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276 Possible Causes for Shortened Upper Limbs

  • Thalidomide

    The mum-of-two, from East Sussex says: “I have shortened upper limbs which are slightly less than half the length they would have been had my mother not been prescribed thalidomide[]

  • Diastrophic Dysplasia

    Prominent among these characteristics were rhizomelia of the lower and upper limbs (shortening of the proximal portions) and mesomelia (shortening of the intermediate portions[] Here we describe two Brazilian sisters, born to healthy and non consanguineous parents, with Robin sequence, mild shortening of upper and lower limbs, brachymetacarpalia/tarsalia[] Both upper limbs showed marked curvature, with the first finger of the upper limbs in abduction and clinodactyly of the fifth finger.[]

  • Ellis-Van Creveld Syndrome

    […] thorax, scoliosis, rhizomelic shortening of the upper limbs, brachydactyly, postaxial polydactyly and clinodactyly of the second and third fingers.[] Acromelic shortening of upper and lower limbs, genu valgum, multiple frenula, deformed teeth, short ribs and narrow thorax and congenital heart diseases complete the picture[] The lower limbs showed rhizomelic shortening with significant genu valgum (knock-knee deformity), small feet with postaxial polydactyly, syndactyly between the second and[]

  • Split Hand-Split Foot Malformation

    On two-dimensional (2D) imaging, she was noted to have a fetus with a shortened right upper limb and a malformed right hand with no clearly visualized digits.[]

  • Cornelia De Lange Syndrome

    The upper limbs often manifest asymmetric involvement.[] Interestingly, the upper limbs are typically much more involved than the lower extremities that generally manifest with small feet and 2-3 syndactyly of the toes and shortened[]

  • Coats Plus Syndrome

    Individuals with Peters plus syndrome also have shortened upper limbs (rhizomelia) and shortened fingers and toes (brachydactyly).[]

  • Leri-Weill Dyschondrosteosis

    […] of the upper and lower limbs and Madelung deformity of the wrists.[] […] homeobox-containing (SHOX) gene cause Leri-Weill Dyschondrosteosis (LWD), which is a dominantly inherited osteochondroplasia characterized by short stature with mesomelic shortening[]

  • Costello Syndrome

    Proximal upper limb shortening, a small bell-shaped chest, talipes, and fixed flexion deformities of the wrists were seen.[]

  • Peters Anomaly

    Individuals with Peters Plus Syndrome also have shortened upper limbs (rhizomelia) and shortened fingers and toes (brachydactyly).[] Individuals with Peters plus syndrome also have shortened upper limbs (rhizomelia) and shortened fingers and toes (brachydactyly).[] There was no brachydactyly or rhizomelic limb shortening [Figure 5] .[]

  • Melorheostosis

    Examination revealed generalised hypoplasia of the right upper limb with shortening of the limb and atrophy of the muscles, also hypoplasia and contracture of the thumb was[] It is often associated with joint contractures (permanent shortening of a muscle or tendon) affecting the upper or lower limbs.[] S.K. is a 14 year old male student who presented to the hospital with an 18 month history of persistent pain in the joints of the right upper limb and a limb length discrepancy[]

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