Severe Pruritus: Causes & Reasons

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Possible Causes for Severe Pruritus

Epidermolysis Bullosa Pruriginosa

Epidermolysis bullosa pruriginosa is a recently recognized variant of dystrophic epidermolysis bullosa (DEB) characterized by severe pruritus and scarring, mainly involving [ncbi.nlm.nih.gov]

Epidermolysis bullosa (EB) pruriginosa is a subtype of dominant dystrophic EB (DDEB), characterized by severe pruritus and blistering localized to the extensor surface of [ncbi.nlm.nih.gov]

Bradykinin possibly interacting with other mediators might be responsible for the severe pruritus. [e-ijd.org]

Polycythemia Vera

He complained of severe pruritus especially after (but not limited to) a shower. He was referred to our center for further evaluation. [ncbi.nlm.nih.gov]

Vellenga, Long‐term treatment with interferon‐α2b for severe pruritus in patients with polycythaemia vera, British Journal of Haematology, 89, 2, (313-318), (2008). [doi.org]

Pruritus can be quite marked in 30-50% and is worse after a hot shower or bath [ 6 ]. [patient.info]

Cutaneous T-Cell Lymphoma

Expression levels of IL-31, IL-31RA, and OSMRβ in the skin were measured using immunohistochemistry and correlated to pruritus severity and disease stage. [ncbi.nlm.nih.gov]

Sézary syndrome (SS), the leukemic form of CTCL, presents as erythroderma – often with severe pruritus. [oncology.medicinematters.com]

The advanced stage of mycosis fungoides is characterized by generalized erythroderma, with severe pruritus and scaling.[4] Cause[edit] The cause of mycosis fungoides is unknown [en.wikipedia.org]

Psychogenic Pruritus

pruritus without any physical signs (i.e. with no lichenification or no signs of scratching) who were labeled as psychogenic pruritus (PP). [karger.com]

Paroxetine in the treatment of severe non-dermatological pruritus: a randomized, controlled trial. [cambridge.org]

We describe a patient with epidermolysis bullosa pruriginosa who was misdiagnosed as having psychogenic pruritus for several years. [ncbi.nlm.nih.gov]

Pruritic Urticarial Papules and Plaques of Pregnancy

Follow-up 2 days later revealed a worsening rash and persistence of severe pruritus. [ncbi.nlm.nih.gov]

There are no systemic alterations seen in PUPPP; however, most patients report severe pruritus. [karger.com]

It presents no long-term risk for either the mother or unborn child despite frequently severe pruritus. [en.wikipedia.org]

Progressive Familial Intrahepatic Cholestasis

Severe pruritus and high serum bile acid concentrations are the most important diagnostic criteria of this autosomal recessive inherited disease. [ncbi.nlm.nih.gov]

Two years postoperatively, 50% were without pruritus and 21% had mild pruritus. In 29%, pruritus had not diminished; 3 of them had severe fibrosis preoperatively. [ncbi.nlm.nih.gov]

Both patients had normal gamma-glutamyl transpeptidase levels, but showed severe pruritus with sleep disturbance, cholestasis, jaundice and growth failure. [ncbi.nlm.nih.gov]

Uremic Pruritus

76), moderate (VAS 4-7, N = 89) and severe pruritus (VAS 8-10, N = 38). [ncbi.nlm.nih.gov]

The purpose was to characterize uremic pruritus in more detail and to investigate whether severe pruritus is a marker for poor prognosis. [ncbi.nlm.nih.gov]

They were asked to score the severity of pruritus twice a day. [ncbi.nlm.nih.gov]

Prurigo Nodularis

(IL)-6 with sleep, depression and pruritus severity. [ncbi.nlm.nih.gov]

We present the case of a forty-two-year-old man who experienced severe pruritus for ten months. [ncbi.nlm.nih.gov]

If patients with prurigo nodularis and severe pruritus do not have a cause of the pruritus, causes of chronic pruritus should be evaluated. [knowledge.statpearls.com]

Herpes Gestationis

It is a rare vesiculo-bullous eruption that develops during the last trimester or even postpartum and creates severe pruritus. [ncbi.nlm.nih.gov]

Severe pruritus is common. VIII. Prednisolone in a dose of about 40 mg/day suppresses the eruption. [gradestack.com]

Severe pruritus is common. Treatment: Topical potent corticosteroids are helpful in mild cases. [skincareguide.ca]

Cholestasis

Benign recurrent intrahepatic cholestasis (BRIC) is characterised by recurrent episodes of jaundice, severe pruritus and low or normal serum γ-glutamyltransferase activity [ncbi.nlm.nih.gov]

Therapeutic plasma exchange (TPE) has been shown to be an effective alternative in the setting of refractory pruritus associated with cholestatic liver disease based on several [ncbi.nlm.nih.gov]

pruritus. [orpha.net]

Alagille Syndrome

In this report, we describe a child with Alagille syndrome who presented with severe pruritus and xanthomas as a consequence of severe hypercholesterolemia and discuss the [ncbi.nlm.nih.gov]

pruritus. [ncbi.nlm.nih.gov]

To our knowledge, median neuropathy has never been associated with Alagille syndrome, although severe pruritus is considered a major symptom and many patients exhibit widespread [ncbi.nlm.nih.gov]

Pityriasis Circinata

Management (No effective treatment) Severe Pruritus See Pruritus Management Topical Corticosteroid Oral Antihistamine Calamine lotion or Zinc Oxide Severe Cases Ultraviolet [fpnotebook.com]

Symptoms Moderate to Severe Pruritus (25-50% of cases) Especially in children Other symptoms present in only 5% of patients Viral prodrome-type constitutional symptoms may [fpnotebook.com]

Folliculotropic Mycosis Fungoides

Severe pruritus was seen in 68% of patients. [ncbi.nlm.nih.gov]

Related features include severe pruritus, alopecia, palmoplantar hyperkeratosis, and bacterial superinfection Histologically the patch/plaque stage of MF is characterized [accessmedicine.mhmedical.com]

Severe pruritus is also a prominent feature. 2 Initial Presentation A 62-year-old man presented with a 20 year history of a pruritic erythematous rash on his scalp and trunk [ispub.com]

Pruritic Rash

Antihistamines and topical hydrocortisone may be used if severe pruritus exists. [aafp.org]

Several skin diseases are associated with pruritus; some are listed in Box 1. [clevelandclinicmeded.com]

No cause was found for her itch Download Figure: 6 Brachioradial pruritus The itch was severe, only affecting the right forearm. [pcds.org.uk]

Pigmented Purpuric Lichenoid Dermatosis

In case of itching purpura the skin lesions affect large portions of the skin and are the cause of severe pruritus (itching). [ic.steadyhealth.com]

In itching purpura of Loewenthal, the lesions are more extensive, and patients typically complain of severe pruritus. [clinicaladvisor.com]

The lesions are much more extensive, and patients typically complain of severe pruritus. Lesions are observed to be red-brown in colour. [sydneyskinandvein.com.au]

Intrahepatic Cholestasis

Patients commonly present in the third trimester with severe pruritus and deranged serum liver tests; bile acids are elevated, in severe cases >40 μmol/L. [ncbi.nlm.nih.gov]

We present two cases of pregnancy after IVF treatment diagnosed with ICP following the development of OHSS, deteriorating liver function tests and severe pruritus. [ncbi.nlm.nih.gov]

[…] months to years; (2) Laboratory values consistent with intrahepatic cholestasis; (3) Severe pruritus secondary to cholestasis; (4) Normal intra and extrahepatic bile ducts [ispub.com]

Phototoxic Eczema

Patients complain about severe pruritus. [ncbi.nlm.nih.gov]

Clinical manifestations The skin lesions develop a few hours to several days after sun exposure. Initially, patchy erythema develops, accompanied by pruritus. [ncbi.nlm.nih.gov]

Pruritus is the primary symptom. [ncbi.nlm.nih.gov]

Notalgia Paresthetica

Paroxetine in the treatment of severe non-dermatological pruritus: a randomized, controlled trial. J Pain Symptom Manage. 2003;26(6):1105–12. [ncbi.nlm.nih.gov]

Benign Recurrent Intrahepatic Cholestasis

Benign recurrent intrahepatic cholestasis (BRIC) is characterised by recurrent episodes of jaundice, severe pruritus and low or normal serum γ-glutamyltransferase activity [ncbi.nlm.nih.gov]

Recurrent self-limited episodes of jaundice and severe pruritus are leading clinical manifestations. [smj.si.mahidol.ac.th]

Since all former approaches to medical treatment of the patients severe pruritus were ineffective, the patient was treated by 3 sessions of albumin dialysis (MARS, Molecular [ncbi.nlm.nih.gov]

Aquagenic Pruritus

Aquagenic pruritus presents with severe pruritus or a stinging, tingling, or burning sensation without any visible skin changes... [read.qxmd.com]

Several skin diseases are associated with pruritus; some are listed in Box 1. [clevelandclinicmeded.com]

She has aquagenic pruritus, a rare disorder making her severely allergic to water. [khaleejtimes.com]

Benign Recurrent Intrahepatic Cholestasis Type 1

Clinically, patients with PFIC1 and PFIC2 present with jaundice and severe pruritus in the first few months of life. [emedicine.medscape.com]

The key to treatment is therefore relief of severe pruritus and other symptoms until attacks resolve spontaneously. [ispub.com]

An attack typically begins with severe itchiness (pruritus), followed by yellowing of the skin and whites of the eyes (jaundice) a few weeks later. [ghr.nlm.nih.gov]

Brachioradial Pruritus

We describe the case of a 60-year old woman recently diagnosed with multiple myeloma who refers paresis, severe pruritus and itching lesions on the right arm with 6 months [read.qxmd.com]

No cause was found for her itch Download Figure: 6 Brachioradial pruritus The itch was severe, only affecting the right forearm. [pcds.org.uk]

However, one can assume that the pruritus was severe enough for the patient to seek medical attention. [onlinelibrary.wiley.com]

Primary Biliary Cirrhosis

Although our patient is a unique case, plasma exchange should be considered in severe pruritus resistant to pharmacological treatment. [ncbi.nlm.nih.gov]

In this case report we illustrate how ultraviolet B phototherapy appears to successfully control severe pruritus and contribute to the healing of pruritic skin lesions caused [ncbi.nlm.nih.gov]

pruritus (itching). [news-medical.net]

Progressive Familial Intrahepatic Cholestasis Type 4

pruritus. [orpha.net]

Clinically, patients with PFIC1 and PFIC2 present with jaundice and severe pruritus in the first few months of life. [emedicine.medscape.com]

[…] months to years; (2) Laboratory values consistent with intrahepatic cholestasis; (3) Severe pruritus secondary to cholestasis; (4) Normal intra and extrahepatic bile ducts [ispub.com]

Pretibial Dystrophic Epidermolysis Bullosa

Bradykinin possibly interacting with other mediators might be responsible for the severe pruritus. [e-ijd.org]

Historically his severe pruritus could not be attributed to atopy, food or drug allergy, cutaneous or any systemic disorder. [ispub.com]

[…] localized or generalized pruritus, scratching-induced secondary skin lesions and pronounced scarring localized predominantly to the extensor surface of the extremities. [ijdvl.com]

Impetigo Herpetiformis

She had a pustular erythroderma covering her entire body, except face, scalp, and palmoplantar regions, with severe pruritus and pain. [ncbi.nlm.nih.gov]

The extent and severity of pruritus fluctuates until the time of delivery. 49, 51 Most severe pruritus occurs at night. 18 About 20% of patients present with mild jaundice [glowm.com]

In cases of severe pruritus unresponsive to conservative measures, systemic corticosteroid administration or induced delivery is considered. [glowm.com]

Cutaneous Amyloidosis

We present a case of DSP with a local amyloid deposit, characterized by association of positive familial background, severe pruritus and pulmonary tuberculosis. [ncbi.nlm.nih.gov]

The cosmetic disfigurement and severe pruritus dramatically affects the patient's quality of life. [ncbi.nlm.nih.gov]

Severity of pruritus (VAS scores) showed the strongest association with DLQI scores. [journals.plos.org]

Ichthyosis-Prematurity Syndrome

Many patients subsequently had chronic, severe pruritus. [ncbi.nlm.nih.gov]

Skin findings change to a mild form of generalized ichthyosis, often associated with severe pruritus. [nature.com]

Scabies

A 30-year-old woman, presented with erythematous scaling plaques on her trunk with severe pruritus and a burning sensation that began 3 months prior to her visit. [ncbi.nlm.nih.gov]

Severe pruritus is a typical symptom in affected individuals, and it is generally worst at night and when the patient is warm. [dermis.net]

A 71-year-old man with cirrhosis presented to the emergency department with severe diffuse pruritus. [nejm.org]

Sjögren-Larsson Syndrome

Patients also suffer from severe pruritus. The degradation of leukotriene (LT) B4 is one of the defective metabolic routes in SLS. [ncbi.nlm.nih.gov]

The severity of the pruritus diminished, and favorable changes in the child's behavior were observed. [ncbi.nlm.nih.gov]

Mild to severe itchiness (pruritus) is also common. [secure.ssa.gov]