Severe Muscle Weakness: Causes & Reasons

Possible Causes for Severe Muscle Weakness

The severe muscle weakness (almost always symmetrical) first affects proximal limbs and then progresses to the extremities (hands and feet). Cries are weak. [orpha.net]

Congenital Muscular Dystrophy

It progresses slowly, with short periods of rapid muscle deterioration and weakness. Severity ranges from very mild to completely disabling. [webmd.com]

Two-year-old Sophie’s severe muscle weakness was making it hard for her to walk. [med.stanford.edu]

Complete absence of this protein is usually associated with a severe phenotype characterized by drastic muscle weakness and characteristic changes in white matter in cerebral [ncbi.nlm.nih.gov]

Spinal Muscular Atrophy

Motor neuron loss often results in severe muscle weakness causing affected infants to die before reaching 2 years of age. [ncbi.nlm.nih.gov]

muscle weakness by wasting mainly confined to the upper limbs. [ncbi.nlm.nih.gov]

The severe muscle weakness (almost always symmetrical) first affects proximal limbs and then progresses to the extremities (hands and feet). Cries are weak. [orpha.net]

Muscular Dystrophy

Some cases may be mild and progress very slowly over a normal lifespan, while others produce severe muscle weakness, functional disability, and loss of the ability to walk [ninds.nih.gov]

It progresses slowly, with short periods of rapid muscle deterioration and weakness. Severity ranges from very mild to completely disabling. [webmd.com]

However, other types of MD may cause functional disability and severe muscle weakness interfering with the individual’s ability to walk. [symptoma.com]

Erb Muscular Dystrophy

Some cases may be mild and progress very slowly over a normal lifespan, while others produce severe muscle weakness, functional disability, and loss of the ability to walk [ninds.nih.gov]

It progresses slowly, with short periods of rapid muscle deterioration and weakness. Severity ranges from very mild to completely disabling. [webmd.com]

Affected individuals have severe progressive proximal muscle weakness. [rarediseases.org]

Limb-Girdle Muscular Dystrophy Type 1F

It progresses slowly, with short periods of rapid muscle deterioration and weakness. Severity ranges from very mild to completely disabling. [webmd.com]

Their main feature is severe muscle weakness that predominantly affects limb, axial and facial muscles to a variable degree. [news-medical.net]

Affected individuals have severe progressive proximal muscle weakness. [rarediseases.org]

Congenital Myopathy with Excess of Thin Filaments

The severe muscle weakness that occurs in actin-accumulation myopathy also affects the muscles used for breathing. [malacards.org]

People with actin-accumulation myopathy have severe muscle weakness ( myopathy ) 2 ... ... [familydiagnosis.com]

People with actin-accumulation myopathy have severe muscle weakness (myopathy) and poor muscle tone (hypotonia) throughout the body. [malacards.org]

Nemaline Myopathy

muscle weakness caused by thin filament dysfunction. [ncbi.nlm.nih.gov]

A sporadic case of congenital myopathy had severe muscle weakness of neonatal onset. [ncbi.nlm.nih.gov]

From Wikidata Jump to navigation Jump to search congenital structural myopathy characterized by generally non-progressive muscle weakness of varying severity nemaline rod [wikidata.org]

Muscular Dystrophy-Dystroglycanopathy Type C4

Fukuyama congenital muscular dystrophy is a more severe disorder characterized by brain malformations, hypotonia and muscle weakness. [sema4genomics.com]

Life span may be affected by severity of muscle weakness; as muscles deteriorate, respiratory function may decrease leading to early death as a result of respiratory failure [geneaware.clinical.bcm.edu]

On examination, there was bilateral proximal muscle weakness with severe atrophy and an abnormal gait. There was sinus bradycardia on electrocardiography. [chs-journal.com]

Distal Spinal Muscular Atrophy Type 3

[…] cough Weak cry Progressive weakness of muscles used to chew and swallow Poor muscle tone “Frog-leg” posture when lying Severe muscle weakness on both sides of body Progressive [togetherinsma.com]

[…] reflexes Muscle fasciculation Muscle atrophy SMA type I Age of onset : Features : the most severe form. [patient.info]

The types differ in age of onset and severity of muscle weakness; however, there is overlap between the types. [ghr.nlm.nih.gov]

X-linked Distal Spinal Muscular Atrophy Type 3

[…] reflexes Muscle fasciculation Muscle atrophy SMA type I Age of onset : Features : the most severe form. [patient.info]

Generalised muscle weakness may follow, affecting the distal muscles (those furthest away from the centre of the body- e.g. the muscles in the hands and feet) more severely [www2.warwick.ac.uk]

Batten-Turner Congenital Myopathy

These patients have very severe muscle weakness and little to no movements. Death usually occurs early on, but there are case reports of patients who survive long-term. [thinkgenetic.com]

muscle weakness of neonatal onset. [scinapse.io]

Clinically it presents as mild to severe muscle weakness. It may be associated with skeletal abnormalities including scoliosis, joint deformities, and hip dislocation. [icd10data.com]

Adult Spinal Muscular Atrophy

Spinal Muscular Atrophy (SMA) is genetic disorder causing severe muscle weakness. The vast majority of children with SMA, like Getty, are born with weaker muscles. [gettyowl.org]

SMA II Sometimes called intermediate SMA, SMA II causes muscle weakness and hypotonia, but the problems are less severe than with SMA I. [gillettechildrens.org]

Central Core Disease

Patients have variable clinical features ranging from asymptomatic to exhibiting severe muscle weakness. [snpedia.com]

Clinically it presents as mild to severe muscle weakness. [ebi.ac.uk]

This condition has several subtypes and often causes severe muscle weakness in the arms and legs, and scoliosis. Myotubular myopathy. [mayoclinic.org]

Emery-Dreifuss Muscular Dystrophy Type 1

It progresses slowly, with short periods of rapid muscle deterioration and weakness. Severity ranges from very mild to completely disabling. [webmd.com]

Some cases may be mild and progress very slowly over a normal lifespan, while others produce severe muscle weakness, functional disability, and loss of the ability to walk [checkorphan.org]

The disease progresses slowly and causes less severe muscle weakness than some other forms of muscular dystrophy. Continued What Are the Causes of Muscular Dystrophy? [webmd.com]

Autosomal Recessive Centronuclear Myopathy

Muscle weakness is seen with variable severity and is usually prominently proximal. [medicbind.com]

The X-linked neonatal form (XLCNM) is due to mutations in MTM1 and involves a severe and generalized muscle weakness at birth. [ncbi.nlm.nih.gov]

In rare instances, the muscle weakness improves over time.Some people with centronuclear myopathy experience mild to severe breathing problems related to the weakness of muscles [icdlist.com]

Nemaline Myopathy Type 5

[…] of respiratory muscles, but less severe muscle weakness than the other forms, with most individuals being able to eventually walk independently Severe Congenital (Neonatal [patientworthy.com]

Typical nemaline myopathy is the most common form, presenting as infantile hypotonia and muscle weakness. [diseaseinfosearch.org]

These patients have very severe muscle weakness and little to no movements. Death usually occurs early on, but there are case reports of patients who survive long-term. [thinkgenetic.com]

Nemaline Myopathy Type 4

Recently, human leiomodin-3 (Lmod3) mutations were found to cause nemaline myopathy with shorter thin filaments and impaired contractility, leading to severe muscle weakness [scripps.edu]

This condition has several subtypes and often causes severe muscle weakness in the arms and legs, and scoliosis. Myotubular myopathy. [mayoclinic.org]

People with cap myopathy have muscle weakness (myopathy) and poor muscle tone (hypotonia) throughout the body, but they are most severely affected in the muscles of the face [malacards.org]

Myasthenia Gravis

Myasthenia gravis is a relatively rare autoimmune nerve-muscle disease that causes severe muscle weakness and, in many cases, a difficult life situation for the affected patient [toleranzia.com]

Myasthenia Gravis (MG) is a debilitating and potentially deadly disease that can afflict anyone, characterized by severe muscle weakness, affecting control of facial expressions [news-medical.net]

weakness or both Class 4 4a 4b Severe weakness of other muscles; may have eye muscle weakness of any severity Predominantly limb or axial muscle weakness or both Predominantly [intechopen.com]

Congenital Fiber-Type Disproportion Myopathy

The five children with severe weakness at birth had profound respiratory muscle weakness and needed assisted ventilation since early infancy. [ncbi.nlm.nih.gov]

It is estimated that up to 25 percent of affected individuals experience severe muscle weakness at birth and die in infancy or childhood. [ghr.nlm.nih.gov]

Clinically it presents as mild to severe muscle weakness. It may be associated with skeletal abnormalities including scoliosis, joint deformities, and hip dislocation. [icd10data.com]

Limb-Girdle Muscular Dystrophy Type 1H

It progresses slowly, with short periods of rapid muscle deterioration and weakness. Severity ranges from very mild to completely disabling. [webmd.com]

Affected individuals have severe progressive proximal muscle weakness. [rarediseases.org]

Presentation is varied and may range from asymptomatic to severe muscle weakness that manifests with absent Achilles reflexes, gait abnormality and/or other motor incapacitations [mendelian.co]

Distal Spinal Muscular Atrophy Type 1

[…] by leg muscle weakness that is most severe in the thigh muscles (quadriceps). [icdlist.com]

She manifested the characteristic clinical features, including early-onset respiratory failure due to diaphragmatic paralysis and severe distal muscle weakness. [ncbi.nlm.nih.gov]

Symptoms seem to appear in reverse order to that of SMA Type 1, with respiratory problems coming first, followed by severe muscle weakness, especially in the lower limbs. [actsma.co.uk]

Respiratory Muscle Paralysis

Complete or severe weakness of the muscles of respiration. [connects.catalyst.harvard.edu]

Facial weakness, dysphasia or dysarthria may develop. In severe cases, muscle weakness may lead to respiratory failure. [patient.info]

This reaches a level of maximum severity two weeks after initial onset of symptoms and usually stops progressing after five weeks. [patient.info]

Familial Periodic Paralysis

Because muscle contraction is needed for movement, a disruption in normal ion transport leads to episodes of severe muscle weakness or paralysis. [ghr.nlm.nih.gov]

Exposure to cold initially causes muscle stiffness in these individuals, and prolonged cold exposure leads to temporary episodes of mild to severe muscle weakness that may [ghr.nlm.nih.gov]

[…] episodes of muscle weakness. [athenadiagnostics.com]

Congenital Muscular Dystrophy Type 1A

It progresses slowly, with short periods of rapid muscle deterioration and weakness. Severity ranges from very mild to completely disabling. [webmd.com]

The development of motor movement is delayed and severe muscle weakness can result in stiffness (contracture) that gradually becomes worse. [mediconvillage.se]

The disease progresses slowly and causes less severe muscle weakness than some other forms of muscular dystrophy. Continued What Are the Causes of Muscular Dystrophy? [webmd.com]

Distal Spinal Muscular Atrophy Type 4

Affected individuals have severe progressive proximal muscle weakness. [rarediseases.org]

[…] reflexes Muscle fasciculation Muscle atrophy SMA type I Age of onset : Features : the most severe form. [patient.info]

weakness and hypotonia (severely reduced muscle tone), causing difficulties when moving, breathing, eating and swallowing Difficulties in raising the head in an upward position [thehumanthebody.com]

Becker Muscular Dystrophy

The clinical distinction between the 2 conditions is relatively easy because (1) less severe muscle weakness is observed in patients with BMD and (2) affected maternal uncles [emedicine.com]

Spinal Muscular Atrophy Type 4

muscles, mostly of the lower extremities Intercostal muscle weakness → paradoxical breathing Diminished or absent deep tendon reflexes Severe bulbar palsy Respiratory failure [amboss.com]

Weakness in the muscles of the arms occurs as well although this is not as severe as in the legs. [asonginthisworld.com]

Here are the types of SMA, according to the Muscular Dystrophy Association (MDA): SMA type 0: At birth, there is severe muscle weakness, lack of reaction to surroundings, [everydayhealth.com]

Hypokalemic Periodic Paralysis

Hypokalemic Periodic Paralyses comprise diverse diseases characterized by acute and reversible attacks of severe muscle weakness, associated with low serum potassium. [ncbi.nlm.nih.gov]

Genetic disorders account for hypokalemic periodic paralysis, a condition of repeated episodes of reduced potassium levels and severe muscle weakness. [symptoma.com]

Because muscle contraction is needed for movement, a disruption in normal ion transport leads to episodes of severe muscle weakness or paralysis. [ghr.nlm.nih.gov]

Muscular Dystrophy-Dystroglycanopathy Type B6

It progresses slowly, with short periods of rapid muscle deterioration and weakness. Severity ranges from very mild to completely disabling. [webmd.com]

There is a wide spectrum of symptoms - from a milder form of LGMD to severe muscle weakness and wasting. May have learning difficulties. May have eye problems. [patient.info]

Distal wasting appeared more prominent than proximal with severe weakness, proximal more tan distal including truncal muscles. Deep tendon reflexes were absent. [neurologyindia.com]