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246 Possible Causes for Severe Osteoarthropathy

  • Pseudoachondroplasia

    Pseudoachondroplasia (PSACH) and multiple epiphyseal dysplasia (EDM1) are allelic disorders caused by mutations in the gene encoding cartilage oligomeric matrix protein (COMP). PSACH is a dominant condition characterized by disproportionate short stature, joint laxity, and early-onset osteoarthritis. EDM1 is a less[…][ncbi.nlm.nih.gov]

  • Hyponatremia

    Rheumatologic: Osteoarthropathy, chondrocalcinosis, psuedogout.[news-medical.net] Odontohypophosphatasia is characterized by premature exfoliation of fully rooted primary teeth and/or severe dental caries, often not associated with abnormalities of the[ojrd.biomedcentral.com] Renal: Hypercalcuria, nephrocalcinosis, severe renal damage. Neurologic: Increased intracranial pressure, seizures.[news-medical.net]

  • Diabetic Enteropathy

    : Frequency increased Discomfort Pain Burning Fatigue Distribution Distal: Usual Orofacial: Occasional; Burning mouth; Fatigue Weakness Severity: Mild or Absent Distribution[neuromuscular.wustl.edu] Distal Association: Chronic DM Autonomic involvement : Some patients Sympathetic denervation: Increased peripheral blood flow Cardiac denervation Charcot joints (Neurogenic osteoarthropathy[neuromuscular.wustl.edu] Vibration sense: Reduced Paresthesias Ankle reflexes: Absent Associated with foot ulcers in chronic DM 7x increase Age: Middle-aged & elderly Location: Soles of feet Neuropathic osteoarthropathy[neuromuscular.wustl.edu]

  • Hip Dysplasia Type Beukes

    BHD is characterised by bilateral dysmorphism of the proximal femur, which results in severe degenerative osteoarthropathy.[research.manchester.ac.uk] The predicted amino acid substitution inactivates UFSP2 proteolytic function, thus implicating the ubiquitin-fold modifier 1 cascade in this form of severe hip osteoarthropathy[research.manchester.ac.uk]

  • Familial Hypercholesterolemia

    Exacerbation In Pregnancy 1 Hyperthyroidism, Familial Gestational 2 Hyperthyroidism, Nonautoimmune 2 Hypertrichotic Osteochondrodysplasia 2 Hypertrophic Osteoarthropathy,[preventiongenetics.com] 1 Hyperpigmentation with or without Hypopigmentation 1 Hyperprolactinemia 2 Hypertension and Brachydactyly Syndrome 1 Hypertension, Early-Onset, Autosomal Dominant, With Severe[preventiongenetics.com]

  • Periostitis

    Primary hypertrophic osteoarthropathy is a hereditary condition in which chemicals released by the immune system causes irritation in the periosteum at several bone sites[hxbenefit.com] Periostitis Treatment The treatment procedure may vary depending on the severity and symptoms of the injury.[hxbenefit.com] Periostitis Physiologic Periostitis Caffey’s Disease Arthritis Pachydermioperiostitis Fluorosis Lyme Disease Hypervitaminosis A Eosinophilic Granuloma Hypertrophic Pulmonary Osteoarthropathy[hxbenefit.com]

  • Foot Deformity

    […] fractures and severe destruction of the foot architecture in association with peripheral neuropathy.[healio.com] Charcot’s arthropathy (diabetic neuropathic arthropathy/diabetic osteoarthropathy) is defined as a progressive deformity of the foot caused by joint dislocation, pathological[healio.com]

  • Autosomal Recessive Pachydermoperiostosis 

    A novel homozygous mutation in the SLCO 2 A1 gene is associated with severe primary hypertrophic osteoarthropathy phenotype in a Saudi patient.[emedicine.medscape.com] The patients had a clinical picture of primary hypertrophic osteoarthropathy but without any signs of disease activity until in the last several months when a malignant bronchopulmonary[ncbi.nlm.nih.gov] […] complications, which include severe kyphosis, restricted motion, and neurologic manifestations.[emedicine.medscape.com]

  • Paraneoplastic Syndrome

    Rheumatologic syndromes The causes of hypertrophic osteoarthropathy remain unknown, although several hypotheses have been developed (eg, estrogen or growth hormone [GH] production[emedicine.medscape.com]

  • Bronchogenic Carcinoma

    The patients had a clinical picture of primary hypertrophic osteoarthropathy but without any signs of disease activity until in the last several months when a malignant bronchopulmonary[ncbi.nlm.nih.gov] Key words: carcinoma, bronchogenic; osteoarthropathy, secondary hypertrophic.[scielo.br] We emphasize the disease's importance in light of its association with several other diseases, including bronchogenic cancer.[scielo.br]

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