Single Transverse Palmar Crease: Causes & Reasons

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Possible Causes for Single Transverse Palmar Crease

Patau Syndrome

A single transverse palmar crease, polydactyly, and hyperconvex narrow fingernails are also common. [merckmanuals.com]

Postaxial Oligodactyly, Tetramelic

transverse palmar crease Symptoms // Phenotype % cases Autosomal recessive inheritance Uncommon - Between 30% and 50% cases Bilateral single transverse palmar creases Uncommon [mendelian.co]

transverse palmar crease 32 HP:0000954 9 radial bowing 32 HP:0002986 10 postaxial oligodactyly 32 HP:0006210 11 partial-complete absence of 5th phalanges 32 HP:0006209 12 [malacards.org]

transverse palmar crease Radial deviation of finger Broad hallux Cleft upper lip Gastrointestinal dysmotility Postnatal macrocephaly Microtia, first degree Branchial fistula [mendelian.co]

Stuve-Wiedemann Syndrome

Clinical characteristics of SWS include bowing of the long bones (bent-bone dysplasia), hypertelorism, micrognathia, single transverse palmar crease, trismus, camptodactyly [ai-online.info]

transverse palmar crease 0000954 Square face Square facial shape 0000321 Talipes 0001883 Talipes valgus 0004684 Thin ribs Slender ribs 0000883 Thin skin 0000963 Tibial bowing [rarediseases.info.nih.gov]

[…] palpebral fissure Short opening between the eyelids 0012745 Short phalanx of finger Short finger bones 0009803 Short tibia Short shinbone Short skankbone [ more ] 0005736 Single [rarediseases.info.nih.gov]

Aarskog-Scott Syndrome

transverse palmar crease 0000954 Strabismus Cross-eyed Squint Squint eyes [ more ] 0000486 Talipes 0001883 1%-4% of people have these symptoms Broad philtrum 0000289 Global [rarediseases.info.nih.gov]

Sporadic Symptoms Round face and a shorter neck, epicanthic folds, maxillary hypoplasia, which causes several facial abnormalities, and single transverse palmar crease may [news-medical.net]

[…] planus Flat feet Flat foot [ more ] 0001763 Round face Circular face Round facial appearance Round facial shape [ more ] 0000311 Short neck Decreased length of neck 0000470 Single [rarediseases.info.nih.gov]

Kaufman Oculocerebrofacial Syndrome

transverse palmar crease 0000954 Sparse and thin eyebrow Thin, sparse eyebrows 0000535 Ventricular septal defect Hole in heart wall separating two lower heart chambers 0001629 [rarediseases.info.nih.gov]

transverse palmar crease Feeding difficulties in infancy Narrow forehead Brachydactyly Hypoplasia of the corpus callosum Craniosynostosis Constipation Hypermetropia Coloboma [mendelian.co]

[…] foot turns inward 0001840 Narrow palm 0004283 Optic disc pallor 0000543 Ovoid vertebral bodies 0003300 Short nose Decreased length of nose Shortened nose [ more ] 0003196 Single [rarediseases.info.nih.gov]

Seckel Syndrome

transverse palmar crease 0000954 Sloping forehead Inclined forehead Receding forehead [ more ] 0000340 Small anterior fontanelle 0000237 Small for gestational age Birth weight [rarediseases.info.nih.gov]

[…] nasal size Increased size of nose Large nose Pronounced nose [ more ] 0000448 Proportionate short stature 0003508 Seizures Seizure 0001250 Selective tooth agenesis 0001592 Single [rarediseases.info.nih.gov]

Trisomy 21

The hands are often short and broad and often have a single transverse palmar crease. [msdmanuals.com]

transverse palmar crease, and short fifth finger with clinodactyly. [dx.doi.org]

[…] brachycephalic head, epicanthic folds, flat nasal bridge, upward slanting palpebral fissures, Brushfield spots, small mouth, small ears, excessive skin at the nape of the neck, single [dx.doi.org]

Zellweger Syndrome

transverse palmar crease 0000954 Subependymal cysts 0002416 Talipes equinovarus Club feet Club foot Clubfeet Clubfoot [ more ] 0001762 Ulnar deviation of the hand 0009487 [rarediseases.info.nih.gov]

[…] bottom foot Rocker bottom feet Rocker-bottom feet Rockerbottom feet [ more ] 0001838 Round face Circular face Round facial appearance Round facial shape [ more ] 0000311 Single [rarediseases.info.nih.gov]

Adams-Oliver Syndrome Type 2

transverse palmar crease Abnormality of prenatal development or birth Oligohydramnios Abnormality of the eye Developmental cataract Hypertelorism Microphthalmia Optic atrophy [ncbi.nlm.nih.gov]

[…] full author information Show allHide all Abnormality of head or neck Bulbous nose Depressed nasal bridge Low anterior hairline Narrow palpebral fissure Abnormality of limbs Single [ncbi.nlm.nih.gov]

Odonto Tricho Ungual Digito Palmar Syndrome

transverse palmar creases first metacarpal hypoplasia prominent interdigital folds single thumb creases Head And Neck Face: prognathism Head And Neck Mouth: thick, coarse [malacards.org]

See also Dermatoglyphics External links An example of a single transverse palmar crease [findzebra.com]

[…] trichodystrophy straw-like fragile hair irregular diameter of hair shaft with hypopigmentation and tendency to fracture (light microscopy) Skeletal Hands: brachydactyly single [malacards.org]

Simpson-Golabi-Behmel Syndrome Type 2

transverse palmar crease Tapered finger Abnormality of prenatal development or birth Thickened nuchal skin fold Abnormality of the breast Wide intermamillary distance Abnormality [ncbi.nlm.nih.gov]

Thin upper lip vermilion U-Shaped upper lip vermilion Wide mouth Wide nose Abnormality of limbs Broad palm Clinodactyly Clubfoot Radial deviation of finger Short finger Single [ncbi.nlm.nih.gov]

Spondyloepiphyseal Dysplasia with Congenital Joint Dislocations

Bilateral single transverse palmar creases MedGen UID: 354661 •Concept ID: C1862095 • Finding The distal and proximal transverse palmar creases are merged into a single transverse [ncbi.nlm.nih.gov]

palmar crease on both hands. [ncbi.nlm.nih.gov]

Langer Nishino Yamaguchi Syndrome

[…] integument Cutis marmorata Single transverse palmar crease Abnormality of the musculoskeletal system Fibular hypoplasia Hypoplasia of the radius Mesomelic arm shortening [ncbi.nlm.nih.gov]

transverse palmar creases Head And Neck Eyes: short palpebral fissures corneal opacities [malacards.org]

transverse palmar crease Ulnar bowing Abnormality of the cardiovascular system Cutis marmorata Abnormality of the eye Opacification of the corneal stroma Abnormality of the [ncbi.nlm.nih.gov]

Johanson-Blizzard Syndrome

transverse palmar crease 0000954 Situs inversus totalis All organs on wrong side of body 0001696 Small for gestational age Birth weight less than 10th percentile Low birth [rarediseases.info.nih.gov]

[…] skin dimples over anterior/posterior fontanelles 0005498 Rectovaginal fistula Abnormal connection between rectum and vagina 0000143 Septate vagina Double vagina 0001153 Single [rarediseases.info.nih.gov]

Acrofacial Dysostosis Type Rodríguez

transverse palmar crease Thin skin Triphalangeal thumb Wide anterior fontanel Wide nasal bridge Very frequently present symptoms in 80-99% of the cases: Hand oligodactyly [dovemed.com]

transverse palmar crease 0000954 Thin skin 0000963 Triphalangeal thumb Finger-like thumb 0001199 Wide anterior fontanel Wider-than-typical soft spot of skull 0000260 Wide [rarediseases.info.nih.gov]

transverse palmar creases. [obgynkey.com]

Chromosome 6q11-q14 Deletion Syndrome

transverse palmar crease Abnormality of the eye Hypertelorism Hypotelorism Abnormality of the musculoskeletal system Generalized hypotonia Hypotonia Inguinal hernia Umbilical [ncbi.nlm.nih.gov]

[…] of head or neck Broad nasal tip Epicanthal fold High palate Long philtrum Short neck Short nose Thin upper lip vermilion Upslanted palpebral fissure Abnormality of limbs Single [ncbi.nlm.nih.gov]

Kleefstra Syndrome 1

Single transverse palmar crease MedGen UID: 96108 •Concept ID: C0424731 • Finding The distal and proximal transverse palmar creases are merged into a single transverse palmar [ncbi.nlm.nih.gov]

transverse palmar crease Abnormality of the cardiovascular system Conotruncal defect Abnormality of the digestive system Gastroesophageal reflux Abnormality of the eye Hypertelorism [ncbi.nlm.nih.gov]

crease. [ncbi.nlm.nih.gov]

Ehlers-Danlos Syndrome Spondylodysplastic Type 2

She had an interrupted single transverse palmar crease. Deep tendon reflexes were sluggish. [cags.org.ae]

Other frequent features comprised facial dysmorphism, hyperextensible skin, joint hypermobility (JHM), single transverse palmar crease, severe hypermetropia, limb bowing, [ojrd.biomedcentral.com]

transverse palmar crease Bladder diverticulum Cleft soft palate Keloids Stroke Arterial rupture High-frequency sensorineural hearing impairment Kyphoscoliosis Adrenal hyperplasia [mendelian.co]

X-Linked Syndromic Mental Retardation Type Chudley-Schwartz

Single transverse palmar crease MedGen UID: 96108 • Concept ID: C0424731 • Finding A single transverse palmar crease is found in 5% of newborns and is frequently inherited [ncbi.nlm.nih.gov]

However, single palmar creases can be associated with Down's syndrome and other genetic disorders, or with fetal alcohol syndrome. [ncbi.nlm.nih.gov]

Syndromic Microphthalmia Type 6

transverse palmar crease ; Small scrotum ; Small sella turcica ; Toe syndactyly ; Uplifted earlobe ; Ventriculomegaly Associated Genes BMP4 (Withdrawn symbols: BMP2B ) Mouse [mousephenotype.org]

transverse palmar crease 0000954 Small scrotum Underdeveloped scrotum 0030276 Toe syndactyly Fused toes Webbed toes [ more ] 0001770 Uplifted earlobe Lobe, uplifted Upturned [rarediseases.info.nih.gov]

Preaxial hand polydactyly ; Protruding ear ; Renal hypoplasia ; Retinal dystrophy ; Retrognathia ; Sclerocornea ; Severe muscular hypotonia ; Short middle phalanx of finger ; Single [mousephenotype.org]

Lichtenstein Syndrome

transverse palmar crease 31 HP:0000954 15 recurrent infections 31 HP:0002719 16 increased susceptibility to fractures 31 HP:0002659 17 hirsutism 31 HP:0001007 18 decreased [malacards.org]

transverse palmar crease 0000954 Synophrys Monobrow Unibrow [ more ] 0000664 Ulnar deviation of finger Finger bends toward pinky 0009465 Showing of 23 | Last updated: 2/1 [rarediseases.info.nih.gov]

31 HP:0001761 10 neutropenia 31 HP:0001875 11 abnormality of the respiratory system 31 HP:0002086 12 ulnar deviation of finger 31 HP:0009465 13 synophrys 31 HP:0000664 14 single [malacards.org]

Coffin-Lowry Syndrome

transverse palmar crease 0000954 Sporadic No previous family history 0003745 Telecanthus Corners of eye widely separated 0000506 Thick eyebrow Bushy eyebrows Dense eyebrow [rarediseases.info.nih.gov]

Prominent lower jaw [ more ] 0000303 Mitral regurgitation 0001653 Prominent supraorbital ridges Prominent brow 0000336 Rectal prolapse Rectum protrudes through anus 0002035 Single [rarediseases.info.nih.gov]

Wolf-Hirschhorn Syndrome

transverse palmar crease, broad hands, fifth digit clinodactyly), joint hyperflexibility, redundant neck skin, pelvic dysplasia, wide gap between first and second toes (sandal [pathophys.org]

[ncbi.nlm.nih.gov] Single Transverse Palmar Crease transverse palmar crease, broad hands, fifth digit clinodactyly), joint hyperflexibility, redundant neck skin, pelvic dysplasia [symptoma.com]

[…] nose, flat nasal bridge, flat face, small dysplastic pinnae, protruding tongue Cardiac : congenital heart defects ( AVSD, VSD, Tetralogy of Fallot, ASD, PDA) MSK : hands (single [pathophys.org]

Warsaw Breakage Syndrome

transverse palmar crease Abnormality of the cardiovascular system ... ... [familydiagnosis.com]

transverse palmar crease ; Sloping forehead ; Small face ; Tetralogy of Fallot ; Ventricular septal defect ; Wide mouth Associated Genes DDX11 (Withdrawn symbols: CHL1, CHLR1 [mousephenotype.org]

(HPO) Abnormality of head or neck Epicanthus High palate Microcephaly Optic nerve coloboma Sloping forehead Small face Wide mouth Abnormality of limbs 2-3 toe syndactyly Single [familydiagnosis.com]

Miller-Dieker Syndrome

transverse palmar crease 0000954 Thick upper lip vermilion Full upper lip Increased volume of upper lip Plump upper lip Prominent upper lip Thick upper lip [ more ] 0000215 [rarediseases.info.nih.gov]

[…] head circumference Small head circumference [ more ] 0000252 Micrognathia Little lower jaw Small jaw Small lower jaw [ more ] 0000347 Midline brain calcifications 0007045 Single [rarediseases.info.nih.gov]

Pallister-Killian Syndrome

transverse palmar crease 0000954 Small scrotum Underdeveloped scrotum 0030276 Somatic mosaicism 0001442 Sparse anterior scalp hair Sparse scalp hair at front of head Thin [rarediseases.info.nih.gov]

Kidney cyst 0000107 Renal dysplasia 0000110 Seizures Seizure 0001250 Short phalanx of finger Short finger bones 0009803 Short toe Short toes Stubby toes [ more ] 0001831 Single [rarediseases.info.nih.gov]

Rubinstein-Taybi Syndrome

transverse palmar crease 0000954 Spina bifida occulta 0003298 Sporadic No previous family history 0003745 Stereotypy Repetitive movements Repetitive or self-injurious behavior [rarediseases.info.nih.gov]

Self-mutilation Deliberate self-harm Self mutilation [ more ] 0000742 Shawl scrotum 0000049 Short attention span Poor attention span Problem paying attention [ more ] 0000736 Single [rarediseases.info.nih.gov]

Opitz-Kaveggia Syndrome

transverse palmar crease 0000954 Skin tags 0010609 Sparse hair 0008070 Split hand Claw hand Claw hand deformities Claw hands Claw-hand deformities Split-hand [ more ] 0001171 [rarediseases.info.nih.gov]

[…] umbilical artery, single transverse palmar creases, and hypotonia. [nature.com]

Single transverse palmar creases and short hands and fingers have been less commonly observed in affected individuals [ Risheg et al 2007 ]. [ncbi.nlm.nih.gov]

Pitt-Hopkins Syndrome

Entry H00756 Disease Name Pitt-Hopkins syndrome Subgroup Pitt-Hopkins like syndrome (PTHSL) Description Pitt-Hopkins Syndrome (PTHS) is a rare disorder of severe mental retardation. Facial dysmorphism include a beaked nose, flared nostrils, and a wide mouth with a 'cupid's-bow' shaped upper lip. A particular[…] [genome.jp]

Distal Symphalangism

(29-5%) 20 tall stature 33 HP:0000098 21 short 1st metacarpal 33 HP:0010034 22 broad foot 33 HP:0001769 23 single transverse palmar crease 33 HP:0000954 24 camptodactyly [malacards.org]

(29-5%) 20 tall stature 32 HP:0000098 21 short 1st metacarpal 32 HP:0010034 22 broad foot 32 HP:0001769 23 single transverse palmar crease 32 HP:0000954 24 camptodactyly [malacards.org]