Severe Metabolic Acidosis: Causes & Reasons

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Possible Causes for Severe Metabolic Acidosis

Phenacetin

Formula : C 10 H 13 NO 2 Molecular weight : 179.2157 IUPAC Standard InChI: IUPAC Standard InChIKey: CPJSUEIXXCENMM-UHFFFAOYSA-N CAS Registry Number: 62-44-2 Chemical structure: This structure is also available as a 2d Mol file or as a computed 3d SD file The 3d structure may be viewed using Java or Javascript.[…] [webbook.nist.gov]

Gasoline Poisoning

Gasoline poisoning can be either acute, subacute or chronic and can be due to accidental or intentional inhalation of gasoline fumes or ingestion of gasoline. Adverse effects are caused by the hydrocarbons present in this compound and these can affect different organ systems. Children are more vulnerable to[…] [symptoma.com]

Acidosis

Here we discuss the pros and cons of bicarbonate therapy for patients with severe metabolic acidosis. [jasn.asnjournals.org]

Podcast 3 – Laryngoscope as a Murder Weapon (LAMW) Series – Ventilatory Kills – Intubating the patient with Severe Metabolic Acidosis. EMCrit Blog. [emcrit.org]

metabolic acidosis remains controversial. [jasn.asnjournals.org]

Dialysis Disequilibrium Syndrome

74.2mmol/L, Potassium 6.3mmol/L, Sodium 137mmol/L) and severe metabolic acidosis (pH 6.99, HC03 1.7mmol/L). [ncbi.nlm.nih.gov]

The acute peritoneal dialysis might not be a good modality in reverting this life threatening severe metabolic acidosis with high catabolic state. [slideshare.net]

metabolic acidosis, and other disorders that cause cerebral edema or increase the permeability of the blood-brain barrier. [visualdx.com]

Enterovesical Fistula

We report a case of a 59-year-old woman who had severe metabolic acidosis and hypokalemia due to an enterovesical fistula. [ncbi.nlm.nih.gov]

[…] of the Bladder. ( 26793552 ) Sellers W....Fiorelli R. 2015 9 Severe Azotemia and Hyperchloremic Metabolic Acidosis Associated With Reverse Flow Enterovesical Fistula. ( 26422804 [malacards.org]

[…] of the Bladder. ( 26793552 ) 2015 13 Severe Azotemia and Hyperchloremic Metabolic Acidosis Associated With Reverse Flow Enterovesical Fistula. ( 26422804 ) 2015 14 Enterovesical [malacards.org]

Metabolic Acidosis

Here we discuss the pros and cons of bicarbonate therapy for patients with severe metabolic acidosis. [jasn.asnjournals.org]

We report two parturient women with severe metabolic acidosis which was considerably reduced very soon after the delivery and how our timely delivery resulted in the birth [ncbi.nlm.nih.gov]

Podcast 3 – Laryngoscope as a Murder Weapon (LAMW) Series – Ventilatory Kills – Intubating the patient with Severe Metabolic Acidosis. EMCrit Blog. [emcrit.org]

Alcoholic Ketoacidosis

Severe metabolic acidosis was also seen in all cases. Some cases also displayed concomitant respiratory acidosis, hypothermia, hypoxia and/or hemorrhage. [ncbi.nlm.nih.gov]

Severe metabolic acidosis in the setting of alcoholism raises diagnostic and therapeutic problems [Levinsky 1994]. [ncbi.nlm.nih.gov]

In the present case, a 26-year-old patient was admitted for a coma associated with severe metabolic acidosis. [ncbi.nlm.nih.gov]

Fructose-1,6-Bisphosphatase Deficiency

Intravenous fructose tolerance tests provoked severe hypoglycaemia and metabolic acidosis. [ncbi.nlm.nih.gov]

A 14-month-old female infant presented with recurrent episodes of acute gastroenteritis accompanied by severe metabolic acidosis and hypoglycemia. [ncbi.nlm.nih.gov]

Abstract A 14-month-old female infant presented with recurrent episodes of acute gastroenteritis accompanied by severe metabolic acidosis and hypoglycemia. [degruyter.com]

Salicylate Poisoning

Stage III: blood pH <7.4, urine pH <6.0 - severe metabolic acidosis and hypokalaemia. [patient.info]

those who suffered seizures, coma or severe metabolic acidosis and in those with chronic toxicity. [emergpa.net]

Risk factors for death include: [ 1 ] Children and the elderly Late presentation Pulmonary oedema, CNS features, hyperpyrexia Metabolic acidosis Salicylate concentration above [patient.info]

Ethylene Glycol Poisoning

Ethylene glycol poisoning is accompanied by a high anion gap metabolic acidosis. [ncbi.nlm.nih.gov]

The metabolites of ethylene glycol cause severe metabolic acidosis and central nervous system, pulmonary, and renal damage. [ncbi.nlm.nih.gov]

If the patient is admitted with severe metabolic acidosis, hemodialysis must be started immediately. [ncbi.nlm.nih.gov]

Glutaric Aciduria Type 2

The first group of MADD-S patients are often premature presenting with severe non-ketotic hypoglycemia, hypotonia, hepatomegaly and severe metabolic acidosis within the first [orpha.net]

The second group of patients usually present within the first 24-48 hours of life with hypotonia, tachypnea, hepatomegaly, metabolic acidosis and hypoketotic hypoglycemia. [orpha.net]

MADD-M patients show a broad clinical spectrum of disease ranging from onset of intermittent episodes of vomiting, metabolic acidosis and hypoketotic hypoglycaemia (+/- cardiac [orpha.net]

Respiratory Alkalosis

Pseudorespiratory alkalosis is low arterial P co 2 and high pH in mechanically ventilated patients with severe metabolic acidosis due to poor systemic perfusion (eg, cardiogenic [msdmanuals.com]

Pseudorespiratory alkalosis is low arterial Pco2 and high pH in mechanically ventilated patients with severe metabolic acidosis due to poor systemic perfusion (eg, cardiogenic [msdmanuals.com]

Proximal Renal Tubular Acidosis

Severe metabolic acidosis and hypokalaemia were linked to an abnormally low renal threshold for bicarbonate reabsorption (8 mmol/l). [ncbi.nlm.nih.gov]

Severe metabolic acidosis was caused by the impairment of bicarbonate reabsorption in the proximal tubules and alkali therapy improved her acidaemia. [ncbi.nlm.nih.gov]

Hypopotassemia and severe metabolic acidosis were found on biochemical examination. [ncbi.nlm.nih.gov]

Isovaleric Acidemia

Isovaleric acidemia may present with symptoms during the acute stage of severe metabolic acidosis, ketosis, vomiting and altered mental status. [ncbi.nlm.nih.gov]

Isovaleric acidemia may present in the neonatal period with an acute episode of severe metabolic acidosis, ketosis, and vomiting and may lead to coma and death in the first [ncbi.nlm.nih.gov]

This inborn error of metabolism leads to body accumulation of isovaleric acid (and its metabolites) resulting in vomiting, dehydration, severe metabolic acidosis, and neurologic [accessanesthesiology.mhmedical.com]

Methanol Poisoning

Acute methanol poisoning produces severe metabolic acidosis and serious neurologic sequelae. [ncbi.nlm.nih.gov]

She presented to a hospital in New Zealand with severe metabolic acidosis and a highly toxic methanol level at 17 mmol/L. [ncbi.nlm.nih.gov]

Acid Base Disorder

Treatment of severe metabolic acidosis requires the use of sodium bicarbonate, but blood pH and gases should be monitored closely to avoid an "overshoot" alkalosis. [ncbi.nlm.nih.gov]

metabolic acidosis (pH 7.2. [quizlet.com]

Specialty consultations: A multidisciplinary approach should be adopted to care for patients with severe metabolic acidosis. [renalandurologynews.com]

5-Oxoprolinuria

Clinically affected patients present with severe metabolic acidosis, 5-oxoprolinuria, increased rate of hemolysis and defective function of the central nervous system. [ncbi.nlm.nih.gov]

In humans, defects in GSS are inherited in an autosomal recessive way and are the cause of severe metabolic acidosis, 5-oxoprolinuria, and increased rate of haemolysis and [ebi.ac.uk]

In order to treat metabolic acidosis, severely affected patients are given large amounts of bicarbonate and antioxidants such as vitamin E and vitamin C. [en.wikipedia.org]

Methyl Ethyl Ketone Poisoning

Symptoms of acute MEKP poisoning include gastrointestinal burns and bleeding, esophageal and gastric perforation, severe metabolic acidosis, rapid hepatic failure, rhabdomyolysis [flore.unifi.it]

Previously reported cases of MEKP ingestion showed high morbidity and mortality as it caused severe metabolic acidosis, acute liver and renal failure, upper gastrointestinal [omicsonline.org]

metabolic acidosis, rapid hepatic failure, rhabdomyolysis, and respiratory insufficiency. [t3db.ca]

Diabetic Ketoacidosis

[…] ketonuria and severe metabolic acidosis (pH 7.08). [ncbi.nlm.nih.gov]

Diabetic ketoacidosis (DKA), a common cause of severe metabolic acidosis, remains a life-threatening condition due to complications of both the disease and its treatment. [ncbi.nlm.nih.gov]

Though the symptoms were rapidly relieved after initiation of treatment, severe hyperglycemia (575 mg/dL), severe metabolic acidosis (pH 6.9), and ketonuria developed at four [ncbi.nlm.nih.gov]

Chronic Respiratory Acidosis

Metabolic acidosis Acute severe metabolic acidosis (pH < 7.1): intravenous sodium bicarbonate Chronic metabolic acidosis : oral sodium bicarbonate along with treatment of [amboss.com]

The best example is the patient with very severe COPD who might have chronic respiratory acidosis with metabolic compensation at baseline. [courses.washington.edu]

Acidosis w/ Metabolic Alkalosis : COPD w/ diuretics, vomiting, NG suction, severe hypokalemia Respiratory alkalosis w/ metabolic acidosis: normal Ph: Sepsis, Aspirin Tox, [emdocs.net]

Acute Respiratory Acidosis

Metabolic acidosis Acute severe metabolic acidosis (pH < 7.1): intravenous sodium bicarbonate Chronic metabolic acidosis : oral sodium bicarbonate along with treatment of [amboss.com]

C) Increase in blood CO2 levels A patient with Kussmaul's respirations most likely has: A) metabolic acidosis. What is the treatment for severe metabolic acidosis? [studystack.com]

The best example is the patient with very severe COPD who might have chronic respiratory acidosis with metabolic compensation at baseline. [courses.washington.edu]

Xanthinuria

Other reported manifestations include severe metabolic acidosis and intracranial hemorrhage. [emedicine.com]

Lactic Acidosis

The patient had severe metabolic acidosis with elevated lactate upon arrival to the emergency department. [ncbi.nlm.nih.gov]

It is characterized by rapid development of neurological symptoms and severe metabolic acidosis, often with a high serum anion gap. [ncbi.nlm.nih.gov]

On day 3, she developed tachypnea and arterial blood gas analysis revealed a severe metabolic acidosis (pH 7.2, PCO2 19 mm Hg, bicarbonates 8 mEq/L) with anion gap of 25 mEq [ncbi.nlm.nih.gov]

Anemia due to Other Disorders of Glutathione Metabolism

Affected infants may also have severe metabolic acidosis caused by an accumulation of 5-oxoproline. [rarediseases.org]

The moderate form of glutathione synthetase deficiency is associated with hemolytic anemia and metabolic acidosis, while patients with the severe form additionally have progressive [ommbid.mhmedical.com]

In the severe systemic form, chronic metabolic acidosis must be managed. Long-term prognosis is guarded. [emedicine.medscape.com]

Toluene Poisoning

[…] for symptom appearance - severe metabolic acidosis and hypokalemia. [symptoma.com]

We report a case of severe metabolic acidosis and hyperlactemia due to toluene sniffing. [saudija.org]

The main clinical presentation was weakness associated to severe hypokalemia. Severe metabolic acidosis was found in 20 patients. [tandfonline.com]

Renal Tubular Acidosis Type 1

Compared to other patients, patients with SLC4A1 mutations showed an older age of onset (3.7 ± 2.6 years) and less severe metabolic acidosis at initial presentation. [ncbi.nlm.nih.gov]

Complications observed were severe metabolic acidosis, profound hypokalemia aggravated by hyperemesis gravidarum, recurrent urinary tract infection (UTI) and ureteric obstruction [ncbi.nlm.nih.gov]

We report two male siblings who presented with severe hyperchloremic metabolic acidosis, high urinary pH, nephrocalcinosis, growth retardation, sensorineural hearing loss, [ncbi.nlm.nih.gov]

Hawkinsinuria

metabolic acidosis, ketosis, FTT, transient tyrosinemia, ↑ excretion of p -hydroxyphenylpyruvic and p -hydroxyphenylacetic acids as well as unusual tyrosine metabolites, [medical-dictionary.thefreedictionary.com]

Biochemistry 49:7218–7226 CrossRef PubMed Danks DM, Tippett P, Rogers J (1975) A new form of prolonged transient tyrosinemia presenting with severe metabolic acidosis. [springermedizin.de]

Danks DM, Tippett P, Rogers J. a new form of prolonged transient tyrosinemia presenting with severe metabolic acidosis. [frontiersin.org]

Anemia due to Glutathione Metabolism Disorder

In the severe systemic form, chronic metabolic acidosis must be managed. Long-term prognosis is guarded. [emedicine.medscape.com]

Missense mutations in the human glutathione synthetase gene result in severe metabolic acidosis, 5-oxoprolinuria, hemolytic anemia and neurological misfunction. [rarediseases.org]

Pyruvate Carboxylase Deficiency

The initial neonatal symptoms started with respiratory distress, severe metabolic acidosis and a tendency to hypoglycemia. [ncbi.nlm.nih.gov]

The patient developed signs of severe liver damage and died at 13 days of age after increasing metabolic acidosis and severe bleedings. [ncbi.nlm.nih.gov]

She has had several episodes of metabolic acidosis with elevated lactate, pyruvate, alanine, beta-hydroxybutyrate, acetoacetate, lysine, and proline values, and undetectably [ncbi.nlm.nih.gov]

Cyanide Poisoning

She had injected herself with cyanide subcutaneously and had severe metabolic acidosis. [ncbi.nlm.nih.gov]

Following a latent period of approximately 12 hours, the patient developed cyanide poisoning with severe metabolic acidosis, seizures, and shallow respirations. [ncbi.nlm.nih.gov]

Metabolic acidosis with high anion is a good surrogated marker of severe cyanide poisoning. [ncbi.nlm.nih.gov]