Severe Pruritus: Causes & Reasons

Possible Causes for Severe Pruritus

Epidermolysis bullosa pruriginosa is a recently recognized variant of dystrophic epidermolysis bullosa (DEB) characterized by severe pruritus and scarring, mainly involving [ncbi.nlm.nih.gov]

Bradykinin possibly interacting with other mediators might be responsible for the severe pruritus. [e-ijd.org]

No history of atopy, food or drug allergy, nor any systemic or cutaneus cause for severe pruritus was detectable. [e-ijd.org]

Polycythemia Vera

He complained of severe pruritus especially after (but not limited to) a shower. He was referred to our center for further evaluation. [ncbi.nlm.nih.gov]

Vellenga, Long‐term treatment with interferon‐α2b for severe pruritus in patients with polycythaemia vera, British Journal of Haematology, 89, 2, (313-318), (2008). [doi.org]

Long-term treatment with interferon-alpha 2b for severe pruritus in patients with polycythaemia vera. Br J Haematol. 1995;89(2):313–318. 35. [aafp.org]

Cutaneous T-Cell Lymphoma

Expression levels of IL-31, IL-31RA, and OSMRβ in the skin were measured using immunohistochemistry and correlated to pruritus severity and disease stage. [ncbi.nlm.nih.gov]

Sézary syndrome (SS), the leukemic form of CTCL, presents as erythroderma – often with severe pruritus. [oncology.medicinematters.com]

The advanced stage of mycosis fungoides is characterized by generalized erythroderma, with severe pruritus and scaling.[4] Cause[edit] The cause of mycosis fungoides is unknown [en.wikipedia.org]

Progressive Familial Intrahepatic Cholestasis

Severe pruritus and high serum bile acid concentrations are the most important diagnostic criteria of this autosomal recessive inherited disease. [ncbi.nlm.nih.gov]

Two years postoperatively, 50% were without pruritus and 21% had mild pruritus. In 29%, pruritus had not diminished; 3 of them had severe fibrosis preoperatively. [ncbi.nlm.nih.gov]

Both patients had normal gamma-glutamyl transpeptidase levels, but showed severe pruritus with sleep disturbance, cholestasis, jaundice and growth failure. [ncbi.nlm.nih.gov]

Psychogenic Pruritus

pruritus without any physical signs (i.e. with no lichenification or no signs of scratching) who were labeled as psychogenic pruritus (PP). [karger.com]

Paroxetine in the treatment of severe non-dermatological pruritus: a randomized, controlled trial. [cambridge.org]

We describe a patient with epidermolysis bullosa pruriginosa who was misdiagnosed as having psychogenic pruritus for several years. [ncbi.nlm.nih.gov]

Uremic Pruritus

The purpose was to characterize uremic pruritus in more detail and to investigate whether severe pruritus is a marker for poor prognosis. [ncbi.nlm.nih.gov]

76), moderate (VAS 4-7, N = 89) and severe pruritus (VAS 8-10, N = 38). [ncbi.nlm.nih.gov]

@article{3f0314455e53422fa550b6994e3ad6a0, title = "A successful case of dupilumab treatment for severe uremic pruritus", keywords = "itch, scratch, treatment, uremic pruritus [scholars.northwestern.edu]

Prurigo Nodularis

(IL)-6 with sleep, depression and pruritus severity. [ncbi.nlm.nih.gov]

We present the case of a forty-two-year-old man who experienced severe pruritus for ten months. [ncbi.nlm.nih.gov]

If patients with prurigo nodularis and severe pruritus do not have a cause of the pruritus, causes of chronic pruritus should be evaluated. [knowledge.statpearls.com]

Pruritic Urticarial Papules and Plaques of Pregnancy

Follow-up 2 days later revealed a worsening rash and persistence of severe pruritus. [ncbi.nlm.nih.gov]

There are no systemic alterations seen in PUPPP; however, most patients report severe pruritus. [karger.com]

It presents no long-term risk for either the mother or unborn child despite frequently severe pruritus. [en.wikipedia.org]

Herpes Gestationis

It is a rare vesiculo-bullous eruption that develops during the last trimester or even postpartum and creates severe pruritus. [ncbi.nlm.nih.gov]

Severe pruritus is common. VIII. Prednisolone in a dose of about 40 mg/day suppresses the eruption. [gradestack.com]

It is usually associated with severe pruritus and the periumbilical area is commonly the first site to be affected. [jpgo.org]

Cholestasis

Therapeutic plasma exchange (TPE) has been shown to be an effective alternative in the setting of refractory pruritus associated with cholestatic liver disease based on several [ncbi.nlm.nih.gov]

Benign recurrent intrahepatic cholestasis (BRIC) is characterised by recurrent episodes of jaundice, severe pruritus and low or normal serum γ-glutamyltransferase activity [ncbi.nlm.nih.gov]

pruritus. [orpha.net]

Pruritic Rash

Antihistamines and topical hydrocortisone may be used if severe pruritus exists. [aafp.org]

Several skin diseases are associated with pruritus; some are listed in Box 1. [clevelandclinicmeded.com]

No cause was found for her itch Download Figure: 6 Brachioradial pruritus The itch was severe, only affecting the right forearm. [pcds.org.uk]

Alagille Syndrome

In this report, we describe a child with Alagille syndrome who presented with severe pruritus and xanthomas as a consequence of severe hypercholesterolemia and discuss the [ncbi.nlm.nih.gov]

To our knowledge, median neuropathy has never been associated with Alagille syndrome, although severe pruritus is considered a major symptom and many patients exhibit widespread [ncbi.nlm.nih.gov]

This case highlights the importance of recognizing the severe pruritus as a manifestation of the disease. [ncbi.nlm.nih.gov]

Pigmented Purpuric Lichenoid Dermatosis

In case of itching purpura the skin lesions affect large portions of the skin and are the cause of severe pruritus (itching). [ic.steadyhealth.com]

In itching purpura of Loewenthal, the lesions are more extensive, and patients typically complain of severe pruritus. [clinicaladvisor.com]

The lesions are much more extensive, and patients typically complain of severe pruritus. Lesions are observed to be red-brown in colour. [sydneyskinandvein.com.au]

Pityriasis Circinata

Management (No effective treatment) Severe Pruritus See Pruritus Management Topical Corticosteroid Oral Antihistamine Calamine lotion or Zinc Oxide Severe Cases Ultraviolet [fpnotebook.com]

Symptoms Moderate to Severe Pruritus (25-50% of cases) Especially in children Other symptoms present in only 5% of patients Viral prodrome-type constitutional symptoms may [fpnotebook.com]

Folliculotropic Mycosis Fungoides

Severe pruritus was seen in 68% of patients. [ncbi.nlm.nih.gov]

Related features include severe pruritus, alopecia, palmoplantar hyperkeratosis, and bacterial superinfection Histologically the patch/plaque stage of MF is characterized [accessmedicine.mhmedical.com]

Benign Recurrent Intrahepatic Cholestasis

Benign recurrent intrahepatic cholestasis (BRIC) is characterised by recurrent episodes of jaundice, severe pruritus and low or normal serum γ-glutamyltransferase activity [ncbi.nlm.nih.gov]

Since all former approaches to medical treatment of the patients severe pruritus were ineffective, the patient was treated by 3 sessions of albumin dialysis (MARS, Molecular [ncbi.nlm.nih.gov]

Therapy during symptomatic periods is supportive and aimed at relief of severe pruritus until the episode resolves spontaneously. [ncbi.nlm.nih.gov]

Itching Purpura

In itching purpura of Loewenthal, the lesions are more extensive, and patients typically complain of severe pruritus. [clinicaladvisor.com]

The lesions are much more extensive, and patients typically complain of severe pruritus. Lesions are observed to be red-brown in colour. [sydneyskinandvein.com.au]

pruritus that accompanies the lesions in the former. [dermatologyadvisor.com]

Phototoxic Eczema

Patients complain about severe pruritus. [ncbi.nlm.nih.gov]

Clinical manifestations The skin lesions develop a few hours to several days after sun exposure. Initially, patchy erythema develops, accompanied by pruritus. [ncbi.nlm.nih.gov]

Pruritus is the primary symptom. [ncbi.nlm.nih.gov]

Aquagenic Pruritus

Aquagenic pruritus presents with severe pruritus or a stinging, tingling, or burning sensation without any visible skin changes... [read.qxmd.com]

Several skin diseases are associated with pruritus; some are listed in Box 1. [clevelandclinicmeded.com]

She has aquagenic pruritus, a rare disorder making her severely allergic to water. [khaleejtimes.com]

Vulvar Psoriasis

Generally, this presentation also includes mild to severe pruritus of the affected area. [clinmedjournals.org]

Causes of vulvar pruritus are vast and may be environmental, inflammatory, infectious or neoplastic. Often, several causes may coexist. [casereports.bmj.com]

Some studies have also shown a significant positive correlation between psoriasis severity and itching intensity (2, 3). [medicaljournals.se]

Brachioradial Pruritus

We describe the case of a 60-year old woman recently diagnosed with multiple myeloma who refers paresis, severe pruritus and itching lesions on the right arm with 6 months [read.qxmd.com]

No cause was found for her itch Download Figure: 6 Brachioradial pruritus The itch was severe, only affecting the right forearm. [pcds.org.uk]

The pruritus was severe, evaluated at 16 according to the 5-D itch-scale and 7/10 on the VAS. [medicaljournals.se]

Benign Recurrent Intrahepatic Cholestasis Type 1

Clinically, patients with PFIC1 and PFIC2 present with jaundice and severe pruritus in the first few months of life. [emedicine.medscape.com]

The key to treatment is therefore relief of severe pruritus and other symptoms until attacks resolve spontaneously. [ispub.com]

An attack typically begins with severe itchiness (pruritus), followed by yellowing of the skin and whites of the eyes (jaundice) a few weeks later. [ghr.nlm.nih.gov]

Scabies

Severe pruritus is a typical symptom in affected individuals, and it is generally worst at night and when the patient is warm. [dermis.net]

A 30-year-old woman, presented with erythematous scaling plaques on her trunk with severe pruritus and a burning sensation that began 3 months prior to her visit. [ncbi.nlm.nih.gov]

A 71-year-old man with cirrhosis presented to the emergency department with severe diffuse pruritus. [nejm.org]

Progressive Familial Intrahepatic Cholestasis Type 3

Evolution was marked by the persistence of jaundice and the appearance of an intense and ferocious pruritus (grade 4) associated with a severe failure to thrive. [latunisiemedicale.com]

During the course, all of them had developed an intense pruritus. [latunisiemedicale.com]

She also presents a sever failure to thrive, despite adequate nutritional support by gastric tube at home. [latunisiemedicale.com]

Progressive Familial Intrahepatic Cholestasis Type 4

pruritus. [orpha.net]

Clinically, patients with PFIC1 and PFIC2 present with jaundice and severe pruritus in the first few months of life. [emedicine.medscape.com]

[…] months to years; (2) Laboratory values consistent with intrahepatic cholestasis; (3) Severe pruritus secondary to cholestasis; (4) Normal intra and extrahepatic bile ducts [ispub.com]

Central Centrifugal Cicatricial Alopecia

Typically, a few short, brittle hairs remain within the scarred expanse.[9] Patients commonly complain of mild dysesthesia (pruritus, tenderness) in the affected area.[7,10 [ncbi.nlm.nih.gov]

] The disease generally progresses slowly, but longstanding or severe disease can result in hair loss covering the entire crown of the scalp.[11] This is in contrast to nonscarring [ncbi.nlm.nih.gov]

Judge-Misch-Wright Syndrome

pruritus without much evidence of a rash * Severe xerosis is common in the elderly, and can cause eczema craquelé –Patient's legs often have scale that resembles cracked [checkorphan.org]

[…] barrier function and allow irritants and allergens to more easily affect the skin –Most common on the legs, but often affecting the entire skin surface –Can present with severe [checkorphan.org]

Arthrogryposis - Renal Dysfunction - Cholestasis Syndrome Type 1

Liver transplant in a case of arthrogryposis-renal tubular dysfunction-cholestasis syndrome with severe intractable pruritus. [ncbi.nlm.nih.gov]

In cases of ARC syndrome that failed to respond to medical therapy, it is also advisable to consider liver transplant to ameliorate severe cholestasis and intractable pruritus [ncbi.nlm.nih.gov]

Notalgia Paresthetica

Massey Medicine Neurology 1978 Notalgia paresthetica affects the posterior rami of several spinal nerves (arising from thoracic segments T2 to T6), causing pruritus, burning [semanticscholar.org]

Paroxetine in the treatment of severe non-dermatological pruritus: a randomized, controlled trial. J Pain Symptom Manage. 2003;26(6):1105–12. [ncbi.nlm.nih.gov]

Hypersensitivity to Insect Stings

Allergic reactions to bee or wasp venom can also be localized to the sting and can vary in severity.1 Patients experiencing a large local reaction will usually experience [thermofisher.com]

[…] ranges from grade I to grade IV:5 Grade I: Generalized pruritus, urticaria, flushing, or sensation of heat or warmth; or angioedema (not laryngeal, tongue or uvular); or [thermofisher.com]

[…] edema, erythema, and pruritus rapidly after the sting.1 These symptoms typically peak between 24 and 48 hours after the sting.1 Systemic reactions occur in approximately less [thermofisher.com]