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136 Possible Causes for Rimmed Vacuoles (Biopsy

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  • Inclusion Body Myopathy

    METHODS: We have analyzed the SFEMG data in 25 patients (mean age: 63; 16 males) with S-IBM which was diagnosed by the presence of classical rimmed vacuoles in the muscle[] Muscle biopsy showed rimmed vacuoles in numerous muscle fibers, and electron microscopy documented accumulation of 15-21 nm filaments.[] Histopathology of an HIBM muscle biopsy shows rimmed vacuoles on Gomori's trichrome stain, small fibers in groups and tubulofilaments without evidence of inflammation.[]

  • Inclusion Body Myositis

    On muscle biopsy, 9 of 10 (90%) had endomysial inflammation, 7 of 10 (70%) had rimmed vacuoles, and none had perifascicular atrophy.[] […] also showed rimmed vacuoles; 2) patients whose biopsies showed no vacuoles but fulfilled clinical criteria for IBM, and 3) patients whose biopsies showed no vacuoles, and[] MATERIAL AND METHODS: Here we report on twelve patients: eight with sporadic inclusion body myositis and four with other myopathies with rimmed vacuoles in muscle biopsy.[]

  • Limb-Girdle Muscular Dystrophy Type 2G

    Muscle biopsy shows a dystrophic pattern, including rimmed vacuoles.[] vacuoles on muscle biopsy [ 2 – 12 ].[] vacuoles in muscle biopsies) that usually are not observed in the analysis of patients with LGMD2A-LGMD2F.[]

  • Oculo-Pharyngo-Distal Myopathy

    Muscle biopsies show basophilic-rimmed vacuoles in the sarcoplasm, and other non-specific dystrophic alterations.[] Muscle biopsy uncovered changes in fiber size and the presence of atrophic fibers with rimmed vacuoles of varying diameter, and core-like structures in type I fibers.[] Muscle biopsy was performed on the tibialis anterior muscle in the proband. Muscular dystrophy changes with rimmed vacuoles were the main histopathological changes.[]

  • Overlap Syndrome

    A muscle biopsy revealed inflammatory myopathy with rimmed vacuoles (RVs). The diagnosis of scleroderma-polymyositis (SSc-PM) overlap syndrome was made.[] None of the muscle biopsies revealed rimmed vacuoles, ruling out inclusion-body myositis [ 21 ].[] RVs on a muscle biopsy in a patient with inflammatory myositis involving axial muscles may be seen either in inclusion body myositis or SSc-PM overlap syndrome.[]

  • Oculopharyngeal Muscular Dystrophy

    vacuoles, but a muscle biopsy is not needed for diagnosis.[] Figure 4 Rimmed vacuoles at the deltoid muscle biopsy (modified Gomori stain, 350 ).[] Muscle biopsy revealed fiber size variations, sporadic rimmed vacuoles, small scattered angulated fibers and a patchy myofibrillar network.[]

  • Autosomal Recessive Limb-Girdle Muscular Dystrophy

    vacuoles in muscle biopsies) that usually are not observed in the analysis of patients with LGMD2A-LGMD2F.[] Histopathology of skeletal muscles biopsies showed typical dystrophic changes with many rimmed vacuoles.[] Muscle biopsy has been reported to show dystrophic features with or without rimmed vacuoles [4], [27]. In our study, rimmed vacuoles were not noted in any case.[]

  • Distal Myopathy Type 3

    Miyoshi Myopathy is distinctive in that most distal myopathies produce "rimmed vacuoles" in muscle biopsies.[] Characteristic pathologic features of DMRV are rimmed vacuoles on muscle biopsy and tubulofilamentous inclusion in ultrastructural study.[] Muscular biopsy shows dystrophic pattern, often with rimmed vacuoles and no inflammatory infiltration 15.[]

  • Myositis

    Inclusion body myositis is frequently misdiagnosed as polymyositis when rimmed vacuoles are absent on muscle biopsy, and a careful neuromuscular evaluation is not performed[] vacuoles", although the extent of myofibers having classic rimmed vacuoles varies ( Dubowitz: Muscle Biopsy: A Practical Approach, 2013, 4th Edition ) The vacuoles disrupt[] Muscle biopsy reveals inclusion bodies i.e. rimmed vacuoles formed due to the collection of abnormal proteins.[]

  • Limb-Girdle Muscular Dystrophy

    Our case suggests that posterior-dominant lower limb muscle impairment with gluteus and truncal muscle involvement and the detection of rimmed vacuoles on a muscle biopsy[] By light microscopy, there were scattered fibers with rimmed vacuoles and myofibrillary disorganization in the patient's muscle biopsy; accumulation of Z disk proteins was[] Muscle biopsy showed dystrophic features with many rimmed vacuoles in the fibers.[]

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