Septal Thickening: Causes & Reasons

Possible Causes for Septal Thickening

Radiologically, the presence of centrilobular nodules, interlobular septal thickening, and significant mediastinal adenopathy are useful in identifying this subgroup from [ncbi.nlm.nih.gov]

However, there was no prominent interlobular septal thickening, pleural effusion, or mediastinal lymphadenopathy. [circ.ahajournals.org]

Some intralobular interstitial thickening is visible in the areas of ground-glass opacity, but interlobular septal thickening is not clearly visible. [thoracickey.com]

Pulmonary Alveolar Microlithiasis

CT reveals ground glass haze with inter and intra lobular septal thickening suggestive of crazy paving pattern. [omicsonline.org]

High-resolution CT (HRCT) revealed diffuse ground-glass opacities throughout both lungs, micronodular densities, interlobular septal thickening, linear calcifications along [ncbi.nlm.nih.gov]

High resolution CT scan revealed diffuse ground-glass attenuation with superimposed septal thickening ("crazy-paving" pattern). [ncbi.nlm.nih.gov]

Pulmonary Alveolar Proteinosis

A chest radiograph showed bilateral mid and lower zone alveolar interstitial shadows and a high-resolution computed tomography scan of her chest revealed septal thickening [ncbi.nlm.nih.gov]

thickening intralobular interstitial thickening polygonal pattern 7. [slideshare.net]

There are areas of patchy ground-glass opacification with smooth interlobular septal thickening and intralobular interstitial thickening (white circles) a polygonal pattern [learningradiology.com]

Idiopathic Acute Eosinophilic Pneumonia

High-resolution chest computed tomography scan revealed patchy ground glass opacity and ill-defined nodules, diffuse interlobar and interlobular septal thickening, and bilateral [ncbi.nlm.nih.gov]

CT Described features include 4,6,9 : bilateral ground-glass areas: common interlobular septal thickening : common pleural effusions : can be present in ~80% (range 60-100% [radiopaedia.org]

Autoimmune Pulmonary Alveolar Proteinosis

Patients with APAP present with ground-glass opacities (GGOs) and interlobular septal thickening on thin-slice chest CT scans. [ncbi.nlm.nih.gov]

thickening in multiple lobes. [pap-guide.jp]

HRCT findings for both autoimmune and secondary PAP demonstrated GGO, consolidation, interlobular septal thickening, and a low-attenuation area. [pap-guide.jp]

Lymphocytic Interstitial Pneumonia

Other common findings included thickening of bronchovascular bundles (n - 19), interlobular septal thickening (n = 18), cystic airspaces (n = 15), and lymph node enlargement [ncbi.nlm.nih.gov]

septal thickening and widespread consolidations. [omicsonline.org]

thickening (80%) Thickening of small bronchovascular bundles (tree-in-bud pattern) Bronchiectasis (20%) Rarely fibrosis and honeycombing Focal (pseudolymphoma) Air-space [radiologykey.com]

Pulmonary Veno-Occlusive Disease

[…] to numerous Peribronchovascular bundle thickening Distribution of septal thickening and ground-glass opacities: Random Lymph nodes Mild lymphadenopathy, mean 15 ± 5 mm (50% [radiologykey.com]

A computed tomography scan of the chest revealed septal thickening and diffuse micronodules. [ncbi.nlm.nih.gov]

Computed tomography revealed septal thickening and diffuse micronodules. Bronchoalveolar lavage revealed occult alveolar hemorrhage. [ncbi.nlm.nih.gov]

Acute Interstitial Pneumonitis

On the left multiple diseases showing septal thickening: Lymphangitic carcinomatosis: irregular septal thickening, usually focal or unilateral, in 50% adenopathy, known carcinoma [radiologyassistant.nl]

Smooth septal thickening, intralobular lines, and ground glass result in a “crazy paving” pattern. Mild bronchial dilatation is present. [radiologykey.com]

HRCT findings in Lymphangitic Carcinomatosis Interlobular septal thickening, thickening of fissures and thickening of the peribronchovascular interstitium (bronchial cuffing [radiologyassistant.nl]

Diffuse Pulmonary Lymphangiomatosis

Diffuse interstitial septal thickening was found on a serial follow-up chest computed tomography scan, and lymphangitic metastasis was the primary radiologic differential [ncbi.nlm.nih.gov]

Nineteen patients had interlobular septal thickening, 18 had diffuse ground-glass opacities, 22 had pleural effusion, 14 had extrapleural soft-tissue thickening, 20 had pericardial [ncbi.nlm.nih.gov]

CT chest Described features include 4 increased interlobular septal thickening peribronchovascular thickening patchy ground glass opacities pleural thickening pleural effusion [radiopaedia.org]

Kaposi Sarcoma of the Lung

No interlobular septal thickening. Small volume mediastinal lymphadenopathy. [radiopaedia.org]

septal thickening. [ncbi.nlm.nih.gov]

Keywords Pulmonary Involvement Mediastinal Adenopathies Human Herpes Virus Type Human Immunodeficiency Virus Load Interlobular Septal Thickening Review Introduction Kaposi [ojrd.biomedcentral.com]

Secondary Pulmonary Fibrosis

CONSUMERS: Click here for the Consumer Version Topic Resources Interstitial lung diseases are a heterogeneous group of disorders characterized by alveolar septal thickening [merckmanuals.com]

thickening, peribronchial nodularity  Septal thickening, peribronchial nodularity – lymphangitic metastases – lymphangitic metastases – +/- miliary infection – +/- miliary [learningradiology.com]

A UIP-pattern of fibrosis is characterized by honeycombing cysts and reticular septal thickening with subpleural and posterior basal predominance. [radiopaedia.org]

Drug-Induced Pulmonary Fibrosis

thickenings, without any pleuro-pericardial effusion. [ccij-online.org]

Wedge resection of the lung revealed AEP, alveolar septal thickening, and intra-alveolar fibrin deposition. [nature.com]

Acute Interstitial Lung Disease

The HRCT findings include diffuse areas of ground-glass attenuation, nodules, smooth interlobular septal thickening; small-to-moderate pleural effusions are frequent ( 62 [shortnessofbreath.it]

Ancillary findings were seen, such as traction bronchioloectasis (n=2), interstitial septal thickening (n=1) and mild bilateral pleural effusion (n=2). [erj.ersjournals.com]

Congenital Pulmonary Lymphangiectasia

In these diseases, interlobular septal thickening tends to be nodular. There is no established treatment for DPL. [kjronline.org]

thickening pleural effusion ( chylothorax ) MRI T1 (especially coronal): interstitial thickening pleural effusion atelectasis T2 (especially axial) usually shows high-signal [radiopaedia.org]

High-resolution CT demonstrated extensive bilateral septal and peribronchovascular interstitial thickening, areas of ground-glass attenuation, and bilateral pleural effusions [ncbi.nlm.nih.gov]

Pneumocystosis Jirovecii Pneumonia

High-resolution CT revealed diffuse, bilateral, and symmetric ground-glass opacities with septal thickening in both lungs; however, the radiation port was spared and appeared [ncbi.nlm.nih.gov]

thickening. [radiopaedia.org]

Diagnosis almost certain From the case: Pneumocystis carinii pneumonia CT Axial lung window There are patches of ground-glass opacities with cystic lesions, reticulation, and septal [radiopaedia.org]

Fat Embolism

Less common findings included lobular ground-glass opacities and lobular consolidations, smooth septal thickening, thickening of the bronchial wall, and areas of crazy paving [ncbi.nlm.nih.gov]

thickening. [ncbi.nlm.nih.gov]

Chest computed tomography (CT) often depicts areas of ground glass opacities with interlobar septal thickening. [symptoma.com]

Necrotizing Alveolitis

On direct imaging there were bilateral diffuse ground-glass opacities and peribronchial alveolar septal thickening predominantly affecting the lower lobes, there were no signs [clinicalcasereports.jacobspublishers.com]

Histology: Alveolar septal thickening with inflammatory cells, intra-alveolar foam macrophages. Diagnosis: Usually by exclusion; compatible clinical picture. [lumen.luc.edu]

Cystic Lung Disease

Focal septal thickening in lymphangitic carcinomatosis On the left we see focal irregular septal thickening in the right upper lobe in a patient with a known malignancy. [radiologyassistant.nl]

thickening, bronchiectasis 13. 1 year later Peribronchiolar Nodules Cavitating nodules and cysts Langerhans Cell Histiocytosis 14. [slideshare.net]

Lymphatic abnormality is common in S-LAM due to lymphatic obstruction, which can lead to interstitial septal thickening, chylous pericardial or pleural effusion, thoracic [err.ersjournals.com]

Left Ventricular Outflow Obstruction

Clinical, haemodynamic, and morphological features are described in 2 patients with disproportionate ventricular septal thickening, left ventricular outflow obstruction with [ncbi.nlm.nih.gov]

Post-event echocardiography showed hypertrophic cardiomyopathy with asymmetrical septal thickening, an under-filled left ventricle, dynamic left ventricular outflow obstruction [ncbi.nlm.nih.gov]

Procedures: septal myectomy, ethanol ablation, pacemaker, ICD Septal myectomy During this surgical procedure, the surgeon removes a small amount of the thickened septal wall [163.178.103.176]

Lipid Pneumonia

Chest CT revealed ground-glass opacities with interlobular septal thickening (crazy-paving pattern) and partial infiltration in the bilateral lower lung fields ( b ). [bmcpulmmed.biomedcentral.com]

Axial CT image (coned view) of right lower lobe shows geographic distribution of ground-glass opacities with associated interlobular septal thickening. [dx.doi.org]

A chest roentgenogram and computed tomography (CT) revealed ground-glass opacity and interlobular septal thickening in the bilateral middle and lower lobes of the lungs that [bmcpulmmed.biomedcentral.com]

Miliary Tuberculosis of the Liver

thickening Differential Diagnosis Pneumoconiosis, especially silicosis or anthrosilicosis Metastatic nodules, especially from thyroid carcinoma Sarcoidosis Treatment Estimated [learningradiology.com]

thickenings with ground-glass areas and centrilobular nodules with a peri-lymphatic distribution. [en.wikipedia.org]

Septal thickening usually accompanies these nodules. [jtd.amegroups.com]

Drug or Radiation Exposure-Related Interstitial Lung Disease

CONSUMERS: Click here for the Consumer Version Topic Resources Interstitial lung diseases are a heterogeneous group of disorders characterized by alveolar septal thickening [merckmanuals.com]

Histology: Alveolar septal thickening with inflammatory cells, intra-alveolar foam macrophages. Diagnosis: Usually by exclusion; compatible clinical picture. [lumen.luc.edu]

The case of a SSc patient with myositis and early-stage ILD was recently described, in which, after i.v. immunoglobulins, the regression of GGOs, septal thickenings and a [err.ersjournals.com]

Acute Berylliosis

thickening 2 Mediastinal and hilar lymphadenopathy may also be present in a proportion of cases. [radiopaedia.org]

License: CC BY-SA 2.0 Upper lobe fibrosis Pulmonary nodules Diffuse interstitial fibrosis Traction bronchiectasis Interlobular septal thickening Hilar and mediastinal lymphadenopathy [lecturio.com]

Histology: Alveolar septal thickening with inflammatory cells, intra-alveolar foam macrophages. Diagnosis: Usually by exclusion; compatible clinical picture. [lumen.luc.edu]

Diffuse Alveolar Hemorrhage

thickening without ground-glass opacity (n = 3, 18.75%). [ncbi.nlm.nih.gov]

The radiological pattern of this disease is defined by ground-glass consolidations and interlobular septal thickening (crazy-paving pattern). [archbronconeumol.org]

thickening superimpose on areas of ground-glass opacity may sometimes give rise to a crazy-paving pattern 10 these can often resolve between chronic recurrent bleeding events [radiopaedia.org]

Nitrofurantoin Toxicity

A high resolution CT (HRCT) showed widespread patchy areas of ground glass shadowing in both lung fields with minor peripheral sub-pleural interlobular septal thickening. [academic.oup.com]

Figure 2: Case 2: CXR showing extensive reticular changes bilaterally Figure 3: Case 2: HRCT showing bibasal and subpleural intra-lobular septal thickening, with some groundglass [nature.com]

Inter- and intralobular septal thickening (IST), traction bronchiectasis (TB), honeycombing cysts (HC) and ground glass (GG) are indicated. [ncbi.nlm.nih.gov]

Congenital Pulmonary Veins Atresia or Stenosis

Lack of a pulmonary vein causing unilateral interlobular septal thickening Hanping Wang 1, Li Zhang 1, Wei Liu 2, Kai-Feng Xu 1, Juhong Shi 1 1 Division of Pulmonary Medicine [thorax.bmj.com]

Chest X ray may demonstrate signs of congestion (peribronchovascular and septal thickening, Kerlley B lines, alveolar edema) either diffuse or localized (mimicking other processes [wjgnet.com]

[…] of the septal walls, mosaic pattern due to inhomogeneous aeration and perfusion, may not be detected with MRI. [err.ersjournals.com]

Hemangiomatosis

However, there was no prominent interlobular septal thickening, pleural effusion, or mediastinal lymphadenopathy. [ahajournals.org]

(a) Coronal reformatted CT scan (lung window level) shows diffuse, ill-defined, ground-glass nodules (arrowhead) and no evidence of interlobular septal thickening. [pubs.rsna.org]

Axial high-resolution computed tomography scan showing multiple bilateral, diffuse, and poorly defined small nodular opacities and no evidence of interlobular septal thickening [ahajournals.org]

Erythema Nodosum

In early lesions edema, hemorrhage, and neutrophils are responsible for the septal thickening, whereas fibrosis, periseptal granulation tissue, lymphocytes, and multinucleated [ncbi.nlm.nih.gov]

thickening, granulomatous infiltration of the septa, and an absence of phlebitis. [emedicine.medscape.com]

thickening, with fibrotic changes in the fat around blood vessels. [en.wikipedia.org]

Familial Hypertrophic Cardiomyopathy Type 27

Ventricular systolic septal thickening and excursion in idiopathic hypertrophic subaortic stenosis. [link.springer.com]

Familial Hypertrophic Cardiomyopathy Type 25

Prevalence, clinical correlates and prognosis of discrete upper septal thickening on echocardiography. The Framingham Heart Study. [scielo.org.mx]

Incidence of basal septal bulge in echocardiographic referrals. Heart Lung Circ. 2013; 22:S1-125. [ Links ] 12. Nishida K, Saito T, Kamijima G, et al. [scielo.org.mx]