Severe Clinical Course: Causes & Reasons

Warning: Do not use in emergencies, if pregnant, if under 18, or as a substitute for a doctor’s advice or diagnosis. Learn more

Possible Causes for Severe Clinical Course

Brazilian Hemorrhagic Fever

Compared to the patients who did not receive ribavirin, the patient who was treated with it had a shorter and less severe clinical course. [en.wikipedia.org]

Acute Pancreatitis

We found (a) that patients with image-proven pancreatitis suffer a more severe clinical course than those without; (b) that the sensitivity, positive predictive value, and [ncbi.nlm.nih.gov]

Hemolytic Uremic Syndrome

Moreover, a shorter period between the onset of diarrhea and a diagnosis of D + HUS indicated a more severe clinical course or long-term sequelae, and it should be considered [ncbi.nlm.nih.gov]

Criteria for both groups were severe thrombocytopenia less than 50/nL, severe hemolysis with administration of packed red blood cells, and a complicated clinical course with [ncbi.nlm.nih.gov]

What is Known: • BCR at admission has been proposed as an accurate predictor of complicated clinical course in children with D+HUS. [ncbi.nlm.nih.gov]

Exfoliation Syndrome

clinical course, and more frequent necessity for surgical intervention. [glaucoma.net]

course and worse prognosis. [meajo.org]

Exfoliative glaucoma has a more serious clinical course and worse prognosis than primary open-angle glaucoma. [glaucoma.net]

Indian Childhood Cirrhosis

[…] far, after a progressive clinical course and severe hepatic failure. [ncbi.nlm.nih.gov]

Abstract Three of the four children of two unrelated German families fell ill in the first year of life with severe hepatopathy leading to death in two of the children so [ncbi.nlm.nih.gov]

Hepatic Rupture

Its clinical courses and our therapeutic approaches are presented. [ncbi.nlm.nih.gov]

courses of disease, and PCLD-related mortality was 2 %. [surgicalcasereports.springeropen.com]

Moreover, the clinical significance, underlying causes, and current views on severe liver trauma management will be discussed briefly. [ncbi.nlm.nih.gov]

Pneumococcal Pneumonia

Before antibiotic therapy the clinical course was characterized by severe fever, dyspnea, debility, and even loss of consciousness. [histopathology-india.net]

Nowadays there is increasing evidence that organism-related factors also play a key role in the clinical course of the disease. [erj.ersjournals.com]

For hospitalized patients with documented penicillin-sensitive (MIC In patients with atypical presentations (eg, diffuse infiltrates, subacute clinical course) or a nondiagnostic [hivinsite.ucsf.edu]

Acute Liver Failure

Liver synthesis parameters further deteriorated reaching a MELD score of 40 points whilst clinical course was complicated by septic pneumonia leading to severe hepatic encephalopathy [ncbi.nlm.nih.gov]

Based on the pathology and detailed clinical course, including the patient's high exposure to organic solvents since just before the first admission, and the spontaneous recovery [ncbi.nlm.nih.gov]

The clinical course of ALF typically follows that of multiple organ failure. [clevelandclinicmeded.com]

Tsutsugamushi Disease

The precise mechanism underlying the more severe clinical course of JSF is not fully understood. [ncbi.nlm.nih.gov]

It is generally said that the clinical course of JSF is worse than that of TD despite antibiotic treatment. [ncbi.nlm.nih.gov]

We therefore examined whether the differential cytokine profile between these two infectious diseases contributes to the difference in clinical severity. [ncbi.nlm.nih.gov]

Acute Peritonitis

Based on the operative findings and her clinical course, the most likely diagnosis was thought to be acute lupus peritonitis. [link.springer.com]

On post-operative day (POD) 3, the severe abdominal pain redeveloped, but responded well to steroid pulse therapy. [link.springer.com]

Meningeal Tuberculosis

The clinical course tends to be subacute, with progressions occurring over a period of several days or longer. [connects.catalyst.harvard.edu]

Staphylococcal Pneumonia

with a clinical course that varies from subacute to fulminant, regardless of the previous health status of the patient. (2,10) There have been few case-series studies that [scielo.br]

[…] hematogenous dissemination, secondary to the infection of skin or soft tissues, as well as of the genital tract (after septic abortion). (8,9) Its presentation is typically severe [scielo.br]

Listerial Meningitis

Despite of our patient had no such data, the disease had severe clinical course with the both of purulent meningoencephalitis and sepsis. [aclr.com.es]

Purpura Fulminans

We believe the underlying congenital hypercoaguable risk factor contributed to the severity of the clinical course. [jamanetwork.com]

Despite the devastating clinical course associated with this hemostatic complication of infection, the mechanism of PF remains poorly understood. [ncbi.nlm.nih.gov]

Severe acquired deficiency of protein C and dysfunction of the protein C-thrombomodulin pathway as well as other systems that exert a negative regulatory effect on coagulation [ncbi.nlm.nih.gov]

Plasma Cell Leukemia

However, the clinical course was very aggressive. The amplification of the IGH/CCND1 fusion gene may contribute to the aggressive course of the disease. [ncbi.nlm.nih.gov]

Discussion We describe the clinical course of a male patient with a MM during the remission phase, who presented to our hospital with a suggestive diagnosis of sPCL. sPCL [jahjournal.org]

These findings indicate that IGH/CCND1 fusion gene was amplified and interspersed in several chromosomes. The patient was treated with intensive chemotherapy. [ncbi.nlm.nih.gov]

Castleman Disease

We report the clinical course from the initial presentation to diagnosis and surgical cure, and discuss the most up-to-date information on CD. [dx.doi.org]

The clinical course is specific due to a rapid onset and regression, frequent relapses and a high occurrence of non-Hodgkin's lymphoma. [erj.ersjournals.com]

Case Report: We describe the case of a 19-year-old Chinese woman with hyaline vascular type of unicentric CD presenting as severe non-iron deficiency microcytic anemia. [dx.doi.org]

Cavernous Sinus Thrombosis

We present an atypical clinical course of CST in a 61-year-old male diabetic patient caused by a distant focus of inflammation. [ncbi.nlm.nih.gov]

In particular nervous system structures are almost regularly affected; however, only few authors reported severe involvement of the internal carotid artery (ICA). [ncbi.nlm.nih.gov]

Stevens-Johnson Syndrome

The aim of are study was to evaluate the clinical course, therapy and prognosis of ocular involvement. [ncbi.nlm.nih.gov]

Practitioners and patients need to be aware of the initial clinical signs of severe cutaneous adverse drug reactions such as fever, influenza-like symptoms, dysphagia or burning [ncbi.nlm.nih.gov]

Due to the clinical course, we distinguish three forms of erythema: mild erythema multiforme, severe erythema multiforme or Stevens-Johnson syndrome and the most severe form [magazyn-stomatologiczny.pl]

Toxic Epidermal Necrolysis

In this manuscript we present a case of a 59-year- old patient with cefaclor-induced severe clinical course of TEN syndrome. [termedia.pl]

It became known as SJS and was recognized as a severe mucocutaneous disease with a prolonged course and potentially lethal outcome that is in most cases drug-induced, and [ncbi.nlm.nih.gov]

Necrotizing Fasciitis

KEY POINTS Necrotizing fasciitis may be misdiagnosed as cellulitis due to the benign appearance of cutaneous findings early in the clinical course. [emdocs.net]

Critical care admission is strongly recommended in view of the aggressive clinical course, high risk of multiorgan failure, and significant mortality rate. [academic.oup.com]

There is usually a triad of symptoms: severe pain, swelling, and elevated temperature. [woundsresearch.com]

Lactic Acidosis

[…] described beta-agonist therapy paradoxically worsening an asthmatic’s clinical course as they struggle to compensate for the rising lactic acidosis.[12-14] Inhaled and IV [aliem.com]

Clinical Course of Patient 2, in Whom Hepatic Failure and Severe Lactic Acidosis Developed after Treatment with Fialuridine for Chronic Hepatitis B. [doi.org]

Multiple case reports have described a rise in lactate following either inhaled or IV beta-agonist therapy for acute asthma.[10-12] Importantly, several case reports have [aliem.com]

Malignant Hypertension

Etiology is variable, but clinical course is severe and if left untreated has a rapidly downhill progression. [auanet.org]

See Hypertension. ma·lig·nant hy·per·ten·sion ( mă-lig'nănt hī'pĕr-ten'shŭn ) Severe hypertension that runs a rapid course, causing necrosis of arteriolar walls in kidney [medical-dictionary.thefreedictionary.com]

[…] severe HTN, retinopathy, renal insufficiency, fibrinoid necrosis of renal arterioles, rapidly progressive and fatal disease Risk groups ♂, African Americans, hypertensives Clinical [medical-dictionary.thefreedictionary.com]

Pneumococcal Meningitis

HIV-1 seropositive patients with moderate to severe pneumococcal pneumonia should be hospitalized and treated with parenteral antimicrobial agents (Table 1). [hivinsite.ucsf.edu]

Weil Disease

Renal involvement is common; it may vary from sub-clinical course with mild proteinuria and urinary sediment changes to severe renal failure. [elsevier.es]

course with mild proteinuria and urinary sediment changes to severe renal failure. [elsevier.es]

Leptospirosis has a biphasic course: initially the leptospiremic phase (lasting 3–10 days) with acute fever, severe headache, anorexia, diarrhoea; later the immune phase with [elsevier.es]

Toxic Shock Syndrome

Measurements were taken on admission and several times during the course of the disease. [ncbi.nlm.nih.gov]

However, the precise cytokine profile is still undefined in clinical cases. [ncbi.nlm.nih.gov]

Amniotic Fluid Embolism

A Caesarean section was performed and postoperatively mother and babies had an uneventful clinical course. [ncbi.nlm.nih.gov]

course. [bmcpregnancychildbirth.biomedcentral.com]

By exclusion of other causes, we diagnosed severe maternal acute respiratory distress due to the amniotic fluid embolism syndrome in a twin pregnancy. [ncbi.nlm.nih.gov]

Scleritis and Episcleritis

Clinical Ophthalmology: A Systematic Approach. China: Elsevier Inc, 201# External Disease and Cornea, Section # Basic and Clinical Science Course, AAO, 2010. [eyewiki.aao.org]

Severity of episcleritis and systemic disease association. Ophthalmology. 1999;106:729. [eyewiki.aao.org]

Psittacosis

Host and microbial factors, route and intensity of exposure, and treatment determine clinical course. [merckvetmanual.com]

The incubation period is typically 3–10 days but may be up to several months in older birds or after low exposure. [merckvetmanual.com]

Yellow Fever

A liver biopsy showed severe and multilobular necrosis. Viral RNA was detectable throughout the clinical course of the disease. [ncbi.nlm.nih.gov]

The clinical course of infection in humans shows a wide spectrum of severity including asymptomatic infection, mild illness with flu-like symptoms, and severe disease including [journals.plos.org]

Colitis Cystica Profunda

Localized colitis cystica profunda developed in a fibrotic radiation-induced colonic stricture 17 years after pelvic radiation for squamous carcinoma of cervix. This uncommon pathologic entity must be distinguished from invasive adenocarcinoma of colon, and colonic radiation injury should be included with other[…] [ncbi.nlm.nih.gov]