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14 Possible Causes for Single Transverse Palmar Crease, Wide Space Between the First and Second Toe

  • Down Syndrome

    transverse palmar crease, and short fifth finger with clinodactyly.[dx.doi.org] spacing, often with a deep plantar groove between the first and second toes.[doi.org] A wide space, often with a deep fissure between the first and second toes, is also common.[dx.doi.org]

  • Ring Chromosome 10

    Their common features were mental and growth retardation, low birth weight, microcephaly, stubby nose, hypertelorism, strabismus, wide set nipples, single transverse palmar[ncbi.nlm.nih.gov] 1st and 2nd toes Gap between first and second toe Increased space between first and second toes Sandal gap between first and second toes Wide space between 1st, 2nd toes[rarediseases.info.nih.gov] The main features are low birth weight, microcephaly, stubby nose with a prominent nasal bridge, hypertelorism, strabismus, wide-set nipples, single transverse palmar creases[malacards.org]

  • Seckel Syndrome

    transverse palmar crease 0000954 Sloping forehead Inclined forehead Receding forehead [ more ] 0000340 Small anterior fontanelle 0000237 Small for gestational age Birth weight[rarediseases.info.nih.gov] 1st and 2nd toes Gap between first and second toe Increased space between first and second toes Sandal gap between first and second toes Wide space between 1st, 2nd toes[rarediseases.info.nih.gov] […] nasal size Increased size of nose Large nose Pronounced nose [ more ] 0000448 Proportionate short stature 0003508 Seizures Seizure 0001250 Selective tooth agenesis 0001592 Single[rarediseases.info.nih.gov]

  • Atelosteogenesis Type 2

    transverse palmar creases.[documents.tips] 1st and 2nd toes Gap between first and second toe Increased space between first and second toes Sandal gap between first and second toes Wide space between 1st, 2nd toes[rarediseases.info.nih.gov] “Mongoloid” facies; simian (Latin simia : “ape”) crease (single transverse palmar); hypotonia; ligamentous laxity; instability of C1-C2 [A], hips [B], and patella; flat feet[musculoskeletalkey.com]

  • Growth Delay due to Insulin-Like Growth Factor I Resistance

    transverse palmar crease 0000954 Truncal obesity 0001956 Percent of people who have these symptoms is not available through HPO Abnormality of metabolism/homeostasis Laboratory[rarediseases.info.nih.gov] 1st and 2nd toes Gap between first and second toe Increased space between first and second toes Sandal gap between first and second toes Wide space between 1st, 2nd toes[rarediseases.info.nih.gov] […] delay 0001270 Myopia Close sighted Near sighted Near sightedness Nearsightedness [ more ] 0000545 Prominent forehead Pronounced forehead Protruding forehead [ more ] 0011220 Single[rarediseases.info.nih.gov]

  • Adactyly of Foot

    […] palpebral fissure Death in infancy Single transverse palmar crease Thin vermilion border Joint hyperflexibility Postnatal growth retardation Monorchism Need help with a diagnosis[mendelian.co] Synonyms:Anterior Polydactyly Replaces: Anterior Duplication of the Limb, Tibial Polydactyly Foot, Preaxial Polydactyly of Subjective: A widely spaced gap between the first[quizlet.com] transverse palmar crease Broad hallux Downslanted palpebral fissures Cleft upper lip Patent foramen ovale Short finger Depressivity Autistic behavior Delayed skeletal maturation[mendelian.co]

  • Cutis Laxa

    Many patients exhibit single transverse palmar creases.[scielo.br] Other reported osteoarticular features are: a wide space between the first and second toes; talipes equinovarus; metatarsus adductus; genu recurvatum or genu valgum; flat[scielo.br] Dermatoglyphic studies of these three conditions showed no significant abnormality other than an increased number of palmar and plantar creases, especially in reports of WSS[scielo.br]

  • Acrofacial Dysostosis Type Catania

    The signs and symptoms of Acrofacial Dysostosis, Catania type may include: Widow's peak Single transverse palmar crease Very frequently present symptoms in 80-99% of the cases[dovemed.com] He had a wide space between the first and second toe of his feet and subungual fibroma on the second and third toe of the right foot and on the third toe of the left foot.[jmg.bmj.com] transverse palmar crease ; Widow's peak Associated Genes - Mouse Orthologs - Source OMIM:101805 (names, synonyms, disease associated genes) , Orphanet (disease classes) ,[mousephenotype.org]

  • Kenny-Caffey Syndrome Type 1

    transverse palmar crease, and wide space between the first and second toes.[medcraveonline.com] space between the first and second toes.[medcraveonline.com] Upward slanted palpebral fissures, single transverse palmar creases, wide gap between the first and second toes, and hypotonia are strongly suggesting the possibility of Down[medcraveonline.com]

  • Baraitser Syndrome

    transverse palmar crease Intestinal malrotation Premature birth Growth hormone deficiency Fine hair Hypoglycemia Macrocephaly Frontal bossing Behavioral abnormality Pes planus[mendelian.co] 1st and 2nd toes Gap between first and second toe Increased space between first and second toes Sandal gap between first and second toes Wide space between 1st, 2nd toes[rarediseases.info.nih.gov] transverse palmar creases Sparse and thin eyebrow Narrow forehead Scarring Sleep disturbance Deeply set eye Upslanted palpebral fissure Arrhythmia Irregular femoral epiphysis[mendelian.co]

Further symptoms