Schistocytosis: Causes & Reasons

Possible Causes for Schistocytosis

Clinical course consists of relapsing acute events triggered mostly by infections, associated icterus and hyperbilirubinemia, severe hemolytic anemia with schistocytosis and [ncbi.nlm.nih.gov]

Peripheral blood smear showed schistocytosis, and a disintegrin and metalloproteinase with thrombospondin motifs 13 (ADAMTS13) activity is low, with normal initial coagulation [ncbi.nlm.nih.gov]

Patients with hematologic abnormalities including hemolysis, schistocytosis, and thrombocytopenia warrant evaluation for vitamin B 12 deficiency. [consultant360.com]

Atypical Hemolytic Uremic Syndrome

Additional work-up revealed schistocytosis on peripheral smear. She underwent kidney biopsy that revealed TMA involving glomeruli and small vessels. [frontiersin.org]

The presence of fragmented red blood cells (schistocytosis). An elevated creatinine concentration indicates decreased kidney function. [rarediseases.org]

• A TMA may be documented in 2 ways: – Clinically, by signs of a microangiopathic hemolytic anemia (schistocytosis on peripheral blood smear, elevated LDH, elevated indirect [hematologyandoncology.net]

Traumatic Hemolytic Anemia

Blood film: moderate poikilocytosis, schistocytosis, and polychromasia may be present (see Table 20–1 ). [mhmedical.com]

However, the presence of lowered haptoglobin, hemosiderinuria, and schistocytosis implicated chronic hemolysis. [bloodjournal.org]

Table | Download (.pdf) TABLE 20–1 SEVERITY OF PROSTHETIC VALVE HEMOLYSIS Mild Moderate Severe Hemosiderinuria Present Present Marked Hemoglobinuria Absent Absent Absent Schistocytosis [mhmedical.com]

Thrombotic Microangiopathy

She was diagnosed with TMA based on thrombocytopenia, schistocytosis, hemolytic anemia and renal dysfunction. [ncbi.nlm.nih.gov]

The presence of schistocytosis and the secondary occurrence of hemolytic anemia were consistent with a diagnosis of thrombotic thrombocytopenic purpura (TTP). [pediatrics.aappublications.org]

Mesenteric Arteriovenous Fistula

Journal List World J Gastroenterol v.20(25); 2014 Jul 7 PMC4081707 World J Gastroenterol. 2014 Jul 7; 20(25): 8298–8303. Abstract Arteriovenous fistulas between the inferior mesenteric artery and vein are rare, with only 26 primary and secondary cases described in the literature. Secondary fistulas occur following[…] [ncbi.nlm.nih.gov]

Clostridium Perfringens Infection

Clostridium perfringens y Clostridium difficile como agentes etiológicos de diarrea nosocomial asociada a antibióticos en niños costarricenses [1] Universidad de Costa Rica Universidad de Costa Rica Hospital, Costa Rica Localización: Revista Biomédica, ISSN-e 0188-493X, Vol. 18, Nº. 2, 2007, págs. 81-87 Idioma: español[…] [dialnet.unirioja.es]

Woronets Trait

OMIM:274150 Hemolytic Uremic Syndrome, Atypical, Susceptibility To, 1 Microangiopathic hemolytic anemia, Reticulocytosis, Thrombocytopenia, Schistocytosis OMIM:235400 Telangiectasia [mousephenotype.org]

ORPHA:231226 Lathosterolosis Hepatosplenomegaly, Anisopoikilocytosis, Acanthocytosis, Schistocytosis, Increased mean platelet ... [mousephenotype.org]

Poikilocytosis, Elliptocytosis, Heinz body anemia OMIM:141700 Anemia, Congenital Dyserythropoietic, Type Ia Anemia of inadequate production, Splenomegaly, Anisocytosis, Schistocytosis [mousephenotype.org]

Macrocytic Hyperchromic Anemia

Noël N, Maigné G, Tertian G, Anguel N, Monnet X, Michot JM, Goujard C, Lambotte O (2013) Hemolysis and schistocytosis in the emergency department: consider pseudothrombotic [link.springer.com]

Microangiopathy

This pentad of signs and symptoms is rarely present in its entirety, and often the triad of thrombocytopenia, elevated lactate dehydrogenase, and schistocytosis is sufficient [ajnr.org]

[…] subendothelial space, and lodging of fibrin-platelet thrombi at the arteriocapillary junction. 2 The mechanical injury to erythrocytes results in intravascular hemolysis and schistocytosis [ajnr.org]

Schistocytosis was present in all subjects at TMA diagnosis so was not included in the models. [bloodjournal.org]

Purtscher's Retinopathy

The presence of schistocytosis and the secondary occurrence of hemolytic anemia were consistent with a diagnosis of thrombotic thrombocytopenic purpura (TTP). [pediatrics.aappublications.org]

GNAO1 Encephalopathy

OMIM:615157 Dehydrated Hereditary Stomatocytosis Increased circulating ferritin concentration, Schistocytosis, Reticulocytosis, Macrocytic anemia,... [mousephenotype.org]

ORPHA:101109 Thrombotic Thrombocytopenic Purpura, Hereditary Schistocytosis, Elevated circulating creatinine concentration, Increased blood urea nitrogen, Ret... [mousephenotype.org]

OMIM:613327 Shiga Toxin-Associated Hemolytic Uremic Syndrome Schistocytosis, Hypokalemia, Leukocytosis, Elevated circulating creatinine concentration, Hyponat... [mousephenotype.org]

Vitamin B12 Deficiency Anemia

Peripheral blood smear showed schistocytosis, anisocytosis, and poikilocytosis with hypersegmented neutrophils. [shmabstracts.com]

Schistocytosis, high LDH and low Haptoglobin pointed towards hemolysis, and the low Reticulocyte count indicated an inadequate bone marrow response to the anemia. [shmabstracts.com]

Neonatal Purpura Fulminans

However, thrombocytopenia became severe (Fig. 3), and the severity of schistocytosis increased progressively (6 percent schistocytes) after three days of treatment. [nejm.org]

However, thrombocytopenia became severe ( Fig. 3 ), and the severity of schistocytosis increased progressively (6 percent schistocytes) after three days of treatment. [nejm.org]

Within four days of the start of treatment with protein C concentrate, the schistocytosis resolved and D-dimer levels and the platelet count (Fig. 3) were within normal ranges [nejm.org]

Cerebral Thrombotic Thrombocytopenic Purpura

This pentad of signs and symptoms is rarely present in its entirety, and often the triad of thrombocytopenia, elevated lactate dehydrogenase, and schistocytosis is sufficient [ajnr.org]

Extremely elevated serum lactate dehydrogenase (LDH); released from fragmenting red cells and ischemic tissue cells Attention - The triad of severe or evolving thrombocytopenia, schistocytosis [cancertherapyadvisor.com]

Uremic Anemia

However, her anemia with schistocytosis, hyper-indirect bilirubinemia, and high LDH level were not controlled. [synapse.koreamed.org]

The MAHA with schistocytosis and the secondary signs of hemolysis were completely resolved after the repeat MVR. [synapse.koreamed.org]

Thrombocytopenia Due to Sequestration

[…] myelofibrosis Suggests impaired bone marrow synthesis Round macrocytosis Myelodysplastic syndrome, myelofibrosis, chronic liver disease Suggests impaired bone marrow synthesis Schistocytosis [aafp.org]

A clinical triad of thrombocytopenia, red blood cell fragments (schistocytosis), and an increased lactate dehydrogenase (LDH) level is enough to suggest the diagnosis. [askhematologist.com]

Uremic Pneumonitis

He finally died. 2: A three-year-old girl with pneumonia and empyema was referred to our hospital for suspected HUS (anemia 6’3 g/dl, schistocytosis, thrombocytopenia 43000 [adc.bmj.com]

Peripheral blood smear showed finding of microangiopathic hemolytic anemia (schistocytosis) Other laboratory results were AST/ALT, 311/101 U/L; LDH, 6419 IU/L; haptoglobin [chikd.org]

Microcytosis

[…] clumping Red blood cell volume outside reference range Red blood cell: auto-agglutination Red blood cells - megaloblasts Reticulocyte count abnormal Rhytiocytosis Rouleaux Schistocytosis [icd9data.com]

MCV Macrocytosis MCV : 100 - 115 MCV : 115 - 125 MCV >125 Hypochromasia MCH : 23 - 26 MCH : 21 - 23 MCH Polychromasia 3 - 5% 5 - 25% >25% Spherocytosis 1 - 5% 5 - 25% >25% Schistocytosis [hkimls.org]

Erythrocyte Membrane Abnormality

Elliptocytosis and schistocytosis in myelodysplasia: report of two cases Acta Haematol 1986 75 : 174–177 25 Alter BP, Weiner MA, Harris MB. [nature.com]

Subcapsular Liver Hematoma

Laboratory results revealed anemia (hemoglobin 8.4 g/dl), thrombocytopenia (76,000/μl), severe azotemia (urea 16.9 mmol/l, creatinine 448.8 μmol/l), schistocytosis, a negative [revistanefrologia.com]

Purpura Fulminans

However, thrombocytopenia became severe ( Fig. 3 ), and the severity of schistocytosis increased progressively (6 percent schistocytes) after three days of treatment. [doi.org]

Within four days of the start of treatment with protein C concentrate, the schistocytosis resolved and D-dimer levels and the platelet count ( Fig. 3 ) were within normal [doi.org]

[…] case reported here, fresh-frozen plasma halted the proliferation of skin lesions and partially resolved the disseminated intravascular coagulation, but thrombocytopenia and schistocytosis [doi.org]

Drug-Induced Thrombocytopenia

The patient’s renal function is normal and in peripheral blood smear there is no found of red cell schistocytosis, TTP was excluded. [file.scirp.org]

Posterior Fusion of Lumbosacral Vertebrae-Blepharoptosis Syndrome

[…] lamellar inclusion bodies Specific learning disability Occipital myelomeningocele Triangular-shaped open mouth Severe generalized osteoporosis Total cataract Sacral meningocele Schistocytosis [mendelian.co]

Hypobetalipoproteinemia

[…] cholesterol (0.63 +/- 0.05 mol x 10(-6)/mg membrane protein) and sphingomyelin/lecithin ratio (0.905 +/- 0.042) of RBC membranes were normal while plasma from the subject with schistocytosis [ncbi.nlm.nih.gov]

Zieve's Syndrome

[…] in serum ferritin (4144 mcg/L, so it was performed the genetic study that affirmed the alcoholic etiology of the hemochromatosis) •Peripheral smear showed the presence of schistocytosis [omicsonline.org]

Refractory Anemia

We present a case of refractory anemia (MDS-RA) with the uncommon features of marked elliptocytosis and schistocytosis in the peripheral blood and isochromosome 14q. [ncbi.nlm.nih.gov]

Diffuse Alveolar Hemorrhage

The classic pentad is hemolytic anemia with associated schistocytosis, thrombocytopenia, fevers, neurological sequelae, and renal dysfunction. [bloodjournal.org]

Thrombocytopenia 2

Early thrombocytopenia was defined as ≥2 platelet counts 11 schistocytosis, 12 prolongation of prothrombin time and activated partial thromboplastin time for age, 11 and elevated [pediatrics.aappublications.org]

Myelophthisis

There was no evidence of schistocytosis, which essentially ruled out intravascular or microangiopathic processes. [karger.com]

Protein C Deficiency

However, thrombocytopenia became severe ( Fig. 3 ), and the severity of schistocytosis increased progressively (6 percent schistocytes) after three days of treatment. [nejm.org]

Within four days of the start of treatment with protein C concentrate, the schistocytosis resolved and D-dimer levels and the platelet count ( Fig. 3 ) were within normal [nejm.org]