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2,685 Possible Causes for Sickle Cell Disease

  • Iron Deficiency

    When a specific gene is damaged, for example, an abnormal protein or lack of protein can cause disease such as hemophilia or sickle cell disease.[hopkinsmedicine.org] Sickle cell anemia Causes: Inherited disease that is most common among African-Americans; red blood cells become sickle-shaped Factors: Hemoglobin doesn't work right; the[my.clevelandclinic.org] Hemolytic anemia Causes: Inherited or acquired diseases that cause the red blood cells to be deformed; harmful substances; reaction to certain drugs Factors: Body breaks down[my.clevelandclinic.org]

  • Influenza

    […] coronary artery disease) Blood disorders (such as sickle cell disease) Endocrine disorders (such as diabetes mellitus) Kidney disorders Liver disorders Metabolic disorders[web.archive.org] ) Blood disorders (such as sickle cell disease) Endocrine disorders (such as diabetes ) Kidney disorders Liver disorders Metabolic disorders (such as inherited metabolic disorders[cdc.gov] (including asthma) Heart conditions (except high blood pressure) Kidney, liver, nerve, and muscle conditions Blood disorders (including sickle cell disease) Diabetes A weakened[nlm.nih.gov]

  • Anemia

    Sickle cell disease is common in regions of Africa, India, Saudi Arabia, and the Mediterranean basin.[emedicine.com] The thalassemias are the most common genetic blood diseases and are found in Southeast Asia and in areas where sickle cell disease is common.[emedicine.com] Although geographic diseases, such as sickle cell anemia, thalassemia, malaria, hookworm, and chronic infections, are responsible for a portion of the increase, nutritional[emedicine.com]

  • Pulmonary Embolism

    Sickle cell disease often creates a diagnostic difficulty with regard to pulmonary embolism. A chest infection is often the presenting symptom.[emedicine.medscape.com] Signs of other organ involvement in patients with sickle cell disease would be elicited, such as sequestration crisis, priapism, anemia, and stroke.[emedicine.medscape.com] Causes and outcomes of the acute chest syndrome in sickle cell disease. National Acute Chest Syndrome Study Group. N Engl J Med. 2000 Jun 22. 342(25):1855-65. [Medline].[emedicine.medscape.com]

  • Bone Necrosis

    BACKGROUND: Avascular necrosis of bone is a frequent and severe complication of sickle cell disease and its treatment is not standardised.[ncbi.nlm.nih.gov] Treatments for people with sickle cell disease in whom poor blood supply to an area of bone leads to bone death Many people with sickle cell disease experience bone death[doi.org] The following are possible causes: Using oral or intravenous steroids Excessive alcohol use Sickle cell disease Dislocation or fractures around a joint Clotting disorders[nlm.nih.gov]

  • Hepatitis

    […] functional asplenia (including sickle cell disease): 12–59 months Unvaccinated or only 1 dose before 12 months: 2 doses, 8 weeks apart 2 or more doses before 12 months: 1[cdc.gov] Special situations Anatomic or functional asplenia (including sickle cell disease), persistent complement component deficiency, eculizumab use: Bexsero: 2-dose series at least[cdc.gov] cell disease), HIV infection, persistent complement component deficiency, eculizumab use: Menveo Dose 1 at age 8 weeks: 4-dose series at 2, 4, 6, 12 months Dose 1 at age[cdc.gov]

  • Hypoxia

    Abstract Polymerization and adhesion, dynamic processes that are hallmarks of sickle cell disease (SCD), have thus far been studied in vitro only separately.[ncbi.nlm.nih.gov] Finally, the nonspecific term sickle cell chronic lung disease has been used to describe patients with lung disease associated with SCD.[bloodjournal.org] ., sickle cell disease, iron deficiency anemia, and methemoglobinemia), or otherwise.[doi.org]

  • Cholelithiasis

    We describe a case of a toddler with sickle cell disease initially presenting with abdominal pain who was found to have symptomatic cholelithiasis.[ncbi.nlm.nih.gov] Abstract Medical and surgical advances have improved the treatment of cholelithiasis (ie, gallstones) in children with sickle cell disease (SCD).[ncbi.nlm.nih.gov] KEYWORDS: acute chest syndrome; cholelithiasis; hydroxyurea; reticulocytes; sickle cell disease children; vaso-occlusive crisis[ncbi.nlm.nih.gov]

  • Hemoglobinopathy

    Treatment for certain types of hemoglobin disorders may involve supportive care, for example during a sickle cell crisis.[labtestsonline.org] Therefore, although this deformity is usually due to sickle cell disease, it is not pathognomonic.[ncbi.nlm.nih.gov] cell disease.[ncbi.nlm.nih.gov]

  • Pulmonary Hypertension

    Some diseases and conditions also can cause group 1 PAH. Examples include HIV infection, congenital heart disease, and sickle cell disease.[web.archive.org] […] connective tissue disease and sickle cell disease, as well as specific medical treatment of pulmonary hypertension and its associated complications.[hopkinsmedicine.org] cell disease, H IV, and chronic obstructive lung disease.[hopkinsmedicine.org]

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