Slowly Progressive Disease: Causes & Reasons

Possible Causes for Slowly Progressive Disease

It should be noted that RP is a slowly progressive disease over many years and that most patients never become completely blind. [uvahealth.com]

Patients initially experience ring scotoma and night vision problems which, in most cases, slowly progress and lead to the loss of all peripheral vision. [nice.org.uk]

Patients should understand the variable, slowly progressive course of the disease that leads to bilateral, initially peripheral and later central vision loss. [institut-vision.org]

Multiple Sclerosis

A patient with RRMS may accumulate significant disability between relapses while a patient with very slowly progressive disease may remain with minimal disability. [va.gov]

progressing disease may be challenging to identify or may have been misdiagnosed with another condition. [biomarin.com]

Discussion Individuals with rapidly advancing MPS VI are diagnosed earlier than the individuals with slowly progressive disease because of the severity of symptoms, including [pediatrics.aappublications.org]

Late-Onset Pompe Disease

However, disease progression and diaphragmatic involvement both are highly variable in LOPD patients with and without ERT making it obligatory to assess and monitor respiratory [ncbi.nlm.nih.gov]

[…] with slowly progressive selective lower extremity weakness, specifically of the hip flexors. [ncbi.nlm.nih.gov]

In untreated patients with LOPD chronic respiratory failure slowly develops in more than 70% with a mean annual decline of the forced vital capacity (FVC) of about 1.5% [17 [ncbi.nlm.nih.gov]

Geographic Atrophy

Small atrophic lesions begin to appear early on in the extrafoveal area that slowly expand into the fovea as the disease progresses. [eyewiki.aao.org]

The first sign is drusen, which can vary in size and number according to stage of disease. [eyewiki.aao.org]

Cerebrotendinous Xanthomatosis

Permanent link CopyPermanent link http://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=18357860 Other title Imaging of cerebrotendmous xanthomatosis (en) Author NAGI, S1 ; BOUCHRIHA, M1 ; SEBAÏ, R1 ; MARRAKCHI-TURKI, Z2 ; ZOUAOUI, W1 ; MRABET, H1 ; MEGDICHE, H1 ; BEN SLAMA, C2 ; TOUIBI, S1 [1][…] [pascal-francis.inist.fr]

Neuronal Intranuclear Inclusion Disease

(NIID) is a slowly progressive neurodegenerative disease characterized by eosinophilic hyaline intranuclear inclusions in the nervous system, and in the visceral organs. [sasappa.co.jp]

Neuronal intranuclear inclusion disease (NIID) is a slowly progressive, neurodegenerative disease. [rarediseases.info.nih.gov]

Nagoya Graduate School of Medicine 2) Department of Therapeutics for Intractable Neurological Disorders, Nagoya Graduate School of Medicine Neuronal intranuclear inclusion disease [sasappa.co.jp]

Pigmented Paravenous Retinochoroidal Atrophy

Pigmented paravenous retinochoroidal atrophy is probably a slowly progressive disease, particularly in older patients. [ncbi.nlm.nih.gov]

CONCLUSION: Patients with PPRCA have a slowly progressive disease with respect to the loss of peripheral vision. [ncbi.nlm.nih.gov]

PPRCA is non-progressive or slowly progressive disease. There is no specific treatment for PPRCA. [eyewiki.org]

Spinal and Bulbar Muscular Atrophy

SBMA is a slowly progressive disease by nature. [ncbi.nlm.nih.gov]

Spinal and bulbar muscular atrophy, or Kennedy disease, is a slowly progressive X-linked neuromuscular disease caused by a trinucleotide (CAG) repeat expansion in the androgen [ncbi.nlm.nih.gov]

Prognosis Kennedy's disease is slowly progressive. [ninds.nih.gov]

Adult Krabbe Disease

It was found in homozygosity in a patient (#17) with severe early-onset disease and in heterozygosity in siblings #15 and #16, both with late-onset slowly progressing disease [ncbi.nlm.nih.gov]

However, the latter too has been shown to be beneficial in patients with very early stage Krabbe disease or a very slowly progressing type. (3, 13) Gene therapy, where scientists [news-medical.net]

It has been found that cord blood transplant stabilizes disease progression faster than bone marrow transplant. [news-medical.net]

Central Centrifugal Cicatricial Alopecia

[…] generally progresses slowly, but longstanding or severe disease can result in hair loss covering the entire crown of the scalp.[11] This is in contrast to nonscarring (non-cicatricial [ncbi.nlm.nih.gov]

Typically, a few short, brittle hairs remain within the scarred expanse.[9] Patients commonly complain of mild dysesthesia (pruritus, tenderness) in the affected area.[7,10] The disease [ncbi.nlm.nih.gov]

Spinal Muscular Atrophy with Microcephaly and Mental Subnormality

The family reported here illustrates the relatively slowly progressive form of this disease. [einstein.pure.elsevier.com]

SUMMARY A wide variety of clinical manifestations are encountered in the various forms of progressive spinal muscular atrophy of childhood. [onlinelibrary.wiley.com]

A wide variety of clinical manifestations are encountered in the various forms of progressive spinal muscular atrophy of childhood. [einstein.pure.elsevier.com]

Retinitis Pigmentosa Type 20

Un estudio genético oftalmológico diseñado y avalado por genetistas clínicos con más de 10 años de experiencia. Basado en un panel de secuenciación masiva (Next Generation Sequencing – NGS) que analiza las regiones codificantes de 515 genes asociados con enfermedades oftalmológicas Ver listade genes El futuro de[…] [qgenomics.com]

Carbon Baby Syndrome

Adrenoleukodystrophy is an X-linked acquired generalized hyperpigmentary disorder, which has been described in association with a slowly progressive disease of the brain and [ijdvl.com]

Juvenile GM2-Gangliosidosis

In contrast, the presence of G269S or W474C mutations is apparently associated with milder and more slowly progressive disease. [ncbi.nlm.nih.gov]

Neurologic defects progress slowly and may lead to lack of coordination; hand tremors; progressive dystonia; dysarthria, dyskinesia; choreoathetosis; ataxia; spinocerebellar [emedicine.medscape.com]

The disease is characterized by slowly progressive neurodegeneration and mild skeletal changes. [bmcmedgenet.biomedcentral.com]

Kaposi Sarcoma of the Rectum

HAART remains the mainstay of treatment and represents the first-line therapy for limited cutaneous and slowly progressive disease. [ncbi.nlm.nih.gov]

Charcot-Marie-Tooth Disease Type 4J

[…] from slowly to rapidly progressive disease. [clinicaltrials.gov]

CMT4J may present either as an early and severe, or a late onset and more slowly progressive disease. [ncbi.nlm.nih.gov]

[…] rapidly progressive disease. [livingcmt4j.com]

Primary Lateral Sclerosis

[…] pri·mar·y lat·er·al scle·ro·sis considered by many to be a subgroup of motor neuron disease; a slowly progressive degenerative disorder of the motor neurons of the cerebral [medical-dictionary.thefreedictionary.com]

Prognosis Because PLS can be a slowly progressing disease, the outlook for a normal life span is good. [encyclopedia.com]

progressing degenerative brain disease characterized by weakness, spasticity, hyperreflexia, and a positive Babinski sign. [medical-dictionary.thefreedictionary.com]

Mucopolysaccharidosis Type 3A

Individuals with MPS III may have rapidly or slowly progressing disease [Valstar et al 2010c]. [ncbi.nlm.nih.gov]

Disease course may be rapidly or slowly progressive; some individuals with an extremely attenuated disease course present in mid-to-late adulthood with early-onset dementia [ncbi.nlm.nih.gov]

Early-onset dementia is observed in some individuals, particularly those with later-onset or more slowly progressing disease. [ncbi.nlm.nih.gov]

Hereditary Motor and Sensory Neuropathy Type 5

Charcot-Marie-Tooth disease type 2 characterized by early childhood-onset of slowly progressive, predominantly distal, lower limb muscle weakness and atrophy, delayed motor [orpha.net]

Homepage Rare diseases Search Search for a rare disease Autosomal dominant Charcot-Marie-Tooth disease type 2O Disease definition A rare, genetic, subtype of autosomal dominant [orpha.net]

Granulomatous Myositis

Here we illustrate a 74-year-old patient presenting with clinical signs of slowly progressive motor neuron disease. [ncbi.nlm.nih.gov]

progressive lower motor neuron disease. ( 18700190 ) Gdynia H.J....Sperfeld A.D. 2008 16 Paediatric contracturing granulomatous myositis. ( 18821276 ) Bowers B....Seidman [malacards.org]

Patients with granulomatous myositis usually present with slowly progressive muscle pain and weakness affecting mainly proximal muscles. [ncbi.nlm.nih.gov]

Limb-Girdle Muscular Dystrophy Type 1F

Myotonic dystrophy is also known as Steinart's disease. It is a slowly progressing disease that onsets anytime from childhood through middle age. [healthcommunities.com]

progressive disease, meaning the muscle weakness slowly continues to worsen. [rarediseases.info.nih.gov]

This form is similar to Duchenne muscular dystrophy, but the disease is much milder: symptoms appear later and progress more slowly. [webmd.com]

Rhinoscleroma

Abstract Rhinoscleroma, or scleroma, is a chronic, slowly progressing granulomatous disease involving the upper respiratory tract, especially the nasal vestibules, choanae [jpatholtm.org]

Rhinoscleroma is a chronic, slowly progressive, inflammatory disease of the upper respiratory tract. It is associated with Klebsiella rhinoscleromatis infection. [ncbi.nlm.nih.gov]

Rhinoscleroma is a chronic, slowly progressive, inflammatory disease of the nose and upper respiratory tract. [patientslikeme.com]

Medullary Cystic Kidney Disease

This disease is autosomal dominant, meaning that it is characterized by a 50% chance of inheritance and slowly progressive chronic kidney disease that leads to the need for [en.wikipedia.org]

Slowly progressive chronic kidney disease. [ncbi.nlm.nih.gov]

Uromodulin-associated kidney disease causes slowly progressive kidney disease, with the signs and symptoms usually beginning during the teenage years. [ghr.nlm.nih.gov]

Mucopolysaccharidosis Type 3C

Individuals with MPS III may have rapidly or slowly progressing disease [Valstar et al 2010c]. [ncbi.nlm.nih.gov]

Disease course may be rapidly or slowly progressive; some individuals with an extremely attenuated disease course present in mid-to-late adulthood with early-onset dementia [ncbi.nlm.nih.gov]

Early-onset dementia is observed in some individuals, particularly those with later-onset or more slowly progressing disease. [ncbi.nlm.nih.gov]

TGFBI-Related Corneal Dystrophy

Corneal findings appear early in life and vision can be severely impaired between 10 and 30 years of age, even though it is a slowly progressive disease. [aboonline.org.br]

Most cases of CD have an autosomal dominant inheritance pattern, starting at the first decades of life, with a stable or slowly progressive course(1,2). [aboonline.org.br]

[…] hereditárias da córnea/epidemiologia; Ceratoplastia penetrante; Substância própria INTRODUCTION Corneal dystrophy (CD) is defined as bilateral and symmetric primary corneal disease [aboonline.org.br]

Diphallus - Rachischisis - Imperforate Anus

It is also known as autosomal dominant interstitial kidney disease to highlight the inheritance pattern and slowly progressive kidney disease due to interstitial fibrosis. [itmedicalteam.pl]

Oculopharyngeal Muscular Dystrophy

OPMD is characterized by slowly progressive muscle disease (myopathy) affecting the muscles of the upper eyelids and the throat. [slodrinks.com]

Oculopharyngeal muscular dystrophy (OPMD) is a genetic disorder characterized by a slowly progressing muscle disease (myopathy) affecting the muscles of the upper eyelids [patientworthy.com]

Myopia Type 19

Clinical Presentation Stargardt disease commonly presents in the second or third decade of life with slowly progressive bilateral visual loss, generally in the range of 20 [aao.org]

/30 to 20/200.2 The classic fundus appearance of eyes with Stargardt disease is characterized by juvenile-onset foveal atrophy, taking on a “beaten-bronze” appearance, with [aao.org]

Carbon Monoxide-Induced Parkinsonism

It is a slowly progressing, degenerative disease that is usually associated with the following symptoms, all of which result from the loss of dopamine-producing brain cells [rwjuh.edu]

Parkinson’s disease (PD, Parkinson Disease, Parkinson Syndrome, Atypical Parkinson, or Parkinsonism or, simply, Parkinson) is a slowly progressing, degenerative disease that [columbianeurosurgery.org]

Parkinson’s disease (PD, Parkinson’s Syndrome, Atypical Parkinson’s, or Parkinsonism or, simply, Parkinson’s) is a slowly progressing, degenerative disease that is the most [neurosurgeonsofnewjersey.com]

Erb Muscular Dystrophy

slowly with swallowing problems common as the disease progresses; inheritance is autosomal dominant [seslisozluk.net]

This form is similar to Duchenne muscular dystrophy, but the disease is much milder: symptoms appear later and progress more slowly. [webmd.com]

(omim 253601) An autosomal dominant degenerative muscle disease characterized by slowly progressive weakness of the muscles of the face, upper-arm, and shoulder girdle. [icd10data.com]