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62 Possible Causes for Skin Plaque, Vacuolation of Granular Layer

  • Ichthyosis Vulgaris

    , characterized by dark-brown scale typical of ichthyosis vulgaris and blaschkolinear, atrophic, scaly plaques.[ncbi.nlm.nih.gov] Histopathologically, the cells of the granular cell layer and the upper part of stratum spinosum develop intracytoplasmic vacuoles, an increased number and size of keratohyaline[medcaretips.com] […] scaly patches and plaques Clinical images Images hosted on other servers: Lamellar ichthyosis Microscopic (histologic) description Increased stratum corneum with loss of[pathologyoutlines.com]

  • Molluscum Contagiosum

    ‘Waxy, painless, skin-colored bumps called molluscum contagiosum, are also caused by a virus.’[en.oxforddictionaries.com] The nucleus becomes compressed at the level of the granular cell layer, and the molluscum bodies lose their internal structural markings.[dermatology.cdlib.org] , Pustules or Necrosis usually occurs over the cheek Lymphatic involvement: – Overlying skin streaking & regional lymphadenopathy indicate lymphatic involvement.[lecturio.com]

  • Pityriasis Lichenoides et Varioliformis

    […] parapsoriasis Clinical Information An inflammatory skin disorder of unknown etiology characterized by papules and plaques or scaly patches resembling psoriasis The term applied[icd9data.com] layer, basilar necrosis of keratinocytes, vacuolar interface dermatitis with a lymphocyte in nearly every vacuole, erythrocyte extravasation, and dermal oedema PLC lesions[pcds.org.uk] New lesions developed abruptly within 1 month, forming generalized annular erythematous plaques with yellowish scales on the border.[tandfonline.com]

  • Ichthyosis

    The dead cells of this horny layer do not slough off at the normal rate but tend instead to adhere to the skin surface to form scales; horny plaques and papules may also be[britannica.com] Histopathologically, the cells of the granular cell layer and the upper part of stratum spinosum develop intracytoplasmic vacuoles, an increased number and size of keratohyaline[medcaretips.com] […] or binucleated cells in the granular and suprabasal layers, although no granular degeneration is seen. 67, 68 Characteristically, the electron microscopic study of both normal‐looking[onlinelibrary.wiley.com]

  • Pityriasis Rubra Pilaris

    In some cases, a skin biopsy will be performed to accurately diagnose a lesion. Plaque Psoriasis of the Gluteal Cleft CDC/Dr.[psoriasis.about.com] Hyperkeratosis, parakeratosis, preserved granular layer and psoriasiform hyperplasia were showed in all biopsies.[ncbi.nlm.nih.gov] Pityriasis rubra pilaris (PRP) is a chronic papulosquamous eruption of the skin characterized by follicular hyperkeratosis, salmon pink scaly plaques with islands of unaffected[ncbi.nlm.nih.gov]

  • Bullous Erythroderma Ichthyosiformes

    Ichthyosis annular epidermolytic (AEI) [MIM:607602]: A skin disorder resembling bullous congenital ichthyosiform erythroderma.[genecards.org] These become mature corps ronds by further vacuolization when in the granular layer.[ijdpdd.com] As the hyperkeratosis became more prominent, the skin developed a foul odor.[ommegaonline.org]

  • Epidermodysplasia Verruciformis

    Widespread skin eruptions of flat-to-papillomatous, wart like lesions and reddish-brown pigmented plaques on the trunk, the hands, the upper and lower extremities, and the[medigoo.com] layer.[ncbi.nlm.nih.gov] Symptoms may include a mix of: flat-topped or bumpy lesions small, raised bumps known as papules large patches of raised and inflamed skin, known as plaques small, raised[healthline.com]

  • Ventral Hernia

    […] colored or erythematous papule / plaque Often multiple Commonly on hands and feets May have black dots within the lesion (correlating with thrombosed capillaries in dermal[pathologyoutlines.com] Malignant skin cancer without pigment and thus typically presents as a pink/flesh-colored papule or plaque with loss of skin lines, but lacks the classic mosaic verrucous[dermatologyadvisor.com] Cells with prominent perinuclear vacuolization around pyknotic, basophilic, centrally located nuclei can be in the granular layer.[ncbi.nlm.nih.gov]

  • Necrobiotic Xanthogranuloma

    Examination of the skin demonstrated variable sized annular plaques with central atrophy, some with prominent indurated border and yellow discoloration.[ncbi.nlm.nih.gov] (D) Large vacuolated cells with grayish cytoplasm and vesicular nuclei in the upper spinal and granular layers (original magnification x100).[avensonline.org] The periorbital skin is the most common site for NXG. Extracutaneous involvement of ocular, respiratory, cardiac, or other tissues may occur.[dpsarmadermpath.com]

  • Glucagonoma

    The skin condition commonly begins as red lumps and plaques in the perineum (the area between the genitals and anus), groins, or abdomen, and it may migrate to the extremities[endocrinediseases.org] A skin biopsy performed on a peritibial lesion showed a spongiotic epidermis with vacuolization of the granular layer and presence of necrotic keratinocytes in the horny layer[jmedicalcasereports.biomedcentral.com] Necrolytic migratory erythema (NME) is a rare skin disorder that is a cutaneous manifestation of the glucagonoma syndrome.[ncbi.nlm.nih.gov]

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