Possible Causes for severe clinical course Exfoliation Syndrome clinical course, and more frequent necessity for surgical intervention. [glaucoma.net] Exfoliative glaucoma has a more serious clinical course and worse prognosis than primary open-angle glaucoma. [glaucoma.net] There is a significantly higher frequency and severity of optic nerve damage at the time of diagnosis, worse visual field damage, poorer response to medications, more severe [glaucoma.net] Pneumococcal Pneumonia Before antibiotic therapy the clinical course was characterized by severe fever, dyspnea, debility, and even loss of consciousness. [histopathology-india.net] Nowadays there is increasing evidence that organism-related factors also play a key role in the clinical course of the disease. [erj.ersjournals.com] For hospitalized patients with documented penicillin-sensitive (MIC In patients with atypical presentations (eg, diffuse infiltrates, subacute clinical course) or a nondiagnostic [hivinsite.ucsf.edu] Acute Pancreatitis We found (a) that patients with image-proven pancreatitis suffer a more severe clinical course than those without; (b) that the sensitivity, positive predictive value, and [ncbi.nlm.nih.gov] Colitis Cystica Profunda Colitis cystica profunda (CCP) is a rare benign disease characterised by mucin-filled cysts beneath the muscularis mucosae, which commonly involves the rectum and sigmoid colon. The disease process involving rectum is termed as proctitis cystica profunda. Trans-rectal ultrasound (TRUS) and magnetic resonance[…] [ncbi.nlm.nih.gov] Disseminated Intravascular Coagulation This interplay between mechanisms tends to vary over the course of the clinical presentation and can be further exacerbated by the underlying disease-specific process. [doi.org] The pathology associated with DIC is further complicated by the presence of several intertwined feedback loops between coagulation, inflammation, complement and immune systems [doi.org] Acute Peritonitis Based on the operative findings and her clinical course, the most likely diagnosis was thought to be acute lupus peritonitis. [link.springer.com] On post-operative day (POD) 3, the severe abdominal pain redeveloped, but responded well to steroid pulse therapy. [link.springer.com] Acute Liver Failure Liver synthesis parameters further deteriorated reaching a MELD score of 40 points whilst clinical course was complicated by septic pneumonia leading to severe hepatic encephalopathy [ncbi.nlm.nih.gov] Based on the pathology and detailed clinical course, including the patient's high exposure to organic solvents since just before the first admission, and the spontaneous recovery [ncbi.nlm.nih.gov] The clinical course of ALF typically follows that of multiple organ failure. [clevelandclinicmeded.com] Staphylococcal Pneumonia with a clinical course that varies from subacute to fulminant, regardless of the previous health status of the patient. (2,10) There have been few case-series studies that [scielo.br] […] hematogenous dissemination, secondary to the infection of skin or soft tissues, as well as of the genital tract (after septic abortion). (8,9) Its presentation is typically severe [scielo.br] Castleman Disease We report the clinical course from the initial presentation to diagnosis and surgical cure, and discuss the most up-to-date information on CD. [dx.doi.org] The clinical course is specific due to a rapid onset and regression, frequent relapses and a high occurrence of non-Hodgkin's lymphoma. [erj.ersjournals.com] Case Report: We describe the case of a 19-year-old Chinese woman with hyaline vascular type of unicentric CD presenting as severe non-iron deficiency microcytic anemia. [dx.doi.org] Hepatic Rupture Its clinical courses and our therapeutic approaches are presented. [ncbi.nlm.nih.gov] courses of disease, and PCLD-related mortality was 2 %. [surgicalcasereports.springeropen.com] Moreover, the clinical significance, underlying causes, and current views on severe liver trauma management will be discussed briefly. [ncbi.nlm.nih.gov] Necrotizing Fasciitis KEY POINTS Necrotizing fasciitis may be misdiagnosed as cellulitis due to the benign appearance of cutaneous findings early in the clinical course. [emdocs.net] Critical care admission is strongly recommended in view of the aggressive clinical course, high risk of multiorgan failure, and significant mortality rate. [academic.oup.com] Diagnosis, clinical course and treatment of acute dermal gangrene. Br J Surg 1975 ; 62 : 364 –72. 16. Aitken, DR, Mackett, T, Smith, LL. [doi.org] Ruptured Aortic Aneurysm Phlegmasia cerulea dolens, characterized by the triad of limb swelling, cyanosis, and acute ischemic pain, usually arises because of acute massive thrombosis of major deep, collateral, and superficial veins of an extremity. We report a patient with an atypically presenting ruptured aortic aneurysm masquerading as[…] [ncbi.nlm.nih.gov] Lactic Acidosis […] described beta-agonist therapy paradoxically worsening an asthmatic’s clinical course as they struggle to compensate for the rising lactic acidosis.[12-14] Inhaled and IV [aliem.com] Clinical Course of Patient 2, in Whom Hepatic Failure and Severe Lactic Acidosis Developed after Treatment with Fialuridine for Chronic Hepatitis B. [doi.org] Multiple case reports have described a rise in lactate following either inhaled or IV beta-agonist therapy for acute asthma.[10-12] Importantly, several case reports have [aliem.com] Stevens-Johnson Syndrome Practitioners and patients need to be aware of the initial clinical signs of severe cutaneous adverse drug reactions such as fever, influenza-like symptoms, dysphagia or burning [ncbi.nlm.nih.gov] The aim of are study was to evaluate the clinical course, therapy and prognosis of ocular involvement. [ncbi.nlm.nih.gov] Due to the clinical course, we distinguish three forms of erythema: mild erythema multiforme, severe erythema multiforme or Stevens-Johnson syndrome and the most severe form [magazyn-stomatologiczny.pl] Bacterial Meningitis Mondini dysplasia is rare, but has an important association with recurrent bacterial meningitis. We herein describe the case of a 3-year-old girl with unilateral sensorineural hearing loss who presented with three independent episodes of bacterial meningitis within 8 months. Temporal bone computed tomography indicated[…] [ncbi.nlm.nih.gov] Hemolytic Uremic Syndrome Moreover, a shorter period between the onset of diarrhea and a diagnosis of D HUS indicated a more severe clinical course or long-term sequelae, and it should be considered [ncbi.nlm.nih.gov] Criteria for both groups were severe thrombocytopenia less than 50/nL, severe hemolysis with administration of packed red blood cells, and a complicated clinical course with [ncbi.nlm.nih.gov] What is Known: • BCR at admission has been proposed as an accurate predictor of complicated clinical course in children with D HUS. [ncbi.nlm.nih.gov] Splenic Rupture A 50-year-old man was diagnosed with multiple myeloma complicating AL amyloidosis. Splenic rupture was complicated during autologous stem cell transplantation (auto-SCT). Granulocyte colony-stimulating factor (G-CSF) was not administered. A pathological examination of the spleen revealed that CD34-positive cells were[…] [ncbi.nlm.nih.gov] Rheumatoid Arteritis A 76-year-old male with a severely deforming rheumatoid arthritis, eosinophilia, polymyositis, and episcleritis developed a transient tonic pupil. The episcleritis, and a muscle biopsy revealing an occlusive arteritis with eosinophilia, suggest that a wide-spread rheumatoid arteritis caused a reversible ischemic insult to[…] [ncbi.nlm.nih.gov] Pneumococcal Meningitis For hospitalized patients with documented penicillin-sensitive (MIC In patients with atypical presentations (eg, diffuse infiltrates, subacute clinical course) or a nondiagnostic [hivinsite.ucsf.edu] HIV-1 seropositive patients with moderate to severe pneumococcal pneumonia should be hospitalized and treated with parenteral antimicrobial agents (Table 1). [hivinsite.ucsf.edu] Cavernous Sinus Thrombosis We present an atypical clinical course of CST in a 61-year-old male diabetic patient caused by a distant focus of inflammation. [ncbi.nlm.nih.gov] In particular nervous system structures are almost regularly affected; however, only few authors reported severe involvement of the internal carotid artery (ICA). [ncbi.nlm.nih.gov] Exsanguination Abstract We describe our experience using a new device that results in a bloodless field in open repair of distal radius fractures. The device, an exsanguinating tourniquet (HemaClear model/40, OHK Medical Devices, Haifa, Israel), replaces the traditional methods of limb elevation, Esmarch bandaging, pneumatic[…] [ncbi.nlm.nih.gov] Viral Myocarditis AIMS: Viral myocarditis (VM) is an important cause of heart failure and sudden cardiac death in young healthy adults; it is also an aetiological precursor of dilated cardiomyopathy. We explored the role of the miR-221/-222 family that is up-regulated in VM. METHODS AND RESULTS: Here, we show that microRNA-221[…] [ncbi.nlm.nih.gov] Plasma Cell Leukemia However, the clinical course was very aggressive. The amplification of the IGH/CCND1 fusion gene may contribute to the aggressive course of the disease. [ncbi.nlm.nih.gov] Discussion We describe the clinical course of a male patient with a MM during the remission phase, who presented to our hospital with a suggestive diagnosis of sPCL. sPCL [jahjournal.org] These findings indicate that IGH/CCND1 fusion gene was amplified and interspersed in several chromosomes. The patient was treated with intensive chemotherapy. [ncbi.nlm.nih.gov] Toxic Epidermal Necrolysis In this manuscript we present a case of a 59-year- old patient with cefaclor-induced severe clinical course of TEN syndrome. [termedia.pl] Practitioners and patients need to be aware of the initial clinical signs of severe cutaneous adverse drug reactions such as fever, influenza-like symptoms, dysphagia or burning [ncbi.nlm.nih.gov] It became known as SJS and was recognized as a severe mucocutaneous disease with a prolonged course and potentially lethal outcome that is in most cases drug-induced, and [ncbi.nlm.nih.gov] Extrinsic Allergic Alveolitis Four mushroom workers have developed an extrinsic allergic alveolitis, after working with the oyster mushroom (Pleurotus ostreatus). After provocation with aerosolized spores under laboratory conditions, the four patients showed the complaints of an extrinsic allergic alveolitis; a rise of body temperature,[…] [ncbi.nlm.nih.gov] Sagittal Sinus Thrombosis We report the case of a 4-year-old boy with acute lymphoblastic leukemia in high-risk group who suffered from generalized tonic-colonic seizure evolving into status epilepticus, and subsequent left hemiparesis during his first reinduction chemotherapy, consisting of dexamethasone, vincristine, l-asparaginase, and[…] [ncbi.nlm.nih.gov] Listerial Meningitis Despite of our patient had no such data, the disease had severe clinical course with the both of purulent meningoencephalitis and sepsis. [aclr.com.es] Toxic Shock Syndrome Measurements were taken on admission and several times during the course of the disease. [ncbi.nlm.nih.gov] However, the precise cytokine profile is still undefined in clinical cases. [ncbi.nlm.nih.gov] Viral Hemorrhagic Fever Abstract In 1988, CDC published guidelines for managing patients with suspected viral hemorrhagic fever (VHF) (1). Pending a comprehensive review of the 1988 guidelines, this notice provides interim recommendations that update the 1988 guidelines for healthcare settings in the United States. This update applies to[…] [ncbi.nlm.nih.gov] Meningeal Tuberculosis The clinical course tends to be subacute, with progressions occurring over a period of several days or longer. [connects.catalyst.harvard.edu]
