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2 Possible Causes for Severe Hypernatremia in Neonatal Period

  • Hyperchloremia

    We observed an infant receiving cholestyramine because of neonatal hepatitis who developed severe hypernatremia (175 mEq/L) and hyperchloremia (145 mEq/L) during a period[]

  • Nephrogenic Syndrome of Inappropriate Antidiuresis

    Affected males are often symptomatic in the neonatal period with a lack of weight gain, dehydration and hypernatremia but mild phenotypes may also occur.[] Females carrying the mutation may be asymptomatic but, sometimes, severe polyuria is found due to the random X chromosome inactivation.[]

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