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768 Possible Causes for Severe Lactic Acidosis

  • Acidosis

    Liver dysfunction and severe lactic acidosis in a previously healthy man Reviewed By Critical Care Assembly Submitted by David A.[] lactic acidosis.[] These other alternative diagnoses should all be considered in the setting of severe lactic acidosis.[]

  • Lactic Acidosis

    We present the first case of severe lactic acidosis after a 3-day course of TMP/SMX alone, involving allegedly safe amounts of PG.A 31-year-old female with neurofibromatosis[] We herein present a case of biguanide-associated severe lactic acidosis complicated with thiamine deficiency that was provoked without predisposing factors for thiamine deficiency[] Liver dysfunction and severe lactic acidosis in a previously healthy man Reviewed By Critical Care Assembly Submitted by David A.[]

  • Pyruvate Carboxylase Deficiency

    We report the significant finding in a child with infantile spasms controlled with adrenocorticotrophin hormone (ACTH) but who then developed severe lactic acidosis; pyruvate[] A 10 month old female infant was evaluated for severe lactic acidosis.[] acidosis.[]

  • Thiamine Deficiency

    The authors report a case of severe lactic acidosis in a 3-year-old boy, after 20 days of total parenteral nutrition without vitamin supplementation.[] We report the case of a child in whom severe lactic acidosis (LA) and hyperammonemia developed after twenty days of total parenteral nutrition (TPN) for diffuse esophageal[] Abstract Two cases of severe lactic acidosis induced by total parenteral nutrition (TPN) are reported.[]

  • Lethal Infantile Mitochondrial Myopathy

    Abstract A 2-month-old boy died of a lethal infantile mitochondrial disease with severe lactic acidosis and involvement of the CNS.[] lactic acidosis 60 33 frequent (33%) Frequent (79-30%) HP:0004900 6 seizures 60 33 occasional (7.5%) Occasional (29-5%) HP:0001250 7 neonatal respiratory distress 60 33 occasional[] On admission at three months of age there was respiratory failure, bradycardia, hypotension, and severe lactic acidosis.[]

  • Mitochondrial Complex 3 Deficiency

    Abstract A 34-year-old man affected by exercise intolerance, mild proximal weakness and severe lactic acidosis is described.[] […] intolerance, mild proximal weakness and severe lactic acidosis is described.[] CC MC3DN9 clinical features include feeding difficulties, CC hypoglycemia, severe lactic acidosis, and delayed psychomotor CC development. {ECO:0000269 PubMed:25008109}.[]

  • Total Parenteral Nutrition

    lactic acidosis with unknown cause.[] Thereafter, the patient suffered from severe hypoglycaemia, and sepsis started to develop, accompanied by a large anion gap and metabolic acidosis which is severe lactic acidosis[] An 11-month-old girl with B-cell leukemia/lymphoma developed profound lethargy due to severe lactic acidosis during chemotherapy and total parenteral nutrition (TPN).[]

  • Mitochondrial Myopathy with Reversible Cytochrome C Oxidase Deficiency

    Abstract A 1-month-old Japanese girl had profound generalized weakness, hypotonia, and severe lactic acidosis.[] lactic acidosis.[] Abstract A 2-month-old girl had generalized weakness, profound muscular hypotonia, hepatomegaly and severe lactic acidosis. She needed ventilatory support.[]

  • Fructose-1,6-Diphosphatase Deficiency

    However, as isolated GH deficiency could not explain all other concomitant features, such as severe lactic acidosis, hepatomegaly, impaired liver function, and hyperuricemia[] Signs and symptoms of fructose-1,6-disphosphatase deficiency stem from hypoglycemia, severe lactic acidosis and ketosis, with lethargy, irritability, hypotonia, and altered[] Thus, its reduced activity will lead to hypoglycemia and lactic acidosis after fasting and under conditions of increased demand for glucose utilization, for example during[]

  • Acute Alcohol Intoxication

    Mild l-lactic acidosis with serum lactate concentration in the range of 2 to 6 mEq/L can be found, but more severe lactic acidosis is infrequent ( 36, 104, 109 ).[] acidosis, hypokalemia, hypoglycemia, thromboembolic events, and cardiac arrhythmias.[] However, the use of fructose is not recommended because significant adverse effects may occur, such as lactic acidosis, severe osmotic diuresis, and GI symptoms The effects[]

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