Severe Osteoporosis: Causes & Reasons

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Possible Causes for Severe Osteoporosis

Nestor-Guillermo Progeria Syndrome

osteoporosis, and marked osteolysis. [uniprot.org]

[MIM:614008]: An atypical progeroid syndrome characterized by normal development in the first years of life, later followed by the emergence of generalized lipoatrophy, severe [genecards.org]

Definition An atypical progeroid syndrome characterized by normal development in the first years of life, later followed by the emergence of generalized lipoatrophy, severe [uniprot.org]

Lichtenstein Syndrome

severe repeated fractures Skeletal Limbs: limited extension at the elbows Head And Neck Eyes: synophrys epicanthal folds white sclera Head And Neck Nose: anteverted nostrils [malacards.org]

severe repeated fractures Skeletal Limbs: limited extension at the elbows Skeletal Feet: pes cavus Head And Neck Eyes: synophrys epicanthal folds white sclera Head And Neck [malacards.org]

0000939 Pectus excavatum Funnel chest 0000767 Pes cavus High-arched foot 0001761 Recurrent infections Frequent infections Frequent, severe infections Increased frequency [rarediseases.info.nih.gov]

Osteoporosis

A 38-year-old man had been diagnosed with severe osteoporosis most likely due to chronic SIADH. The SIADH was believed to be idiopathic. [ncbi.nlm.nih.gov]

We present a patient with multiple vertebral fractures in the context of severe osteoporosis, who, in the course of investigation for intractable spine and hip pain, was found [ncbi.nlm.nih.gov]

We report the first series of 4patients with histologically documented sarcoidosis who received teriparatide therapy for severe osteoporosis manifesting as a fracture cascade [ncbi.nlm.nih.gov]

Vertebral Compression Fracture

Nonunion of L3 with severe spinal stenosis was recognized in the preoperative films. Bone mineral analysis showed severe osteoporosis with a T-score of -4.7. [ncbi.nlm.nih.gov]

BACKGROUND: Teriparatide (recombinant human parathyroid hormone 1-34) is increasingly used for the treatment of severe osteoporosis because it stimulates bone formation and [ncbi.nlm.nih.gov]

Occasionally, bracing beyond twelve weeks is indicated in those patients with severe osteoporosis. [spineuniverse.com]

Senile Osteoporosis

Our sample consisted of 40 elderly women of the mean age of 78+/-5 years, having severe osteoporosis. [ncbi.nlm.nih.gov]

severe osteoporosis. [ncbi.nlm.nih.gov]

There are several other possible medical therapies (e.g., teriparatide, raloxifene), which may be indicated in special cases (e.g., severe osteoporosis, breast cancer prophylaxis [amboss.com]

Osteoporosis-Pseudoglioma Syndrome

[…] is characterized by severe osteoporosis and blindness. [radiopaedia.org]

[…] blindness and severe osteoporosis alongside seemingly random bone fractures. [en.wikipedia.org]

Abstract Isteoporosis-pseudoglioma syndrome (OPPG) is a rare heritable entity that features severe osteoporosis and many variable ophthalmic findings leading to congenital [ncbi.nlm.nih.gov]

Lumbar Compression Fracture

Treatment options vary since these patients are elderly and most have medical co-morbidities with severe osteoporosis. [cureus.com]

Fractures are usually caused by osteoporosis, and range from mild to severe. [uclahealth.org]

In severe osteoporosis, the vertebrae become so weak that they collapse upon themselves, leading to spinal deformity. [my.clevelandclinic.org]

Osteopenia and Osteoporosis

Features of Osteoporosis patients 11.1 Cardiovascular and metabolic comorbidities 11.2 Arthritis in patients with osteoporosis 11.3 Respiratory comorbidities 11.4 Severe Osteoporosis [globenewswire.com]

Any score below -2.5 The World Health Organization went on to further classify established (severe) osteoporosis as a score below -2.5 with a non-traumatic fracture. [2] [healthcentral.com]

If you have severe osteoporosis, the risk of fracture increases up to 25-fold! [parathyroid.com]

Idiopathic Juvenile Osteoporosis

Bone mineral density (BMD) showed severe osteoporosis [Table 2]. [jnsbm.org]

Studies of young patients with severe osteoporosis. Medicine (Baltimore). 1997, 76: 266-283. 10.1097/00005792-199707000-00005. [ped-rheum.biomedcentral.com]

CrossRef CAS PubMed Google Scholar Brumsen C, Hamdy NAT, Papapoulos SE (1997) Long-term effects of bisphosphonates on the growing skeleton: studies of young patients with severe [link.springer.com]

X-Linked Osteoporosis with Fractures

osteoporosis deformed, gracile (over-tubulated) bones cortical thinning hyperplastic callus formation popcorn calcification : the metaphyses and epiphyses exhibit numerous [radiopaedia.org]

osteoporosis. [nytimes.com]

In severe osteoporosis, thin bones or vertebral fractures may be seen on simple X-rays.. [yourhormones.info]

Premature Aging Type Okamoto

[…] erythroid macrocytosis severe developmental delay. [malacards.org]

[…] mellitus, osteoporosis, erythroid macrocytosis, severe growth and developmental deficiency" Am J Med Genet. 1997 Mar 17;69(2):169-70 �The statements on this Web site have [wellnessadvocate.com]

Heritability: Autosomal recessive inheritance AKA: premature aging syndrome with osteosarcoma cataracts diabetes osteoporosis erythroid macrocytosis severe developmental delay [monarchinitiative.org]

Osteogenesis Imperfecta Type 13

OI13 is characterized by normal teeth, faint blue sclerae, severe growth deficiency, borderline osteoporosis, severe bone deformity, and recurrent fractures affecting both [malacards.org]

Frontal radiograph of the leg in a patient with type I osteogenesis imperfecta (OI) shows evidence of severe osteoporosis, overtubulation of both the tibia and fibula, and [emedicine.medscape.com]

Other features include severe osteoporosis by DEXA. Type VI Manifestations include moderate-to-severe deformities. They may have blue sclera. [ijem.in]

Primary Pigmented Nodular Adrenocortical Disease

As the clinical presentation of Cushing syndrome in this group of patients may be atypical (severe osteoporosis or short stature), the detection of multiple, small adrenocortical [ncbi.nlm.nih.gov]

The first was a thirteen and a half year old male who presented with Cushing syndrome for three years and severe osteoporosis. [ncbi.nlm.nih.gov]

The clinical presentation of CS in this group of patients may be atypical, with common manifestations including an asthenic body habitus, short stature, severe osteoporosis [doi.org]

Exudative Vitreoretinopathy Type 3

The authors describe a rare case of the disease associated with severe infantile osteoporosis in a young female patient. [sistemacbo.com]

Since early childhood, the patient suffered from severe osteoporosis and showed reduced bone mineral density (BMD) on sequential densitometries, sustaining spontaneous fractures [sistemacbo.com]

Hajdu-Cheney Syndrome

Conclusions Hajdu-Cheney syndrome is a rare metabolic bone disorder that results in severe osteoporosis and skeletal abnormalities. [cureus.com]

At a glance Hajdu Cheney Syndrome (HCS) is a rare disease characterized by acroosteolysis, severe osteoporosis, short stature, specific craniofacial features, wormian bones [accesspediatrics.mhmedical.com]

Citation: Date Published: 2013 Aug Abstract: UNLABELLED: The Hajdu-Cheney syndrome is a very rare disease that affects several organ system, leading to severe osteoporosis [scholar.harvard.edu]

Kallmann Syndrome Type 5

The first case reported was a 52-year-old male who was referred for severe osteoporosis with hypogonadal phenotype. [elsevier.es]

Androgen or estrogen replacement therapy may prevent or ameliorate osteoporosis in men or women, respectively. [emedicine.medscape.com]

Hormone tests revealed hypogonadotropic hypogonadism, a densitometric study showed osteoporosis, and brain MRI confirmed severe hypoplasia of both olfactory bulbs. [elsevier.es]

Eosinophilic Cryptitis

Oral administration of ketotifen in a patient with eosinophilic colitis and severe osteoporosis. American Journal of Gastroenterology. 2002;97(4):1072–1074. [ncbi.nlm.nih.gov]

Kirghizian Dermatoosteolysis

Vigorous use of water jets should be avoided with fractures, known blood clots, bleeding disorders, severe osteoporosis, open wounds, or during pregnancy. [portsmouthhealthfood.com]

Spinal Compression Fracture

However, few reports are available in the management of multiple-level compression fractures due to severe osteoporosis. [ncbi.nlm.nih.gov]

Vertebral compression fractures in individuals with severe osteoporosis may stem from smaller traumas. [symptoma.com]

Even coughing or sneezing can cause compression fractures if you have severe osteoporosis. [webmd.com]

Osteogenesis Imperfecta Type 3

[…] bone dysplasia, severe osteoporosis with multiple fractures and bone deformities (more than 3 prepubertal fractures per annum), soft and shorter long bones, joint laxity, [iofbonehealth.org]

Other features include severe osteoporosis by DEXA. Type VI Manifestations include moderate-to-severe deformities. They may have blue sclera. [ijem.in]

Lytic Bone Lesion

Clinical manifestations include: transverse band of acro-osteolysis involving the phalanges of both hands and feet, severe osteoporosis short stature, deformities involving [iofbonehealth.org]

[…] entitled "Surgical challenges in the management of cervical kyphotic deformity in patients with severe osteoporosis: an illustrative case of a patient with Hajdu-Cheney [malacards.org]

Severe osteoporosis in familial Hajdu-Cheney syndrome: progression of acro-osteolysis and osteoporosis during long-term follow-up. [rarediseases.org]

Gallamine Allergy

[…] muscle weakness) or Osteoporosis or Peptic ulcer, active or history of or Personality changes or Stomach or intestinal problems (eg, diverticulitis, perforation, ulcerative [mayoclinic.org]

Glaucoma or Heart attack, recent or Hyperglycemia (high blood sugar) or Hypertension (high blood pressure) or Mental health problems (eg, depression) or Myasthenia gravis (severe [mayoclinic.org]

Secondary Osteoporosis

More detailed testing may be required in patients with severe osteoporosis. [ncbi.nlm.nih.gov]

Several inherited disorders have been linked to osteoporosis. [en.wikipedia.org]

Serum interleukin-6 reflects disease severity and osteoporosis in mastocytosis patients. Int Arch Allergy Immunol. 2002; 128 :344–350. [ PubMed ] [ Google Scholar ] 175. [ncbi.nlm.nih.gov]

Poultry Workers Lung

Vigorous use of water jets should be avoided with fractures, known blood clots, bleeding disorders, severe osteoporosis, open wounds, or during pregnancy. [healthnutvitamin.com]

Primary Pigmented Nodular Adrenocortical Disease 1

Patients with PPNAD often present with atypical CS, which is characterized by an asthenic, rather than obese, body habitus caused by severe osteoporosis, short stature and [rarediseases.info.nih.gov]

severe muscle and skin wasting. [rarediseases.info.nih.gov]

Thyrotoxicosis Factitia

These complications include: Atrial fibrillation Chest pain ( angina ) Heart attack Irregular heart rhythm Loss of bone mass (if severe, osteoporosis ) Weight loss When to [oer2go.org]

osteoporosis) Weight loss Infertility Problems sleeping When to Contact a Medical Professional Contact your provider if you have symptoms of hyperthyroidism. [ufhealth.org]

osteoporosis) Weight loss Prevention Thyroid hormone should be taken only by prescription and under the supervision of a provider. [account.allinahealth.org]

Ehlers-Danlos Syndrome Classic-Like Type 2

OMIM® : 57 Ehlers-Danlos syndrome classic-like-2 is characterized by severe joint and skin laxity, osteoporosis involving the hips and spine, osteoarthritis, soft redundant [malacards.org]

EDSCLL2 patients show severe joint and skin laxity, osteoporosis affecting the hips and spine, osteoarthritis, soft redundant skin that can be acrogeria-like, delayed wound [malacards.org]

[…] joint and skin laxity, osteoporosis involving the hips and spine, osteoarthritis, soft redundant skin that can be acrogeria-like, delayed wound healing with abnormal atrophic [malacards.org]

Osteogenesis Imperfecta Type 2

It shows severe osteoporosis of skeleton with fractures of upper extremities, crumpled femora, flared rib cage with narrow apex and multiple beads of callus on each rib. [iofbonehealth.org]

osteoporosis deformed, gracile (over-tubulated) bones cortical thinning hyperplastic callus formation popcorn calcification : the metaphyses and epiphyses exhibit numerous [radiopaedia.org]

Osteogenesis Imperfecta Type 15

It shows severe osteoporosis of skeleton with fractures of upper extremities, crumpled femora, flared rib cage with narrow apex and multiple beads of callus on each rib. [iofbonehealth.org]

osteoporosis deformed, gracile (over-tubulated) bones cortical thinning hyperplastic callus formation popcorn calcification : the metaphyses and epiphyses exhibit numerous [radiopaedia.org]

[…] skull Severe osteoporosis Severe fragility of bones; usually in utero fractures Factures heal with deformity and bowing Associated with tinted sclerae (blue, purple, or grey [physio-pedia.com]

Primary Pigmented Nodular Adrenocortical Disease 4

Patients with PPNAD often present with atypical CS, which is characterized by an asthenic, rather than obese, body habitus caused by severe osteoporosis, short stature and [orpha.net]

[…] symptoms. 4 One case of this report had severe pain of hip joint, the X-ray of pelvic indicated severe osteoporosis. [124.205.33.103]

severe muscle and skin wasting. [orpha.net]