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25 Possible Causes for Sensitivity to Genotoxic Agents

  • Rothmund Thomson Syndrome

    Little is known about the sensitivity of RECQL4-deficient cells to these and other genotoxic agents.[ncbi.nlm.nih.gov] The sensitivity of RTS cells to genotoxic agents exploiting cells with a known RECQL4 status is being elucidated and is aimed at optimizing the chemotherapeutic regimen for[ncbi.nlm.nih.gov] […] to genotoxic agents.[doi.org]

  • Oculomotor Apraxia

    In addition, APTX-defective cells show increased sensitivity to genotoxic agents, which result in SSBs. These results indicate an important role ofAPTX in SSBR.[ncbi.nlm.nih.gov] A novel nonsense mutation in the APTX gene associated with delayed DNA single-strand break removal fails to enhance sensitivity to different genotoxic agents.[annalsofian.org] The authors demonstrate the instability of the mutant aprataxin products and showed that the AOA1 patients’ cells are more sensitive to agents that cause single-strand DNA[link.springer.com]

  • Ruijs Aalfs Syndrome

    Symptoms related to Ruijs-Aalfs syndrome include: Triangular face Bulbous nose Prominent nasal bridge Frontal bossing Delayed skeletal maturation Skeletal muscle atrophy Weight Loss Down-sloping shoulders • • • Back to: « Ruijs-Aalfs syndrome Related Symptom Articles Triangular face : Summary Facial contour, as[…][familydiagnosis.com]

  • Ewing's Sarcoma

    Enhanced ROS production in oncogenically transformed cells potentiates c-Jun N-terminal kinase and p38 mitogen-activated protein kinase activation and sensitization to genotoxic[doi.org] The chemopreventive agent N-(4-hydroxyphenyl)retinamide induces apoptosis through a mitochondrial pathway regulated by proteins from the Bcl-2 family.[doi.org]

  • Baller-Gerold Syndrome

    Jin W, Liu H, Zhang Y et al (2008) Sensitivity of RECQL4-deficient fibroblasts from Rothmund-Thomson syndrome patients to genotoxic agents.[doi.org] agents.[doi.org] Cabral RE, Queille S, Bodemer C et al (2008) Identification of new RECQL4 mutations in Caucasian Rothmund-Thomson patients and analysis of sensitivity to a wide range of genotoxic[doi.org]

  • Ataxia Telangiectasia

    Ginder, Depletion of the chromatin remodeler CHD4 sensitizes AML blasts to genotoxic agents and reduces tumor formation, Blood, 10.1182/blood-2015-03-631606, 126, 12, (1462[doi.org]

  • Ewing Family of Tumors

    Enhanced ROS production in oncogenically transformed cells potentiates c-Jun N-terminal kinase and p38 mitogen-activated protein kinase activation and sensitization to genotoxic[doi.org] The chemopreventive agent N-(4-hydroxyphenyl)retinamide induces apoptosis through a mitochondrial pathway regulated by proteins from the Bcl-2 family.[doi.org]

  • Friedreich Ataxia

    […] indicative of genotoxicity stress. 13 The accumulation of DNA lesions may ultimately lead to apoptosis and cell death via p53-mediated pathways.[doi.org] […] to DNA-damaging agents. 34 In a study on FRDA peripheral blood mononuclear cells, increased mitochondrial and nuclear DNA damage also results in changes in gene expression[doi.org] […] model of FRDA also suggests that increased levels of DNA damage occurs in FRDA and the absence of frataxin leads to nuclear damage, chromosomal instability and a greater sensitivity[doi.org]

  • Multiple Endocrine Neoplasia Type 1

    […] that had integrated the targeting vector outside of the ATR locus did not display heightened sensitivity to these DNA‐damaging agents ( Supplementary Figure 1 and data not[doi.org] Monoallelic disruption of the ATR gene led to a further increase in the sensitivity of HCT 116 cells to all three forms of genotoxic stress, whereas two drug‐resistant clones[doi.org]

  • Acquired Fanconi Syndrome

    . • Patients with FA are exquisitely sensitive to genotoxic agents such as cyclophosphamide, busulfan and ionizing radiation.[slideshare.net]

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