Skin Necrosis: Causes & Reasons

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Possible Causes for Skin Necrosis

Necrotizing Fasciitis

necrosis, island type with necrotic skin coverage, and broad type with whole skin necrosis. [ncbi.nlm.nih.gov]

CONCLUSION: This surgical management restricts skin excision to the area of definite skin necrosis, limiting skin excision to one-tenth of excised fascia, with long-term favorable [ncbi.nlm.nih.gov]

Initially, bacterial cellulitis was suspected, and ampicillin/sulbactam was initiated; however, 3 days later, skin necrosis occurred and pain increased. [ncbi.nlm.nih.gov]

Hereditary Protein C Deficiency

Heparin appears to be ineffective in the prevention of both the purpura fulminans syndrome and the coumarin-induced skin necrosis. [ncbi.nlm.nih.gov]

necrosis in protein C deficiency. [ncbi.nlm.nih.gov]

Pyoderma Gangrenosum

Abstract Postoperative pyoderma gangrenosum (PPG) is an unusual clinical entity, which shows rapidly progressive skin necrosis that can occur within surgical sites after any [ncbi.nlm.nih.gov]

[…] by rapidly progressing skin necrosis. [jmedicalcasereports.com]

Pyoderma gangrenosum is a chronic, neutrophilic, progressive skin necrosis of unknown etiology often associated with systemic illness and sometimes skin injury. [msdmanuals.com]

Primary Hyperoxaluria

There's deposition in the skin that can also lead to skin necrosis. Deposition at the retina can cause blindness. [raredr.com]

[…] e (Painful) skin nodules, skin necrosis, gangrene, calciphylaxis-like skin lesions, pruritus Skin biopsy Nerves e Ischaemic neuropathy Clinical assessment Muscle e Myopathy [academic.oup.com]

[…] heart block, left ventricular hypertrophy, systolic and diastolic dysfunction ECG, echocardiography CT: calcifications Thyroid d Hypothyroidism US Thyroid function tests Skin [academic.oup.com]

Primary Hyperoxaluria Type 1

[…] e (Painful) skin nodules, skin necrosis, gangrene, calciphylaxis-like skin lesions [academic.oup.com] Heart Failure We report a 38-year-old male with cardiac oxalosis, a [symptoma.com]

[…] problems, including livedo reticularis, rash, necrosis, and gangrene of the hands and feet Primary hyperoxaluria is a rare genetic disorder that can cause an accumulation [healthline.com]

Primary Hyperoxaluria Type 2

[…] e (Painful) skin nodules, skin necrosis, gangrene, calciphylaxis-like skin lesions [academic.oup.com] Heart Failure We report a 38-year-old male with cardiac oxalosis, a [symptoma.com]

[…] problems, including livedo reticularis, rash, necrosis, and gangrene of the hands and feet Primary hyperoxaluria is a rare genetic disorder that can cause an accumulation [healthline.com]

Mucormycosis

Rhino-orbital skin necrosis with positive samples for the organism Rhizopus on eventual orbital exenteration revealed angioinvasive fungal infection, mucormycosis, to be the [ncbi.nlm.nih.gov]

other forms of manifesting are abscesses, skin swelling, and necrosis. [ncbi.nlm.nih.gov]

The disease typically involves the rhino-facial-cranial area, lungs, gastrointestinal tract, skin, or less commonly other organ systems. [icd9data.com]

Epidemic Typhus

Photophobia- Skin necrosis- digit gangrene, Untreated case mortality : 40% The diagnosis of epidemic typhus was established by demonstrating increasing antibody titers from [the-travel-doctor.com]

Fibrin thrombi also occlude blood vessels, and cutaneous necrosis (gangrene of the skin) develops in a few patients. [histopathology-india.net]

The angiitis is most marked in the skin, heart, central nervous system, skeletal muscle, and kidneys. [intranet.tdmu.edu.ua]

Rothmann-Makai Syndrome

The diagnosis is made by skin biopsy, which discloses acute fat necrosis with characteristic ghost cells. [lymphedemapeople.com]

Acute panniculitis is also called nodular fat necrosis. Causes and Risk Factors of Panniculitis Panniculitis may result from a variety of conditions. [lymphedemapeople.com]

Panniculitis Definition of Panniculitis Panniculitis is an inflammation of the layer of subcutaneous fat underlying the epidermis of the skin. [lymphedemapeople.com]

Noma

It is frequently a consequence of an odontogenic infection and is characterized by an irregular pattern of rapidly spreading necrosis of fascia, muscle, and skin. [ncbi.nlm.nih.gov]

Immune Complex-Mediated Small Vessel Vasculitis

Patient showing erythematous skin changes, ulceration and necrosis of right breast. B. [synapse.koreamed.org]

Often, immunofluorescence microscopy can be used to visualize the immune complexes. [5] Skin response to a hypersensitivity of this type is referred to as an Arthus reaction [en.wikipedia.org]

Levamisole-induce leukocytoclastic vasculitis and neutropenia in a patient with cocaine use: An extensive case with necrosis of skin, soft tissue, and cartilage. [scielo.org.mx]

Calciphylaxis

Calciphylaxis is a poorly understood and highly morbid syndrome of vascular calcification and skin necrosis. [ncbi.nlm.nih.gov]

The serum parathyroid hormone, calcium, and phosphorus levels improved, but the skin necrosis and clinical status worsened. [doi.org]

Some authors describe as a syndrome of vascular calcification, thrombosis and skin necrosis. [radiopaedia.org]

Heparin-Induced Thrombocytopenia

necrosis Skin necrosis at subcutaneous heparin injection sites +3 Acute systemic reaction Acute systemic reaction after intravenous heparin bolus +2 Bleeding Presence of [depts.washington.edu]

necrosis syndromes). [ncbi.nlm.nih.gov]

This typical HIT can result in deep vein thrombosis, pulmonary embolism, occlusion of a limb artery, acute myocardial infarct, stroke, and a systemic reaction or skin necrosis [ncbi.nlm.nih.gov]

Pituitary Cushing Syndrome

The clinical features, diagnosis and management of 16 consecutive patients with ectopic ACTH production are described and biochemical data are compared with those of 48 consecutive patients with pituitary-dependent Cushing's disease. In 10 cases the ectopic ACTH secreting tumour was completely occult to routine[…] [ncbi.nlm.nih.gov]

Protein C Deficiency

Non-vitamin K antagonist anticoagulant options should be considered in patients with warfarin-induced skin necrosis (WISN) in the setting of protein C. [ncbi.nlm.nih.gov]

Warfarin induced skin necrosis associated with acquired protein C deficiency. [jnma.com.np]

Idiopathic Recurrent and Disabling Cutaneous Herpes

skin necrosis on the lower abdomen. [emedicine.medscape.com]

Skin ulceration or necrosis is unusual. Jaundice and/or pallor can follow a severe episode of hemolysis. [emedicine.medscape.com]

necrosis [10] Warfarin-induced skin necrosis is an uncommon serious complication of oral anticoagulation therapy (see the image below). [11, 12, 13] Warfarin (Coumadin)–induced [emedicine.medscape.com]

Neonatal Purpura Fulminans

In the early hours of life, the neonate presents with extensive purpura fulminans and substantial skin necrosis contrasting with a preserved general state and a negative infectious [chu-fes.ma]

necrosis, disseminated intravascular coagulation. [nepjol.info]

[…] resulting from coagulation in small blood vessels within the skin and rapidly leads to skin necrosis and disseminated intravascular coagulation.[2][3] Causes[edit] Purpura [en.wikipedia.org]

Purpura Fulminans

Dermal vascular skin necrosis is associated with a complex group of clinical disorders. [ncbi.nlm.nih.gov]

This book is the first to discuss skin necrosis as a symptom related to a broad range of pathologies. [books.google.it]

KEYWORDS: anticoagulant; factor V Leiden; protein C; protein S; skin necrosis; thrombosis [ncbi.nlm.nih.gov]

Hypertensive Ischemic Ulcer

Martorell hypertensive ischemic leg ulcer is a severe type of skin necrosis (skin infarction) which occurs in long-term hypertensive subjects. [clinicaltrials.gov]

necrosis in chronic renal insufficiency, (3) nonuremic calciphylaxis in morbid obesity with proximal skin necrosis (eutrophication: body water enriched with nutrients or [journals.lww.com]

Both patients had severe necrosis of the skin of buttocks and lower extremities, often originating in localized areas of livedo reticularis. [annals.org]

Protein S Deficiency

Cases of skin necrosis have been documented in patients with protein C or S deficiency while being treated with warfarin. [ncbi.nlm.nih.gov]

[…] the microthrombosis responsible for skin necrosis. [ncbi.nlm.nih.gov]

Abstract We report a case of a 6-year-old girl with severe protein S deficiency due to a homozygous mutation and recurrent episodes of skin necrosis. [ncbi.nlm.nih.gov]

Brown Recluse Spider Bite

[…] changes over several days leading to skin necrosis. [ijam-web.org]

Abstract The objectives in the treatment of the brown recluse spider bite are to prevent skin necrosis and the need for reconstructive surgery. [ncbi.nlm.nih.gov]

Pictured: the same person as in the previous slide, after three days, with initial stages of skin necrosis. [onhealth.com]

Scedosporiosis

Case report Open Access Published: 14 January 2017 Sung-Chul Lim2, Joa Kim3, Hoe-Soo Jang3, Jong-Hun Chung3, Na-Ra Yun3, Dong-Min Kim3, Piyush Jha3, Babita Jha3, Seok Won Kim4, Sook Jin Jang5 & […] Jong Hee Shin6 BMC Infectious Diseases volume 17, Article number: 72 (2017) Cite this article 1442 Accesses 4 Citations 1[…] [bmcinfectdis.biomedcentral.com]

Fat Necrosis of the Breast

We believe that the patient developed skin and fat necrosis secondary to the MB dye injection. [issoonline.biomedcentral.com]

Fat necrosis is a self limiting condition where fat beneath the skin dies; usually the result of blunt trauma, sometimes the result of surgery. [realself.com]

Additional symptoms of breast fat necrosis include pain/ tenderness and there may also be a fluid discharge. Dimpling of the skin is possible as well. [ic.steadyhealth.com]

Hereditary Thrombophilia due to Congenital Protein S Deficiency

Tornjen S, Somell A: Warfarin skin necrosis of the breast. Acta Chir Scand 1982;148:471–472. Sternberg ML, Pettyjohn FS: Warfarin sodium-induced skin necrosis. [karger.com]

necrosis. [pediatrics.aappublications.org]

Inherited causes of thrombosis Factor V Leiden Prothrombin 202010 Mutation Hyperhomocysteinemia Elevated Clotting Factor Levels Antithrombin Protein C Deficiency Skin Necrosis [ihtc.org]

Mycotoxin T2 Exposure

Symptoms and signs Skin Local pain Pruritus Skin redness Vesicle s Skin necrosis and sloughing Respiratory Nose and throat pain Nasal discharge Itch ing and sneezing Cough [fpnotebook.com]

When skin is exposed to mycotoxins, burning, redness, blistering, and skin necrosis occur. [mycotoxintestinglab.com]

Initial symptoms include burning skin pain, redness, tenderness, blistering, and progression to skin necrosis (tissue death) with leathery blackening and sloughing of large [firehouse.com]

Ischemic Ulcer

necrosis in chronic renal insufficiency, (3) nonuremic calciphylaxis in morbid obesity with proximal skin necrosis (eutrophication: body water enriched with nutrients or [journals.lww.com]

[…] anorganic substances leading to calcification), and (4) calciphylaxis with proximal skin necrosis, were compared with PG on pathophysiological features. 3,4 Martorell HYTILU [journals.lww.com]

[…] and morbid obesity (proximal skin necrosis), ischemic subcutaneous arteriolosclerosis represents the common hallmark of these conditions. [journals.lww.com]

Calcaneus Fracture

[…] underwent open reduction and internal fixation had postoperative wound infections and skin necrosis. [ncbi.nlm.nih.gov]

Management: Surgical Management Emergent Surgery Indications Compartment Syndrome Tongue -Type (extra-articular Fracture ) Risk of skin necrosis from ankle tendons (gastrocnemius [fpnotebook.com]

No patient who underwent a minimally invasive reduction had skin lesions, but showed pain due to osteoarthritis lesions that appeared in the subtalar joint. 4 of them, who [ncbi.nlm.nih.gov]

Penile Gangrene

Warfarin-induced skin necrosis. Annals of dermatology. 2014;26(1):96-8. Chan Y, Valenti D, Mansfield A, Stansby G. Warfarin induced skin necrosis. [journals.sbmu.ac.ir]

We present in the current study, a patient who presented with progressive penile gangrene and skin necrosis due to CUA. [ncbi.nlm.nih.gov]

Surgery may be necessary to excise the remaining necrosis [ 3 ]. [em-consulte.com]

Subcutaneous Fat Necrosis of the Newborn

Self-skin examination New smartphone apps to check your skin Learn more (Sponsored content) Related information References Subcutaneous fat necrosis of the newborn: a systematic [dermnetnz.org]

[…] w subcutaneous nodular fat necrosis Pancreatitis with subcutaneous nodular fat necrosis Skin disorder, degenerative Subcutaneous nodular fat necrosis in pancreatitis Xanthomatosis [icd9data.com]

Perinatal stress like in aspyhxia, meconium aspiration or hypothermia, followed by skin hypoperfusion may lead to subcutaneous fat necrosis. [humpath.com]

Subcutaneous Fat Necrosis

It leads to fat crystillisation and necrosis. Skin biopsy revealed necrotic focus and crystallisation in fat cells. Hypercalcemia may be a potential complication. [ncbi.nlm.nih.gov]

Self-skin examination New smartphone apps to check your skin Learn more (Sponsored content) Related information References Subcutaneous fat necrosis of the newborn: a systematic [dermnetnz.org]