Create issue ticket

19 Possible Causes for Severe Axonal Sensory and Motor Peripheral Neuropathy

  • Ataxia-Oculomotor Apraxia Syndrome

    You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser . Format Definition An autosomal recessive syndrome characterized by early-onset cerebellar ataxia, oculomotor apraxia, early areflexia and late peripheral neuropathy. Acronym AOA[…][uniprot.org]

  • Immune Thrombocytopenic Purpura

    Multiple variants of GBS exist, with acute motor and sensory axonal neuropathy (AMSAN) being the most severe.[ncbi.nlm.nih.gov] Guillain-Barré syndrome (GBS) is a potentially life-threatening autoimmune disease causing demyelination of peripheral nerves.[ncbi.nlm.nih.gov]

  • Transverse Myelitis

    axonal neuropathy (AMAN, more rapidly evolving and more severe motor deficits, no sensory deficits), acute motor and sensory axonal neuropathy (AMSAN, reported nearly exclusively[jped.elsevier.es] […] in adults), Miller-Fisher syndrome (ataxia, ophthalmoplegia, and areflexia without peripheral weakness), pharyngeal-cervical-brachial motor variant (ptosis, facial, pharyngeal[jped.elsevier.es] […] is actually a descriptive term for the most common clinical presentation of GBS, while in 10–15% of cases, the clinical features comprise variant GBS forms, such as acute motor[jped.elsevier.es]

  • Acute Intermittent Porphyria

    Motor weakness and sensory involvement presumably result from the peripheral axonal neuropathy, and mental symptoms do not have clear cerebral morphological findings. 1 Although[doi.org] Acute attacks are characterized by severe abdominal pain, vomiting, constipation, hypertension, tachycardia, and bladder dysfunction, presumably due to an autonomic neuropathy[doi.org]

  • Ataxia

    Peripheral nerve conduction and nerve biopsy findings may show moderate to severe axonal sensory-motor neuropathy with axonal regeneration.[orpha.net]

  • Hereditary Motor and Sensory Neuropathy

    Abstract Hereditary motor and sensory neuropathies (HMSN) are genetically heterogeneous disorders affecting peripheral motor and sensory functions.[ncbi.nlm.nih.gov] Many different pathogenic variants in several genes involved in the demyelinating, the axonal and the intermediate HMSN forms have been identified, for which all inheritance[ncbi.nlm.nih.gov]

  • Early-Onset Cerebellar Ataxia

    Peripheral nerve conduction and nerve biopsy findings may show moderate to severe axonal sensory-motor neuropathy with axonal regeneration.[orpha.net]

  • Charcot-Marie-Tooth Disease Type 2S

    MFN2 gene testing must be a first-line analysis in axonal HMSN irrespective of the mode of inheritance or the severity of the peripheral neuropathy.[jamanetwork.com] Charcot-Marie-Tooth disease (CMT) represents a subset of hereditary motor and sensory neuropathy (HMSN) and is characterized by the presence of an isolated polyneuropathy.[jamanetwork.com]

  • Adult Polyglucosan Body Disease

    […] and a MR with cortical-subcortical diffuse atrophy and white matter changes considered as a microlacunar vascular encephalopathy Axonal-myelinic sensory-motor peripheral[docplayer.it] neuropathy 21 Rov.[docplayer.it] Right Babinski Medium degree cognitive deficiency Severe decrease of nerve conduction velocities Galactocerebrosidase leucocyte activity: 0,05 nmoles/h/mg prot (nv 2-6) G809A[docplayer.it]

  • Cerebellar Ataxia

    Peripheral nerve conduction and nerve biopsy findings may show moderate to severe axonal sensory-motor neuropathy with axonal regeneration.[orpha.net]

Further symptoms