Skin Necrosis Causes & Reasons

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Skin Necrosis Symptom Checker: Possible causes include Pyoderma Gangrenosum. Check the full list of possible causes and conditions now! Talk to our Chatbot to narrow down your search.

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Possible Causes

Pyoderma Gangrenosum

Abstract Postoperative pyoderma gangrenosum (PPG) is an unusual clinical entity, which shows rapidly progressive skin necrosis that can occur within surgical sites after any [ncbi.nlm.nih.gov]

[…] by rapidly progressing skin necrosis. [jmedicalcasereports.com]

necrosis of unknown etiology often associated with systemic illness and sometimes skin injury. [merckmanuals.com]

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Hereditary Protein C Deficiency

Heparin appears to be ineffective in the prevention of both the purpura fulminans syndrome and the coumarin-induced skin necrosis. [ncbi.nlm.nih.gov]

necrosis in protein C deficiency. [ncbi.nlm.nih.gov]

Heparin appears to be ineffective in the prevention of both the purpura fulminans syndrome and the coumarin-induced skin necrosis. 1985 S. [karger.com]

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Calciphylaxis

Calciphylaxis is a poorly understood and highly morbid syndrome of vascular calcification and skin necrosis. [ncbi.nlm.nih.gov]

The serum parathyroid hormone, calcium, and phosphorus levels improved, but the skin necrosis and clinical status worsened. [doi.org]

Clinically, calciphylaxis causes livedo racemosa, which progresses to retiform purpura and skin necrosis. First-line treatment is with sodium thiosulfate. [ncbi.nlm.nih.gov]

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Heparin-induced Thrombocytopenia

necrosis syndromes). [ncbi.nlm.nih.gov]

This typical HIT can result in deep vein thrombosis, pulmonary embolism, occlusion of a limb artery, acute myocardial infarct, stroke, and a systemic reaction or skin necrosis [ncbi.nlm.nih.gov]

[…] can present in many ways, ranging from common—isolated thrombocytopenia, venous thromboembolism, acute limb ischemia—to less common but specific presentations—necrotizing skin [doi.org]

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Rothmann-Makai Syndrome

The diagnosis is made by skin biopsy, which discloses acute fat necrosis with characteristic ghost cells. [lymphedemapeople.com]

/injuries Skin Neoplasms/diagnosis PMID: 9674398 [PubMed - indexed for MEDLINE] ... t Citation ............ [lymphedemapeople.com]

Acute panniculitis is also called nodular fat necrosis. Causes and Risk Factors of Panniculitis Panniculitis may result from a variety of conditions. [lymphedemapeople.com]

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Cushing's Disease

Here we report an adolescent male with Cushing's disease secondary to a pituitary adenoma who was admitted with cholestatic hepatitis. A detailed work-up for hepatitis was negative except for a novel heterozygous ABCB4 gene mutation encoding multidrug resistance type III (MDR3) protein. Upon resection of the[…] [ncbi.nlm.nih.gov]

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Protein C Deficiency

Non-vitamin K antagonist anticoagulant options should be considered in patients with warfarin-induced skin necrosis (WISN) in the setting of protein C. [ncbi.nlm.nih.gov]

Warfarin induced skin necrosis associated with acquired protein C deficiency. [jnma.com.np]

This therapy was also complicated by Warfarin-induced skin necrosis. [ncbi.nlm.nih.gov]

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Ischemic Ulcer

necrosis in chronic renal insufficiency, (3) nonuremic calciphylaxis in morbid obesity with proximal skin necrosis (eutrophication: body water enriched with nutrients or [journals.lww.com]

[…] anorganic substances leading to calcification), and (4) calciphylaxis with proximal skin necrosis, were compared with PG on pathophysiological features. 3,4 Martorell HYTILU [journals.lww.com]

[…] and morbid obesity (proximal skin necrosis), ischemic subcutaneous arteriolosclerosis represents the common hallmark of these conditions. [journals.lww.com]

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Protein S Deficiency

Cases of skin necrosis have been documented in patients with protein C or S deficiency while being treated with warfarin. [ncbi.nlm.nih.gov]

[…] the microthrombosis responsible for skin necrosis. [ncbi.nlm.nih.gov]

Abstract We report a case of a 6-year-old girl with severe protein S deficiency due to a homozygous mutation and recurrent episodes of skin necrosis. [ncbi.nlm.nih.gov]

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Noma

It is frequently a consequence of an odontogenic infection and is characterized by an irregular pattern of rapidly spreading necrosis of fascia, muscle, and skin. [ncbi.nlm.nih.gov]

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Hypertensive Ischemic Ulcer

Martorell hypertensive ischemic leg ulcer is a severe type of skin necrosis (skin infarction) which occurs in long-term hypertensive subjects. [clinicaltrials.gov]

necrosis in chronic renal insufficiency, (3) nonuremic calciphylaxis in morbid obesity with proximal skin necrosis (eutrophication: body water enriched with nutrients or [journals.lww.com]

Both patients had severe necrosis of the skin of buttocks and lower extremities, often originating in localized areas of livedo reticularis. [annals.org]

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Purpura Fulminans

Dermal vascular skin necrosis is associated with a complex group of clinical disorders. [ncbi.nlm.nih.gov]

This book is the first to discuss skin necrosis as a symptom related to a broad range of pathologies. [books.google.it]

KEYWORDS: anticoagulant; factor V Leiden; protein C; protein S; skin necrosis; thrombosis [ncbi.nlm.nih.gov]

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Neonatal Purpura Fulminans

DOI: 10.3126/jnps.v34i1.8975 Keywords: Neonatal purpura fulminans, skin necrosis, disseminated intravascular coagulation. [oalib.com]

It is very similar to the lesions seen in idiopathic purpura fulminans, warfarin-induced skin necrosis, and acute infectious purpura fulminans. [ncbi.nlm.nih.gov]

The clinical presentation is that of acute disseminated intravascular coagulation and hemorrhagic skin necrosis. [ncbi.nlm.nih.gov]

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Mucormycosis

Rhino-orbital skin necrosis with positive samples for the organism Rhizopus on eventual orbital exenteration revealed angioinvasive fungal infection, mucormycosis, to be the [ncbi.nlm.nih.gov]

other forms of manifesting are abscesses, skin swelling, and necrosis. [ncbi.nlm.nih.gov]

The disease typically involves the rhino-facial-cranial area, lungs, gastrointestinal tract, skin, or less commonly other organ systems. [icd9data.com]

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Scedosporium Infection

Scedosporium apiospermum, the asexual stage of Pseudoallescheria boydii, is a fungus ubiquitous in soil as well as organically polluted areas, where nitrogen-containing compounds are abundant. It is an emerging opportunistic pathogen that can range from cutaneous to disseminated infection and can be fatal within[…] [ncbi.nlm.nih.gov]

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Brown Recluse Spider Bite

Abstract The objectives in the treatment of the brown recluse spider bite are to prevent skin necrosis and the need for reconstructive surgery. [ncbi.nlm.nih.gov]

[…] changes over several days leading to skin necrosis. [ijam-web.org]

Cause an open sore (ulcer) and dead skin (necrosis), treatment includes removing the dead skin from the sore. [stlukesonline.org]

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Calcaneus Fracture

[…] underwent open reduction and internal fixation had postoperative wound infections and skin necrosis. [ncbi.nlm.nih.gov]

Management: Surgical Management Emergent Surgery Indications Compartment Syndrome Tongue -Type (extra-articular Fracture ) Risk of skin necrosis from ankle tendons (gastrocnemius [fpnotebook.com]

No patient who underwent a minimally invasive reduction had skin lesions, but showed pain due to osteoarthritis lesions that appeared in the subtalar joint. 4 of them, who [ncbi.nlm.nih.gov]

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Fat Necrosis of the Breast

We believe that the patient developed skin and fat necrosis secondary to the MB dye injection. [issoonline.biomedcentral.com]

Fat necrosis is a self limiting condition where fat beneath the skin dies; usually the result of blunt trauma, sometimes the result of surgery. [realself.com]

Additional symptoms of breast fat necrosis include pain/ tenderness and there may also be a fluid discharge. Dimpling of the skin is possible as well. [ic.steadyhealth.com]

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Necrotizing Fasciitis

necrosis, island type with necrotic skin coverage, and broad type with whole skin necrosis. [ncbi.nlm.nih.gov]

CONCLUSION: This surgical management restricts skin excision to the area of definite skin necrosis, limiting skin excision to one-tenth of excised fascia, with long-term favorable [ncbi.nlm.nih.gov]

Initially, bacterial cellulitis was suspected, and ampicillin/sulbactam was initiated; however, 3 days later, skin necrosis occurred and pain increased. [ncbi.nlm.nih.gov]

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Epidemic Typhus

Photophobia- Skin necrosis- digit gangrene, Untreated case mortality : 40% The diagnosis of epidemic typhus was established by demonstrating increasing antibody titers from [the-travel-doctor.com]

Fibrin thrombi also occlude blood vessels, and cutaneous necrosis (gangrene of the skin) develops in a few patients. [histopathology-india.net]

Gangrene and necrosis of toes and fingers that necessitates amputation has been observed. Neurologic symptoms include confusion and drowsiness. [microbiologysociety.org]

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Idiopathic Recurrent and Disabling Cutaneous Herpes

skin necrosis on the lower abdomen. [emedicine.medscape.com]

Skin ulceration or necrosis is unusual. Jaundice and/or pallor can follow a severe episode of hemolysis. [emedicine.medscape.com]

necrosis [10] Warfarin-induced skin necrosis is an uncommon serious complication of oral anticoagulation therapy (see the image below). [11, 12, 13] Warfarin (Coumadin)–induced [emedicine.medscape.com]

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Insect Bite

Most cases of skin necrosis have no prior history of any spider bite. Approximately 25% of cases are associated with skin cultures positive for staphlococci. [anaesthesia.med.usyd.edu.au]

A condition mainly seen in Japanese children, in which a mosquito bite is followed by local skin necrosis combined with fever, lymphadenopathy, and hepatosplenomegaly ( 21 [doi.org]

When skin necrosis occurs after a presumed bite, the precise cause is unknown. It seems likely to not be due to the spider's venom. [anaesthesia.med.usyd.edu.au]

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Vulvitis

The irritant also may be potent enough to cause erosion, ulceration, or necrosis. [www1.cgmh.org.tw]

This initially presents as red and edematous skin followed by exudation and weeping, which may lead to secondary infections. [www1.cgmh.org.tw]

Repetitive exposure to weak irritants with an insufficient period of healing and restoration of skin integrity between each exposure characterizes chronic contact dermatitis [www1.cgmh.org.tw]

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Penile Gangrene

Warfarin-induced skin necrosis. Annals of dermatology. 2014;26(1):96-8. Chan Y, Valenti D, Mansfield A, Stansby G. Warfarin induced skin necrosis. [journals.sbmu.ac.ir]

We present in the current study, a patient who presented with progressive penile gangrene and skin necrosis due to CUA. [ncbi.nlm.nih.gov]

Here we discuss a case of 60 year old male who developed penile skin necrosis and urethral fistula due to chronic use of condom catheter. [journalmedica.com]

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Hereditary Thrombophilia due to Congenital Protein S Deficiency

Tornjen S, Somell A: Warfarin skin necrosis of the breast. Acta Chir Scand 1982;148:471–472. Sternberg ML, Pettyjohn FS: Warfarin sodium-induced skin necrosis. [karger.com]

Attention should be paid to the risk of coumarin-induced skin necrosis. [orpha.net]

Jillella AP, Lutcher CL: Reinstituting warfarin in patients who develop warfarin skin necrosis. [karger.com]

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Fournier Gangrene

Physical examination revealed edema (91.4%), erythema (88.6%) and perineal skin necrosis (60%). All the patients underwent surgical debridement of necrotic tissue. [ncbi.nlm.nih.gov]

PATIENT CONCERNS: A 61-year-old Chinese male complained of perineal skin necrosis for 19 days. [ncbi.nlm.nih.gov]

External genitalia and perianal examination revealed skin necrosis, pussy drainage and subcutaneous crepitations, in addition to above mentioned signs. [ncbi.nlm.nih.gov]

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Hypersensitivity

[…] findings Localized swelling, erythema, hemorrhage Sometimes superficial skin necrosis within a few hours of booster vaccination Reaction peaks 12–36 hours later. [amboss.com]

TNF-α was highly expressed and suggested to be responsible for the extensive necrosis of skin lesions of SCAR patients [140, 141]. [hindawi.com]

[…] factor-alpha promoter polymorphism TNF2 is associated with a stronger delayed-type hypersensitivity reaction in the skin of borderline tuberculoid leprosy patients. 54 61 [malacards.org]

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Drug Eruptions

[…] and warfarin-induced skin necrosis are potentially life-threatening adverse events. [symptoma.com]

Anticoagulant Skin Necrosis 40. Approach to drug eruptions 41. [slideshare.net]

necrosis. [aocd.org]

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Ovarian Cyst

[…] factor biologics, and botulism toxins as treatment to reduce keratinization and patient symptoms.1,2 Our patient underwent blunt debridement of the affected skin and nails [journals.lww.com]

[…] painful blistering and secondary infections.1,2 Current medical research is examining the possible role of using mutation-specific small interfering RNA, rapamycin, anti-tumor necrosis [journals.lww.com]

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Cold Exposure

There is a four-tier classification in common use: First-degree: hyperaemia and oedema without skin necrosis. [patient.info]

Second-degree: large clear vesicle formation in addition to hyperaemia and oedema with partial-thickness skin necrosis. [patient.info]

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