Scleromalacia Perforans & Skin Lesion & Symblepharon: Causes & Reasons

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Patient File

Sex unknown, Age unknown

Reported Symptoms

Scleromalacia Perforans, Skin Lesion, Symblepharon,

Negated

None

Unsure

None

Possible Causes

Erythropoietic Porphyria

lesions. [ncbi.nlm.nih.gov]

The patient had normal vision in both eyes with bilateral scleromalacia perforans. The right eye showed painful, nodular scleritis. [ncbi.nlm.nih.gov]

There was scarring of the entire face, bilaterally severely scarred retracted eye lids with incomplete lid closure (Fig 1 ), loss of eye lashes, scarred conjunctiva with symblepharon [bjo.bmj.com]

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Porphyria Cutanea Tarda

Biopsy of her bullous skin lesions was consistent with porphyria cutanea tarda, as were her serological and urinary exams. [ncbi.nlm.nih.gov]

perforans. [nature.com]

A 31-year-old man presented with bilateral inferior symblepharon, superior tarsal conjunctival scarring and concretions, and recurrent conjunctival and episcleral injection [ncbi.nlm.nih.gov]

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Sclerosing Keratitis

Depending on their location, dying and dead microfilariae produce symptoms typical of the disease: itching and lesions of the skin and the eye. [flipper.diff.org]

It is often associated with scleromalacia perforans. b. Is corneal graft useful in this patient? [mrcophth.com]

right eye H11.232 Symblepharon, left eye H11.233 Symblepharon, bilateral H11.239 Symblepharon, unspecified eye H11.241 Scarring of conjunctiva, right eye H11.242 Scarring [app.drchrono.com]

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Scleral Staphyloma

Skin biopsy revealed an epidermal nevus. [ncbi.nlm.nih.gov]

Scleromalacia Perforans from long-standing bulbar conjunctival Rhinosporidiosis. [ncbi.nlm.nih.gov]

Case A mass lesion was noted on the left eyeball of a newborn Japanese girl. The lesion appeared to be a scleral staphyloma. [link.springer.com]

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Epidemic Keratoconjunctivitis

(e.g., gingivitis ), skin lesions on head, neck or upper trunk Diagnostics : biopsy histologic staining (immunofluorescent staining of antibodies ) Treatment Systemic immunosuppression [amboss.com]

Occasionally, an atypical presentation of necrotizing scleritis without inflammation may occur; this is known as scleromalacia perforans. [medicalstudy.blogspot.com]

Two case reports are presented in which patients with epidemic keratoconjunctivitis (EKC) develop symblepharon during the course of their infection. [ncbi.nlm.nih.gov]

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Pulsating Exophthalmos

The most common features of the disease include multiple neural tumors (neurofibromas) on the skin or within the body, pigmented skin lesions (ie. cafe au lait spots), and [webeye.ophth.uiowa.edu]

perforans, right eye H15.052 Scleromalacia perforans, left eye H15.053 Scleromalacia perforans, bilateral H15.059 Scleromalacia perforans, unspecified eye H15.091 Other scleritis [app.drchrono.com]

right eye H11.232 Symblepharon, left eye H11.233 Symblepharon, bilateral H11.239 Symblepharon, unspecified eye H11.241 Scarring of conjunctiva, right eye H11.242 Scarring [app.drchrono.com]

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Spastic Ataxia with Congenital Miosis

Dry skin, melanomas, pre-malignant lesions, other cancers. Ophthalmic and neurologic abnormalities. [kumc.edu]

In decreasing order: necrotizing scleritis without inflammation ie. scleromalacia perforans (over 90%), nodular and necrotizing scleritis (50%), diffuse scleritis (30%) and [mrcophth.com]

Conjunctival argyrosis 372.56 Conjunctival deposits 372.6 Conjunctival scars 372.61 Granuloma of conjunctiva 372.62 Localized adhesions and strands of conjunctiva 372.63 Symblepharon [theodora.com]

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Isolated Congenital Sclerocornea

Symptoms of Fabry disease also include skin lesions and peripheral neuropathy; renal failure is a common and serious complication. [emedicine.medscape.com]

Ashton N, Hobbs HE: Effect of cortisone on rheumatoid nodules of the sclera (scleromalacia perforans). Br J Ophthalmol 36:373, 1952 PubMed Google Scholar 15. [link.springer.com]

Progression usually results in symblepharon, foreshortening of the fornices, and ankyloblepharon. [doctorlib.info]

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Hereditary Corneal Dystrophy

SJS is characterized by painful, blistery lesions on the skin and the mucous membranes (the thin, moist tissues that line body cavities) of the mouth, throat, genital region [web.archive.org]

Graefes-Arch-Clin-Exp-Ophthalmol. 1998 Apr; 236(4): 291-4 Ayyala,-R-S; Armstrong,-S Corneal melting and scleromalacia perforans in a patient with pyoderma gangrenosum and [malattierare.regione.veneto.it]

[…] burr Excimer laser phototherapeutic keratectomy Amniotic Membrane Inserts ProKera Amniotic Membrane Insert Cryopreserved amniotic membrane graft fastened to a thermoplastic symblepharon [decisionmakerplus.net]

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Periodic Sialadenosis

Oral lesions are the initial manifestation in 50 to 80 percent of patients with pemphigus vulgaris, and may precede skin lesions by one year or more. 12 Patients typically [aafp.org]

(perforans) H15.05- Scleromyxedema L98.5 Sclérose en plaques G35 Sclerosis, sclerotic Scoliosis (acquired) (postural) M41.9 Scoliotic pelvis Scorbutus, scorbutic - see also [icd.codes]

704.8 mycotic 110.0 parasitic 110.0 vulgaris 704.8 Sydenham's chorea - see Chorea, Sydenham's Sylvatic yellow fever 060.0 Sylvest's disease (epidemic pleurodynia) 074.1 Symblepharon [theodora.com]

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Keratitis

Abstract Keratitis-ichthyosis-deafness (KID) syndrome is a rare genodermatosis causing ichthyosis-like skin lesions, keratitis, and deafness. [ncbi.nlm.nih.gov]

perforans), as well as posterior scleritis 61. • Corneal findings  PUK  Sclerosing keratitis(gradual thickening and opacification of corneal stroma adjacent to site of [slideshare.net]

[…] keratitis, mucus clumping, increased tear debris, ulceration Lid and meibomian glands MGD variably present MGD variably present MGD frequent Trichiasis, keratinization, symblepharon [emedicine.medscape.com]

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Photophthalmia

lesions on the lid margins Eye redness Eyelid edema Nonspecific lid edema Non-mucopurulent discharge Hyperemia Vesicular lesions on the skin or lid margins Chemical Occurs [wikidoc.org]

perforans, right eye H15.052 Scleromalacia perforans, left eye H15.053 Scleromalacia perforans, bilateral H15.091 Other scleritis, right eye H15.092 Other scleritis, left [hmsa.com]

[…] priority QQ (comes in exam once,rare, 3 out of 10Q) lagophthalmos anatomy of eyelids lid edema clinical evaluation of ptosis 3rd priority Q (never come in exam, 2 out of 10Q) symblepharon [medicalclick.blogspot.com]

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Uveal Disease

ICD-10-CM Codes › A00-B99 Certain infectious and parasitic diseases › B00-B09 Viral infections characterized by skin and mucous membrane lesions › B00- Herpesviral [herpes [icd10data.com]

Scleromalacia perforans. Note the thinning of the sclera, which leaves the choroid bare and covered by a thin layer of conjunctiva. FIGURE 6. Scleromalacia perforans. [aafp.org]

[…] carcinoma, Ocular rosacea Deadly fungal infection, orbital cellulitis, concern in diabetics Kochers sign, Von Graefes sign Periorbital swelling and shared cosmetics (make-up) Symblepharon [quizlet.com]

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Lacrimal Gland Disorder

lesions are epiphenomena of Kimura’s disease. [bmcophthalmol.biomedcentral.com]

Anterior Scleritis Necrotizing, without inflammation Scleromalacia perforans Seen in RA Painless scleral thinning with marked ischaemia Perforation rare Treatment is difficult [slideshare.net]

Over time, this leads to bands of scar tissue connecting the surface of the eye to the inside of the eyelid (symblepharon), with a loss of the space between the eyelid and [richmondeye.com]

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Lymphoma

Patients with skin lymphoma might experience a variety of vague or unusual symptoms, including: Peeled skin Rash, which sometimes can itch Mushroom-like skin lesions Swollen [utswmed.org]

[…] multiple 731.0 perforans 379.04 Scleromyxedema 701.8 Scleroperikeratitis 379.05 Sclerose en plaques 340 Sclerosis, sclerotic adrenal (gland) 255.8 Alzheimer's 331.0 with [theodora.com]

Skin lesions: associated with cutaneous T-cell lymphoma (mycosis fungoides), anaplastic large-cell lymphoma and angio-immunoblastic lymphoma. [patient.info]

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Juvenile Paralysis Agitans of Hunt

red hair, recurrent staphylococcal skin abscesses with concurrent other bacterial infections and skin lesions, as well as chronic purulent pulmonary infections and infected [cram.com]

perforans 379.05 Scleritis with corneal involvement Scleroperikeratitis 379.06 Brawny scleritis 379.07 Posterior scleritis Sclerotenonitis 379.09 Other Scleral abscess 379.1 [theodora.com]

Chickenpox is a common, highly communicabledisease that causes fever and fluid-filled blisters on the skin.Shingles are characterised by extremely painful skin eruptions. [kmle.co.kr]

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Familial Congenital Nasolacrimal Duct Obstruction

Anorectal malformation Clinical: Low lesions: rectum continues beyond pelvic levator ani musculature. Often have fistulous communication with skin. [aimted.com]

perforans 379.05 Scleritis with corneal involvement Scleroperikeratitis 379.06 Brawny scleritis 379.07 Posterior scleritis Sclerotenonitis 379.09 Other Scleral abscess 379.1 [theodora.com]

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Stromal Keratitis

There were no skin lesions. [nejm.org]

[…] inhibits martix metalloproteinase does scleromalacia perforans have inflammation? What alpha hemolytic strep? [brainscape.com]

lesions • Treated with acyclovir cream five times daily 11. [de.slideshare.net]

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Punctate Keratitis

vital organ, andneurologic lesions. HSV infections in latter two periods are furtherclassified as skin, eyes, or mouth (SEM) with orwithout the other involvement seen in [slideshare.net]

Scleromalacia perforans. Note the thinning of the sclera, which leaves the choroid bare and covered by a thin layer of conjunctiva. FIGURE 6. Scleromalacia perforans. [aafp.org]

 Dry eye or symblepharon formation may be long termsequela of this conjuctival damage. Severe pain comes with development of keratitis,which occurs in approx 80% pt and [slideshare.net]

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Keratoglobus

A syndrome called microphthalmia with linear skin defects (MLS) includes microphthalmos, reddish linear skin lesions, and life-threatening cardiac arrhythmias. [entokey.com]

Ashton N, Hobbs H: Effect of cortisone on rheumatoid nodules of the sclera (scleromalacia perforans). Br J Ophthalmol 36:373, 1976. 281. [oculist.net]

Figure 20-4 Preauricular skin tags in a case of Goldenhar syndrome. (Courtesy of Ken K. Nischal, MD.) [entokey.com]

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Vertical Heterotropia

The overlying skin may have telangiectasias. [jiaps.com]

perforans 379.05 Scleritis with corneal involvement Scleroperikeratitis 379.06 Brawny scleritis 379.07 Posterior scleritis Sclerotenonitis 379.09 Other Scleral abscess 379.1 [theodora.com]

Although high-resolution multiplanar magnetic resonance imaging (MRI) is the preferred modality for evaluating these lesions, it is limited in its ability to distinguish a [jiaps.com]

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Ayerza Syndrome

[…] of eye V80.2 sexually transmitted diseases V74.5 bacterial V74.5 spirochetal V74.5 sickle-cell anemia, disease, or trait V78.2 skin condition V82.0 sleeping sickness V75.3 [theodora.com]

[…] multiple 731.0 perforans 379.04 Scleromyxedema 701.8 Scleroperikeratitis 379.05 Sclerose en plaques 340 Sclerosis, sclerotic adrenal (gland) 255.8 Alzheimer's 331.0 with [theodora.com]

704.8 mycotic 110.0 parasitic 110.0 vulgaris 704.8 Sydenham's chorea - see Chorea, Sydenham's Sylvatic yellow fever 060.0 Sylvest's disease (epidemic pleurodynia) 074.1 Symblepharon [theodora.com]

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Congenital Corneal Opacities - Cornea Guttata - Corectopia

Symptoms of Fabry disease also include skin lesions and peripheral neuropathy; renal failure is a common and serious complication. [odlarmed.com]

A) Diffuse anterior scleritis B) Necrotizing scleritis with inflammation C) Nodular anterior scleritis D) Scleromalacia perforans 136 All of the following have been associated [doctorlib.info]

Fig. 16.22.11A: Molten metal—dry eye, Fig. 16.22.11B: Molten metal—dry eye, keratectasia and symblepharon keratectasia and symblepharonMiscellaneous Injuries Fig. 16.23.1: [pubhtml5.com]

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Congenital Ectropion Uveae

Skin lesions found around the eye can be confusing—benign ones may have a dramatic appearance while malignant lesions look unassuming. [reviewofoptometry.com]

perforans, right eye H15.052 Scleromalacia perforans, left eye H15.053 Scleromalacia perforans, bilateral H15.091 Other scleritis, right eye H15.092 Other scleritis, left [hmsa.com]

The most frequently associated ocular anomaly was dermoid cyst (two cases) and symblepharon (two cases). [docksci.com]

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Corneal Dystrophies

SJS is characterized by painful, blistery lesions on the skin and the mucous membranes (the thin, moist tissues that line body cavities) of the mouth, throat, genital region [emedicinehealth.com]

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Arthrogryposis, Perthes Disease and Upward Gaze Palsy

Some patients have ectodermal abnormalities such as sparse and friable hair, hyperkeratotic skin lesions, and a generalized ichthyosis-like condition. [mendelian.co]

[…] multiple 731.0 perforans 379.04 Scleromyxedema 701.8 Scleroperikeratitis 379.05 Sclerose en plaques 340 Sclerosis, sclerotic adrenal (gland) 255.8 Alzheimer's 331.0 with [theodora.com]

Definition Klinefelter's tx: testosterone replacement prognosis: higher risk of breast cancer, DM, hypothyroid/parathyroid, SLE, sjogrens, RA Term s/s: open lesion with skin-covered [flashcardmachine.com]

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Adult Sandhoff Disease

[…] of eye V80.2 sexually transmitted diseases V74.5 bacterial V74.5 spirochetal V74.5 sickle-cell anemia, disease, or trait V78.2 skin condition V82.0 sleeping sickness V75.3 [theodora.com]

[…] multiple 731.0 perforans 379.04 Scleromyxedema 701.8 Scleroperikeratitis 379.05 Sclerose en plaques 340 Sclerosis, sclerotic adrenal (gland) 255.8 Alzheimer's 331.0 with [theodora.com]

704.8 mycotic 110.0 parasitic 110.0 vulgaris 704.8 Sydenham's chorea - see Chorea, Sydenham's Sylvatic yellow fever 060.0 Sylvest's disease (epidemic pleurodynia) 074.1 Symblepharon [theodora.com]

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