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147 Possible Causes for Severe Diffuse Muscle Weakness

  • Endocrine Dysfunction

    Hyperthyroid muscle disease. Hyperthyroid muscle disease takes several forms. Diffuse muscle disease is not uncommon with an overactive thyroid gland.[speakingofwomenshealth.com] This frequently causes thigh muscle weakness that may be mild or severe. Shrinkage of muscle and collection of fat in the muscles does occur.[speakingofwomenshealth.com]

  • Non-Hodgkin Lymphoma

    As the disease progressed, needle electromyography showed diffuse severe denervation changes including thoracic paraspinal muscles.[ncbi.nlm.nih.gov] The patient developed severe fasciculations and then progressive atrophy and weakness several months after the diagnosis and initial treatment of non-Hodgkin lymphoma.[ncbi.nlm.nih.gov]

  • X-linked Parkinsonism-Spasticity Syndrome

    , and weakness that may be localized or diffuse, mild or profound, and that may be fatal if the respiratory or bulbar muscles are involved.[britannica.com] This may later cause severe pain with further fever, occasional delirium and meningism (due to accompanying encephalitis), and a rapid onset of muscle atrophy, fasciculations[britannica.com]

  • Hurthle Cell Carcinoma

    She was overtly thyrotoxic and had a large asymmetric goiter and severe weakness of proximal muscles in lower limbs.[casereports.in] Clinical and investigation results were consistent with the diagnosis of diffuse toxic goiter and mononeuritis multiplex.[casereports.in]

  • Ischemic Peripheral Neuropathy

    , and weakness that may be localized or diffuse, mild or profound, and that may be fatal if the respiratory or bulbar muscles are involved.[britannica.com] This may later cause severe pain with further fever, occasional delirium and meningism (due to accompanying encephalitis), and a rapid onset of muscle atrophy, fasciculations[britannica.com]

  • Spinal Demyelination

    , and weakness that may be localized or diffuse, mild or profound, and that may be fatal if the respiratory or bulbar muscles are involved.[britannica.com] This may later cause severe pain with further fever, occasional delirium and meningism (due to accompanying encephalitis), and a rapid onset of muscle atrophy, fasciculations[britannica.com]

  • Autosomal Recessive Lower Motor Neuron Disease with Childhood Onset

    Spinal Muscular Atrophies SMA type I – Acute infantile or Werdnig-Hoffman disease The condition is usually evident by the time the infant reaches 6 months of age Diffuse muscle[thehumanthebody.com] weakness and hypotonia (severely reduced muscle tone), causing difficulties when moving, breathing, eating and swallowing Difficulties in raising the head in an upward position[thehumanthebody.com]

  • Distal Spinal Muscular Atrophy Type 3

    Spinal Muscular Atrophies SMA type I – Acute infantile or Werdnig-Hoffman disease The condition is usually evident by the time the infant reaches 6 months of age Diffuse muscle[thehumanthebody.com] weakness and hypotonia (severely reduced muscle tone), causing difficulties when moving, breathing, eating and swallowing Difficulties in raising the head in an upward position[thehumanthebody.com]

  • Systemic Lupus Erythematosus

    CASE REPORT A 38-year-old male patient presented with severe muscle weakness, diffuse abdominal cramps with vomiting and incontinence of stool, confusion, cough, and sweating[ncbi.nlm.nih.gov] […] increasing in severity for about 1 week.[ncbi.nlm.nih.gov]

  • Spinal Muscular Atrophy with Respiratory Distress Type 1

    Spinal Muscular Atrophies SMA type I – Acute infantile or Werdnig-Hoffman disease The condition is usually evident by the time the infant reaches 6 months of age Diffuse muscle[thehumanthebody.com] weakness and hypotonia (severely reduced muscle tone), causing difficulties when moving, breathing, eating and swallowing Difficulties in raising the head in an upward position[thehumanthebody.com]

Further symptoms