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2,582 Possible Causes for Skin Thickening

  • Ichthyosis Vulgaris

    Symptoms may include any of the following: Dry skin, severe Scaly skin ( scales ) Possible skin thickening Mild itching of the skin The dry, scaly skin is usually most severe[] As older skin cells build up on the skin’s surface, the skin thickens and becomes scaly.[] Symptoms of ichthyosis vulgaris include: a flaky scalp itchy skin polygon-shaped scales on the skin scales that are brown, grey or white severely dry skin thickened skin When[]

  • Rosacea

    Skin thickening: In some cases of rosacea, the skin might thicken and enlarge from excess tissue, resulting in a condition called rhinophyma.[] The central facial skin may be rough, and thus appear to be very dry. Plaques. Raised red patches may develop without changes in the surrounding skin. Skin thickening.[] Dry appearance: The central facial skin might be rough, and thus appear to be very dry.[]

  • Mucopolysaccharidosis

    Thickened skin and mild changes in facial features, bone, and skeletal structures become noticeable with age. Growth in height usually stops by age 10.[] Non-specific cutaneous changes that can be seen in all mucopolysaccharidoses are thickened skin with a loss of elasticity on elbows and knees, rough hair and hypertrichosis[] Skin Tough, thickened skin in individuals with MPS I often makes needle sticks difficult. Examine optic nerve for compression and atrophy.[]

  • Mucopolysaccharidosis 2

    thickening, claw and shortened fingers (bradydactyly) with painless nodules.[] Additional dermatological findings include hypertrichosis, thickened skin, and multiple Mongolian spots. Hypertrichosis may result in synophrys.[] Some of the clinical manifestations of GAG accumulation include coarse facial features, corneal clouding, thickened skin, and organomegaly.[]

  • Acromegaly

    (sebaceous glands) causing oily skin, thickening of the skin, skin tags (growths) Sleep apnea Widened fingers or toes, with swelling, redness, and pain Other symptoms that[] Hands and feet become enlarged; facial features are exaggerated as the jaw lengthens and the nose and forehead grow thicker; the skin thickens; and most internal organs enlarge[] […] joint Large bones of the face, large jaw and tongue, widely spaced teeth Large feet (change in shoe size), large hands (change in ring or glove size) Large glands in the skin[]

  • Ichthyosis

    As older skin cells build up on the skin’s surface, the skin thickens and becomes scaly.[] Symptoms Dry skin, severe Scaly skin ( scales ) Possible skin thickening Mild itching of the skin The dry, scaly skin is usually most severe on the legs.[] The project in short Sjögren-Larsson Syndrome (SLS) is a rare inborn error of aldehyde metabolism characterized by severe skin thickening (ichthyosis), retinal disease, and[]

  • Diffuse Scleroderma

    […] symptoms - fatigue, weight loss, pruritis Skin thickening - no or minimal progression Skin thickening - rapid progression, usually reaching peak involvement within 2 years[] METHODS: Diffuse cutaneous SSc patients older than 16 years of age evaluated at the University of Pittsburgh within 2 years of the first evidence of skin thickening between[] A rapid onset form of SYSTEMIC SCLERODERMA with progressive widespread SKIN thickening over the arms, the legs and the trunk, resulting in stiffness and disability.[]

  • Congenital Ichthyosis

    As the cells are TGM1 deficient, like those of a patient with lamellar ichthyosis, they form abnormal, thickened skin.[] Patients with HI are born with profoundly thickened skin. Rigidity of the skin results in marked ectropion, everted lips and distorted nose and ears.[] The term "ichthyosis" is derived from Greek and means "fish disease", referring to the dry, thickened, scaling skin that characterises the condition.[]

  • Systemic Scleroderma

    Progressive skin thickening and organ damage decrease.[] Indications for Testing Individuals with skin thickening of the fingers that extends proximal to the metacarpophalangeal joints should be tested for SSc.[] Raynaud's phenomenon is often experienced for years before skin thickening is evident.[]

  • Acanthosis Nigricans

    Clinically, AMN is characterized by rapidly progressive symmetrical skin thickening and hyperpigmentation of the intertriginous areas with peripheral acrochorda.[] Acanthosis nigricans (OMIM ID % 100600) is a dermatosis characterized by velvety hyperpigmentation, skin thickening, and papillomatosis.[] In general, patients show an area of darkening and thickening of skin without any symptoms. Occasionally, pruritus may be seen.[]

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