Severe Lactic Acidosis Causes & Reasons

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Severe Lactic Acidosis Symptom Checker: Possible causes include Acidosis. Check the full list of possible causes and conditions now! Talk to our Chatbot to narrow down your search.

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Possible Causes

Acidosis

Liver dysfunction and severe lactic acidosis in a previously healthy man Reviewed By Critical Care Assembly Submitted by David A. [thoracic.org]

lactic acidosis. [calpoison.org]

Blood gas analysis at this time revealed severe lactic acidosis. [acutecaretesting.org]

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Lactic Acidosis

We herein present a case of biguanide-associated severe lactic acidosis complicated with thiamine deficiency that was provoked without predisposing factors for thiamine deficiency [ncbi.nlm.nih.gov]

We present the first case of severe lactic acidosis after a 3-day course of TMP/SMX alone, involving allegedly safe amounts of PG.A 31-year-old female with neurofibromatosis [ncbi.nlm.nih.gov]

Liver dysfunction and severe lactic acidosis in a previously healthy man Reviewed By Critical Care Assembly Submitted by David A. [thoracic.org]

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Pyruvate Carboxylase Deficiency

We report the significant finding in a child with infantile spasms controlled with adrenocorticotrophin hormone (ACTH) but who then developed severe lactic acidosis; pyruvate [ncbi.nlm.nih.gov]

A 10 month old female infant was evaluated for severe lactic acidosis. [ncbi.nlm.nih.gov]

acidosis. [ncbi.nlm.nih.gov]

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Fructose-1,6-Diphosphatase Deficiency

However, as isolated GH deficiency could not explain all other concomitant features, such as severe lactic acidosis, hepatomegaly, impaired liver function, and hyperuricemia [ncbi.nlm.nih.gov]

Signs and symptoms of fructose-1,6-disphosphatase deficiency stem from hypoglycemia, severe lactic acidosis and ketosis, with lethargy, irritability, hypotonia, and altered [symptoma.com]

Thus, its reduced activity will lead to hypoglycemia and lactic acidosis after fasting and under conditions of increased demand for glucose utilization, for example during [symptoma.com]

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Mitochondrial Complex 3 Deficiency

Abstract A 34-year-old man affected by exercise intolerance, mild proximal weakness and severe lactic acidosis is described. [unboundmedicine.com]

[…] intolerance, mild proximal weakness and severe lactic acidosis is described. [moh-it.pure.elsevier.com]

CC MC3DN9 clinical features include feeding difficulties, CC hypoglycemia, severe lactic acidosis, and delayed psychomotor CC development. {ECO:0000269 PubMed:25008109}. [genome.jp]

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Lethal Infantile Mitochondrial Myopathy

Abstract A 2-month-old boy died of a lethal infantile mitochondrial disease with severe lactic acidosis and involvement of the CNS. [ncbi.nlm.nih.gov]

lactic acidosis 60 33 frequent (33%) Frequent (79-30%) HP:0004900 6 seizures 60 33 occasional (7.5%) Occasional (29-5%) HP:0001250 7 neonatal respiratory distress 60 33 occasional [malacards.org]

On admission at three months of age there was respiratory failure, bradycardia, hypotension, and severe lactic acidosis. [pediatricneurologybriefs.com]

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Mitochondrial Myopathy with Reversible Cytochrome C Oxidase Deficiency

Abstract A 1-month-old Japanese girl had profound generalized weakness, hypotonia, and severe lactic acidosis. [ncbi.nlm.nih.gov]

lactic acidosis. [semanticscholar.org]

Abstract A 2-month-old girl had generalized weakness, profound muscular hypotonia, hepatomegaly and severe lactic acidosis. She needed ventilatory support. [ncbi.nlm.nih.gov]

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Thiamine Deficiency

The authors report a case of severe lactic acidosis in a 3-year-old boy, after 20 days of total parenteral nutrition without vitamin supplementation. [ncbi.nlm.nih.gov]

We report the case of a child in whom severe lactic acidosis (LA) and hyperammonemia developed after twenty days of total parenteral nutrition (TPN) for diffuse esophageal [ncbi.nlm.nih.gov]

Abstract Two cases of severe lactic acidosis induced by total parenteral nutrition (TPN) are reported. [ncbi.nlm.nih.gov]

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Total Parenteral Nutrition

lactic acidosis with unknown cause. [ncbi.nlm.nih.gov]

Thereafter, the patient suffered from severe hypoglycaemia, and sepsis started to develop, accompanied by a large anion gap and metabolic acidosis which is severe lactic acidosis [ncbi.nlm.nih.gov]

An 11-month-old girl with B-cell leukemia/lymphoma developed profound lethargy due to severe lactic acidosis during chemotherapy and total parenteral nutrition (TPN). [ncbi.nlm.nih.gov]

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Strychnine Poisoning

She subsequently survived despite the development of convulsions, severe lactic acidosis (pH 6.86), hyperthermia (Temp 40.5 degrees C) and rhabdomyolysis. [ncbi.nlm.nih.gov]

We report a case in which intractable convulsions led to severe lactic acidosis which secondarily resulted in visceral (lung, heart, kidney, liver, and brain) collapse and [ncbi.nlm.nih.gov]

A significant clinical sign of strychnine poisoning is severe lactic acidosis (low blood pH, i.e. acidic). [naturespoisons.com]

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Amish Lethal Microcephaly

A severe lactic acidosis was present during metabolic crises and responded to treatment with a high fat diet. [ir.lib.uwo.ca]

Severe lactic acidosis Spastic diplegia Generalized tonic-clonic seizures Developmental regression Limb muscle weakness Spastic paraplegia Abnormality of movement Peripheral [mendelian.co]

CLINICAL CHARACTERISTICS: Amish lethal microcephaly is characterized by severe congenital microcephaly and highly elevated 2-ketoglutarate or lactic acidosis. [ncbi.nlm.nih.gov]

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Acute Alcohol Intoxication

Mild l-lactic acidosis with serum lactate concentration in the range of 2 to 6 mEq/L can be found, but more severe lactic acidosis is infrequent ( 36, 104, 109 ). [cjasn.asnjournals.org]

acidosis, hypokalemia, hypoglycemia, thromboembolic events, and cardiac arrhythmias. [symptoma.com]

However, the use of fructose is not recommended because significant adverse effects may occur, such as lactic acidosis, severe osmotic diuresis, and GI symptoms The effects [emedicine.medscape.com]

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Combined Oxidative Phosphorylation Defect Type 14

Severe lactic acidosis. Death is typical within the first year. Cause: Probably autosomal recessive. [umdf.org]

lactic acidosis [20]. [acutecaretesting.org]

[…] neonatal lactic acidosis with mtDNA depletion: SUCLG1 ; Multiple complex deficiencies Neonatal cardiomyopathy with lactic acidosis Portneuf spastic ataxia with leukoencephalopathy [neuromuscular.wustl.edu]

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Alcohol Abuse

He developed moderate neutropenia and severe lactic acidosis. [ncbi.nlm.nih.gov]

In our case, the main pathogenesis could be accounted for low systemic perfusion caused by severe alcoholic lactic acidosis. [ncbi.nlm.nih.gov]

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Hypoglycemia

On day 4 of her hospitalization, the patient developed severe lactic acidosis (24 mmol/L) and hypoglycemia (11 mg/dL), and she was transferred to our institution. [ncbi.nlm.nih.gov]

Fructose-1,6-diphosphatase deficiency Typical scenario : Episodes of severe hypoglycemia and metabolic (lactic) acidosis triggered by ingestion of fructose or fasting. [pedclerk.bsd.uchicago.edu]

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Acute Infantile Liver Failure-Multisystemic Involvement Syndrome

Liver disease per se can cause severe lactic acidosis when there is severe shock and metabolic. [ijpmonline.org]

Our finding that bi-allelic, c. 941T C and c.187G T, mutations in ACAD9 may present with lactic acidosis and severe coagulopathy phenocopying severe MDS highlights the importance [journals.plos.org]

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Hyperalaninemia

Some individuals with severe lactic acidosis have also had severe hyperammonemia (high levels of ammonia in the blood). [xpertdox.com]

Affected individuals present in infancy with hypertrophic cardiomyopathy and lactic acidosis. [mendelian.co]

Abstract The cause of severe intermittent lactic acidosis was investigated in a female infant with profound psychomotor retardation. [pediatrics.aappublications.org]

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Maple Syrup Urine Disease Mild Variant

However, this form of MSUD is accompanied with severe lactic acidosis. Initially, for the first few months of life, the affected infants remain relatively normal. [maplesyrupstory.blogspot.com]

Clinical presentation is similar to those with intermediate MSUD, but severe lactic acidosis is also present. [motherbabyuniversity.com]

The symptoms of the E3-deficient form are similar to those of intermediate MSUD, but there is an accompanying severe lactic acidosis. [themedicalbiochemistrypage.org]

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Metabolic Syndrome

Among antidiabetic agents, sulfonylureas and insulin are associated with risk for severe hypoglycemia, metformin with risk for lactic acidosis, and troglitazone with risk [liebertonline.com]

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Isolated Complex I Deficiency

Severe lactic acidosis. Death is typical within the first year. Cause: Probably autosomal recessive. [umdf.org]

[…] congenital lactic acidosis and dysmorphic features associated with a COX assembly defect. [genecards.org]

Severe lactic acidosis. Prominent ragged-red fibers. Death due to respiratory failure usually occurs prior to one year of age. [umdf.org]

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Isomaltose Intolerance

lactic acidosis. [glucosesafety.com]

lactic acidosis, and in patients with glycogen storage disease. [baxter.nl]

[…] patients with a known allergy to cornstarch or icodextrin, in patients with maltose or isomaltose intolerance, in patients with glycogen storage disease, and in patients with severe [glucosesafety.com]

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Disorders of Pyruvate Metabolism and Gluconeogenesis

Affected infants have severe lactic acidosis, a buildup of ammonia in the blood (hyperammonemia), and liver failure. [icdlist.com]

lactic acidosis. [emedicine.medscape.com]

[…] hypoglycemia, lactic acidosis, and hepatomegaly; later, hepatic adenomas, renomegaly with progressive renal insufficiency and hypertension, short stature, hypertriglyceridemia [msdmanuals.com]

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Glycogen Storage Disease due to Glucose-6-Phosphat Transport Defect

Remark Type Ib; Panamanian Ind; severe hypoglycemia, lactic acidosis, and neutropenia; liver biopsy shows G6P transport defect Lei KJ, Shelly LL, Lin B, Sidbury JB, Chen YT [catalog.coriell.org]

The severity of the hypoglycemia and lactic acidosis can be such that in the past affected individuals died in infancy. [themedicalbiochemistrypage.org]

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Periodontitis

A lactic acid level taken on hospital day 2 was elevated at 19 mEq/L, demonstrating the severity, morbidity, and progression of PCD. [mdedge.com]

Extensive thrombi led to severely decreased venous return and cardiac output, causing life-threatening shock, ischemia, and metabolic acidosis. [mdedge.com]

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Renal Function Impairment

Despite the severity of the metabolic acidosis, both female patients survived. [ncbi.nlm.nih.gov]

Notably, the incidence of lactic acidosis associated with metformin is as low as 0.03 cases per 1000 patient-years. [pharmacytimes.com]

Hepatic Impairment: Metformin use in patients with hepatic impairment has been associated with some cases of lactic acidosis. [invokanahcp.com]

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Glycogen Storage Disease Type 1

The patient presented at 9 months of age with severe lactic acidosis and hypoglycaemia. [ncbi.nlm.nih.gov]

In the present case, an acidification test was omitted because the patient had a past history of severe lactic acidosis. [academic.oup.com]

This later group of patients present in the newborn period, or shortly thereafter, with severe hypoglycemia and lactic acidosis. [journalofpediatriccriticalcare.com]

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Renal Tubular Dysfunction

Acute lymphoblastic leukemia (ALL) in children can rarely present with severe lactic acidosis in the absence of a high white blood cell count or other complications. [ncbi.nlm.nih.gov]

lactic acidosis when tenofovir was added to his antiretroviral regimen, including didanosine. 17 All our patients were extensively pretreated with NRTIs, which are known [journals.lww.com]

The authors describe a 7-year-old boy with ALL presenting with severe lactic acidosis and renal tubular dysfunction, both of which were refractory to conventional management [ncbi.nlm.nih.gov]

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MELAS Syndrome

Severe lactic acidosis may even induce confusion, somnolence or stupor. [symptoma.com]

We present an acute case of recurrent seizures and severe lactic acidosis precipitated by cocaine use in a patient with MELAS syndrome. [omicsgroup.org]

Among the more severe side effects patients may experience are a hepatotoxicity or a lactic acidosis. [diki.pl]

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Metabolic Acidosis

Tachycardia, tachypnea (with severe lactic acidosis), hypotension with symptoms similar to septic shock. [clinicaladvisor.com]

Lactic acidosis results from a buildup of lactic acid. [nlm.nih.gov]

"Severe lactic acidosis complicating metformin overdose successfully treated with high-volume venovenous hemofiltration and aggressive alkalinization". [clinicaladvisor.com]

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Bjornstad Syndrome

lactic acidosis, Fanconi type tubulopathy, cholestasis, iron overload and early death without any dysmorphological or neurological features. [read.qxmd.com]

Indications for Test Candidates for this test include neonates who present with severe intrauterine growth retardation and fulminant lactic acidosis during the first days [preventiongenetics.com]

[…] disorder of intrauterine growth retardation, aminoaciduria, cholestasis, iron overload, lactic acidosis, and early death, termed the GRACILE syndrome (OMIM number 603358) [content.nejm.org]

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