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1,592 Possible Causes for Severe Failure to Thrive

  • Costello Syndrome

    Heterozygous germline mutations in the proto-oncogene HRAS cause Costello syndrome (CS), an intellectual disability condition with severe failure to thrive, cardiac abnormalities[ncbi.nlm.nih.gov] We present a 7 months old child with severe failure to thrive whose "subtle" facial dysmorphism at the time eluded clinical recognition of the syndrome.[ncbi.nlm.nih.gov] PURPOSE OF REVIEW: Costello syndrome is a rare congenital disorder affecting multiple organ systems, encompassing severe failure to thrive, cardiac anomalies including hypertrophic[ncbi.nlm.nih.gov]

  • Vitamin D Deficiency

    Children with established vitamin D deficiency present with features of rickets (skeletal abnormalities, developmental delay, failure to thrive), whereas adults present with[bestpractice.bmj.com] This is largely because patients do not typically present with overt clinical signs and symptoms until the deficiency is severe and prolonged.[bestpractice.bmj.com]

  • Vitamin B12 Deficiency

    Severe vitamin B(12) deficiency produces a cluster of neurological symptoms in infants, including irritability, failure to thrive, apathy, anorexia, and developmental regression[ncbi.nlm.nih.gov] Vitamin B12 deficiency is rare in children, with nonspecific symptoms including failure to thrive, vomiting, anorexia, and neurologic changes with or without hematologic disturbances[ncbi.nlm.nih.gov] […] to thrive, and diarrhea.[ncbi.nlm.nih.gov]

  • Arthrogryposis-Renal Dysfunction-Cholestasis Syndrome

    Additional features include severe failure to thrive, platelet dysfunction (which may be responsible for severe bleeding), facial dysmorphism (low set ears, lax skin, a high[rarediseases.info.nih.gov] Additional features include ichthyosis, central nervous system malformation, platelet anomalies, and severe failure to thrive.[unboundmedicine.com] A parenteral feeding support was needed because of a failure to thrive and severe polyuria. At age 6 months, growth failure persisted (weight VPS33B and VIPAR genes.[journals.lww.com]

  • Cockayne Syndrome

    Classical symptoms of CS patients include failure to thrive and a severe neuropathology characterized by microcephaly, hypomyelination, calcification and neuronal loss.[ncbi.nlm.nih.gov] Typical features include developmental delay, failure to thrive, microcephaly, cutaneous photosensitivity, dental anomalies, progressive hearing loss, pigmentary retinopathy[ncbi.nlm.nih.gov] Feeding difficulties and failure to thrive are universal or near-universal in this group, with cachexia being a significant problem.[forgottendiseases.org]

  • Habrodysplasia

    There was recently a documentary on Channel 4 (in Britain) that highlighted an individual with Fibrodysplasia Ossificans Progressiva (FOP), a progressive bone disease in which the bodies natural repair mechanism causes fibrous tissues (including ligaments, tendons and muscles) to become ossified when damaged or hurt.[…][thesebonesofmine.wordpress.com]

  • Donohue Syndrome

    Features include severe hyperinsulinism and fasting hypoglycemia, along with severe failure to thrive despite feeding.[ncbi.nlm.nih.gov] failure to thrive Severe faltering weight Severe weight faltering [ more ] 0001525 Short stature Decreased body height Small stature [ more ] 0004322 Skeletal muscle atrophy[rarediseases.info.nih.gov] DS is characterized by pre- and postnatal growth retardation with failure to thrive, lipoatrophy, muscle wasting, acanthosis nigricans, hypertrichosis, and dysmorphic features[ncbi.nlm.nih.gov]

  • Hypertension

    Signs and symptoms that should alert the physician to the possibility of hypertension include the following: Neonates Failure to thrive Seizure Irritability or lethargy Respiratory[web.archive.org] […] drinking alcohol, and ingesting illicit substances Presenting symptoms and signs are not specific in neonates and absent in most older children unless their hypertension is severe[web.archive.org]

  • Sexually Transmitted Disease

    As well they may experience severe forms of bacterial infections such as: conjunctivitis (pink eye) ear infections tonsillitis as well as delayed development failure to thrive[herpes-coldsores.com]

  • Esophagitis

    It presents with failure to thrive, nausea, and vomiting in children and is a common reason for dysphagia and food impaction in adults.[ncbi.nlm.nih.gov] In infants, this disease may be associated with failure to thrive. In some situations, avoiding certain food allergens will be an effective treatment for EoE.[aarda.org] […] to thrive, and fatigue.[gutscharity.org.uk]

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