Skin Pigmentation Causes & Reasons

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Possible Causes

Vitamin D Deficiency

Vitamin D variations among races are attributed to differences in skin pigmentation. [sciencedaily.com]

Vitamin D levels varied according to the pigmentation of the skin. People with dark skin often record lower levels of vitamin D, according to the researchers. [news.uga.edu]

The most common nutritional deficiency worldwide, characterised by serum 25-hydroxyvitamin D Main causes include sun avoidance, using sun protection, increased skin pigmentation [bestpractice.bmj.com]

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Vitiligo

DETROIT - A treatment regimen is safe and effective for restoring skin pigmentation in vitiligo patients, according to a Henry Ford Hospital study. [eurekalert.org]

These patches of skin are chalk white in color because they have no pigment. [ucihealth.org]

pigmentation. [sciencedaily.com]

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Hemochromatosis

pigmentation, and cirrhosis. [doi.org]

Eight of the 16 homozygous subjects had clinical findings that were consistent with the presence of hereditary hemochromatosis, such as hepatomegaly, skin pigmentation, and [ncbi.nlm.nih.gov]

Changes in the pigment of the skin may appear, such as grayness in certain areas, or a tanned or yellow ( jaundice ) appearance. [medical-dictionary.thefreedictionary.com]

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Cronkhite-Canada Syndrome

175500 POLYPOSIS, SKIN PIGMENTATION, ALOPECIA, AND FINGERNAIL CHANGES Alternative titles; symbols CRONKHITE-CANADA SYNDROME SNOMEDCT: 76304001; ORPHA: 2930; DO: 6225; TEXT [omim.org]

pigmentation, alopecia, and fingernail changes Cronkhite-Canada Syndrome Gastrointestinal polyposis-skin pigmentation-alopecia-fingernail changes syndrome Cronkhite-Canada [wikidata.org]

[…] disease Gastrointestinal polyposis-ectodermal changes syndrome Polyposis skin pigmentation alopecia fingernail changes intestinal polyposis edit Language Label Description [wikidata.org]

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Acanthosis Nigricans

Tristimulus colorimetry and diffuse reflectance spectroscopy (DRS) are white-light skin reflectance techniques used to measure the intensity of skin pigmentation. [ncbi.nlm.nih.gov]

Call your provider if you develop areas of thick, dark, velvety skin. AN; Skin pigment disorder - acanthosis nigricans Habif TP. [nlm.nih.gov]

Acanthosis nigricans (AN) is (usually) a benign skin condition typically characterized by hyperpigmentation (darkening of skin pigment) often accompanied by a velvety change [pre-diabetes.com]

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Hallervorden-Spatz Syndrome

These features include abnormal hair and pigmentation, laxity of the skin, metaphyseal dysplasia, cerebellar degeneration, and failure to thrive. [ommbid.mhmedical.com]

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Skin Cancer

More than 95% are shades of brown (melanin skin pigment) and develop in previously ‘normal’ moles that change (30%) or begin as completely new moles (70%). [bapras.org.uk]

Melanomas begin in melanocytes, the specialized cells in your skin that produce melanin (a skin pigment). [healthinaging.org]

Non-melanoma and melanoma skin cancer is more common in lighter-skinned populations than in darker-skinned populations due to their paler skin pigmentation. [wcrf.org]

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Lentigo Maligna Melanoma

Melanin is the dark pigment that gives the skin its natural colour. Melanin is made in the skin by pigment cells called melanocytes. [cedarsderm.co.uk]

Melanocytes are cells that produce melanin; the pigment that gives skin its color Lentigo Maligna Melanoma (LMM) is a type of skin cancer, wherein skin invasion by the melanocytes [dovemed.com]

They develop when the skin pigment cells (melanocytes) become cancerous and multiply in an uncontrolled way. [cedarsderm.co.uk]

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Dyskeratosis Congenita

Patient's one son and one daughter also had similar skin pigmentation. [ncbi.nlm.nih.gov]

The typical clinical features consist of lacy reticular skin pigmentation, nail dystrophy and oral leukoplakia. [ncbi.nlm.nih.gov]

Dyskeratosis congenita is a general term for genetic disorders that lead to excess skin pigmentation, nail dystrophy and mucosal leukoplakia. [symptoma.com]

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Skin Neoplasm

MOLE a benign overgrowth of skin pigment forming cells called melanocytes (melanin, the skin pigment, and cyte, cell) on the skin surface, present at birth or appearing early [quizlet.com]

Freckles; discolored areas of the skin, called mottled pigmentation; and sallowness, yellow discoloration of the skin. [my.clevelandclinic.org]

Non-solar factors are the predominant risk factor in the darkly pigmented. The pattern of skin cancer in Caucasians contrast sharply with the darkly pigmented in Africa. [scitechnol.com]

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Penile Intraepithelial Neoplasia

Lesions may also be heavily pigmented, resembling melanoma. Occasionally they may have associated leukoplakic, nodular, or ulcerated changes. [ncbi.nlm.nih.gov]

[…] the mucosal surfaces of the genitalia, such as the inner prepuce and glans, are called EQ, while BD is essentially considered the same pathological process affecting the skin [ncbi.nlm.nih.gov]

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Hoyeraal-Hreidarsson Syndrome

He had progressive skin pigmentation, oral leukoplakia, and nail dysplasia leading to anonychia. Whole exome sequencing identified novel biallelic variants in PARN. [ncbi.nlm.nih.gov]

We report here a case of a 6-year-old girl with HH who presented with bone marrow hypoplasia, skin pigmentation, nail dystrophy, growth retardation, and bilateral retinal [ncbi.nlm.nih.gov]

X-linked dyskeratosis congenita (DC) is an inherited bone-marrow-failure syndrome characterized by skin pigmentation, nail dystrophy and leucoplakia which usually develop [ncbi.nlm.nih.gov]

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Sunburn

Lighter skin pigmentation is a factor, whether congenital or acquired. Being suntanned gives protection. Skin type is graded I to VI according to risk of burning. [patient.info]

[…] damage. [9] The increased skin pigmentation occurs in 2 phases: (1) immediate pigment darkening and (2) delayed tanning. [emedicine.com]

Less intense or shorter-duration exposure to UVR leads to increased skin pigmentation (tanning) which provides some protection against further UVR-induced damage. [patient.info]

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Carney Complex

CNC is characterized by the presence of myxomas, spotty skin pigmentation, and endocrine overactivity. [ncbi.nlm.nih.gov]

All 6 patients with this PRKAR1A gene mutation had skin pigmentation. [ncbi.nlm.nih.gov]

Carney complex is an autosomal dominant disease that is clinically characterized by cardiac myxomas, spotty skin pigmentation, and endocrine overactivity. [ncbi.nlm.nih.gov]

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Chloasma

There is an increase in melanin – the pigment that is responsible for skin color. [healthhype.com]

Its breakthrough lasers are capable of safely and precisely shattering pigment without injuring the surrounding skin. [belomed.com]

A Wood’s lamp highlights the pigmentation since it is arises in the epidermis (superficial layer of the skin). Dermal Lighter brown patches. Poorly-defined borders. [healthhype.com]

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McCune-Albright Syndrome

She had multiple fibrous dysplasia, skin pigmentation, and acromegaly. The markedly high bone turnover rate during pregnancy tended to decrease after a normal delivery. [ncbi.nlm.nih.gov]

McCune -Albright syndrome is a rare benign disorder characterized by the association of polyostotic fibrous dysplasia, cafè-au-lait skin pigmentations and endocrine dysfunction [ncbi.nlm.nih.gov]

Recently we encountered a patient with MAS with fibrous dysplasia, skin pigmentation, acromegaly, hyperprolactinemia and a thyroid nodule. [ncbi.nlm.nih.gov]

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Congenital Nevus

Talk to your child's provider if your child has a large pigmented area anywhere on their skin. [medlineplus.gov]

Definition A congenital pigmented or melanocytic nevus is a dark-colored, often hairy, patch of skin. It is present at birth or appears in the first year of life. [ufhealth.org]

A congenital pigmented or melanocytic nevus is a dark-colored, often hairy, patch of skin. It is present at birth or appears in the first year of life. [medlineplus.gov]

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Actinic Keratosis

Melanocytes, the cells responsible for skin pigmentation, are more sensitive than keratinocytes; thus cryosurgery often leaves white spots. [advancedplasticde.com]

skin lesions. [ncbi.nlm.nih.gov]

To investigate the frequency of dermatoscopic findings suggestive of LM/lentigo maligna melanoma (LMM) in the other facial pigmented skin lesions (FPSL) and to assess the [ncbi.nlm.nih.gov]

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Acromelanosis

[…] of skin Argyria of skin (disorder) Arsenic-induced skin pigmentation Arsenic-induced skin pigmentation (disorder) Carotene pigmentation of skin Carotene pigmentation of skin [averbis.com]

Among the four normal skin pigments oxyhemoglobin, reduced hemoglobin, melanin, and carotene, melanin is the most important The skin can protect itself effectively. [ucypunireqy.cf]

Abstract Acromelanosis is an independent disease entity, characterized by increased skin pigmentation, usually located on the acral areas of the fingers and toes. [unboundmedicine.com]

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Primary Pigmented Nodular Adrenocortical Disease

PPNAD may occur in an isolated form or associated with a multiple neoplasia syndrome, the complex of spotty skin pigmentation, myxomas, and endocrine overactivity, or Carney [ncbi.nlm.nih.gov]

[…] multiple neoplasia syndrome characterized by spotty skin pigmentation, cardiac myxomas, and endocrine tumors or be isolated (i). [ncbi.nlm.nih.gov]

The CNC is an autosomal dominant multiple neoplasia syndrome characterized by the association of myxoma, spotty skin pigmentation and endocrine overactivity. [ncbi.nlm.nih.gov]

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Bloch Sulzberger Syndrome

Incontinentia pigmenti, sometimes referred to as IP or Bloch-Sulzberger syndrome, is an unusual inherited disorder of skin pigmentation that is associated with abnormalities [emedicinehealth.com]

She presented in early childhood with inflammatory vesicular skin changes which changed into pigmented skin alterations especially on the trunk. [ncbi.nlm.nih.gov]

Discolored skin is caused by excessive deposits of melanin (normal skin pigment) Males are more severely affected than females Most newborns with IP will develop discolored [internationalpain.org]

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Albinism

CONCLUSION: The majority of pigmented lesions were dendritic freckles that occurred on sun-exposed skin. [ncbi.nlm.nih.gov]

Albinism is a disorder of skin pigmentation that occurs in people of all ethnicities and throughout the world. [merckmanuals.com]

BACKGROUND: Oculocutaneous albinism (OCA) is a group of genetic disorders characterized by diminished pigmentation of the skin, hair and eyes. [ncbi.nlm.nih.gov]

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Congenital Non-Neoplastic Nevus

Definition A congenital pigmented or melanocytic nevus is a dark-colored, often hairy, patch of skin. [nicklauschildrens.org]

Talk to your child's provider if your child has a large pigmented area anywhere on their skin. [medlineplus.gov]

pigmented naevus (lip) Q82.5 Benign skin neoplasm, pigmented naevus (lower limb, hip) Q82.5 Benign skin neoplasm, pigmented naevus (other specified site) Q82.5 Benign skin [cdc.gov]

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Oculocutaneous Albinism

Five different gene products (NCKX1-5) have been identified in humans, which play key roles in biological processes including vision, olfaction, and skin pigmentation. [ncbi.nlm.nih.gov]

Genetic and developmental disorders affecting the skin Genetic syndromes affecting the skin EC23 Genetic disorders of skin pigmentation H00168 Oculocutaneous albinism Pathway [genome.jp]

To evaluate methods of quantifying eye pigmentation, skin pigmentation and other clinical parameters that may be usable as outcome measures in future treatment studies. [clinicaltrials.gov]

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Blue Nevus

(which makes melanin pigment) in the dermis or skin. [dovemed.com]

A blue nevus is a benign proliferation of melanocytes (which makes melanin pigment) in the dermis or skin that is generally bluish in appearance In a Cellular Blue Nevus, [dovemed.com]

It is performed to examine the change in skin pigmentation Skin biopsy: A skin biopsy is performed and sent to a laboratory for a pathological examination. [dovemed.com]

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Ocular Albinism

Affected individuals usually manifest both ocular and cutaneous features of the disease, but occasionally hair and skin pigmentation may appear normal. [ncbi.nlm.nih.gov]

Do some kids with OCA have normal hair and skin pigment? [visionofchildren.org]

Some of them will also have blotchy skin changes with relative hyper- and hypo- pigmentation. [visionofchildren.org]

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Pigmented Purpuric Lichenoid Dermatosis

Degenerative disorder (disorder) Disorder of skin pigmentation Idiopathic capillaritis (disorder) Lichenoid dermatitis Purpuric disorder Name: Pigmented purpuric lichenoid [snomedbrowser.com]

Skin Pigmentation Disorders Also called: Hyperpigmentation, Hypopigmentation Pigmentation means coloring. Skin pigmentation disorders affect the color of your skin. [icdlist.com]

Medical dictionary Pigmented purpuric dermatosis — Classification and external resources ICD 10 L81.7 OMIM 172900 Diseases … Wikipedia lichenoid dermatosis — any skin disorder [translate.academic.ru]

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Nodular Malignant Melanoma

[…] neoplasms, Skin pigmentation Abstract Eccrine poroma is a relatively rare benign adnexal tumor with multiple clinical presentations, mimicking several other cutaneous neoplasms [revista.spdv.com.pt]

Both nodular melanomas and the more typical "spreading" melanomas begin in skin cells called melanocytes, which produce the skin pigment melanin. [livescience.com]

Overview Melanoma, the most serious type of skin cancer, develops in the cells (melanocytes) that produce melanin — the pigment that gives your skin its color. [mayoclinic.org]

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Becker Nevus Syndrome

It is due to an overgrowth of the epidermis (upper layer of the skin) pigment cells (clonocytes) and hair follicles. [jcnonweb.com]

It is due to an overgrowth of the epidermis (upper layers of the skin), pigment cells ( melanocytes ) and hair follicles. [dermnetnz.org]

[…] darker, and excessive hair growth ( hypertrichosis ) and acne may develop within the nevus. [1] [2] Becker's nevus is due to overgrowth of the epidermis (upper layer of the skin [rarediseases.info.nih.gov]

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Piebaldism

Those subjects who have used skin ointments and any pigmentation disorders / skin diseases were excluded. [mafiadoc.com]

This removes the outer layer of dead skin cells and also stimulates the nearby cells to produce pigments. [lybrate.com]

In albinism hair and skin are completely without skin pigment. In piebaldism, the patches are static and do not increase in size or number. [dynamicnaturesite.blogspot.com]

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