Severe Thrombocytopenia (Birth) Causes & Reasons

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Severe Thrombocytopenia (Birth) Symptom Checker: Possible causes include Amegakaryocytic Thrombocytopenia. Check the full list of possible causes and conditions now! Talk to our Chatbot to narrow down your search.

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Possible Causes

Amegakaryocytic Thrombocytopenia

[…] as a severe thrombocytopenia at birth due to ineffective megakaryocytopoiesis and no characteristic physical anomalies. [ncbi.nlm.nih.gov]

In the last 10 years, we collected data from 20 patients diagnosed with CAMT based on a severe thrombocytopenia since birth and absent or markedly decreased numbers of megakaryocytes [ncbi.nlm.nih.gov]

Although both are characterized by severe ( 50,000/microL) thrombocytopenia at birth, the molecular mechanisms underlying these disorders and their clinical presentations [ncbi.nlm.nih.gov]

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Thrombocytopenia

Four (8%) infants had severe thrombocytopenia (counts 50,000/μL) at birth. [emedicine.medscape.com]

The isolated thrombocytopenia is severe, with the platelet count being below 20 10 9 /L. [haematologica.org]

Three variables had predictive correlations: (1) gestational age at birth (shorter gestation was associated with higher likelihood of severe, persistent thrombocytopenia); [pediatrics.aappublications.org]

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Toxoplasmosis

[…] delay, thrombocytopenia and anaemia. [patient.info]

May have no apparent symptoms at birth, with complications developing only later in life. [patient.info]

Neonatal features of infection vary and include hydrocephalus, microcephaly, intracranial calcifications, chorioretinitis, strabismus, severe sight impairment, epilepsy, developmental [patient.info]

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Fetal and Neonatal Alloimmune Thrombocytopenia

It occurs in approximately 1 in 1000 live births and is the most common cause of severe thrombocytopenia in fetuses and term neonates. [ncbi.nlm.nih.gov]

Outcome was neonatal platelet (PLT) count at birth and amount of severe thrombocytopenia. Furthermore the appearance of ICH was analyzed. [ncbi.nlm.nih.gov]

CONCLUSIONS: All neonates with thrombocytopenia at birth should be evaluated for FNAIT. [ncbi.nlm.nih.gov]

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Growth Failure

One patient died at the age of 6 months following severe infections from birth and therefore developmental data is not available (F10). [ncbi.nlm.nih.gov]

Marked Thrombocytopenia with Milder Leukopenia Occurs Frequently in Early to Mid-Childhood Nine patients ( 80%) have had documented cytopenia requiring platelet transfusions [ncbi.nlm.nih.gov]

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Abruptio Placentae

Women who had thrombocytopenia (platelet count, The risk factors for preeclampsia were derived from data obtained before randomization. [nejm.org]

Neonatal outcome data included gestational age, preterm birth ( 10 ), admission to a neonatal intensive care unit, and neonatal complications. [nejm.org]

110 mm Hg no more than one week before delivery if the woman had been treated with an antihypertensive drug), plus one of the following: increasing proteinuria, persistent severe [nejm.org]

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Cholestasis

After birth at 33 0 weeks the newborn presented only transfused RBCs and suffered from anemia, thrombocytopenia, leukopenia, and a cholestatic liver disease. [ncbi.nlm.nih.gov]

The fetus developed fetal anemia and a severe hydrops requiring three intrauterine red blood cell (RBC) transfusions. [ncbi.nlm.nih.gov]

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Infantile Hepatic Hemangioendothelioma

It is clinically evident within the first six months after birth and can be life threatening because of heart failure, intraperitoneal hemorrhage or thrombocytopenia. [ncbi.nlm.nih.gov]

In less severe forms spontaneous regression has been described. [ncbi.nlm.nih.gov]

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Bone Lymphoma

Severe combined immunodeficiency (SCID, all types)—SCID is a group of inherited immune system disorders that are present at birth. [bethematch.org]

Fanconi anemia Paroxysmal nocturnal hemoglobinuria (PNH) Pure red cell aplasia Amegakaryocytosis/congenital thrombocytopenia Inherited immune system disorders, including: [bethematch.org]

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Purpura

[…] of neonatal thrombocytopenia is often most marked 1 to 3 days after birth. [ashpublications.org]

[…] severe thrombocytopenia (platelet counts 20 000 109/L), but importantly few have platelet counts that are less than 5000 109/L unless alloantibodies are also present.87 The severity [ashpublications.org]

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Thrombocytopenia Due to Sequestration

The thrombocytopenia improves over time], Congenital amegakaryocytic thrombocytopenia (CAMT) [CAMT severe thrombocytopenia presenting at birth or shortly thereafter with no [learn.pediatrics.ubc.ca]

Four (8%) infants had severe thrombocytopenia (counts 50,000/μL) at birth. [emedicine.medscape.com]

Severe Thrombocytopenia in the neonates ( 120. CAMT Course : Severe CAMT is recognized during the first few days of birth due to easy bleeding/bruising. [slideshare.net]

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Kasabach Merritt Syndrome

Hemogram revealed anemia severe thrombocytopenia, prolongation of bleeding, clotting time and increased fibrin degradable products, suggestive of KMS. [e-ijd.org]

KMS is characterized by giant hemangiomas and severe thrombocytopenia, which may result in life-threatening multi-organ hemorrhage. [bmcpediatr.biomedcentral.com]

A 14-month old female child was brought with a reddish lesion on the left scapular area noticed at birth, which suddenly increased in size since 3 days. [e-ijd.org]

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Exchange Transfusion

The baby later on developed renal failure and blood picture was suggestive of severe thrombocytopenia and microangiopathic haemolytic anaemia. [springerplus.springeropen.com]

Case description A term vaginally born baby, meconium stained and floppy at birth presented with severe anaemia in the first few hours of life. [springerplus.springeropen.com]

No extra renal manifestations of birth asphyxia were noted. [springerplus.springeropen.com]

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Cor Triloculare Biventriculare

Tran Dinh Nguyen - - 2011 Rubella virus (RV) infection during the first trimester of pregnancy often leads to severe birth defects known as congenital rubella syndrome (CRS [biomedsearch.com]

A premature newborn male was clinically diagnosed as CRS with cataracts, congenital heart defects, microcephaly, hepatosplenomegaly, and thrombocytopenia. [biomedsearch.com]

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Autoimmune Thrombocytopenia

In future pregnancies, the thrombocytopenia can be more severe and ICH can occur prior to birth (while in the uterus). Why Does This Occur? [verywell.com]

INCIDENCE At birth Thrombocytopenia is present in 1–5% of newborns at birth, 7– 9 and severe thrombocytopenia (platelets 50 10 9 /l) occurs in 0.1–0.5%. 9– 13 In NICU patients [fn.bmj.com]

If NAIT is suspected, it if very important to confirm the diagnosis as future pregnancies can be more severely affected with more severe thrombocytopenia and intracranial [verywell.com]

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Chronic Immune Thrombocytopenic Purpura

[…] vaginal birth. [medical-dictionary.thefreedictionary.com]

[…] of neonatal thrombocytopenia is often most marked 1 to 3 days after birth. [ashpublications.org]

ITP can also occur during pregnancy, and 5% to 20% of the neonates born to these mothers will have severe thrombocytopenia and are at risk of intracranial hemorrhage during [medical-dictionary.thefreedictionary.com]

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Maternal Infection

The effect on the fetus is more severe from a primary infection. Effects on the fetus or neonate include: Intrauterine growth restriction and low birth weight. [patient.info]

Thrombocytopenia. Anaemia. Hydrops and ascites. Petechiae and/or purpura. Microcephaly. Intracranial calcifications. Choroidoretinitis. Deafness. Speech defects. [patient.info]

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Immune Thrombocytopenic Purpura

The frequency of moderate or severe neonatal thrombocytopenia at birth documented in this study is similar to that in our previous analysis of the literature. [doi.org]

[…] vaginal birth. [medical-dictionary.thefreedictionary.com]

[…] of neonatal thrombocytopenia is often most marked 1 to 3 days after birth. [doi.org]

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Cytomegalovirus Infection

The neutropenia resolved spontaneously, and only thrombocytopenia was persistent at birth. [ncbi.nlm.nih.gov]

The principal clinical manifestations of severe congenital CMV infection include hepatosplenomegaly, thrombocytopenia with resultant petechiae, intracranial calcifications [perinatology.com]

Infants born with a severe form of the disease typically have a low birth weight and develop a fever, hepatitis with jaundice, and hemorrhagic manifestations such as purpura [rarediseases.org]

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Autosomal Recessive Deafness 22

TAR syndrome includes shortened or absent forearms due to defects in development of the bilateral radii, associated with severe thrombocytopenia at birth. [bloodjournal.org]

Usually, the degree of thrombocytopenia is greatest at the time of birth, and platelet transfusions are frequently required. [bloodjournal.org]

However, thrombocytopenia becomes less severe during the first year of life, and most affected individuals with TAR will not require platelet transfusions after infancy. 44 [bloodjournal.org]

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Familial Pterygium of the Conjunctiva

– Easy Bruising: Ecchymoses - Petechiae No congenital malformations Normal Radii• No congenital malformations – Normal Radii Laboratory Severe thrombocytopenia Mean Plts [de.slideshare.net]

Clinical and Laboratory Features Presentation • At birth or during first month of life Signs and symptoms: y • Signs and symptoms: – Intracranial Hemorrhage in-utero or after birth [de.slideshare.net]

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Cytomegalovirus

The principal clinical manifestations of severe congenital CMV infection include hepatosplenomegaly, thrombocytopenia with resultant petechiae, intracranial calcifications [perinatology.com]

Symptomatic newborns present with a variety of abnormalities including low birth weight, microcephaly, seizure, chorioretinitis hepatomegaly, hepatitis, jaundice, thrombocytopenia [pedclerk.bsd.uchicago.edu]

Infants born with a severe form of the disease typically have a low birth weight and develop a fever, hepatitis with jaundice, and hemorrhagic manifestations such as purpura [rarediseases.org]

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Congenital Aplastic Anemia

[…] with absent radii) Cause is mRNA processing Genetics is deletion in chromosome 1 Hematological problem – severe thrombocytopenia at birth often with megakaryocytes Congenital [pediatriceducation.org]

[…] abnormalities – bilateral absent radii, facial, cardiac and genitorurinary defects, short stature Increased risk of malignancy – leukemias Severe congenital neutropenias [pediatriceducation.org]

[…] next 3-5 years of aplastic anemia Congenital abnormalities – does not have them Early death is common Other bone marrow failures syndromes that have similar features TAR (thrombocytopenia [pediatriceducation.org]

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Retinal Hemorrhage

Non-accidental trauma Accidental trauma Birth trauma Coagulopathy DIC, Thrombocytopenia, Von Willebrand, Vitamin K deficiency. [webeye.ophth.uiowa.edu]

However, extensive bilateral retinal hemorrhages involving multiple layers of the retina, and extending into the far periphery are rarely seen in other conditions, even severe [webeye.ophth.uiowa.edu]

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Fetal Erythroblastosis

Management of severe alloimmune thrombocytopenia in the newborn. Arch Dis Child Fetal Neonatal Ed 2000 ; 82 : F173 –5. Ohlsson A, Lacy JB. [doi.org]

Intravenous immunoglobulin for preventing infection in preterm and/or low-birth-weight infants. (Cochrane Review). [doi.org]

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Thrombocytopenia-Absent Radius Syndrome

The aim of this report was to describe the phenotypic characterization of several patients with thrombocytopenia-absent radius (TAR) syndrome and the orthopaedic interventions [ncbi.nlm.nih.gov]

Of the 4 million birth annually occurring in United States, about 36,000 can be expected to have congenital thrombocytopenia and 11,000 of these can be expected to have severe [pediatriconcall.com]

OBJECTIVE: Developmental abnormalities of the appendicular skeleton are among the most common and easily identified birth defects. [ncbi.nlm.nih.gov]

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Leukemoid Reaction

We present a case of a preterm infant with severe myeloid leukemoid reaction (leukocyte count 100,000/mm) at birth who was diagnosed with congenital CMV infection on the basis [ncbi.nlm.nih.gov]

Cytomegalovirus (CMV) infection causes a multisystem disease, and symptomatic infants generally present with intrauterine growth restriction, hepatosplenomegaly, cholestasis, rash, thrombocytopenia [ncbi.nlm.nih.gov]

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Dursun Syndrome

Intermittent thrombocytopenia is seen frequently but usually does not cause symptoms. [ncbi.nlm.nih.gov]

Persistent severe neutropenia is present in all affected individuals and is the core phenotype of the condition. [ncbi.nlm.nih.gov]

The first serious infection can occur at any age, ranging from immediately after birth to adulthood. Hematologic. [ncbi.nlm.nih.gov]

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Disseminated Cytomegalovirus Infection

In such cases, thrombocytopenia is also present in 75% at birth. Chorioretinitis occurs in approximately 10-20% of infants with symptomatic congenital CMV. [antimicrobe.org]

[…] manifestations including petechiae, jaundice hepatosplenomegaly, microcephaly and hearing loss are termed to have cytomegalic inclusion disease and are at greatest risk for having severe [antimicrobe.org]

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Cytomegalovirus Esophagitis

In such cases, thrombocytopenia is also present in 75% at birth. Chorioretinitis occurs in approximately 10-20% of infants with symptomatic congenital CMV. [antimicrobe.org]

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