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51 Possible Causes for Schistocytosis

  • Atypical Hemolytic Uremic Syndrome

    Additional work-up revealed schistocytosis on peripheral smear. She underwent kidney biopsy that revealed TMA involving glomeruli and small vessels.[] The presence of fragmented red blood cells (schistocytosis). An elevated creatinine concentration indicates decreased kidney function.[] . • A TMA may be documented in 2 ways: – Clinically, by signs of a microangiopathic hemolytic anemia (schistocytosis on peripheral blood smear, elevated LDH, elevated indirect[]

  • Microangiopathy

    This pentad of signs and symptoms is rarely present in its entirety, and often the triad of thrombocytopenia, elevated lactate dehydrogenase, and schistocytosis is sufficient[] Schistocytosis was present in all subjects at TMA diagnosis so was not included in the models.[] […] subendothelial space, and lodging of fibrin-platelet thrombi at the arteriocapillary junction. 2 The mechanical injury to erythrocytes results in intravascular hemolysis and schistocytosis[]

  • Traumatic Hemolytic Anemia

    Blood film: moderate poikilocytosis, schistocytosis, and polychromasia may be present (see Table 20–1 ).[] However, the presence of lowered haptoglobin, hemosiderinuria, and schistocytosis implicated chronic hemolysis.[] Favorite Table Download (.pdf) TABLE 20–1 SEVERITY OF PROSTHETIC VALVE HEMOLYSIS Mild Moderate Severe Hemosiderinuria Present Present Marked Hemoglobinuria Absent Absent Absent Schistocytosis[]

  • Thrombotic Microangiopathy

    She was diagnosed with TMA based on thrombocytopenia, schistocytosis, hemolytic anemia and renal dysfunction.[] The presence of schistocytosis and the secondary occurrence of hemolytic anemia were consistent with a diagnosis of thrombotic thrombocytopenic purpura (TTP).[]

  • Thrombocytopenia

    Early thrombocytopenia was defined as 2 platelet counts 11 schistocytosis, 12 prolongation of prothrombin time and activated partial thromboplastin time for age, 11 and elevated[] […] myelofibrosis Suggests impaired bone marrow synthesis Round macrocytosis Myelodysplastic syndrome, myelofibrosis, chronic liver disease Suggests impaired bone marrow synthesis Schistocytosis[]

  • Thrombotic Thrombocytopenic Purpura

    Peripheral blood smear showed schistocytosis, and a disintegrin and metalloproteinase with thrombospondin motifs 13 (ADAMTS13) activity is low, with normal initial coagulation[] Clinical course consists of relapsing acute events triggered mostly by infections, associated icterus and hyperbilirubinemia, severe hemolytic anemia with schistocytosis and[] Patients with hematologic abnormalities including hemolysis, schistocytosis, and thrombocytopenia warrant evaluation for vitamin B 12 deficiency.[]

  • Purtscher's Retinopathy

    The presence of schistocytosis and the secondary occurrence of hemolytic anemia were consistent with a diagnosis of thrombotic thrombocytopenic purpura (TTP).[]

  • Vitamin B12 Deficiency Anemia

    Peripheral blood smear showed schistocytosis, anisocytosis, and poikilocytosis with hypersegmented neutrophils.[] Schistocytosis, high LDH and low Haptoglobin pointed towards hemolysis, and the low Reticulocyte count indicated an inadequate bone marrow response to the anemia.[]

  • Uremic Pneumonitis

    He finally died. 2: A three-year-old girl with pneumonia and empyema was referred to our hospital for suspected HUS (anemia 6’3 g/dl, schistocytosis, thrombocytopenia 43000[] Peripheral blood smear showed finding of microangiopathic hemolytic anemia (schistocytosis) Other laboratory results were AST/ALT, 311/101 U/L; LDH, 6419 IU/L; haptoglobin[]

  • Carcinoma of the Prostate

    […] patients presented with evidence of widespread metastatic disease. 2,4–7 Our case involves mostly findings similar to aHUS, including intravascular hemolysis with evidence of schistocytosis[]

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