Severe-pruritus: Causes & Reasons

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Possible Causes for severe pruritus

Polycythemia Vera

He complained of severe pruritus especially after (but not limited to) a shower. He was referred to our center for further evaluation. [ncbi.nlm.nih.gov]

Vellenga, Long‐term treatment with interferon‐α2b for severe pruritus in patients with polycythaemia vera, British Journal of Haematology, 89, 2, (313-318), (2008). [doi.org]

We currently do not recommend treatment with ruxolutinib or other JAK2 inhibitors in PV or ET, unless in the presence of severe and protracted pruritus or marked splenomegaly [ncbi.nlm.nih.gov]

Cutaneous T-Cell Lymphoma

Expression levels of IL-31, IL-31RA, and OSMRβ in the skin were measured using immunohistochemistry and correlated to pruritus severity and disease stage. [ncbi.nlm.nih.gov]

Sézary syndrome (SS), the leukemic form of CTCL, presents as erythroderma – often with severe pruritus. [oncology.medicinematters.com]

The advanced stage of mycosis fungoides is characterized by generalized erythroderma, with severe pruritus and scaling.[4] Cause[edit] The cause of mycosis fungoides is unknown [en.wikipedia.org]

Epidermolysis Bullosa Pruriginosa

Epidermolysis bullosa pruriginosa is a recently recognized variant of dystrophic epidermolysis bullosa (DEB) characterized by severe pruritus and scarring, mainly involving [ncbi.nlm.nih.gov]

Epidermolysis bullosa (EB) pruriginosa is a subtype of dominant dystrophic EB (DDEB), characterized by severe pruritus and blistering localized to the extensor surface of [ncbi.nlm.nih.gov]

Bradykinin possibly interacting with other mediators might be responsible for the severe pruritus. [e-ijd.org]

Uremic Pruritus

The purpose was to characterize uremic pruritus in more detail and to investigate whether severe pruritus is a marker for poor prognosis. [ncbi.nlm.nih.gov]

[…] moderate (VAS 4-7, N 89) and severe pruritus (VAS 8-10, N 38). [ncbi.nlm.nih.gov]

@article{3f0314455e53422fa550b6994e3ad6a0, title "A successful case of dupilumab treatment for severe uremic pruritus", keywords "itch, scratch, treatment, uremic pruritus [scholars.northwestern.edu]

Progressive Familial Intrahepatic Cholestasis

Severe pruritus and high serum bile acid concentrations are the most important diagnostic criteria of this autosomal recessive inherited disease. [ncbi.nlm.nih.gov]

Both patients had normal gamma-glutamyl transpeptidase levels, but showed severe pruritus with sleep disturbance, cholestasis, jaundice and growth failure. [ncbi.nlm.nih.gov]

Two years postoperatively, 50% were without pruritus and 21% had mild pruritus. In 29%, pruritus had not diminished; 3 of them had severe fibrosis preoperatively. [ncbi.nlm.nih.gov]

Pruritic Urticarial Papules and Plaques of Pregnancy

Follow-up 2 days later revealed a worsening rash and persistence of severe pruritus. [ncbi.nlm.nih.gov]

It presents no long-term risk for either the mother or unborn child despite frequently severe pruritus. [en.wikipedia.org]

There are no systemic alterations seen in PUPPP; however, most patients report severe pruritus. [karger.com]

Prurigo Nodularis

(IL)-6 with sleep, depression and pruritus severity. [ncbi.nlm.nih.gov]

We present the case of a forty-two-year-old man who experienced severe pruritus for ten months. [ncbi.nlm.nih.gov]

Patients often: seek treatment during middle-age, although PN can occur at any age. have a history of chronic severe pruritus. have a significant medical history for unrelated [en.wikipedia.org]

Psychogenic Pruritus

pruritus without any physical signs (i.e. with no lichenification or no signs of scratching) who were labeled as psychogenic pruritus (PP). [karger.com]

We describe a patient with epidermolysis bullosa pruriginosa who was misdiagnosed as having psychogenic pruritus for several years. [ncbi.nlm.nih.gov]

Paroxetine in the treatment of severe non-dermatological pruritus: a randomized, controlled trial. [cambridge.org]

Common Cold

P. sidoides was assigned to the second class with moderate side effects, such as severe nausea or pruritus. [doi.org]

Vulvitis

SYMPTOMS—They include burning, severe pain, pruritus, redness, swelling, ulceration, pustular formation, edema, and vesicular itching. [medical.tpub.com]

Clinical Clinical symptoms consist of varying degrees of tenderness, pain, burning, and pruritus. Urinary retention may occur in severe cases. [www1.cgmh.org.tw]

Symptoms include severe pruritus, burning, irritation, and pain. This patient group usually is older, obese, and often has long-standing diabetes mellitus. [www1.cgmh.org.tw]

Cholestasis

Benign recurrent intrahepatic cholestasis (BRIC) is characterised by recurrent episodes of jaundice, severe pruritus and low or normal serum γ-glutamyltransferase activity [ncbi.nlm.nih.gov]

pruritus. [orpha.net]

Therapeutic plasma exchange (TPE) has been shown to be an effective alternative in the setting of refractory pruritus associated with cholestatic liver disease based on several [ncbi.nlm.nih.gov]

Vaginitis

It is caused by invasion of the Candida organism into the superficial epithelial cells of the vagina causing mild to severe vaginal inflammation, pruritus, and discharge. [unboundmedicine.com]

She reported severe vul-vovaginal pruritus, nonodourous vaginal discharge and dyspareunia associated with moderate symptoms of rhino-conjunctivitis. [asbai.org.br]

pruritus. [ncbi.nlm.nih.gov]

Herpes Gestationis

It is a rare vesiculo-bullous eruption that develops during the last trimester or even postpartum and creates severe pruritus. [ncbi.nlm.nih.gov]

Severe pruritus is common. VIII. Prednisolone in a dose of about 40 mg/day suppresses the eruption. [gradestack.com]

Severe pruritus is common. Treatment: Topical potent corticosteroids are helpful in mild cases. [skincareguide.ca]

Viral Upper Respiratory Tract Infection

[…] pain and pruritus, minimal edema of the ear canal) to severe (severe pain and pruritus, complete occlusion of the ear canal, auricular and periauricular erythema, and, frequently [microbiologybook.org]

· Chronic otitis externa presents with mild discomfort and flaking of the skin of long duration, often with a history Otitis media can be graded in severity from mild (minor [microbiologybook.org]

Upper Respiratory Infection

Antitussives, Non-Narcotic Combos Class Summary Several agents (eg, codeine, guaifenesin, dextromethorphan) are intended for the symptomatic relief of cough. [emedicine.medscape.com]

Brompheniramine (Bromphen) View full drug information This oral H1 blocker is used for allergic conjunctivitis and rhinitis, angioedema, pruritus, and urticaria. [emedicine.medscape.com]

Urinary Tract Infection

Side effects Study Severe side effects (n/N) Non‐severe side effects (n/N) Martens 1995 Cinoxacin 250: 3/32 Nausea and vomiting (1) Pruritus and urticaria (1) Dizziness, abdominal [dx.doi.org]

Insect Bite

If previous exposure to insect allergens led to mast cell sensitization, an insect bite may trigger a type I hypersensitivity reaction manifesting in severe urticaria, pruritus [symptoma.com]

The wheel bug (Arilus cristatus) is common in the eastern US and can cause a severely painful bite if mishandled. [clinicaladvisor.com]

Most insect bites are presented in form of puncture wounds, papule formation, localized urticaria and pruritus. [symptoma.com]

Vaginal Candidiasis

The severity score was based on the presence of symptoms (e.g., pruritus, irritation, and burning) and vulvovaginal signs (e.g., erythema, edema, and excoriation, or fissures [doi.org]

There are several treatment options for Candida infection, such as antifungals and antiseptics, with corticosteroids as a useful addition for pruritus and erythema. [cfp.ca]

as previously described. 21 The severity of each sign or symptom was scored on a scale of 0 (absent or normal) to 3 (severe). [doi.org]

Atopic Dermatitis

The scratching of severe pruritus may cause the appearance of pigmentation, erosion, and lichenification. [neliti.com]

Moreover, a positive correlation between serum IL-31 levels and severity of pruritus was identified. [ncbi.nlm.nih.gov]

Pruritus was graded on a 4-point scale of none (0) to severe (3). [ncbi.nlm.nih.gov]

Acute Cystitis

- Hypersensitivity reactions Skin reactions, e.g. rash, pruritus, drugs fever. [caprifarmindo.com]

Vaginitis is suggested by the presence of vaginal discharge or odour, pruritus, dyspareunia, external dysuria and no increased frequency or urgency. [antimicrobe.org]

Pityriasis Circinata

Management (No effective treatment) Severe Pruritus See Pruritus Management Topical Corticosteroid Oral Antihistamine Calamine lotion or Zinc Oxide Severe Cases Ultraviolet [fpnotebook.com]

Symptoms Moderate to Severe Pruritus (25-50% of cases) Especially in children Other symptoms present in only 5% of patients Viral prodrome-type constitutional symptoms may [fpnotebook.com]

Dermatitis

An 84-year-old man was referred for treatment of severe pruritus primarily of his arms and legs of 5 years’ duration. [doi.org]

Additionally, exploratory investigation was performed on the efficacy for disease severity and pruritus score in AD patients. [ncbi.nlm.nih.gov]

In severe disease, yellow-red scaling papules appear along the hairline, behind the ears, in the external auditory canals, on the eyebrows, in the axillae, on the bridge of [merckmanuals.com]

Iron Deficiency

Severe side effects other than allergic reactions are rare and include urticaria (hives), pruritus (itching), and muscle and joint pain. [hematology.org]

Other serious or severe adverse reactions potentially associated with hypersensitivity which included, but were not limited to, pruritus, rash, urticaria, wheezing, or hypotension [injectafer.com]

Blood Transfusions Red blood cell transfusions may be given to patients with severe iron-deficiency anemia who are actively bleeding or have significant symptoms such as chest [hematology.org]

Adenovirus Infection

Severe pain is atypical, but mild pain or discomfort, tearing, pruritus, and morning crusting are common. [emedicine.medscape.com]

Hypersensitivity

Treat acute type I hypersensitivity reactions supportively with antihistamines for pruritus, NSAIDs for arthralgias, corticosteroids for severe reactions (eg, exfoliative [msdmanuals.com]

In our opinion, an exhaustive medical history should be obtained from every candidate for total joint replacement and in cases of prior severe allergic reactions to metals [ncbi.nlm.nih.gov]

nasal stuffiness, decrease in frequency, severity, or resolution of symptoms with anti-mediator therapy including H 1 /H 2 receptor antagonists, anti-leukotrienes, or mast [doi.org]

Anemia

Severe side effects other than allergic reactions are rare and include urticaria (hives), pruritus (itching), and muscle and joint pain. [hematology.org]

diarrhea, and dizziness); serious reactions such as anaphylaxis and vascular thrombosis may occur; severe hypokalemia may result after correction of megaloblastic anemia [web.archive.org]

Blood Transfusions Red blood cell transfusions may be given to patients with severe iron-deficiency anemia who are actively bleeding or have significant symptoms such as chest [hematology.org]

Viral Disease

Olysio has been linked with a severe rash in about 1% of patients. [drugs.com]

In general, a mild-to-moderate rash occurs in 10-15% of patients; photosensitivity in 6 to 7%, and pruritus/itching in roughly 11%. [drugs.com]

Skin Infection

Lesions would be limited to exposed area Distinguished by: Sudden onset of severe pruritus Asymmetric distribution Location Allergy history Ecthyma : An ulcerative, deeper [medsask.usask.ca]

The purpose of this study, is to test the safety and effectiveness of an investigational study drug for Pruritus (“Itch”) Relief. [centerwatch.com]

Pruritus is common and the infected area is often extended by scratching. [apps.who.int]

Alagille Syndrome

In this report, we describe a child with Alagille syndrome who presented with severe pruritus and xanthomas as a consequence of severe hypercholesterolemia and discuss the [ncbi.nlm.nih.gov]

To our knowledge, median neuropathy has never been associated with Alagille syndrome, although severe pruritus is considered a major symptom and many patients exhibit widespread [ncbi.nlm.nih.gov]

This case highlights the importance of recognizing the severe pruritus as a manifestation of the disease. [ncbi.nlm.nih.gov]

Folliculotropic Mycosis Fungoides

Severe pruritus was seen in 68% of patients. [ncbi.nlm.nih.gov]

Pruritus is especially common in patients with FMF. Among our cases, 68% had severe pruritus requiring separate treatment aside from the lymphoma (n 30). [jamanetwork.com]

pruritus. 15 One review of 43 patients with folliculotropic MF found that if truncal involvement was present, follicular accentuation and follicular papules and nodules were [pediatrics.aappublications.org]