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51 Possible Causes for Severe Growth Retardation if Untreated

  • Congenital Non-Goitrous Hypothyroidism Type 4

    Abstract Thyroid hormone status was assessed in 132 children with congenital heart defects undergoing cardiac surgery (median age 3.1 y; range 2 d to 16.2 y). Plasma TSH, thyroxine (T4), free thyroxine (fT4), triiodothyronine (T3), reverse triiodothyronine (rT3), thyroglobulin (Tg), and urinary iodine excretion were[…][ncbi.nlm.nih.gov]

  • Hypothyroidism

    Severe untreated hypothyroidism, called myxedema, can lead to heart failure, seizures, and coma.[labtestsonline.org] Severe impairment of linear growth and bone maturation also occurs.[emedicine.medscape.com] In children, hypothyroidism can stunt growth and delay sexual development. In infants, it can cause mental retardation.[labtestsonline.org]

  • Obstructive Sleep Apnea

    Pregnant women Several case reports associate intrauterine growth restriction (also termed intrauterine growth retardation) in pregnant women with concomitant untreated OSA[emedicine.medscape.com]

  • Zinc Deficiency

    Severe deficiency of zinc, if untreated, may become fatal.[doi.org] Moderate deficiency of zinc The manifestations of a moderate deficiency of zinc include growth retardation, male hypogonadism in adolescents, rough skin, poor appetite, mental[doi.org]

  • Celiac Disease

    […] celiac disease, failure to thrive and growth retardation are common Weakness and fatigue - 78-80% of patients; usually related to general poor nutrition Severe abdominal[emedicine.com] […] following: Diarrhea - 45-85% of patients Flatulence - 28% of patients Borborygmus - 35-72% of patients Weight loss - 45% of patients; in infants and young children with untreated[emedicine.com]

  • Brandt Syndrome

    Untreated infants exhibit severe growth retardation, dermatitis, alopecia, secondary bacterial and fungal infections, and neurologic and behavioral changes; however, all symptoms[emedicine.medscape.com]

  • Skeletal Dysplasia

    growth retardation is a major finding The good growth response Ring chromosome 18 Thomas JV et al. (2006), [ 67 ] GHD was made due to low GH levels The hGH therapy did not[intechopen.com] […] patients No significant change in bone age velocity, body proportions, or cardiovascular function was observed Ring chromosome 15 Nuutinen M wt al. (1995), [ 66 ] severe[intechopen.com] Positive impact on the linear growth RASopathies Tamburrino F et al. (2015), [ 65 ] Starting early during childhood, resulted in a positive height response compared with untreated[intechopen.com]

  • Thalassemia

    Severe growth retardation Bony deformities These stigmata are typically not observed; instead, patients look healthy.[emedicine.medscape.com] Thalassemia major (Cooley anemia): This condition is characterized by transfusion-dependent anemia, massive splenomegaly, bone deformities, growth retardation, and peculiar[emedicine.medscape.com] In Cooley's original 4 patients, the stigmata of severe untreated β thalassemia major included the following: Severe anemia, with an Hb level of 3-7g/dL Massive hepatosplenomegaly[emedicine.medscape.com]

  • Thalassemia Minor

    Thalassemia major (Cooley anemia): This condition is characterized by transfusion-dependent anemia, massive splenomegaly, bone deformities, growth retardation, and peculiar[emedicine.medscape.com] Findings in untreated or poorly transfused individuals with thalassemia major, as seen in some developing countries, are growth retardation, pallor, jaundice, poor musculature[doi.org] […] facies in untreated individuals, 80% of whom die within the first 5 years of life from complications of anemia.[emedicine.medscape.com]

  • Beta Thalassemia

    Findings in untreated or poorly transfused individuals with thalassemia major, as seen in some developing countries, are growth retardation, pallor, jaundice, poor musculature[ncbi.nlm.nih.gov] Individuals with thalassemia major usually present within the first two years of life with severe anemia, requiring regular red blood cell (RBC) transfusions.[ncbi.nlm.nih.gov]

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