Sister Mary Joseph's Nodule: Causes & Reasons

Possible Causes for Sister Mary Joseph's Nodule

If cutaneous metastases do indeed occur, it is often near the umbilicus, known as the Sister Mary Joseph's nodule. [ncbi.nlm.nih.gov]

Subcutaneous metastases (referred to as a Sister Mary Joseph nodule or nodules) in the paraumbilical area signify advanced disease. [emedicine.medscape.com]

Mary Joseph nodule or nodules) Possible presence of palpable metastatic mass in the rectal pouch (Blumer shelf) Possible presence of palpable metastatic cervical nodes: Nodes [emedicine.medscape.com]

Adenocarcinoma of the Ovary

Mary Joseph nodule* Table 6 History and Examination Findings Associated with Ovarian Cancer Family history Bilateral breast cancer Early-onset breast cancer (younger than [aafp.org]

Mary Joseph nodule.[21] Rarely, teratomas can cause growing teratoma syndrome or peritoneal gliomatosis.[21] Some experience menometrorrhagia and abnormal vaginal bleeding [en.wikipedia.org]

Mary Joseph nodule* Another study examined the presenting symptoms in women older than 60 years for up to 12 months before a diagnosis of ovarian cancer. 26 Patients with [aafp.org]

Malignant Neoplasm of the Stomach

Other possible signs of metastatic disease include left supraclavicular adenopathy (Virchow's node), periumbilical node (Sister Mary Joseph nodule), and an anterior axillary [symptoma.com]

Signs may include a palpable enlarged stomach with succussion splash; hepatomegaly; periumbilical metastasis (Sister Mary Joseph nodule); and enlarged lymph nodes such as [emedicine.medscape.com]

Gastric Adenocarcinoma

Signs may include a palpably enlarged stomach, a primary mass (rare), an enlarged liver, Virchow’s node (i.e., left supraclavicular), Sister Mary Joseph’s nodule (periumbilical [aafp.org]

Malignant Neoplasm of the Pancreas

Important signs include an upper abdominal mass, icterus, hepatomegaly, splenomegaly, palpable gallbladder (Courvoisier’s sign), periumbilical nodules (Sister Mary Joseph’ [omicsonline.org]

a palpable abdominal mass, hepatomegaly from liver metastases, or splenomegaly from portal vein obstruction Advanced disease: Paraumbilical subcutaneous metastases (or Sister [emedicine.medscape.com]

Adenocarcinoma of the Colon

A Sister Marie Joseph nodule may develop at the umbilicus from tumour infiltration. Liver metastases are quite asymptomatic in the early stages. [surgwiki.com]

Metastasis

[…] appearing at the umbilicus is called a Sister Mary Joseph nodule and is a sign of extensive colorectal cancer What is the treatment for cutaneous metastasis ? [dermnetnz.org]

[…] metastasis occurs on the chest, extremities and back In women, metastasis to the lower extremities is more common Colon and stomach Common sites are the abdomen and the pelvis A nodule [dermnetnz.org]

Lymph Node Metastasis

European Respiratory Journal 2016 48: PA2042; DOI: 10.1183/13993003.congress-2016.PA2042 Abstract Introduction: There may be causes of mediastinal lymph node enlargement other than metastasis in cancer patients and anthracosis is one of them. Aim: The aim of this study was to evaluate if anthracotic lymph node[…] [erj.ersjournals.com]

Cutaneous Metastasis in Breast Cancer

The Sister Mary Joseph nodule is a well known cutaneous metastasis. [radiopaedia.org]

[…] appearing at the umbilicus is called a Sister Mary Joseph nodule and is a sign of extensive colorectal cancer October is breast cancer awareness month. [comderm.com]

Mary Joseph's nodule) - stomach, colon, ovary, kidney, breast Pelvis - colon Extremities - melanoma, breast, lung, renal, intestinal Morphology Patients may present with [pcds.org.uk]

Endometrial Adenocarcinoma

Prognosis of endometrial adenocarcinoma is favorable; however, the risk of recurrence ranges from 7% to 13%. Recurrence has been related to age, tumor type, International Federation of Gynecology and Obstetrics grade, depth of invasion, and lymphovascular invasion (LVI); however, morphologic features that would[…] [ncbi.nlm.nih.gov]

Celiac Disease with Diffuse Intestinal Ulceration

Sister Mary Joseph's nodule: a clinical and histologic study. J Am Acad Dermatol. 1984 Apr. 10(4):610-5. [Medline]. [emedicine.medscape.com]

Sister Mary Joseph nodule in a patient with gastric carcinoma. Note the shiny, reddish, telangiectatic group of papules in the umbilicus. [emedicine.medscape.com]

Thus, it is important to look for these findings when FCP is suspected. [39] Sister Mary Joseph nodule As head nurse and skilled surgical assistant to William Mayo, MD, Sister [emedicine.medscape.com]

Antral G-Cell Hyperplasia

Mary Joseph nodule What 2 structures are commonly involved in peritoneal metastatic spread? [quizlet.com]

Morphology Gross Microscopic Special stains Immunohistochemistry Metastases- Virchow node Krukenberg Tumour- Bilateral ovarian Sister Mary Joseph nodule- paraumbilical [slideshare.net]

[…] lesser curvature of stomach, & occasionally supraclavicular nodes (Virchows nodes) via the thoracic duct periumbilical region nodes that gastric carcinoma can metastasize to: Sister [quizlet.com]

Metastatic Skin Carcinoma

[…] appearing at the umbilicus is called a Sister Mary Joseph nodule and is a sign of extensive colorectal cancer What is the treatment for cutaneous metastasis ? [dermnetnz.org]

Gastrointestinal carcinomas may spread along the urachus and produce nodules at the umbilicus; those at the umbilicus have been referred to as Sister Mary Joseph nodules. [emedicine.medscape.com]

Scalp Angiosarcoma

Sister Mary Joseph’s nodule: a clinical and histologic study. J Am Acad Dermatol 1984; 10:610–615. CrossRef PubMed CAS Google Scholar Baran R, Tosti A. [link.springer.com]

Benign Intermediate Mesothelioma

Malignant peritoneal mesothelioma presenting umbilical hernia and Sister Mary Joseph's nodule. World J Gastrointest Endosc. 2013;5(8):407-11. [ Links ] 10. [scielo.org.mx]

Transient Sarcoidosis

Malignancy Sister Mary Joseph’s nodule (colon cancer) Sister Mary Joseph’s nodule is a nodular umbilical metastatic tumor. [bobbybukamd.com]

Sister Mary Joseph’s nodule is associated with cancers of the gastrointestinal tract and ovary. [bobbybukamd.com]

It was named after Sister Mary Joseph, the first surgical assistant to Dr. William Mayo and the superintendent of St. [bobbybukamd.com]

Cecal Adenocarcinoma

Umbilical metastasis (Sister Mary Joseph's nodule) is a rare occurrence and indicates, in most of the patients, an advanced intraabdominal malignancy. [ncbi.nlm.nih.gov]

Mary Joseph's nodule as a very early sign of an occult cecal adenocarcinoma. 61 Salemis NS 19089666 2007 46 Abscess and cecum carcinoma in inguinal hernia: case report. 61 [malacards.org]

An extremely rare case of a Sister Mary Joseph's nodule is described herein, where the metastatic umbilical nodule was the first sign of a cecal adenocarcinoma and became [ncbi.nlm.nih.gov]

Necrotic Neoplasm

Conclusion Sister Mary Joseph nodule might be an unusual indicator of occult visceral and other malignancies. [acanceresearch.com]

A peculiar lymph node lesion known as the Sister Mary Joseph nodule is invariably associated with metastatic intra-abdominal cancer (e.g., ovary, gastric, etc.). [antimicrobe.org]

Giner GV (1999) Sister Mary Joseph’s nodule. Its clinical significance and management. An Med Interna 16:365-370. [acanceresearch.com]

Esophageal Metastasis

Sister Mary Joseph's nodule. Ann Int Med 1998;128(5):410 24. Usha Dutta, Manish Kumar, SC SharmaBirendr Nagi. [ispub.com]

Incidence of Sister Mary Joseph's nodule due to oesophageal carcinoma was found to be (0.2%). FNAC is an adequate method of diagnosis. [ispub.com]

Original Article S Marupaka, S Modi, S Singh Keywords acrometastases, bone metastases, esophageal adenocarcinoma, micrometastases, sister mary joseph's nodule, skin metastases [ispub.com]

Optic Nerve Edema-Splenomegaly Syndrome

Sister Mary Joseph Nodule An external umbilical metastatic nodule from an internal abdominal malignancy. Dry disease. [quizlet.com]

Pancreatic Carcinoma

Mary Joseph's nodule. [ncbi.nlm.nih.gov]

The most common site of cutaneous metastasis is the umbilicus, and this is also known as the 'Sister Mary Joseph' nodule. [ncbi.nlm.nih.gov]

Joseph's nodule. [ncbi.nlm.nih.gov]

Gallbladder Carcinoma

Umbilical metastasis, alias Sister Mary Joseph's nodule, is a rare clinical phenomenon. [ncbi.nlm.nih.gov]

Hirschsprung Disease - Deafness - Polydactyly Syndrome

MARY JOSEPH NODULE abdominal carcinoma, especially gastric, may metastasize to the navel; Sister Joseph, in the early days of the Mayo Clinic, noted periumbilical nodules [rxpgonline.com]

[…] localized to the true vocal cords SIPPLE'S SYNDROME MEN type IIa; pheochromacytoma, medullary carcinoma of the thyroid, and hyperparathyroidism due to hyperplasia or tumor SISTER [rxpgonline.com]

Gastric Lymphoma

The Sister Mary Joseph nodule is a peri-umbilical metastasis most commonly found with adenocarcinomas of the gastrointestinal tract and ovary. [ncbi.nlm.nih.gov]

Familial Primary Localized Cutaneous Amyloidosis

Malignancy Sister Mary Joseph’s nodule (colon cancer) Sister Mary Joseph’s nodule is a nodular umbilical metastatic tumor. [bobbybukamd.com]

Sister Mary Joseph’s nodule is associated with cancers of the gastrointestinal tract and ovary. [bobbybukamd.com]

It was named after Sister Mary Joseph, the first surgical assistant to Dr. William Mayo and the superintendent of St. [bobbybukamd.com]

Ovarian Metastasis

Conclusion Sister Mary Joseph nodule might be an unusual indicator of occult visceral and other malignancies. [acanceresearch.com]

Giner GV (1999) Sister Mary Joseph’s nodule. Its clinical significance and management. An Med Interna 16:365-370. [acanceresearch.com]

Majumdar B, Wiskind AK, Croft BN, Dudley AG (1991) The Sister Mary Joseph nodule: its significance in gynecology. Gynecol Oncol 40:152-159. [acanceresearch.com]

Abdominal Tuberculosis

A 10 years experience in an endemic area. ( 28709483 ) Noomene R...Cherif A 2017 31 A benign cause of Sister Mary Joseph's nodule: Abdominal tuberculosis. ( 28776536 ) Sharma [malacards.org]

Umbilical Cellulitis

Sister Mary Joseph’s nodule of the umbilicus caused by abdominal cancer (source: DermNet NZ, CC license) 3. [ehealthstar.com]

Mary Joseph nodule of the umbilicus” can appear. [ehealthstar.com]

[…] source: DermNet NZ, CC license) Abdominal Cancer In advanced stomach, colorectal, pancreatic or other abdominal cancer, irritating red rash around the belly button called “Sister [ehealthstar.com]

Gastric Carcinoma

Abstract Sister Mary Joseph nodule is a metastatic lesion of the umbilicus, which is an uncommon phenomenon that carries an ominous prognosis. [ncbi.nlm.nih.gov]

Signs may include a palpably enlarged stomach, a primary mass (rare), an enlarged liver, Virchow’s node (i.e., left supraclavicular), Sister Mary Joseph’s nodule (periumbilical [aafp.org]

Sister Mary Joseph nodule can be the first presenting sign of an occult malignancy, or as demonstrated in this case, a sign of disease progression. [ncbi.nlm.nih.gov]

Mediastinal Metastasis

Skin metastases are rare and are classified as umbilical metastasis (Sister Mary Joseph’s nodule [SJN]) and nonumbilical metastasis. [cardiothoracicsurgery.biomedcentral.com]

Sister Mary Joseph’s nodule as the first presenting sign of primary fallopian tube adenocarcinoma. J Minim Invasive Gynecol. 2006;13(3):234–6. [cardiothoracicsurgery.biomedcentral.com]

Fifty-three percent of Sister Mary Joseph’s nodules originated from malignancies of the female genital tract, particularly ovarian carcinoma [20]. Jonathan P. [cardiothoracicsurgery.biomedcentral.com]