Possible Causes for Skeletal Muscle Damage Acute Exertional Rhabdomyolysis During exercise it is necessary and normal for minor skeletal muscle damage to occur. [columbusgeorgiaonline.com] CCL2 and CCR2 polymorphisms are associated with markers of exercise-induced skeletal muscle damage. J Appl Physiol (1985). 2010;108(6):1651–8. [ojrd.biomedcentral.com] […] in skeletal muscle damage, rhabdomyolysis, or acute renal injury [27]. [healthdocbox.com] Rhabdomyolysis Rhabdomyolysis can be caused by trauma or any condition that causes damage to skeletal muscle. [diabetesselfmanagement.com] Myoglobin breaks down into substances that can damage kidney cells. Rhabdomyolysis may be caused by injury or any other condition that damages skeletal muscle. [mountsinai.org] Aiuto Da Wikimedia Commons, l'archivio di file multimediali liberi Jump to navigation Jump to search rabdomiolisi condition in which damaged skeletal muscle breaks down rapidly [commons.wikimedia.org] Traumatic Rhabdomyolysis muscle damaged by ischemic conditions). [whonamedit.com] (the breakdown of skeletal muscle damaged by ischemic conditions). [en.wikipedia.org] Myoglobin breaks down into substances that can damage kidney cells. Rhabdomyolysis may be caused by injury or any other condition that damages skeletal muscle. [medlineplus.gov] Myopathy, Endocrine Xin is a marker of skeletal muscle damage severity in myopathies. Am J Pathol. 2013 Dec. 183(6):1703-9. [Medline]. al-Lozi MT, Pestronk A, Lee WC, et al. [emedicine.medscape.com] muscles with resultant muscle fiber damage and subsequent clinical weakness These are relatively uncommon about 1 in 13 Classification of Inflammatory myopathies Idiopathic [slideplayer.com] […] ambulation by 3 to 4 years Gene replacement therapy in the future 12 Inflammatory myopathies Definition: Heterogenous group of disorders characterised by inflammation in the skeletal [slideplayer.com] Paroxysmal Rhabdomyolysis In this condition, there is death of the muscle fibers due to damage of the skeletal muscles and release of deadly intracellular matter into the bloodstream. [firstaidcprvictoria.ca] CCL2 and CCR2 polymorphisms are associated with markers of exercise-induced skeletal muscle damage. J Appl Physiol (1985). 2010;108(6):1651–8. [ojrd.biomedcentral.com] It increases with muscle damage, this can be stroke that causes an overuse damage of muscle, MI due to myocardial damage and damage or overuse of skeletal muscle. [therapyteampta.forumchitchat.com] Muscular Dystrophy-Dystroglycanopathy Type A8 The damaged fibers weaken and die over time, leading to progressive weakness of the skeletal muscles. [medlineplus.gov] Without functional α-dystroglycan to stabilize muscle cells, muscle fibers become damaged as they repeatedly contract and relax with use. [medlineplus.gov] CK Syndrome skeletal muscle damage. [labtestsonline.org] muscle damage. [questdiagnostics.com] A very high level of plasma CK activity due to skeletal muscle damage will show quite high absolute levels of CK-MB, but the relative index, i.e. [bioline.org.br] Crush Syndrome (the breakdown of skeletal muscle damaged by ischemic conditions). [en.wikipedia.org] If a significant amount of skeletal muscle is damaged (>100 g),excess myoglobin is filtered by the kidneys and can cause renal tubular obstruction and renal damage: the excess [patient.info] Mannitol also scavenges oxygen free-radicals and may help to prevent damage of renal parenchyma, cardiac and skeletal muscles that may be caused during reperfusion. [cancertherapyadvisor.com] Tissue Breakdown Abstract Indirect indices of exercise-induced human skeletal muscle damage and connective tissue breakdown were studied following a single bout of voluntary eccentric muscle [ncbi.nlm.nih.gov] Myoglobin breaks down into substances that can damage kidney cells. Rhabdomyolysis may be caused by injury or any other condition that damages skeletal muscle. [medlineplus.gov] Rhabdomyolysis is a condition that may occur when muscle tissue is damaged due to an injury in which muscle in the body is damaged (rhabdomyo=skeletal muscle + lysis= rapid [emedicinehealth.com] ACTN3 Deficiency […] exertional rhabdomyolysis is a condition in which unaccustomed, strenuous exercise results in damage to skeletal muscle. [journals.physiology.org] Deficiency of α-actinin-3 is associated with increased susceptibility to contraction-induced damage and skeletal muscle remodeling. Hum. Mol. [ncbi.nlm.nih.gov] Previously, using an Actn3KO mouse model, we have shown in fast-twitch muscles, eccentric contractions at L0 + 20% stretch did not cause eccentric damage. [read.qxmd.com] Insulin-Like Growth Factor 1 Resistance Mechanical strain and subsequent skeletal muscle damage resulting from RE of sufficient volume and intensity produce structural disruptions of the contractile elements within [journals.physiology.org] In particular, resistance exercise (RE) is a potent stimulus resulting in acute muscle fatigue that may persist for several hours to days following a workout. [journals.physiology.org] Secondary Polyarteritis nodosa Blood vessels in any organ or organ system may be affected, including those supplying the kidneys, heart, intestine, nervous system, and/or skeletal muscles. [rarediseases.org] Blood vessels in any organ or organ system may be affected, including arteries supplying the kidneys, heart, intestine, nervous system, and/or skeletal muscles. [rarediseases.org] Disease Overview Polyarteritis nodosa is a rare multi-system disorder characterized by widespread inflammation, weakening, and damage to small and medium-sized arteries. [rarediseases.org] Ehlers-Danlos Syndrome Spondylodysplastic Type 1 0001075 Narrow mouth Small mouth 0000160 Osteopenia 0000938 Skeletal dysplasia 0002652 Skeletal muscle atrophy Muscle degeneration Muscle wasting [ more ] 0003202 Sparse [rarediseases.info.nih.gov] […] skin pigmentation Abnormality of pigmentation Pigmentary changes Pigmentary skin changes Pigmentation anomaly [ more ] 0001000 Atrophic scars Sunken or indented skin due to damage [rarediseases.info.nih.gov] Secondary Myopathy Tidus Peter (ed) (2008) Skeletal muscle damage and repair. Human Kinetics, Champaign Google Scholar 5. [link.springer.com] Xin is a marker of skeletal muscle damage severity in myopathies. Am J Pathol. 2013 Dec. 183(6):1703-9. [Medline]. al-Lozi MT, Pestronk A, Lee WC, et al. [emedicine.medscape.com] Colchicine and vincristine can also cause neuropathy Differential Diagnosis of Creatine Kinase Elevation CK is a nonspecific marker of muscle damage. [sites.google.com] Myoglobinemia muscle breaks down rapidly. [dictionary.babylon-software.com] Davis et al. examined the muscle biopsies of 36 cases of falciparum malaria and found parasite sequestration in skeletal muscle and muscle damage, along with a significant [bmcinfectdis.biomedcentral.com] This results from damage to skeletal muscle with release of myoglobin into the blood (myoglobinemia) and subsequent excretion in the urine (myoglobinuria). [vet.uga.edu] Electric Countershock These data suggest that myocardial damage following electric countershock was minimal and that elevation of h-FABP may result from skeletal muscle damage. [jstage.jst.go.jp] A lower incidence of skin burns (18) and less skeletal muscle damage (19) have also been reported. [escardio.org] muscle cells damaged by electrical current can contain as much as 20% to 25% CK-MB fraction, as opposed to the usual 2% to 3%, suggesting injured skeletal muscle as the source [lightninginjury.lab.uic.edu] Andermann Syndrome This occurs by axonal disease paralyzing the skeletal muscles, including the respiratory muscles, as a result of axonal damage in peripheral nerves. [en.wikipedia.org] Polyarteritis Nodosa Blood vessels in any organ or organ system may be affected, including those supplying the kidneys, heart, intestine, nervous system, and/or skeletal muscles. [rarediseases.org] Blood vessels in any organ or organ system may be affected, including arteries supplying the kidneys, heart, intestine, nervous system, and/or skeletal muscles. [rarediseases.org] Disease Overview Polyarteritis nodosa is a rare multi-system disorder characterized by widespread inflammation, weakening, and damage to small and medium-sized arteries. [rarediseases.org] Hereditary Myopathy with Lactic Acidosis due to ISCU Deficiency CCL2 and CCR2 polymorphisms are associated with markers of exercise-induced skeletal muscle damage. J Appl Physiol (1985). 2010;108(6):1651–8. [ojrd.biomedcentral.com] Rhabdomyolysis is a medical condition in which damaged striated skeletal muscles break down easily and rapidly. [blueprintgenetics.com] Introduction Rhabdomyolysis (RM) is characterised by acute and often severe skeletal muscle damage resulting in the release of intracellular muscle components into the blood [ojrd.biomedcentral.com] Steroid Myopathy Definition : A non-neoplastic disorder affecting the skeletal muscles. [sideeffects.embl.de] Excessive alcohol intake can also damage skeletal muscle. [manchesterneurophysio.co.uk] Toxic Myopathies Exposure to certain medications, chemicals, and excessive alcohol intake can damage skeletal muscle. [healthcommunities.com] Late-Onset Pompe Disease […] fibers.25 Moreover, currently unknown abnormalities in a subset of lysosomes interfere with the recycling of autophagosomes and their contents, which leads to skeletal muscle [ncbi.nlm.nih.gov] damage.25 The GAA gene is highly pleomorphic; 289 sequence variations have been reported to date that include 197 proven pathogenic mutations, 67 non-pathogenic mutations [ncbi.nlm.nih.gov] […] evidence has shown a failure of productive autophagy in patients with Pompe disease and the progressive accumulation of autophagosomes that disrupt the contractile apparatus in muscle [ncbi.nlm.nih.gov] Pompe Disease Pim Pijnappel, Elevated Plasma Cardiac Troponin T Levels Caused by Skeletal Muscle Damage in Pompe Disease, Circulation: Cardiovascular Genetics, 10.1161/CIRCGENETICS.115.001322 [dx.doi.org] Lack of lysosomal acid α-glucosidase results in the accumulation of glycogen within the cell organelles, and this may cause cardiac and skeletal muscle damage as well as neurologic [symptoma.com] Suppression of autophagy in skeletal muscle uncovers the accumulation of ubiquitinated proteins and their potential role in muscle damage in Pompe disease. Hum. Mol. [ncbi.nlm.nih.gov] Caveolinopathy Although caveolin-3 deficiency represents the primary event, multiple secondary molecular mechanisms lead to muscle tissue damage. [unboundmedicine.com] skeletal muscle cells results in increased total serum CK. [typeset.io] Among these, sarcolemmal membrane alterations, disorganization of skeletal muscle T-tubule network, and disruption of distinct cell signaling pathways have been determined [unboundmedicine.com] Combined Oxidative Phosphorylation Deficiency 29 muscle damage. [frontiersin.org] […] kinase (CK) (3,395.6 U/L, normal: 26–308 U/L), CK-MB (99.7 U/L, normal: 0–24 U/L), and myoglobin (656.2 U/L, normal: 0–90 U/L) levels were markedly elevated, consistent with skeletal [frontiersin.org] Crush Injury Part 2: The local injury: Here we look in more detail at the pathophysiology of skeletal muscle damage following crush injuries and discuss how to minimise morbidity by salvaging [journals.sagepub.com] If a significant amount of skeletal muscle is damaged (>100 g),excess myoglobin is filtered by the kidneys and can cause renal tubular obstruction and renal damage: the excess [patient.info] The more skeletal muscle mass involved, the greater the potential complications could be. [limmereducation.com] Autoimmune Necrotizing Myopathy Rhabdomyolysis is a more severe form of skeletal muscle damage that occurs with muscle related symptoms and creatine kinase levels greater than 10 times the upper limit of [medsafe.govt.nz] Self-Limiting Myopathy and Rhabdomyolysis Statins can cause myopathy that presents as muscle pain, tenderness, or weakness with or without raised levels of creatine kinase [medsafe.govt.nz] Glycogen Storage Disease Type 13 CCL2 and CCR2 polymorphisms are associated with markers of exercise-induced skeletal muscle damage. J Appl Physiol (1985). 2010;108(6):1651–8. [ojrd.biomedcentral.com] Raben N, Hill V, Shea L, et al. (2008) Suppression of autophagy in skeletal muscle uncovers the accumulation of ubiquitinated proteins and their potential role in muscle damage [els.net] Introduction Rhabdomyolysis (RM) is characterised by acute and often severe skeletal muscle damage resulting in the release of intracellular muscle components into the blood [ojrd.biomedcentral.com] Xanthine Nephrolithiasis Analyst. 1995 Aug;120(8):2181-4. [ PubMed:7677251 ] Ihara H, Shino Y, Morita Y, Kawaguchi E, Hashizume N, Yoshida M: Is skeletal muscle damaged by the oxidative stress following [hmdb.ca] [PubMed:12847698 ] General References Ihara H, Shino Y, Morita Y, Kawaguchi E, Hashizume N, Yoshida M: Is skeletal muscle damaged by the oxidative stress following anaerobic [hmdb.ca] Organophosphate Insecticide Antagonists Results indicate that acute organophosphate exposure through inhalation can lead to skeletal muscle fiber damage in humans, similar to results obtained by ingestion. [ncbi.nlm.nih.gov] Histological analysis indicated the presence of muscle fibers with subsarcolemmal grouped granular basophilic inclusions and scattered necrotic fibers. [ncbi.nlm.nih.gov] Hereditary Proximal Myopathy with Early Respiratory Failure […] generally limited to certain skeletal muscles and respiratory muscles. [ivami.com] It is unclear why these effects are usually limited to skeletal muscles and respiratory muscles, and do not involve cardiac muscle. [ghr.nlm.nih.gov] Although work is being done to determine how abnormally bent titin contributes to muscle damage and the signs and symptoms of HMERF, it is not clear why these effects are [ivami.com]
