Symptoms may include large, low-set ears, small eyes, microcephaly (abnormal smallness of the head), micrognathia (abnormal smallness of the jaws), clenched fists, wide-set
[ninds.nih.gov]
Children with COFS syndrome have distinctive facial features, including low-set ears, small eyes, small head size ( microcephaly ), and a small jaw ( micrognathia ).
[rarediseases.info.nih.gov]