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160 Possible Causes for Severe Peripheral Sensory Neuropathy, Toe Pain

  • Peripheral Neuropathy

    Peripheral Neuropathy symptoms usually start with numbness, prickling or tingling in the toes or fingers.[foundationforpn.org] Neuropathy occurs in several different syndromes and is identified in the literature as distal sensory polyneuropathy or distal sensory peripheral neuropathy.[ncbi.nlm.nih.gov] Most of the time the problem starts in the fingers and toes. As it gets worse, it moves into the limbs, causing pain and loss of feeling in the feet, legs, and hands.[stanfordhealthcare.org]

  • Raynaud Phenomenon

    Painful ulcers and gangrene are fairly common and can be difficult to treat. In addition, a person may experience heartburn or difficulty in swallowing.[medic8.com] Ulcers develop over the fingertips or toe tips. Pain is unrelenting.[emedicinehealth.com] When Raynaud's syndrome is associated with scleroderma (Systemic Sclerosis) problems may involve skin ulcers (sores) or gangrene (tissue death) in the fingers or toes.[medic8.com]

  • Scleroderma

    Puffy or swollen or painful fingers and/or toes Painful or swollen joints Muscle weakness Dry eyes or mouth (called Sjogren's syndrome ) Swelling -- mostly of the hands and[webmd.com] Pain and stiffness in the joints Persistent cough Shortness of breath Heartburn ( acid reflux ) Difficulty swallowing Digestive and gastrointestinal problems Constipation[my.clevelandclinic.org] […] skin (telangectasias) Excessive calcium deposition in the skin (calcinosis) Joint contractures (rigidity) Tight, mask-like facial skin Ulcerations on the fingertips and toes[my.clevelandclinic.org]

  • Ischemic Peripheral Neuropathy

    Therapy may also include pain relievers, calcium channel blockers, quitting smoking, and avoiding cold temperatures and emotional upset.[texasheart.org] The other “diabetic foot” clinical findings were ranked with the revised Wagner’s classification [ 11 ] and the UK peripheral neuropathy screening score (0-2: normal, 3-4:[omicsonline.org] Accordingly, peripheral neuropathy is neuropathy that affects the nerves of the extremities- the toes, feet , legs, fingers, hands, and arms.[emedicinehealth.com]

  • Diabetes Mellitus Type 1

    This can cause tingling, numbness, burning or pain that usually begins at the tips of the toes or fingers and gradually spreads upward.[mayoclinic.org]

  • Fabry Disease

    Recurrent fevers and vague pain in the hands and feet, resulting in periodically incapacitating pain in the fingers, toes, and occasionally the entire extremity, usually precede[dermaamin.com] Standardized quantitative sensory testing demonstrated severe impairment of thermal discrimination compared to patients with sensory neuropathies of large nerve fibres and[ncbi.nlm.nih.gov] Ki Bum Park, Kyung Ream Han, Jae Woo Lee, Seung Ho Kim, Do Wan Kim, Chan Kim and Jung Min Ko, Early Diagnosis of Fabry Disease in a Patient with Toe Tip Pain, The Korean Journal[oadoi.org]

  • Syphilis

    , resulting in bone pain and digital swelling ( Fig. 2E ) ( 38 ).[dx.doi.org] During the early stages, periostitis and osteitis may affect the bones of the upper and lower limbs (tibia, fibula, and forearm) and the proximal phalanges of fingers and toes[dx.doi.org]

  • Alcoholic Neuropathy

    Valengilda/iStock Boozing Can Cause Gout Gout is a type of arthritis that affects the big toe, causing excruciating pain, redness and swelling.[footfiles.com] […] progressing over several weeks with predominant sensory symptoms and signs.[jamanetwork.com] […] weakness, (“painful legs and moving toes”) and, in severe cases, the same symptoms in fingertips and hands (giving the so-called “stocking and glove” pattern) [13,14,15].[nutrientsreview.com]

  • Erythromelalgia

    The major clinical characteristics of EM cases included burning, sharp, tingling and/or stinging pain in toes, soles and/or dorsum of feet, fever, erythema and swelling.[ncbi.nlm.nih.gov] Indeed, small-diameter sensory neurons are thought to play a crucial role in several chronic painful neuropathies that arise from injury to peripheral nerves, such as those[doi.org] From that day on, the burning pain and redness in my toes continued until spring.[livewithcfs.blogspot.com]

  • Arsenic-Induced Polyneuropathy

    […] when walking Difficulty lifting up foot or toes Difficulty picking up or holding objects, or manipulating them in your hand.[oncolink.org] Peripheral neuropathy may also be caused by several heavy metals.[questdiagnostics.com] Some individuals may experience skin changes such as painful swelling and pink coloration of the fingers and toes (acrodynia); persistent redness or inflammation of the skin[rarediseases.org]

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