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49 Possible Causes for Sacral Dimple, Syndactyly of Second and Third Toes

  • Smith Lemli Opitz Syndrome

    Other rare associated malformations include diaphragmatic hernia, anal atresia, thymus hypoplasia, sacral dimple, pyloric stenosis, Hirschsprung’s disease.[omicsgroup.org] Cutaneous syndactyly of the second and third toes commonly occurs. Chromosome karyotype is normal. The present case represents the fortieth to be reported.[pediatrics.aappublications.org] The limbs had syndactyly of second and third toes with short and stubby fingers (Figure 4) and simian crease.[omicsgroup.org]

  • Dubowitz Syndrome

    Minor anomalies as clinodactylyl of the firth digits, cutaneous syndactyly of toes, foot deformity, sacral dimple and cryptorchidism may be seen.[ncbi.nlm.nih.gov] The orthopedic manifestations of this condition primarily involve the hands and feet with brachyclinodactyly of the fifth finger and syndactyly of the second and third toes[ncbi.nlm.nih.gov] There also can be sacral dimple (s), sparse scalp hair, and some hypotonia .[ric.edu]

  • Crossed Polysyndactyly

    dimple Large beaked nose Ptosis Epicanthus Frontal bossing Hydrocephalus Abnormality of the pinna Renal cyst Encephalocele Exotropia Type II diabetes mellitus Cephalocele[mendelian.co] The feet showed syndactyly involving second and third toes. The maternal second cousin also had the same deformity.[nature.com] In the feet, there is polydactyly of first toe and the first metacarpal is short and tibially deviated. Syndactyly of second and third toe (or all toes) is present.[myslide.es]

  • Eyebrow Duplication - Syndactyly Syndrome

    dimple, bilateral undescended testis p15 6678317, 2679090, 8839888, 10494083 case 1 [6678317], Ref. 17 [8839888], case 22 [10494083] trisomy of 7p15-pter; mother had balanced[chr7.org] […] of second and third toes hypermobility of interphalangeal joints HEENT: excess periorbital skin wrinkling congenital fibromata of lips Skin: excessively stretchable skin[malacards.org] Note the socklike appearance of the feet with syndactyly involving the second, third, fourth, and fifth toes. The patient also has contiguous nail beds (synonychia).[emedicine.medscape.com]

  • Cerebro-Costo-Mandibular Syndrome

    […] spina bifida Sacral dimple Cystic fibrosis Miscellaneous 6 5 1 5 1 1 1 1 1 1 2 3 3 6 5 2 1 1 1 2 1 1 1 1 1 1 1 1 2 1 1 4 1 1 1 1 1 1 2 1 Parent-to-child transmission was[docslide.com.br] […] between the second and third toes.[doctiktak.com] Left renal ectopy Medullary cysts kidneys Tracheal Orthopedic Renal Heart Ventricular seDtal defect Neurological Occult spina bifida Closed lumbar meningo-myelocele Lumbo-sacral[docslide.com.br]

  • Microdontia

    dimple Calcinosis Amblyopia Hemiparesis Hypercalcemia Varicose veins Ventricular hypertrophy Abnormality of extrapyramidal motor function Narrow forehead Otitis media Sudden[mendelian.co] The labia majora are hypoplastic as are the distal phalanges of the fingers and toes. Mild syndactyly of the second and third fingers and toes have been described.[disorders.eyes.arizona.edu] […] fingernails Spina bifida occulta Hemivertebrae Cutis laxa Cardiomegaly Hoarse voice Abnormal dermatoglyphics Bicuspid aortic valve Reduced bone mineral density Ischemic stroke Sacral[mendelian.co]

  • Opitz-Kaveggia Syndrome

    dimple, flat feet, wide flat thumbs, and great toes.[nature.com] […] of the second and third toes.[medical-dictionary.thefreedictionary.com] , macrocephaly (62.2 cm, 98th percentile), frontal upsweep, high forehead, dolicocephaly, strabismus, narrow ear canals, narrow high palate, crowded teeth, low set ears, sacral[nature.com]

  • Radioulnar Synostosis-Microcephaly-Scoliosis Syndrome

    […] proximal metacarpal ossification centers talipes equinovarus metatarsus adductus polydactyly posterior midline scalp defects sacral dimple hyperconvex fingernails cerebral[humpath.com] Apart from transverse limb defects, syndactyly, most commonly of second and third toes, can also be observed.[nectarmutation.org] dimple sacral sinus scoliosis kyphosis fused vertebrae bifid vertebrae hip dislocation absence of pubic rami thin limbs radioulnar synostosis transverse palmar creases accessory[humpath.com]

  • Lenz-Majewski Syndrome

    Toenail dysplasia Hypoplasia of penis Beaking of vertebral bodies Broad neck Protruding tongue Amelogenesis imperfecta Metaphyseal dysplasia Peripheral axonal neuropathy Sacral[mendelian.co] Note severe aplasia cutis congenita (A, B) with scalpand skull defects, limbs anomalies with brachydactyly of toes, bilateralcutaneous syndactyly of second and third toes,[dokumen.tips] dimple Hoarse voice Rhizomelia Postnatal microcephaly Depressed nasal ridge Abnormality of the cerebral white matter Hepatosplenomegaly Elevated hepatic transaminase Unexplained[mendelian.co]

  • Congenital Absence of Both Lower Leg and Foot

    No sacral dimple or sacral hair tuft were present. The rest of the physical examination findings were within normal limits.[consultant360.com] The most frequent site is between the second and third toes. Syndactyly is thought to be genetic, with an autosomal dominant pattern of inheritance.[aafp.org] (webbed toes) Most commonly affects second and third toes Problem is more cosmetic, rarely requires treatment Various levels of webbing, from partial to complete If surgery[aafp.org]

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