Slow Progression: Causes & Reasons

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Possible Causes for Slow Progression

Retinitis Pigmentosa

Findings of controlled trials indicate that nutritional interventions, including vitamin A palmitate and omega-3-rich fish, slow progression of disease in many patients. [ncbi.nlm.nih.gov]

Some extreme cases may have a rapid evolution over two decades or a slow progression that never leads to blindness. [ncbi.nlm.nih.gov]

A six-year study at Harvard that included 600 patients ranging in age from 18 to 49 showed that vitamin A slowed the progression of retinitis pigmentosa by about 20 percent [drweil.com]

Nuclear Cataract

Cortical cataracts also tend to have a slow, steady progression but cause more trouble with glare and haziness. [health.clevelandclinic.org]

In addition, a balanced diet containing a reasonable amount of antioxidant vitamins may help slow the progression of cataracts, while supporting overall health. [ophthalmicconsultants.com]

[…] cataract progression. [aoa.org]

Multiple Sclerosis

High vitamin D levels are probably protective against the development of MS, although the efficacy of vitamin D supplementation in slowing progression of MS remains to be [ncbi.nlm.nih.gov]

Over time, some patients will experience “progression,” less inflammatory changes and more of a slow, progressive worsening of multiple symptoms and disability. [umms.org]

In either case, incremental progress in slowing disability progression in future MS dinical trials will require much larger sample sizes, more sensitive outcome measures, [ncbi.nlm.nih.gov]

Myofibrillar Myopathy Type 3

[…] is typically slow with most remaining ambulatory. [practicalneurology.com]

[…] is slow but relentless, eventually involving proximal muscles, and leading to wheelchair dependency 10 to 20 years after symptom onset. [practicalneurology.com]

[…] presenting with the triad of onset before age 20 years, early involvement of posterior foreleg muscles, and markedly elevated CK levels (20-50 times normal upper limit).18 Progression [practicalneurology.com]

Autosomal Dominant Spastic Paraplegia Type 38

UniProtKB/Swiss-Prot : 76 Spastic paraplegia 56, autosomal recessive: A form of spastic paraplegia, a neurodegenerative disorder characterized by a slow, gradual, progressive [malacards.org]

Chronic Kidney Insufficiency

It’s important to be tested for kidney disease if you have diabetes so it can be detected early and treated to slow progression of the damage. [heart.org]

Control of high blood pressure: This also slows progression of chronic kidney disease. [emedicinehealth.com]

Glycaemic control for diabetic nephropathy and optimisation of blood pressure are key in slowing the progression of disease. Increased risk for cardiovascular disease. [bestpractice.bmj.com]

Geographic Atrophy

GA is a slow progressing disease making clinical trial design challenging for treatments that not only slow GA progression, but also dry AMD progression. [spherixglobalinsights.com]

My ultimate goal, and the focus of all of us at Gyroscope, is to develop a one-time gene therapy designed to slow GA’s devastating progression. [gyroscopetx.com]

[…] the progression of geographic atrophy [gene.com]

Macular Degeneration

Your doctor may recommend a combination of vitamins or diet changes to slow progression. [share.upmc.com]

Although there is currently no way to treat dry AMD, age-related eye disease studies have shown that a vitamin supplement can slow the progression. [starlingphysicians.com]

However, taking supplements of omega-3 fatty acids does not slow the progression of the disorder. [merckmanuals.com]

Diabetic Nephropathy

Angiotensin converting enzyme (ACE) inhibitors can help slow down the progression of kidney damage. [webmd.com]

progression of diabetic nephropathy in patients with type 2 diabetes makes the drug the first new treatment option in nearly 20 years indicated for slowing diabetic kidney [renalandurologynews.com]

progression to renal failure. [accessmedicine.mhmedical.com]

Pulmonary Fibrosis

A large clinical trial published in May 2014 showed that NAC does not slow progression of IPF. [lung.ca]

How can pulmonary rehabilitation slow disease progression? [pulmonaryfibrosisnews.com]

Nintedanib is a tyrosine kinase inhibitor that efficiently slows idiopathic pulmonary fibrosis progression and has an acceptable tolerability profile. [ncbi.nlm.nih.gov]

Biliary Cirrhosis

They consider a liver transplant when they cannot control complications through treatment. 3 Primary biliary cirrhosis is a slow, progressive disease. [badgut.org]

Will this slow down the progression of the disease? Will any medications be prescribed? What are the side effects? [healthcentral.com]

The development of cirrhosis in the liver is the end result of PBC. 4 Since PBC is incurable, physicians aim treatment at slowing progression of the disease, relieving symptoms [badgut.org]

Muscular Dystrophy

[…] is slow. [urmc.rochester.edu]

Distal 40 to 60 years Age at onset Age at onset Symptoms include weakness and wasting of muscles of the hands, forearms, and lower legs; progression is slow; rarely leads [hopkinsmedicine.org]

An ACE inhibitor and/or a beta-blocker may help prevent or slow progression of cardiomyopathy. [merckmanuals.com]

Limb-Girdle Muscular Dystrophy Type 2F

It is characterized by early weakness and atrophy of the pelvic and shoulder girdle muscles in adolescence or young adulthood, with slow progression. [jewishgeneticdiseases.org]

In general slow progression of weakness is to be expected. The affected muscles get worse and it spreads to more muscles. [checkorphan.org]

There is usually slow progression. [patient.info]

Limb-Girdle Muscular Dystrophy Type 2Q

It is characterized by early weakness and atrophy of the pelvic and shoulder girdle muscles in adolescence or young adulthood, with slow progression. [jewishgeneticdiseases.org]

There is usually slow progression. [patient.info]

In general slow progression of weakness is to be expected. The affected muscles get worse and it spreads to more muscles. [checkorphan.org]

Lung Scarring

New therapy The findings also reveal promising signs that the drug – called TD139 – may help to slow progression of disease. [medicalxpress.com]

A large clinical trial published in May 2014 showed that NAC does not slow progression of IPF. [lung.ca]

The findings also reveal promising signs that the drug – called TD139 – may help to slow progression of disease. [ed.ac.uk]

Primary Progressive Multiple Sclerosis

progressive multiple sclerosis has been hailed as “big news” by doctors and charities. [telegraph.co.uk]

This new drug also appears to slow progression of a more severe type of the disease, called primary progressive MS. [belmarrahealth.com]

The Food and Drug Administration approved Ocrevus late Tuesday after a large study found it slowed progression of the neurological disease and reduced symptoms. [chicagotribune.com]

Primary Biliary Cirrhosis

PBC is a slowly progressive disease. The disease often can be slowed further with a medication called ursodeoxycholic acid, or UDCA. [newsnetwork.mayoclinic.org]

It has been shown to slow progression of the disease and prevent the need for liver transplantation, which is the last recourse for patients with end-stage disease. [ncbi.nlm.nih.gov]

They consider a liver transplant when they cannot control complications through treatment. 3 Primary biliary cirrhosis is a slow, progressive disease. [badgut.org]

Myopia

The largest positive effects for slowing myopia progression were exhibited by anti-muscarinic medications. [ncbi.nlm.nih.gov]

The largest positive effects for slowing myopia progression were exhibited by anti‐muscarinic medications. [doi.org]

Although none of these modalities are US Food and Drug Administration-approved to slow myopia progression, they have been shown to slow the progression by approximately 50% [ncbi.nlm.nih.gov]

Primary Lateral Sclerosis

Primary lateral sclerosis denotes a clinical state with the insidious onset and slow progression of neurological dysfunction limited to the corticospinal tract. [ncbi.nlm.nih.gov]

CONCLUSIONS: Clinically pure PLS can be defined by isolated UMN signs 4 years after symptom onset, and is a syndrome of slow progression with high levels of function. [ncbi.nlm.nih.gov]

At the other end, there are cases that begin in young adult life and have a slow progression. [web.archive.org]

Retinitis

However, patients generally demonstrate a slow, progressive loss of peripheral vision over many years, until only central (tunnel) vision remains. [uclahealth.org]

Vitamin A palmitate, omega-3 fatty acids, and lutein plus zeaxanthin may help slow progression of vision loss. [merckmanuals.com]

[…] macular edema Intraocular computer chip implants There is no way to reverse damage caused by retinitis pigmentosa, but vitamin A palmitate 15,000 IU orally once a day may help slow [merckmanuals.com]

Limb-Girdle Muscular Dystrophy Type 2J

It is characterized by early weakness and atrophy of the pelvic and shoulder girdle muscles in adolescence or young adulthood, with slow progression. [jewishgeneticdiseases.org]

In general slow progression of weakness is to be expected. The affected muscles get worse and it spreads to more muscles. [checkorphan.org]

There is usually slow progression. [patient.info]

Muscular Dystrophy-Dystroglycanopathy Type C3

It is characterized by early weakness and atrophy of the pelvic and shoulder girdle muscles in adolescence or young adulthood, with slow progression. [jewishgeneticdiseases.org]

In general slow progression of weakness is to be expected. The affected muscles get worse and it spreads to more muscles. [checkorphan.org]

There is usually slow progression. [patient.info]

Muscular Dystrophy-Dystroglycanopathy Type C9

There is usually slow progression. [patient.info]

In general slow progression of weakness is to be expected. The affected muscles get worse and it spreads to more muscles. [checkorphan.org]

progression. [genecards.org]

Limb-Girdle Muscular Dystrophy Type 2B

progressive course. [ncbi.nlm.nih.gov]

LGMD 2B is characterized by early weakness and atrophy of the pelvic and shoulder girdle muscles in adolescence or young adulthood, with slow progression. [egl-eurofins.com]

There is usually slow progression. [patient.info]

Spinocerebellar Ataxia Type 15

Other than notably slow progression, its main distinguishing characteristic is tremor, often affecting the head, which is seen in about half of affecteds and which may be [ncbi.nlm.nih.gov]

The characteristic clinical feature was of very slow progression, with two affected individuals remaining ambulant without aids after over 50 years of symptoms. [ncbi.nlm.nih.gov]

Abstract Background: Spinocerebellar ataxia type 15 (SCA15) is a progressive neurodegenerative disorder characterized by pure cerebellar ataxia, very slow progression, and [n.neurology.org]

Limb-Girdle Muscular Dystrophy Type 2E

It is characterized by early weakness and atrophy of the pelvic and shoulder girdle muscles in adolescence or young adulthood, with slow progression. [jewishgeneticdiseases.org]

There is usually slow progression. [patient.info]

progression. [genecards.org]

Retinal Macular Dystrophy Type 2

progression of the disease. [diabetesdaily.com]

Although there is no cure for macular degeneration, early detection and treatment may slow progression of the disease. [pgheyemds.com]

[…] its progression. [everydayhealth.com]

Limb-Girdle Muscular Dystrophy Type 2L

It is characterized by early weakness and atrophy of the pelvic and shoulder girdle muscles in adolescence or young adulthood, with slow progression. [jewishgeneticdiseases.org]

In general slow progression of weakness is to be expected. The affected muscles get worse and it spreads to more muscles. [checkorphan.org]

There is usually slow progression. [patient.info]

Muscular Dystrophy-Dystroglycanopathy Type C14

It is characterized by early weakness and atrophy of the pelvic and shoulder girdle muscles in adolescence or young adulthood, with slow progression. [jewishgeneticdiseases.org]

There is usually slow progression. [patient.info]

In general slow progression of weakness is to be expected. The affected muscles get worse and it spreads to more muscles. [checkorphan.org]

Upper Motor Neuron Disease

It may slow the progression and extend life by 2-3 months. [can.ubc.ca]

It slows the progression of ALS by a small amount. Physical therapy and bracing can also help with symptoms. [aanem.org]

At the other end, there are cases that begin in young adult life and have a slow progression. [neuropathology-web.org]