Severe Lactic Acidosis: Causes & Reasons

Possible Causes for Severe Lactic Acidosis

Liver dysfunction and severe lactic acidosis in a previously healthy man Reviewed By Critical Care Assembly Submitted by David A. [thoracic.org]

We would suggest that continuous renal replacement with bicarbonate buffer should be indicated in the treatment of severe lactic acidosis. [kci.go.kr]

lactic acidosis. [calpoison.org]

Lactic Acidosis

We herein present a case of biguanide-associated severe lactic acidosis complicated with thiamine deficiency that was provoked without predisposing factors for thiamine deficiency [ncbi.nlm.nih.gov]

We present the first case of severe lactic acidosis after a 3-day course of TMP/SMX alone, involving allegedly safe amounts of PG.A 31-year-old female with neurofibromatosis [ncbi.nlm.nih.gov]

Liver dysfunction and severe lactic acidosis in a previously healthy man Reviewed By Critical Care Assembly Submitted by David A. [thoracic.org]

Fructose-1,6-Bisphosphatase Deficiency

However, as isolated GH deficiency could not explain all other concomitant features, such as severe lactic acidosis, hepatomegaly, impaired liver function, and hyperuricemia [ncbi.nlm.nih.gov]

Signs and symptoms of fructose-1,6-disphosphatase deficiency stem from hypoglycemia, severe lactic acidosis and ketosis, with lethargy, irritability, hypotonia, and altered [symptoma.com]

Thus, its reduced activity will lead to hypoglycemia and lactic acidosis after fasting and under conditions of increased demand for glucose utilization, for example during [symptoma.com]

Mitochondrial Complex 3 Deficiency Nuclear Type 1

Abstract A 34-year-old man affected by exercise intolerance, mild proximal weakness and severe lactic acidosis is described. [unboundmedicine.com]

[…] exercise intolerance, mild proximal weakness and severe lactic acidosis is described. [moh-it.pure.elsevier.com]

MC3DN9 clinical features include feeding difficulties, hypoglycemia, severe lactic acidosis, and delayed psychomotor development. [uniprot.org]

Lethal Infantile Mitochondrial Myopathy

Abstract A 2-month-old boy died of a lethal infantile mitochondrial disease with severe lactic acidosis and involvement of the CNS. [ncbi.nlm.nih.gov]

lactic acidosis 60 33 frequent (33%) Frequent (79-30%) HP:0004900 6 seizures 60 33 occasional (7.5%) Occasional (29-5%) HP:0001250 7 neonatal respiratory distress 60 33 occasional [malacards.org]

On admission at three months of age there was respiratory failure, bradycardia, hypotension, and severe lactic acidosis. [pediatricneurologybriefs.com]

Pyruvate Carboxylase Deficiency

We report the significant finding in a child with infantile spasms controlled with adrenocorticotrophin hormone (ACTH) but who then developed severe lactic acidosis; pyruvate [ncbi.nlm.nih.gov]

A 10 month old female infant was evaluated for severe lactic acidosis. [ncbi.nlm.nih.gov]

acidosis. [ncbi.nlm.nih.gov]

Mitochondrial Myopathy with Reversible Cytochrome C Oxidase Deficiency

Abstract A 1-month-old Japanese girl had profound generalized weakness, hypotonia, and severe lactic acidosis. [ncbi.nlm.nih.gov]

lactic acidosis. [herbal-organic.com]

226-34 } } Published in Annals of neurology 1981 DOI: 10.1002/ana.410140209 A 2-week-old boy had profound generalized weakness, hypotonia, hyporeflexia, macroglossia, and severe [semanticscholar.org]

Strychnine Poisoning

She subsequently survived despite the development of convulsions, severe lactic acidosis (pH 6.86), hyperthermia (Temp 40.5 degrees C) and rhabdomyolysis. [ncbi.nlm.nih.gov]

We report a case in which intractable convulsions led to severe lactic acidosis which secondarily resulted in visceral (lung, heart, kidney, liver, and brain) collapse and [ncbi.nlm.nih.gov]

Thiamine Deficiency

The authors report a case of severe lactic acidosis in a 3-year-old boy, after 20 days of total parenteral nutrition without vitamin supplementation. [ncbi.nlm.nih.gov]

We report the case of a child in whom severe lactic acidosis (LA) and hyperammonemia developed after twenty days of total parenteral nutrition (TPN) for diffuse esophageal [ncbi.nlm.nih.gov]

Abstract Two cases of severe lactic acidosis induced by total parenteral nutrition (TPN) are reported. [ncbi.nlm.nih.gov]

Amish Lethal Microcephaly

A severe lactic acidosis was present during metabolic crises and responded to treatment with a high fat diet. [ir.lib.uwo.ca]

Severe lactic acidosis Spastic diplegia Generalized tonic-clonic seizures Developmental regression Limb muscle weakness Spastic paraplegia Abnormality of movement Peripheral [mendelian.co]

CLINICAL CHARACTERISTICS: Amish lethal microcephaly is characterized by severe congenital microcephaly and highly elevated 2-ketoglutarate or lactic acidosis. [ncbi.nlm.nih.gov]

Isolated Complex I Deficiency

Severe lactic acidosis. Death is typical within the first year. Cause: Probably autosomal recessive. [umdf.org]

[…] congenital lactic acidosis and dysmorphic features associated with a COX assembly defect. [genecards.org]

Severe lactic acidosis. Prominent ragged-red fibers. Death due to respiratory failure usually occurs prior to one year of age. [umdf.org]

Acute Infantile Liver Failure-Multisystemic Involvement Syndrome

Liver disease per se can cause severe lactic acidosis when there is severe shock and metabolic. [ijpmonline.org]

[…] neonatal lactic acidosis with mtDNA depletion: SUCLG1 ; Multiple complex deficiencies Neonatal cardiomyopathy with lactic acidosis Portneuf spastic ataxia with leukoencephalopathy [neuromuscular.wustl.edu]

Our finding that bi-allelic, c. 941T>C and c.187G>T, mutations in ACAD9 may present with lactic acidosis and severe coagulopathy phenocopying severe MDS highlights the importance [journals.plos.org]

Glycogen Storage Disease Type 1C

Remark Type Ib; Panamanian Ind; severe hypoglycemia, lactic acidosis, and neutropenia; liver biopsy shows G6P transport defect Lei KJ, Shelly LL, Lin B, Sidbury JB, Chen YT [catalog.coriell.org]

[…] hypoglycemia, lactic acidosis, and hepatomegaly; later, hepatic adenomas, renomegaly with progressive renal insufficiency and hypertension, short stature, hypertriglyceridemia [msdmanuals.com]

The severity of the hypoglycemia and lactic acidosis can be such that in the past affected individuals died in infancy. [themedicalbiochemistrypage.org]

Maple Syrup Urine Disease Mild Variant

However, this form of MSUD is accompanied with severe lactic acidosis. Initially, for the first few months of life, the affected infants remain relatively normal. [maplesyrupstory.blogspot.com]

Clinical presentation is similar to those with intermediate MSUD, but severe lactic acidosis is also present. [motherbabyuniversity.com]

The symptoms of the E3-deficient form are similar to those of intermediate MSUD, but there is an accompanying severe lactic acidosis. [themedicalbiochemistrypage.org]

Disorders of Pyruvate Metabolism and Gluconeogenesis

Affected infants have severe lactic acidosis, a buildup of ammonia in the blood (hyperammonemia), and liver failure. [icdlist.com]

lactic acidosis. [emedicine.medscape.com]

Isomaltose Intolerance

lactic acidosis. [glucosesafety.com]

lactic acidosis, and in patients with glycogen storage disease. [baxter.nl]

[…] patients with a known allergy to cornstarch or icodextrin, in patients with maltose or isomaltose intolerance, in patients with glycogen storage disease, and in patients with severe [glucosesafety.com]

Hyperalaninemia

Some individuals with severe lactic acidosis have also had severe hyperammonemia (high levels of ammonia in the blood). [xpertdox.com]

Abstract The cause of severe intermittent lactic acidosis was investigated in a female infant with profound psychomotor retardation. [pediatrics.aappublications.org]

Affected individuals present in infancy with hypertrophic cardiomyopathy and lactic acidosis. [mendelian.co]

Total Parenteral Nutrition

lactic acidosis with unknown cause. [ncbi.nlm.nih.gov]

Thereafter, the patient suffered from severe hypoglycaemia, and sepsis started to develop, accompanied by a large anion gap and metabolic acidosis which is severe lactic acidosis [ncbi.nlm.nih.gov]

An 11-month-old girl with B-cell leukemia/lymphoma developed profound lethargy due to severe lactic acidosis during chemotherapy and total parenteral nutrition (TPN). [ncbi.nlm.nih.gov]

Hereditary Myopathy with Lactic Acidosis due to ISCU Deficiency

Prevention - Infantile myopathy and lactic acidosis Diagnosis - Infantile myopathy and lactic acidosis Prognosis - Infantile myopathy and lactic acidosis Treatment - Infantile [checkorphan.org]

[…] breath, and cardiac palpitations in association with lactic acidosis. [abcam.com]

Swedish type (MEIS); also known as myopathy with deficiency of succinate dehydrogenase and aconitase or myoglobinuria due to abnormal glycolysis or hereditary myopathy with lactic [mybiosource.com]

Metabolic Acidosis

Tachycardia, tachypnea (with severe lactic acidosis), hypotension with symptoms similar to septic shock. [clinicaladvisor.com]

Lactic acidosis results from a buildup of lactic acid. [medlineplus.gov]

"Severe lactic acidosis complicating metformin overdose successfully treated with high-volume venovenous hemofiltration and aggressive alkalinization". [clinicaladvisor.com]

Mitochondrial Myopathy

We report an interesting case of a teenager in which mitochondrial myopathy with severe lactic acidosis presented following a bout of infectious mononucleosis and minocycline [ncbi.nlm.nih.gov]

Severe lactic acidosis. Death is typical within the first year. Cause: Probably autosomal recessive. [umdf.org]

RESULTS: All three patients had tachycardia, acute lactic acidosis, dyspnea and sudden severe muscle weakness. [ncbi.nlm.nih.gov]

Beriberi

lactic acidosis and refractory cardio-circulatory collapse caused by acute fulminant beriberi, which drastically responded to thiamine administration.In critical care settings [ncbi.nlm.nih.gov]

After 4 weeks of total parenteral nutrition (TPN), a 12-yr-old girl exhibited an acute heart failure with high cardiac output, anuria, and severe lactic acidosis. [ncbi.nlm.nih.gov]

This report describes a case of severe acidosis with cardiac failure due to alcohol in a black man. Treatment with parenteral thiamine produced a prompt response. [ncbi.nlm.nih.gov]

Cyanide Poisoning

He presented unconsciousness, with severe lactic acidosis and arteriolisation of venous blood gases. [ncbi.nlm.nih.gov]

Both patients demonstrated features of life-threatening cyanide poisoning, including hemodynamic instability, severe lactic acidosis, and high blood cyanide concentration. [ncbi.nlm.nih.gov]

Initial blood gas analysis demonstrated severe metabolic/lactic acidosis. [ncbi.nlm.nih.gov]

Acid Base Disorder

Hyperchloremic acidosis is when your body loses too much sodium bicarbonate, often after severe diarrhea. Lactic acidosis is when too much lactic acid builds up. [healthline.com]

[…] initiating events: renal and extrarenal diabetes mellitus and ketoacidosis (larger than normal anion gap) severe shock or heart failure and lactic acidosis (larger than normal [lumen.luc.edu]

In patients with severe acidosis (pH For lactic acidosis, it is most important to correct the underlying abnormalities, such as restoration of tissue perfusion and treatment [renalandurologynews.com]

MELAS Syndrome

We present an acute case of recurrent seizures and severe lactic acidosis precipitated by cocaine use in a patient with MELAS syndrome. [omicsgroup.org]

Severe lactic acidosis may even induce confusion, somnolence or stupor. [symptoma.com]

Among the more severe side effects patients may experience are a hepatotoxicity or a lactic acidosis. [diki.pl]

Disorder of Fructose Metabolism

Frequently severe lactic acidosis, hypoglycemia, dyspnea, tachycardia, apneic spells, irritability, lethargy, coma, convulsions are observed. [agris.fao.org]

However, severe infections precipitate attacks of hypoglycaemia and lactic acidosis. [ncbi.nlm.nih.gov]

Hepatomegaly (with hepatic adenomas ) Severe fasting hypoglycemia, mild ketosis Severe hyperlipidemia → doll-like facies Hyperuricemia Lactic acidosis Anemia Failure to thrive [amboss.com]

Pyruvate Carboxylase Deficiency Type A

Affected infants have severe lactic acidosis, a buildup of ammonia in the blood (hyperammonemia), and liver failure. [medlineplus.gov]

Abstract: A child with lactic acidosis, severe mental and developmental retardation, and proximal renal tubular acidosis is presented. [typeset.io]

lactic acidosis. [emedicine.medscape.com]

Pyruvate Dehydrogenase Deficiency

Affected infants have severe lactic acidosis, a buildup of ammonia in the blood (hyperammonemia), and liver failure. [medlineplus.gov]

Lactic acidosis, ketoacidosis and elevated ammonia (hyperammonemia) are characteristic. [rarediseases.org]

Characteristic features include developmental delay and a buildup of lactic acid in the blood (lactic acidosis). [medlineplus.gov]

Fatal Infantile Lactic Acidosis with Methylmalonic Aciduria

[…] methylmalonic aciduria is a rare neurometabolic disease characterized by infantile onset of severe encephalomyopathy, lactic acidosis and elevated methylmalonic acid urinary [orpha.net]

Homepage Rare diseases Search Search for a rare disease Fatal infantile lactic acidosis with methylmalonic aciduria Disease definition Fatal infantile lactic acidosis with [orpha.net]

Clinically it manifests with severe psychomotor delay, hypotonia, failure to thrive, feeding difficulties and dystonia. [orpha.net]

Mitochondrial Complex 3 Deficiency Nuclear Type 4

The most severe form begins in infancy and causes life-threatening muscle and nervous system dysfunction (encephalomyopathy), lactic acidosis at birth, hypotonia (poor muscle [rarediseases.info.nih.gov]

multisystem disorder that includes features such as lactic acidosis, hypotonia, hypoglycemia, failure to thrive, encephalopathy, and delayed psychomotor development. [rarediseases.info.nih.gov]

Ragged-red fibers and lactic acidosis may be present.[5] A fourth described form is characterized by infantile histiocytoid cardiomyopathy.[5] This is a condition characterized [rarediseases.info.nih.gov]