMD2F.[ncbi.nlm.nih.gov] Histopathology of skeletal muscles biopsies showed typical dystrophic changes with many rimmed vacuoles.[ncbi.nlm.nih.gov] Muscle biopsy has been reported to show dystrophic features with or without rimmed vacuoles [4], [27]. In our study, rimmed vacuoles were not noted in any case.[journals.plos.org]

  • Distal Myopathy Type 3

    Miyoshi Myopathy is distinctive in that most distal myopathies produce "rimmed vacuoles" in muscle biopsies.[jain-foundation.org] Characteristic pathologic features of DMRV are rimmed vacuoles on muscle biopsy and tubulofilamentous inclusion in ultrastructural study.[karger.com] Muscular biopsy shows dystrophic pattern, often with rimmed vacuoles and no inflammatory infiltration 15.[doi.org]

  • Myositis

    Inclusion body myositis is frequently misdiagnosed as polymyositis when rimmed vacuoles are absent on muscle biopsy, and a careful neuromuscular evaluation is not performed[ncbi.nlm.nih.gov] vacuoles", although the extent of myofibers having classic rimmed vacuoles varies ( Dubowitz: Muscle Biopsy: A Practical Approach, 2013, 4th Edition ) The vacuoles disrupt[pathologyoutlines.com] Muscle biopsy reveals inclusion bodies i.e. rimmed vacuoles formed due to the collection of abnormal proteins.[kenhub.com]

  • Limb-Girdle Muscular Dystrophy

    Our case suggests that posterior-dominant lower limb muscle impairment with gluteus and truncal muscle involvement and the detection of rimmed vacuoles on a muscle biopsy[ncbi.nlm.nih.gov] By light microscopy, there were scattered fibers with rimmed vacuoles and myofibrillary disorganization in the patient's muscle biopsy; accumulation of Z disk proteins was[ncbi.nlm.nih.gov] Muscle biopsy showed dystrophic features with many rimmed vacuoles in the fibers.[ncbi.nlm.nih.gov]

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