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799 Possible Causes for Risk of Leukemia Increased

  • Kostmann Syndrome

    Children diagnosed with this disease are at increased risk for leukemia later in life. Symptoms Infections are the most common symptom for this disease.[] The main features of severe congenital neutropenia are the onset of severe bacterial infections early in life, a paucity of mature neutrophils, and an increased risk of leukemia[] Although treatment can prolong life for Kostmann syndrome patients, they have an increased risk of developing leukemia compared with the population as a whole.[]

  • Rubinstein-Taybi Syndrome

    […] incidence of pilomatricomas Hematologic/Oncologic Possible increased risk of benign and malignant tumors Possible increased risk of leukemia and lymphoma (Acute lymphocytic[] People with this condition have an increased risk of developing noncancerous and cancerous tumors, leukemia, and lymphoma.[] An increased risk of tumors (mainly leukemia in childhood and meningeoma in adulthood) has been observed.[]

  • Anemia

    […] coupled with an increased risk of leukemia transformation.[] Although severe anemia contributes to symptoms of fatigue and reduced quality of life, transfusion dependence increases the risk of organ complications from iron overload[]

  • Adenovirus Infection

    The risk for HAdV-associated disease is increased in children, and risk factors for HAdV disease are T-cell depletion, unrelated and cord blood hematopoietic stem cell transplantation[] The 4th European Conference of Infections in Leukemia (ECIL-4) has developed evidence-based guidelines for diagnosis and management of HAdV infections.[]

  • Sinusitis

    Medications that are designed to modify the immune system may increase the risk of developing sinus infections.[] […] infections are caused by viruses, bacteria, allergens, pollutants, and fungal infections , especially people with diseases that weaken the immune system, for example, HIV/AIDS , leukemia[] , likely owing to rising numbers of at-risk persons. [18] Mucormycosis was found in 1% of patients with acute leukemia in an Italian multicenter review. [19] A related disease[]

  • Periodontitis

    Other diseases, such as leukemia, inflammatory bowel disease and HIV infection, also can increase the risk.[]

  • Pregnancy

    A 10–20 mGy fetal exposure may increase the risk of leukemia by a factor of 1.5–2.0 over a background rate of approximately 1 in 3,000 (7, 18).[] A 10–20 mGy fetal exposure may increase the risk of leukemia by a factor of 1.5–2.0 over a background rate of approximately 1 in 3,000 (7, 20).[] The risk of carcinogenesis as a result of in-utero exposure to ionizing radiation is unclear but is probably very small.[]

  • Asthma

    : acute thunderstorm asthma and increased risk of childhood leukemia near HVPL.[] Abstract Thunderstorm asthma and increased childhood leukemia risk near high-voltage power lines (HVPL) are occurrences whose mechanism of effect is not fully understood.[] The demonstrated series of events leading to increased deposition and retention of ionized particles in airways provides support for explaining both adverse health outcomes[]

  • Peripheral Neuropathy

    Hashimoto N, Yokoyama K, Sadahira K et al (2012) Itraconazole may increase the risk of early-onset bortezomib-induced peripheral neuropathy.[] Harnicar S, Adel N, Jurcic J (2009) Modification of vincristine dosing during concomitant azole therapy in adult acute lymphoblastic leukemia patients.[]

  • Thrombocytopenia

    Familial thrombocytopenia caused by heterozygous mutations in RUNX1 is associated with increased risk of acute myeloid leukemia (40% of cases).[]

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