Slowly Progressive Disease: Causes & Reasons

Possible Causes for Slowly Progressive Disease

[…] with slowly progressive selective lower extremity weakness, specifically of the hip flexors. [ncbi.nlm.nih.gov]

However, disease progression and diaphragmatic involvement both are highly variable in LOPD patients with and without ERT making it obligatory to assess and monitor respiratory [ncbi.nlm.nih.gov]

Abstract Adult-onset Pompe disease (acid maltase deficiency, glycogen storage disease type II) should be considered in the differential diagnosis in the adult patient presenting [ncbi.nlm.nih.gov]

Retinitis Pigmentosa

It should be noted that RP is a slowly progressive disease over many years and that most patients never become completely blind. [uvahealth.com]

Patients initially experience ring scotoma and night vision problems which, in most cases, slowly progress and lead to the loss of all peripheral vision. [nice.org.uk]

Patients should understand the variable, slowly progressive course of the disease that leads to bilateral, initially peripheral and later central vision loss. [institut-vision.org]

Multiple Sclerosis

A patient with RRMS may accumulate significant disability between relapses while a patient with very slowly progressive disease may remain with minimal disability. [va.gov]

progressing disease may be challenging to identify or may have been misdiagnosed with another condition. [biomarin.com]

Discussion Individuals with rapidly advancing MPS VI are diagnosed earlier than the individuals with slowly progressive disease because of the severity of symptoms, including [pediatrics.aappublications.org]

Geographic Atrophy

progressive disease. [retinatoday.com]

Geographic atrophy is a progressive disease. It will start slowly but gradually worsen. The sooner the condition is diagnosed, the sooner treatment can be started. [bolingvisioncenter.com]

Although it begins slowly, geographic atrophy is a progressive and irreversible disease that leads to central scotomas. [associatedretinaconsultants.com]

Cerebrotendinous Xanthomatosis

Continuing Education Activity Cerebrotendinous xanthomatosis is a rare autosomal recessive lipid storage disease associated with abnormally high cholestanol levels in the blood, accumulating in the nervous system and other organ systems. The cholestanol accumulates most notably in the brain, tendons, eyes, arteries[…] [ncbi.nlm.nih.gov]

Neuronal Intranuclear Inclusion Disease

(NIID) is a slowly progressive neurodegenerative disease characterized by eosinophilic hyaline intranuclear inclusions in the nervous system, and in the visceral organs. [sasappa.co.jp]

Neuronal intranuclear inclusion disease (NIID) is a slowly progressive, neurodegenerative disease. [rarediseases.info.nih.gov]

Nagoya Graduate School of Medicine 2) Department of Therapeutics for Intractable Neurological Disorders, Nagoya Graduate School of Medicine Neuronal intranuclear inclusion disease [sasappa.co.jp]

Pigmented Paravenous Retinochoroidal Atrophy

Pigmented paravenous retinochoroidal atrophy is probably a slowly progressive disease, particularly in older patients. [ncbi.nlm.nih.gov]

CONCLUSION: Patients with PPRCA have a slowly progressive disease with respect to the loss of peripheral vision. [ncbi.nlm.nih.gov]

PPRCA is non-progressive or slowly progressive disease. There is no specific treatment for PPRCA. [eyewiki.org]

Spinal and Bulbar Muscular Atrophy

SBMA is a slowly progressive disease by nature. [ncbi.nlm.nih.gov]

Spinal and bulbar muscular atrophy, or Kennedy disease, is a slowly progressive X-linked neuromuscular disease caused by a trinucleotide (CAG) repeat expansion in the androgen [ncbi.nlm.nih.gov]

These findings should be thoroughly considered when designing clinical trials for slowly progressive neurodegenerative diseases such as SBMA. [ncbi.nlm.nih.gov]

Adult Krabbe Disease

It was found in homozygosity in a patient (#17) with severe early-onset disease and in heterozygosity in siblings #15 and #16, both with late-onset slowly progressing disease [ncbi.nlm.nih.gov]

However, the latter too has been shown to be beneficial in patients with very early stage Krabbe disease or a very slowly progressing type. (3, 13) Gene therapy, where scientists [news-medical.net]

It has been found that cord blood transplant stabilizes disease progression faster than bone marrow transplant. [news-medical.net]

Primary Lateral Sclerosis

[…] pri·mar·y lat·er·al scle·ro·sis considered by many to be a subgroup of motor neuron disease; a slowly progressive degenerative disorder of the motor neurons of the cerebral [medical-dictionary.thefreedictionary.com]

Prognosis Because PLS can be a slowly progressing disease, the outlook for a normal life span is good. [encyclopedia.com]

progressing degenerative brain disease characterized by weakness, spasticity, hyperreflexia, and a positive Babinski sign. [medical-dictionary.thefreedictionary.com]

Limb-Girdle Muscular Dystrophy Type 1F

Myotonic dystrophy is also known as Steinart's disease. It is a slowly progressing disease that onsets anytime from childhood through middle age. [healthcommunities.com]

progressive disease, meaning the muscle weakness slowly continues to worsen. [rarediseases.info.nih.gov]

This form is similar to Duchenne muscular dystrophy, but the disease is much milder: symptoms appear later and progress more slowly. [webmd.com]

Central Centrifugal Cicatricial Alopecia

[…] generally progresses slowly, but longstanding or severe disease can result in hair loss covering the entire crown of the scalp.[11] This is in contrast to nonscarring (non-cicatricial [ncbi.nlm.nih.gov]

Typically, a few short, brittle hairs remain within the scarred expanse.[9] Patients commonly complain of mild dysesthesia (pruritus, tenderness) in the affected area.[7,10] The disease [ncbi.nlm.nih.gov]

Spinal Muscular Atrophy with Microcephaly and Mental Subnormality

The family reported here illustrates the relatively slowly progressive form of this disease. [onlinelibrary.wiley.com]

A wide variety of clinical manifestations are encountered in the various forms of progressive spinal muscular atrophy of childhood. [einstein.pure.elsevier.com]

SUMMARY A wide variety of clinical manifestations are encountered in the various forms of progressive spinal muscular atrophy of childhood. [onlinelibrary.wiley.com]

Retinitis Pigmentosa Type 20

Un estudio genético oftalmológico diseñado y avalado por genetistas clínicos con más de 10 años de experiencia. Basado en un panel de secuenciación masiva (Next Generation Sequencing – NGS) que analiza las regiones codificantes de 515 genes asociados con enfermedades oftalmológicas Ver listade genes El futuro de[…] [qgenomics.com]

Carbon Baby Syndrome

Adrenoleukodystrophy is an X-linked acquired generalized hyperpigmentary disorder, which has been described in association with a slowly progressive disease of the brain and [ijdvl.com]

Kaposi Sarcoma of the Rectum

HAART remains the mainstay of treatment and represents the first-line therapy for limited cutaneous and slowly progressive disease. [ncbi.nlm.nih.gov]

TGFBI-Related Corneal Dystrophy

Corneal findings appear early in life and vision can be severely impaired between 10 and 30 years of age, even though it is a slowly progressive disease. [aboonline.org.br]

Most cases of CD have an autosomal dominant inheritance pattern, starting at the first decades of life, with a stable or slowly progressive course(1,2). [aboonline.org.br]

[…] hereditárias da córnea/epidemiologia; Ceratoplastia penetrante; Substância própria INTRODUCTION Corneal dystrophy (CD) is defined as bilateral and symmetric primary corneal disease [aboonline.org.br]

Charcot-Marie-Tooth Disease Type 4J

[…] from slowly to rapidly progressive disease. [clinicaltrials.gov]

CMT4J may present either as an early and severe, or a late onset and more slowly progressive disease. [ncbi.nlm.nih.gov]

[…] rapidly progressive disease. [livingcmt4j.com]

Granulomatous Myositis

Here we illustrate a 74-year-old patient presenting with clinical signs of slowly progressive motor neuron disease. [ncbi.nlm.nih.gov]

progressive lower motor neuron disease. ( 18700190 ) Gdynia H.J....Sperfeld A.D. 2008 16 Paediatric contracturing granulomatous myositis. ( 18821276 ) Bowers B....Seidman [malacards.org]

Patients with granulomatous myositis usually present with slowly progressive muscle pain and weakness affecting mainly proximal muscles. [ncbi.nlm.nih.gov]

Hereditary Motor and Sensory Neuropathy Type 5

Charcot-Marie-Tooth disease type 2 characterized by early childhood-onset of slowly progressive, predominantly distal, lower limb muscle weakness and atrophy, delayed motor [orpha.net]

Homepage Rare diseases Search Search for a rare disease Autosomal dominant Charcot-Marie-Tooth disease type 2O Disease definition A rare, genetic, subtype of autosomal dominant [orpha.net]

Rhinoscleroma

Rhinoscleroma is a chronic, slowly progressive, inflammatory disease of the upper respiratory tract. It is associated with Klebsiella rhinoscleromatis infection. [ncbi.nlm.nih.gov]

progressive, inflammatory disease of the upper respiratory tract. [smj.org.sg]

Rhinoscleroma is a chronic, slowly progressive, inflammatory disease of the nose and upper respiratory tract. [patientslikeme.com]

Mucopolysaccharidosis Type 3A

Individuals with MPS III may have rapidly or slowly progressing disease [Valstar et al 2010c]. [ncbi.nlm.nih.gov]

Disease course may be rapidly or slowly progressive; some individuals with an extremely attenuated disease course present in mid-to-late adulthood with early-onset dementia [ncbi.nlm.nih.gov]

Early-onset dementia is observed in some individuals, particularly those with later-onset or more slowly progressing disease. [ncbi.nlm.nih.gov]

Medullary Cystic Kidney Disease

Slowly progressive chronic kidney disease. [ncbi.nlm.nih.gov]

Uromodulin-associated kidney disease causes slowly progressive kidney disease, with the signs and symptoms usually beginning during the teenage years. [ghr.nlm.nih.gov]

This disease is autosomal dominant, meaning that it is characterized by a 50% chance of inheritance and slowly progressive chronic kidney disease that leads to the need for [en.wikipedia.org]

Distal Spinal Muscular Atrophy Type 4

Slowly progressive SMA (group 1) After a median disease duration of 11 years, these patients had generalized and severe weakness. [academic.oup.com]

Almost all patients presented with late onset proximal weakness and a slowly progressive disease course without upper motor neuron signs, which were classified as FSMA. [scielo.br]

Postpolio syndrome Postpolio syndrome (PPS) is a slowly progressive disease that is rarely fatal. [emedicine.medscape.com]

Myopia Type 19

Clinical Presentation Stargardt disease commonly presents in the second or third decade of life with slowly progressive bilateral visual loss, generally in the range of 20 [aao.org]

/30 to 20/200.2 The classic fundus appearance of eyes with Stargardt disease is characterized by juvenile-onset foveal atrophy, taking on a “beaten-bronze” appearance, with [aao.org]

Oculopharyngeal Muscular Dystrophy

OPMD is characterized by slowly progressive muscle disease (myopathy) affecting the muscles of the upper eyelids and the throat. [slodrinks.com]

This condition is characterized by slowly progressive muscle disease (myopathy) affecting the muscles of the upper eyelids and the throat. [diseaseinfosearch.org]

Mucopolysaccharidosis Type 3C

Individuals with MPS III may have rapidly or slowly progressing disease [Valstar et al 2010c]. [ncbi.nlm.nih.gov]

Disease course may be rapidly or slowly progressive; some individuals with an extremely attenuated disease course present in mid-to-late adulthood with early-onset dementia [ncbi.nlm.nih.gov]

Early-onset dementia is observed in some individuals, particularly those with later-onset or more slowly progressing disease. [ncbi.nlm.nih.gov]

Limb-Girdle Muscular Dystrophy Type 1H

Five subjects presented with a slowly progressive proximal muscle weakness, in both upper and lower limbs, with onset during the fourth-fifth decade of life, which fulfilled [moh-it.pure.elsevier.com]

Five subjects presented with a slowly progressive proximal muscle weakness, in both upper and lower limbs, with onset during the fourth-fifth decade that fulfilled the consensus [hal.archives-ouvertes.fr]

Five subjects presented with a slowly progressive proximal muscle weakness, in both… CONTINUE READING From This Paper Figures, tables, and topics from this paper. [semanticscholar.org]

Erb Muscular Dystrophy

slowly with swallowing problems common as the disease progresses; inheritance is autosomal dominant [seslisozluk.net]

This form is similar to Duchenne muscular dystrophy, but the disease is much milder: symptoms appear later and progress more slowly. [webmd.com]

(omim 253601) An autosomal dominant degenerative muscle disease characterized by slowly progressive weakness of the muscles of the face, upper-arm, and shoulder girdle. [icd10data.com]

Hereditary Proximal Myopathy with Early Respiratory Failure

Background: Hereditary myopathy with early respiratory failure is a rare dominantly inherited muscle disease characterized by slowly progressive proximal weakness and respiratory [neurology.org]

Effects of respiratory muscle training on pulmonary functions in patients with slowly progressive neuromuscular disease: a randomized controlled trial. [dovepress.com]

progressive Paget disease of bone (100%) May be severe & widespread Location: Long bones Cognitive disorders (40%) Motor neuron disease (40%) Weakness Rapidly progressive [neuromuscular.wustl.edu]