Second Wind Phenomenon: Causes & Reasons

Possible Causes for Second Wind Phenomenon

The second wind phenomenon in McArdle's disease. Brain 1986 ;109: 1087 - 1101 14. Haller RG, Vissing J. [doi.org]

This can be followed by a ‘second-wind phenomenon’. [symptoma.com]

A 'second wind' phenomenon with relief of myalgia and fatigue after a few minutes of rest is observed in many patients. [orpha.net]

Glycogen Storage Disease Type 13

Phenotype Similar to GSDV but there is no second wind phenomenon. [ojrd.biomedcentral.com]

wind phenomenon GSD VI / GSD 6 ( Hers' disease ) Liver glycogen phosphorylase ( PYGL ) Muscle phosphoglycerate mutase ( PGAM2 ) 1 in 65,000 – 85,000 [10] Yes Yes Yes [11] [en.wikipedia.org]

 An interesting constant phenomenon is the second wind that affected individuals experience when they rest briefly at the first appearance of exercise-induced myalgia. [slideshare.net]

Glycogen Storage Disease Type 10

It is characterized by exercise intolerance, and severe cramping that may last several hours, myoglobinuria, proximal muscle involvement, and a "second wind" phenomenon in [rrnursingschool.biz]

Phenotype Similar to GSDV but there is no second wind phenomenon. [ojrd.biomedcentral.com]

Some patients are able to work through the initial symptoms and find that prolonged exercise becomes possible (the so-called “second wind” phenomenon), because of the mobilization [clinicalgate.com]

Muscle Phosphorylase Kinase Deficiency

None of the patients developed a second wind phenomenon or improved their work capacity with an IV glucose infusion. [ncbi.nlm.nih.gov]

wind phenomenon: Less common than in McArdle's High carbohydrate meals exacerbate exercise intolerance Diet (vs McArdle's ) High carbohydrate meal: More symptoms Prolonged [neuromuscular.wustl.edu]

wind phenomenon: Less common than in McArdle's High carbohydrate meals exacerbate exercise intolerance Diet (vs McArdle's) High carbohydrate meal: More symptoms Prolonged [neuromuscular.wustl.edu]

Phosphoglycerate Kinase 1 Deficiency

wind phenomenon ), Rhabdomyolysis and myoglobinuria Flat venous lactate curve with exaggerated elevations in blood ammonia during exercise Hepatomegaly Fasting hypoglycemia [amboss.com]

 An interesting constant phenomenon is the second wind that affected individuals experience when they rest briefly at the first appearance of exercise-induced myalgia. [slideshare.net]

Genetic Recurrent Myoglobinuria

This “second wind” phenomenon is present in approximately ~90% of people with GSD-V. [rarediseases.org]

Phenotype Similar to GSDV but there is no second wind phenomenon. [ojrd.biomedcentral.com]

Improvement in symptoms after a brief rest, the so-called “second-wind” phenomenon, is frequently reported. [the-rheumatologist.org]

Glycogen Storage Disease Type 9

None of the patients developed a second wind phenomenon or improved their work capacity with an IV glucose infusion. [ncbi.nlm.nih.gov]

wind" phenomenon: Brief rest after myalgias allows further activity 7 Sudden, marked improvement in exercise capacity Exercise that previously produced muscle fatigue, tachycardia [neuromuscular.wustl.edu]

Glycogen Storage Disease Type 11

wind phenomenon GSD VI / GSD 6 (Hers' disease) Liver glycogen phosphorylase (PYGL) Muscle phosphoglycerate mutase (PGAM2) 1 in 65,000 85,000[10] Yes Yes Yes [11] None initially [scientiait.com]

GSD 5 (McArdle disease) Muscle glycogen phosphorylase (PYGM) 1 in 100,000 500,000[9][8] No No No Exercise-induced cramps, Rhabdomyolysis Renal failure by myoglobinuria, second [scientiait.com]

Glycogen Storage Disease Type 12

wind phenomenon GSD type VI liver glycogen phosphorylase Hers' disease 1 in 65,000- 85,000 births [14] Yes Yes Yes [15] None initially benign, growth retardation follows. [ipfs.io]

wind phenomenon ), Rhabdomyolysis and myoglobinuria Flat venous lactate curve with exaggerated elevations in blood ammonia during exercise Hepatomegaly Fasting hypoglycemia [amboss.com]

wind phenomenon GSD VI / GSD 6 ( Hers' disease ) Liver glycogen phosphorylase ( PYGL ) Muscle phosphoglycerate mutase ( PGAM2 ) 1 in 65,000 – 85,000 [10] Yes Yes Yes [11] [en.wikipedia.org]

Autosomal Dominant Myoglobinuria

Phenotype Similar to GSDV but there is no second wind phenomenon. [ojrd.biomedcentral.com]

Often a “second wind” phenomenon (improvement after rest) is found. [neuroweb.us]

If patients rest briefly after exercise-induced myalgia and stiffness, they can resume activity with better endurance (second-wind phenomenon), owing to increased mobilization [what-when-how.com]

Hereditary Myopathy with Lactic Acidosis due to ISCU Deficiency

Phenotype Similar to GSDV but there is no second wind phenomenon. [ojrd.biomedcentral.com]

The second wind phenomenon in McArdle’s disease. Brain. 1986;109(Pt 6):1087–101. [ojrd.biomedcentral.com]

There is no second wind phenomenon. Symptoms include exercise-induced myalgia and cramps [ 26, 27 ]. [ojrd.biomedcentral.com]

Aldolase A Deficiency

wind phenomenon: Less common than in McArdle's High carbohydrate meals exacerbate exercise intolerance Diet (vs McArdle's) High carbohydrate meal: More symptoms Prolonged [neuromuscular.wustl.edu]

Clinically, PFK deficiency, first described in 1965 in a Japanese family (46), is indistinguishable from McArdle disease, except for the absence of a typical second wind phenomenon [ncbi.nlm.nih.gov]

Congenital Disorder of Glycosylation Type 1T

Conclusions: The second wind phenomenon has been considered to be pathognomonic for McArdle disease, but we demonstrate that it can also be present in PGM1 deficiency. [utsouthwestern.influuent.utsystem.edu]

Glucose tolerance is slightly impaired, and the “second wind” phenomenon occurs very rarely in GSD type VII. [link.springer.com]

Phenotype Similar to GSDV but there is no second wind phenomenon. [ojrd.biomedcentral.com]

Disorder of Carbohydrate Metabolism

wind phenomenon ), Rhabdomyolysis and myoglobinuria Flat venous lactate curve with exaggerated elevations in blood ammonia during exercise Hepatomegaly Fasting hypoglycemia [amboss.com]

This second-wind phenomenon seems to be due to early mobilization of fatty acids and to increased blood flow to exercising muscles. [ncbi.nlm.nih.gov]

"Second wind" phenomenon in most. Rhabdomyolysis and myoglobinuria possible. [en.wikipedia.org]

Myopathy with Abnormal Lipid Metabolism

Improvement in symptoms after a brief rest, the so-called “second-wind” phenomenon, is frequently reported. [the-rheumatologist.org]

Many patients with exercise-induced muscular pain or cramps are able to continue with their activities after 10 minutes of exercise (ie, second-wind phenomenon). [emedicine.medscape.com]

They may develop rhabdomyolysis with myoglobinuria. (1, 5) With a reduction in exercise and slower resumption, they may get a "second wind" as lipid metabolism kicks in. [path.upmc.edu]

Disorder of Phosphorus Metabolism

[…] operate normally in vivo in this glycogenolytic disorder, suggesting a sufficient alternate fuel supply. (2) Blood-borne glucose may serve as one alternate fuel for the “second [neurology.org]

Glycogen Storage Disease Type 0

This “second wind” phenomenon is present in approximately ~90% of people with GSD-V. [rarediseases.org]

Dantrolene sodium versus placebo Poels 1990 studied the effect of dantrolene sodium on the second wind phenomenon. [cochranelibrary.com]

Additionally, the measure of plasma CK levels as well as the determination of the “second wind” phenomenon help to precisely provide a correct diagnosis. [rarediseases.org]

Glycogen Storage Disease Type 7

The reason for absence of the second wind phenomenon being inability to properly metabolize blood glucose. [symptoma.com]

During studies no consistent second wind phenomenon was found in Glycogen Storage Disease type 7 as it is seen in GSD type 5. [symptoma.com]

Metabolic Myopathy

Many patients with exercise-induced muscular pain or cramps are able to continue with their activities after 10 minutes of exercise (ie, second-wind phenomenon). [emedicine.com]

[…] the development of a typical spontaneous second wind. [clinicalgate.com]

Glycogen storage Lipid storage Exercise Usually cramps with short strenuous exercise Usually myalgia and tenderness (without cramps) with prolonged exercise, worse with fasting Second-wind [emedicine.com]

Glycogen Storage Disease

She reported several episodes of second-wind phenomenon. Physical examination did not show any neurological abnormality, including fixed muscle weakness or atrophy. [ncbi.nlm.nih.gov]

wind" phenomenon, elevated Creatine Kinase (CK) levels at rest, and previous episodes of raised CK levels following exercise. [ncbi.nlm.nih.gov]

An unexplained symptom in this disease is the so-called “second wind” phenomenon: during physical activity, patients initially fatigue rapidly, but then recover to a degree [watcut.uwaterloo.ca]

Glycogen Storage Disease Type 1C

Glycogen Storage Disease Type 4

Some patients are able to adapt exercise to take advantage of the second wind phenomenon, as long as it is not too strenuous. [encyclopedia.com]

Dantrolene sodium versus placebo Poels 1990 studied the effect of dantrolene sodium on the second wind phenomenon. [cochranelibrary.com]

Individuals with McArdle's disease often experience a " second wind " phenomenon in energy levels during exercise because of these secondary fuel sources. [encyclopedia.com]

Pompe Disease

There is also a second-wind phenomenon they tend to be okay. This is becuase they can replenish glucose and Fatty Acid store and use that instead of glycogen. [youtube.com]

This test records the cardiac frequency to detect the pathognomonic heart rate response observed in the second wind phenomenon. [heighpubs.org]

Some patients are able to adapt exercise to take advantage of the second wind phenomenon, as long as it is not too strenuous. [encyclopedia.com]

Polyglucosan Body Myopathy Type 2

 An interesting constant phenomenon is the second wind that affected individuals experience when they rest briefly at the first appearance of exercise-induced myalgia. [slideshare.net]

The second-wind phenomenon is seen as another aspect of the condition. [sites.google.com]

wind phenomenon.  Muscle histochemistry shows subsarcolemmal accumulation of glycogen that is normally digested by diastase.  A specific histochemical stain for phosphorylase [slideshare.net]

Secondary Myopathy

Improvement in symptoms after a brief rest, the so-called “second-wind” phenomenon, is frequently reported. [the-rheumatologist.org]

The second-wind phenomenon is seen as another aspect of the condition. [sites.google.com]

For example, the presentation of a patient with recurrent rhabdomyolysis and second-wind phenomenon should prompt blood testing for mutations underlying McArdle’s disease. [the-rheumatologist.org]

Late-Onset Carnitine Palmitoyl Transferase II Deficiency

Many patients with exercise-induced muscular pain or cramps are able to continue with their activities after 10 minutes of exercise (ie, second-wind phenomenon). [emedicine.medscape.com]

Braakhekke JP, de Bruin MI, Stegeman DF, Wevers RA, Binkhorst RA, Joosten EM (1986) The second wind phenomenon in McArdle's disease. [link.springer.com]

A second wind phenomenon is common. [jnnp.bmj.com]

Myoadenylate Deaminase Deficiency

Often a “second wind” phenomenon (improvement after rest) is found. [neuroweb.us]

Many patients with exercise-induced muscular pain or cramps are able to continue with their activities after 10 minutes of exercise (ie, second-wind phenomenon). [emedicine.medscape.com]

wind" phenomenon almost exactly 7 minutes after a significant load increment. [en.wikipedia.org]

Acute Exertional Rhabdomyolysis

Phenotype Similar to GSDV but there is no second wind phenomenon. [ojrd.biomedcentral.com]

wind phenomenon routinely (McArdle disease) Avoid exercising if catabolic stress; eg, infection (fatty acid oxidation disorders) Additional advice in case of type 1 ryanodine [bmjopensem.bmj.com]

The second wind phenomenon in McArdle’s disease. Brain. 1986;109(Pt 6):1087–101. [ojrd.biomedcentral.com]

Myopathic Carnitine Deficiency

Many patients with exercise-induced muscular pain or cramps are able to continue with their activities after 10 minutes of exercise (ie, second-wind phenomenon). [emedicine.medscape.com]

wind phenomenon No post exertional myoglobinuria 50% of patients: Mild to moderate muscle weakness Atrophy and muscle tenderness Early muscle fatigue with exercise Higher [neurodiffdx.com]

In contrast to patients with glycogen storage diseases of muscle, patients suffering from FAOD do not experience a “second-wind” phenomenon. [hindawi.com]

Paroxysmal Rhabdomyolysis

Phenotype Similar to GSDV but there is no second wind phenomenon. [ojrd.biomedcentral.com]

The second wind phenomenon in McArdle’s disease. Brain. 1986;109(Pt 6):1087–101. [ojrd.biomedcentral.com]

There is no second wind phenomenon. Symptoms include exercise-induced myalgia and cramps [ 26, 27 ]. [ojrd.biomedcentral.com]