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30 Possible Causes for Small Face, Wide Space Between the First and Second Toe

  • Dubowitz Syndrome

    1st and 2nd toes Gap between first and second toe Increased space between first and second toes Sandal gap between first and second toes Wide space between 1st, 2nd toes[rarediseases.info.nih.gov] For example, many people affected by the disease have a small face and head. Sometimes they have a high forehead that slopes as well.[wisegeek.net] Affected individuals have small face which is often triangular in shape with a pointed, receding chin.[brighthub.com]

  • Down Syndrome

    A wide space, often with a deep fissure between the first and second toes, is also common.[dx.doi.org] Morphological features (upslanting palpebral fissures, epicanthus, flat neck, round face, small nose, bilateral single palmar crease) can be mild and do not constitute a hallmark[orpha.net] spacing, often with a deep plantar groove between the first and second toes.[dx.doi.org]

  • Russell-Silver Syndrome

    1st and 2nd toes Gap between first and second toe Increased space between first and second toes Sandal gap between first and second toes Wide space between 1st, 2nd toes[rarediseases.info.nih.gov] The wide prominent forehead contrasts with the small, triangular face with a small pointed chin, a wide mouth with thin lips and down-turned corners, large eyes and bluish[orpha.net] […] triangular face; and fifth-finger clinodactyly.[ncbi.nlm.nih.gov]

  • Ring Chromosome 10

    1st and 2nd toes Gap between first and second toe Increased space between first and second toes Sandal gap between first and second toes Wide space between 1st, 2nd toes[rarediseases.info.nih.gov] In addition, the syndrome causes a prognathism, the face is long and small and the patient has large ears.[embryology.ch] […] triangular-shaped face, prominent forehead, hypertelorism, smallmouth with thin lips, micrognathia with pointed chin, low posterior-rotated and overfolded ears p11.2 q11.21[chr7.org]

  • Atelosteogenesis Type 2

    1st and 2nd toes Gap between first and second toe Increased space between first and second toes Sandal gap between first and second toes Wide space between 1st, 2nd toes[rarediseases.info.nih.gov] Note moderate short stature, flat facial profile (fetal face–like appearance), short forearms, and small hands.[thehealthscience.com] Approximately one third of infants and children with diastrophic dysplasia also have dental abnormalities, such as abnormally small teeth and dental crowding.[rarediseases.org]

  • Kleiner Holmes Syndrome

    ; High, flat forehead; Low frontal hairline; Maxillary hypoplasia; Facial asymmetry; Long and prominent ear crus; Small ears; Low-set ears; Apical cartilage deformity; Deafness[panelapp.genomicsengland.co.uk] […] gap between first and second toes Wide space between 1st, 2nd toes Wide space between first and second toes Widely spaced 1st-2nd toes Widely spaced first and second toes[rarediseases.info.nih.gov] It informs some of his actions, but it's just a small part of what makes Colin entertaining.[goodreads.com]

  • Seckel Syndrome

    General appearance of the patient was characterized by a small, narrow face and forehead, slightly beaked nose, midfacial hypoplasia, very stunted stature with microcephaly[termedia.pl] 1st and 2nd toes Gap between first and second toe Increased space between first and second toes Sandal gap between first and second toes Wide space between 1st, 2nd toes[rarediseases.info.nih.gov] […] head, narrow bird-like face with a beak-like nose, large eyes with down-slanting palpebral fissures, receding mandible and intellectual disability.[liveleak.com]

  • Craniofrontonasal Dysplasia

    The upper face (base of the nose to height of the commissure of the mouth) is relatively small compared with the width of the face (lateral points of zygoma).[nature.com] 1st and 2nd toes Gap between first and second toe Increased space between first and second toes Sandal gap between first and second toes Wide space between 1st, 2nd toes[rarediseases.info.nih.gov] In addition, abnormal facial proportions were observed in all patients. 34 These proportions are reflected in a relatively small upper face compared with the width of the[nature.com]

  • Short Stature due to Endocrine Disorder

    1st and 2nd toes Gap between first and second toe Increased space between first and second toes Sandal gap between first and second toes Wide space between 1st, 2nd toes[rarediseases.info.nih.gov] […] feet [ more ] 0001773 Small hand Disproportionately small hands 0200055 Strabismus Cross-eyed Squint Squint eyes [ more ] 0000486 Synophrys Monobrow Unibrow [ more ] 0000664[rarediseases.info.nih.gov] Wide space between first and second toes Wide-spaced big toe Widely spaced 1st-2nd toes Widely spaced first and second toes Widened gap 1st-2nd toes Widened gap first and[rarediseases.info.nih.gov]

  • Kenny-Caffey Syndrome Type 1

    space between the first and second toes.[medcraveonline.com] , and frontal bossing with a triangular face.[uniprot.org] […] head, narrow face Deep-set eyes, up-slanting eyes Extremely thin lips Under-developed jaw Flat nasal bridge, beaked nose Large ears, which may be floppy Liver disease in[dovemed.com]

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