Slowly Progressive Neurologic Deterioration: Causes & Reasons

Possible Causes for Slowly Progressive Neurologic Deterioration

The full text of this article hosted at iucr.org is unavailable due to technical difficulties. Rapid Communication Mucolipidosis type IV: Novel MCOLN1 mutations in Jewish and non‐Jewish patients and the frequency of the disease in the Ashkenazi Jewish population First published: 16 April 2001 Cited by: 51 Abstract The[…] [doi.org]

Pituicytoma

HGA is an autosomal-dominant systemic amyloidosis, characterized by slowly progressive neurological deterioration with corneal lattice dystrophy, cranial neuropathy, and cutis [mayoclinic.pure.elsevier.com]

Platybasia

progressive or acute neurologic deterioration. [ncbi.nlm.nih.gov]

The congenital and acquired deformities of the craniovertebral junction (CVJ), such as basilar invagination, basilar impression, or platybasia, can present in the form of slowly [ncbi.nlm.nih.gov]

Infantile Sialic Acid Storage Disease

[…] findings at birth followed by slowly progressive neurologic deterioration resulting in mild to moderate psychomotor retardation, spasticity, athetosis, and epileptic seizures [flipper.diff.org]

Children who do not experience an acute encephalopathic crisis may present with a slowly progressive neurologic disorder with seizures, physical disability, and fasting hypoglycemia [msunites.com]

CLINICAL DESCRIPTION Salla disease is the mildest phenotype characterized by a normal appearance and normal neurologic findings at birth followed by slowly progressive neurologic [flipper.diff.org]

Primary Dystonia Type DYT2

Affected individuals also show slowly progressive nonparoxysmal neurologic deterioration in a rostrocaudal gradient with prominent bulbar dysfunction. [genica.bg]

Dysmyelination with Jaundice

Affected individuals also show slowly progressive nonparoxysmal neurologic deterioration in a rostrocaudal gradient with prominent bulbar dysfunction (summary by Rosewich [mendelian.co]

Kyphoscoliosis

slowly. [ncbi.nlm.nih.gov]

Spontaneous neurological deterioration due to compression of the spinal cord occurred in ten patients (seven of whom had a type-I kyphosis and three of whom had an unclassifiable [ncbi.nlm.nih.gov]

[…] anterolateral unsegmented bar had produced a kyphoscoliosis (nine patients) than it was when a midline anterior bar had produced a pure kyphosis (fifteen patients), which usually progressed [ncbi.nlm.nih.gov]

Niemann-Pick Disease

Slowly progressive neurologic deterioration begins within 2 years. [epilepsy.com]

Two subtypes of type-C Niemann-Pick disease have been identified based on the temporal sequence of neurologic events, neurophysiologic abnormalities, and longevity. 73 Neonates [epilepsy.com]

Spinal Trauma

Patients with Chiari malformation (CM) Type I typically experience chronic, slowly progressive symptoms. [ncbi.nlm.nih.gov]

✓Patients with Chiari malformation (CM) Type I typically experience chronic, slowly progressive symptoms. [thejns.org]

Rarely, however, do they suffer acute neurological deterioration following an iatrogenic decrease in caudal cerebrospinal fluid pressure due to, for example, a lumbar puncture [ncbi.nlm.nih.gov]

Fucosidosis

Since the age of 2 years, progressive neurological deterioration occurred. [ncbi.nlm.nih.gov]

No clinical signs typical for fucosidosis were present at this time, and psychomotor development still progressed slowly. [ncbi.nlm.nih.gov]

CAMFAK Syndrome

The disease onset is usually in the second year of life with slowly progressive neurologic degeneration. [dermaamin.com]

Intellectual deterioration may be non-uniform, with some functions preserved better than others. [dermaamin.com]

Kyphosis

slowly. [ncbi.nlm.nih.gov]

Multifocal Motor Neuropathy

Nevertheless, follow-up studies have reported contradictory results regarding the long-term efficacy of treatment: while some authors report a slowly progressive neurological [symptoma.com]

deterioration over the course of years, others state that therapy effectively diminishes disability and to promotes reinnervation. [symptoma.com]

Autosomal Recessive Spastic Ataxia with Leukoencephalopathy

In its classic form, it affects children and and is slowly progressive with episodes of neurologic deterioration triggered by physical (febrile illness, head trauma) or emotional [neuropathology-web.org]

[…] autosomal recessive leukoencephalopathy (previously reported as orthochromatic sudanophilic leukodystrophy) which causes ataxia and spasticity and, less frequently, gognitive deterioration [neuropathology-web.org]

Pick Disease of The Brain

[…] condition characterized by a slowly progressive deterioration of behavior, personality, or language. [1] People with Pick's disease have abnormal substances (called Pick [rarediseases.info.nih.gov]

[…] the brain; Dementia with lobar atrophy and neuronal cytoplasmic inclusions; bvFTD; Pick's disease See More Categories: This disease is grouped under: Pick’s disease is a neurological [rarediseases.info.nih.gov]

Hematomyelia

Group B (41%) suffered slowly progressive neurological deterioration. [springermedizin.de]

Group A (30%) suffered multiple episodes of discrete neurological deterioration and varying degrees of recovery in between. [springermedizin.de]

Adults, on the other hand, present with slowly progressive deficits or an acute deficit followed by a slow, stepwise deterioration with episodes of some clinical improvement [springermedizin.de]

Leigh's Disease

Despite this dietary therapy, neurologic deterioration progressed slowly. He died of pneumonia after artificial respiration for 3 wk. [ncbi.nlm.nih.gov]

Leukoencephalopathy with brain stem and spinal cord involvement and lactate elevation (LBSL) is a result of a DARS2 gene mutation and is characterized by slowly progressive [umdf.org]

The neurologic dysfunction involves the legs more than the arms. The tendon reflexes are retained. [umdf.org]

Alexander Disease

Pelizaeus-Merzbacher Disease

Canavan Disease

Dementia

progressive. 13, 14 Neurological symptoms and signs related to SVD include cognitive deterioration, gait disturbance (imbalance, fall, short-stepped gait), urinary dysfunction [doi.org]

The onset of SVD is insidious in over half of patients and the course is usually continuous and slowly progressive. 13, 14 Neurological symptoms and signs related to SVD include [ncbi.nlm.nih.gov]

[…] retinopathy, elevated homocysteine levels, and ischemic heart diseases. 13 The onset of SVD is insidious in over half of patients and the course is usually continuous and slowly [doi.org]

Perineurioma

Revisions were necessary following postoperative progressive neurological deterioration. Explorations of the nerves showed nerve tumors. [egms.de]

Results: The predominant symptom was a slowly progressive paralysis. Long-term follow-ups were available in three patients. No relapse could be observed. [egms.de]

West African Trypanosomiasis

East African sleeping sickness is a rapidly progressive disease causing mental deterioration, neurological problems and death within months. [military-medicine.com]

While West African sleeping sickness is a slowly progressive disease, CNS involvement occurs in 1 - 2 years and death usually occurs within three years, but this period may [military-medicine.com]

CNS involvement results in ‘sleeping sickness syndrome’ comprising changes in personality, increased day time sleepiness with disturbed night sleep, and progressive confusion [military-medicine.com]

Paraparesis

The most common neurological manifestation of HTLV-1 associated myelopathy is a slowly progressing chronic spastic paraparesis with bowel and bladder dysfunction and lower [radiopaedia.org]

A preceding episode of acute deterioration is reported in a minority of patients 1. [radiopaedia.org]

Luft Disease

Leukoencephalopathy with brain stem and spinal cord involvement and lactate elevation (LBSL) is a result of a DARS2 gene mutation and is characterized by slowly progressive [umdf.org]

progressive cerebellar ataxia and spasticity with dorsal column dysfunction (decreased position and vibration sense). [specialneedshomeschooling.com]

The neurologic dysfunction involves the legs more than the arms. The tendon reflexes are retained. [umdf.org]

Hereditary Spastic Paraplegia

The patient presented an early-onset, slowly progressive paraparesis associated with mild mental retardation. [ncbi.nlm.nih.gov]

Neurological assessments included the Spastic Paraplegia Rating Scale (SPRS), Mental Deterioration Battery (MDB), and Wechsler Adult Intelligence Scale (WAIS), neurophysiological [ncbi.nlm.nih.gov]

Galactosialidosis

[…] found in Japan, which is characterized by slowly progressive neurological symptoms, skeletal and eye abnormalities, dysmorphism, angiokerato- mas, and long survival.1 Herein [ri.conicet.gov.ar]

Late infantile and juvenile/adult galactosialidosis are slowly progressive diseases that are less severe than the early infantile type. [omicsonline.org]

Three clinical phe- notypes had been described: a severe early infantile form; a milder late infantile type with minor mental deterioration; and a juvenile/adult form, mainly [ri.conicet.gov.ar]

Lethal Infantile Mitochondrial Myopathy

Leukoencephalopathy with brain stem and spinal cord involvement and lactate elevation (LBSL) is a result of a DARS2 gene mutation and is characterized by slowly progressive [umdf.org]

progressive cerebellar ataxia and spasticity with dorsal column dysfunction (decreased position and vibration sense). [specialneedshomeschooling.com]

The neurologic dysfunction involves the legs more than the arms. The tendon reflexes are retained. [umdf.org]

Autosomal Recessive Spastic Paraplegia Type 35

The patient presented an early-onset, slowly progressive paraparesis associated with mild mental retardation. [readbyqxmd.com]

Neurological assessments included the Spastic Paraplegia Rating Scale (SPRS), Mental Deterioration Battery (MDB), and Wechsler Adult Intelligence Scale (WAIS), neurophysiological [readbyqxmd.com]

Dilated Cardiomyopathy Type 2B

[…] is Charcot-Marie-Tooth (CMT) disease, with an estimated prevalence of 1:2500. 2 This slowly progressive neurologic atrophy predominantly affects the distal muscles of the [mdmag.com]

These clinically and genetically heterogeneous group of conditions produce progressive deterioration of the peripheral nerves. l The most common hereditary peripheral neuropathy [mdmag.com]