Shagreen Patch: Causes & Reasons

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Possible Causes for Shagreen Patch

Tuberous Sclerosis

patches; and 14 lesions (12%), large shagreen patches. [ncbi.nlm.nih.gov]

Only 1 of 5 patients treated for shagreen patches showed improvement at 12 months. Treatment was well tolerated with no serious adverse events. [ncbi.nlm.nih.gov]

patch Flesh coloured orange-peel connective tissue naevi of varying sizes, usually on the lower back Shagreen patches Shagreen patch in tuberous sclerosis Shagreen patch [dermnetnz.org]

Lymphangioleiomyomatosis

Besides facial angiofibromas and shagreen patches over the back, no other physical signs such as those referable to the respiratory system were noted. [nature.com]

patch Forehead plaque Retinal hamartoma Laboratory Findings Pulmonary function tests are used to assess the lung damage caused by lymphangiomyomatosis. [wikidoc.org]

Finally, signs consistent with TSC, such as facial angiofibromas, periungual fibromas, nail ridging and the shagreen patch, are seen in patients with TSC-LAM. [err.ersjournals.com]

Subungual Fibroma

SHAGREEN PATCH- Leathery plaques of subepidermal fibrosis,usually situated on the trunk. 13. SHAGREEN PATCH. 14. [slideshare.net]

Other lesions which may be present (usually on the trunk) are shagreen patches (these are localized thickening of the skin with a rough surface) and ash-leaf patches (hypopigmented [mrcophth.com]

Shagreen Patch The shagreen patch is an area of thickened, elevated pebbly skin (like an orange peel) usually found on the lower back. It can be single or multiple. [tsalliance.org]

Renal Fibroma

Shagreen patch was seen in the right lumbosacral region ( Fig. 1 b). [revistanefrologia.com]

Shagreen patch (connective tissue naevus). Cortical tuber. Subependymal nodule (SEN). Subependymal giant cell astrocytoma (SEGA). [patient.info]

patch Cerebral white matter migration lines Multiple retinal nodular hamartomas Gingival fibromas Cortical tuber Non-renal hamartoma Subependymal nodule Retinal achromatic [academic.oup.com]

Rhabdomyoma of the Myocardium

A shagreen patch was present in the right lower lumbar region. Patient was put on valproate. Patient became conscious and oriented over a span of 1 h. [mjdrdypu.org]

Clinical manifestations of tuberous sclerosis include skin lesions (depigmented marks, adenoma sebaceum, shagreen patches), cerebral abnormalities (periventricular calcifications [jcnonweb.com]

Finally, about the other lesions of TSC, we found hypomelanotic macules in all, facial angiofibroma in 45,1% and shagreen patches in only 19,3%. [bmccardiovascdisord.biomedcentral.com]

Zosteriform Lentiginosis

Patch,) Carney Complex (48 %) ( Lamb Syndrome, Name Syndrome,) Seborrheic Keratosis (48 %) ( Seborrheic Verruca, Senile Wart,) Grovers Disease (45 %) ( Benign Papular Acantholytic [gulfdoctor.net]

patch skin colored indurated plaque (collagenoma) usually on lumbosacral area; tuberous sclerosis shin spots macules or papules on anterior legs; diabetes, normal persons [dermadvocate.net]

Bathing Trunk Nevus, Congenital Nevomelanocytic Nevus, Garment Nevus, Giant Hairy Nevus, Nevus Pigmentosus Et Pilosus,) Connective Tissue Nevus (48 %) ( Collagenoma, Elastoma, Shagreen [gulfdoctor.net]

Dyschromatosis Universalis Hereditaria Type 1

Shagreen patch (connective tissue nevus) 5. Multiple retinal nodular hamartomas 6. Cortical tuber 7. Subependymal nodule 8. Subependymal giant cell astrocytoma 9. [ijdvl.com]

She also had multiple angiofibromas on the face [Figure - 2], numerous oval, hypopigmented macules all over the trunk, confetti skin lesions, a shagreen patch over the right [ijdvl.com]

Hamartoma of the Central Nervous System

patches -Minimal to no risk of malignant transformation of skin lesions -Skin lesions tend to increase in size and number through puberty, and then tend to stabalize over [pedclerk.bsd.uchicago.edu]

Major features are cortical tubers, subependymal nodules, subependymal giant cell astrocytomas (SEGA), hypomelanotic skin macules, shagreen patches, retinal nodular hamartomas [neuropathology-web.org]

Salient dermatologic findings of TSC are hypopigmented macules (ash-leaf spots), shagreen patches, periungual fibromas, and adenoma sebaceum. [emedicine.medscape.com]

Hereditary Mucoepithelial Dysplasia

Shagreen patches can be seen in patients with: a. Multiple Hamartoma syndrome b. Hereditary hemorrhagic telangictasia c. Tuberous sclerosis * d. [fac.ksu.edu.sa]

/periungual fibromas, shagreen patches, ash-leaf spots, CNS findings (seizures, mental retardation), cardiac rhabdomyomas, and angiomyolipoma CNS findings associated with [studystack.com]

• Two other characteristic skin lesions are • connective tissue hamartomas –shagreen patches • ovoid areas of hypopigmentation -ashleaf spots. [slideshare.net]

Tuberous Sclerosis Type 2

Diagnostic methods Diagnosis is based on presence of major (cortical dysplasias; subependymal nodules; SEGA; hypomelanotic macules (≥3, diameter ≥5 mm); shagreen patch; angiofibromas [orpha.net]

Detailed examination of the skin and mucosa revealed Shagreen patches, nontraumatic subungual and gingival fibroma, all features of tuberous sclerosis complex. [content.sciendo.com]

patch — Multiple retinal hamartomas — Cortical dysplasias† — Subependymal nodules — Subependymal giant cell astrocytoma — Cardiac rhabdomyoma — Lymphangioleiomyomatosis‡ [merckmanuals.com]

Tuberous Sclerosis Type 1

Other tuberous sclerosis complex symptoms and signs Areas of Thick Leathery Skin (Shagreen Patches) Autism Benign Tumors Developmental Delays Learning Disabilities Raised, [medicinenet.com]

Detailed examination of the skin and mucosa revealed Shagreen patches, nontraumatic subungual and gingival fibroma, all features of tuberous sclerosis complex. [content.sciendo.com]

Sequeiros Sack Syndrome

Symptoms * Absent fingernails * Small fingernails * Thin skin * Sparse scalp hair * Shagreen patch * Premature birth * Lipoatrophy * Reduced sweating Diagnosis The signs and [checkorphan.org]

Bird-Headed Dwarfism Type Montreal

patch 59 32 hallmark (90%) Very frequent (99-80%) HP:0009721 26 congenital pyloric atresia 59 32 hallmark (90%) Very frequent (99-80%) HP:0004399 27 retrognathia 32 HP:0000278 [malacards.org]

patch 0009721 Vertebral segmentation defect 0003422 Wide intermamillary distance Wide-spaced nipples Widely spaced nipples Widely-spaced nipples [ more ] 0006610 Percent [rarediseases.info.nih.gov]

0003510 23 vertebral segmentation defect 59 32 hallmark (90%) Very frequent (99-80%) HP:0003422 24 convex nasal ridge 59 32 hallmark (90%) Very frequent (99-80%) HP:0000444 25 shagreen [malacards.org]

Enamel Hypoplasia - Cataracts - Aqueductal Stenosis

Major Features: Facial angiofibromas or forehead plaque Ungual or periungual fibroma Hypomelanotic macules >3 Shagreen patch Multiple retinal nodular hamartomas Cortical tuber [sites.google.com]

Cutaneous Features The cutaneous lesions of TSC include hypomelanotic macules, the shagreen patch, ungual fibromas, and facial angiofibromas. [clinicalgate.com]

A Shagreen patch is an isolated raised plaque in the skin over the lower back or buttocks that is seen in 50% of affected children by adolescence. 2 Ungual fibromas, small [healio.com]

Progeroid Syndrome Type Petty

patch * Reduced fat under skin Causes - Progeroid syndrome Petty type * Hypothyroidism –Primary congenital hypothyroidism occurs in 1/4,000 live births, more in females [checkorphan.org]

patch 0009721 Short distal phalanx of finger Short outermost finger bone 0009882 Short stature Decreased body height Small stature [ more ] 0004322 Sparse hair 0008070 Strabismus [rarediseases.info.nih.gov]

patch Long eyelashes in irregular rows Pain Brachydactyly Fever Behavioral abnormality Vomiting Constipation Small foramen magnum Need help with a diagnosis? [mendelian.co]

Fibular Dimelia-Diplopodia Syndrome

patch Skin hypoplasia/aplasia/atrophy Skin photosensitivity Skin tumours/lumps/epidermal cysts Adenoma sebaceum Cutaneous neurofibromas/facial angiofibromas/Koenen tumors [readbag.com]

[…] www.orphanet.net/ 15 of 39 Thesaurus of Clinical Signs and Symptoms Anomalies of skin, subcutanoeus tissue and mucosae (continued) Seborrhea/hyperseborrhea/seborrheic dermatitis Shagreen [readbag.com]

Subependymal Giant Cell Astrocytoma

Skin manifestations like shagreen patches were present in two, facial angiofibromas in three, periungal fibromas in two, hypopigmented macules in two and ash-leaf spot in [ncbi.nlm.nih.gov]

(J Child Neurol 1999;14:401) Major features Facial angiofibromas or forehead plaque Nontraumatic ungual or periungual fibroma Hypomelanotic macules (more than 3) Shagreen [pathologyoutlines.com]

patch(subepidermal fibrosis) The most common skin lesions are hypomelanotic macules, which are ovoid depigmented areas with irregular margins that are best visualized by [slideshare.net]

Akesson Syndrome

Åkesson syndrome - X-linked recessive condition featuring cutis verticis gyrata, shagreen patch, hypoplastic thyroid disease, mental retardation, skull abnormality, and short [medical-dictionary.thefreedictionary.com]

patch Weak eye muscles Causes - Akesson syndrome Not supplied. [checkorphan.org]

[…] retardation Excessive skin folds on scalp Excessive skin furrows on scalp Scoliosis Short stature Seizures Restricted joint mobility Small head Increased muscle tone Spasticity Shagreen [checkorphan.org]

Benign Cephalic Histiocytosis

Patch,) Differentials from Google. [gulfdoctor.net]

( Infantile Papular Acrodermatitis, Papular Acrodermatitis Of Childhood, Papulovesicular Acrolocated Syndrome,) Connective Tissue Nevus (57 %) ( Collagenoma, Elastoma, Shagreen [gulfdoctor.net]

Deafness - Opticoacoustic Nerve Atrophy - Dementia Syndrome

[…] signs/sxsloss of pain/temp in upper extremeties (spinothalamis) motor loss in hands (anterior horn cells) Tuberous sclerosisAD mental retardations hamartomas of CNS/kidney shagreen [memorize.com]

patches skin Tuberous sclerosis angiomyolipomas kidneys; rhabdomyoma of heart Neurofibromatosis AD; pigmented neurofibromas; cafe au lait spots Associations pheochromocytoma [studystack.com]

patches on skin - "ash-leaf" hypopigmented lesions angiomyolipomas of kidneys rhabdomyoma of heart NeurofibromatosisAD pigmented neurofibromas cafe au lait spots Neurofibromatosis [memorize.com]

Northern Epilepsy

Shagreen patches are plaques with an irregular surface, typically located in the lumbosacral area. [clinicaladvisor.com]

Clinically the condition is recognised by the typical cutaneous lesions—hypopigmented macules (fig 1), flat forehead fibromata, adenoma sebaceum, shagreen patches, and sub-ungual [jnnp.bmj.com]

patches, cephalic plaques, ungual fibromas); brain (cortical dysplasias, sub-ependymal nodules and sub-ependymal giant cell astrocytomas [SEGAs], seizures, intellectual disability [aetna.com]

Isolated Congenital Breast Hypoplasia or Aplasia

The shagreen patch is a collagenoma, the dermis being replaced by broad bundles of fibrous tissue with diminished or absent elastica ( Figs 21.24, 21.25 ). [basicmedicalkey.com]

[…] may also affect the hair (poliosis), eyebrows, eyelashes, and occasionally the iris. 5, 6, 8, 11, 12, 15 Frequently seen is the shagreen patch – peau de chagrin (skin like [basicmedicalkey.com]

11 These macular lesions are said to be present in 70% of patients with tuberous sclerosis. 2 They are evident at birth or develop in the neonatal period. 6 Hypopigmented patches [basicmedicalkey.com]

Hirschsprung Disease - Nail Hypoplasia - Dysmorphism

Facial angiofibromas, forehead plaque, periungual fibroma, hypomelanotic macules, Shagreen patches, multiple retinal hamartomas, Giant cell astrocytomas, SENs, Cortical tumors [quizlet.com]

Severe Idiopathic Pneumococcemia

patch (raised orange peel appearance) adenoma sebaceum (skin colored or pink lesion often present on face in late childhood to early adolescence) - which is a misnomer as [brainscape.com]

[…] rash on the back lasts 4-6 weeks nobody knows what causes it itchy The classic lesions are: - ash leaf macule (often present at birth, most easily seen with a wood's lamp) shagreen [brainscape.com]

Diffuse Pulmonary Lymphangiomatosis

patch Hypopigmented patch in the retina Angiofibroma in the face (more than three) Ungal and periungal fibromas Retinal hamartomas Rhabdomyoma in the heart Lymphangiomatosis [medical-dictionary.thefreedictionary.com]

皮膚：葉状白斑、 shagreen patch、血管線維腫等なし。家族歴：特記事項なし。頭部CT/MRI：所見なし。 [trc-rad.jp]

Cortical tubers Non-renal hamartoma Subependymal nodules Confetti-like skin lesions Hypomelanocytic macule Multiple renal cysts (at least 3 or more and larger than 5 mm) Shagreen [medical-dictionary.thefreedictionary.com]

Congenital Smooth Muscle Hamartoma

Shagreen patch is commonly associated with tuberous sclerosis. [dermnetnz.org]

Connective tissue nevi of the collagen type may appear as the shagreen patch of tuberous sclerosis, and patients found to have collagen-type connective tissue nevi should [the-medical-dictionary.com]

Collagenomas Collagenomas include: Familial cutaneous collagenoma (FCC) Isolated collagenomas Shagreen patch (associated with tuberous sclerosis ) Connective tissuse naevi [dermnetnz.org]

Cerebellar Vermis Aplasia with Associated Features Suggesting Smith-Lemli-Opitz Syndrome and Meckel Syndrome

Extrarenal manifestations of TS include mental retardation, epilepsy, facial angiofibromas, dermatologic findings (shagreen patch, hypomelanotic macules), retinal hamartoma [hawaii.edu]

Shagreen patches are present in about half of people with TSC, appearing in childhood. [6] They are areas of thick leathery skin that are dimpled like an orange peel, and [en.wikipedia.org]

Retinal involvement, occurring in 50% of “Shagreen patches” (lower back) 30 ≥10 cases, is almost always asymptomatic. [slideshare.net]

Sacrococcygeal Dysgenesis Association

الصفحة 376 - Major features Facial angiofibromas or forehead plaque Nontraumatic ungual or periungual fibroma Hypomelanotic macules (three or more) Shagreen patch (connective [books.google.com]

Hereditary Neurocutaneous Angioma

Cutaneous Features The cutaneous lesions of TSC include hypomelanotic macules, the shagreen patch, ungual fibromas, and facial angiofibromas. [neupsykey.com]

Shagreen or sharkskin patches are dermal fibromas which usually develop after 10 years of age. They occur mostly in the lumbosacral region. [thamburaj.com]

The shagreen patch most often is found on the back or flank area; it is an irregularly shaped, slightly raised, or textured skin lesion (see Fig. 65.2, B ). [neupsykey.com]

Helsmoortel-van der Aa Syndrome

Cutaneous manifestations are facial angiofibromas (adenoma sebaceum), Shagreen patches, hypopigmented macules, ash leaf spots, café-au-lait spots, facial hypoplasia and periungual [japi.org]

Shagreen patches, a form of collagenoma, may be seen in the lumbosacral region in half of patients. [omicsonline.org]

Fibrous plaques on the forehead or in hairy skin may be regarded as a variant of the shagreen patch. [omicsonline.org]