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105 Possible Causes for Small Platelet Size

  • Wiskott Aldrich Syndrome

    Despite the heterogeneity of genetic and clinical findings, a correlation with small platelet size is routinely observed.[ncbi.nlm.nih.gov] WAS is an X-linked recessive disorder characterized by thrombocytopenia, small platelet size, eczema, recurrent infections, and increased risk of autoimmune disorders and[ncbi.nlm.nih.gov] Small platelet size is the one consistent feature. Eczema and recurrent infections are common. Autoimmunity complicates up to 70% of cases.[bestpractice.bmj.com]

  • Platelet Storage Pool Deficiency

    Platelet storage pool deficiency is a type of coagulopathy characterized by defects in the granules in platelets , particularly a lack of granular non-metabolic ADP. Sandrock, Kirstin; Zieger, Barbara (2010). "Current Strategies in Diagnosis of Inherited Storage Pool Defects" . Transfusion Medicine and Hemotherapy .[…][en.wikipedia.org]

  • X-linked Severe Congenital Neutropenia

    Wiskott-Aldrich syndrome, the most severe presentation, is classically characterized by thrombocytopenia (with small platelet size), eczema, increased susceptibility to pyogenic[genedx.com] […] mL) 4 Small platelet size Absence of other clinical findings of Wiskott-Aldrich syndrome Family history of one or more maternally related males with a WAS-related phenotype[centogene.com] platelet size ( 2 SD below the mean) Recurrent bacterial or viral infection Eczema Autoimmune disorder Lymphoma Family history of one or more maternally related males with[centogene.com]

  • Severe Autosomal Recessive Macrothrombocytopenia

    […] mL) 4 Small platelet size Absence of other clinical findings of Wiskott-Aldrich syndrome Family history of one or more maternally related males with a WAS-related phenotype[centogene.com] platelet size ( 2 SD below the mean) Recurrent bacterial or viral infection Eczema Autoimmune disorder Lymphoma Family history of one or more maternally related males with[centogene.com] […] thrombocytopenia, including the following: Wiskott-Aldrich syndrome caused by mutations in the WAS gene should be suspected in males affected with: Profound thrombocytopenia ( Small[centogene.com]

  • Autosomal Dominant Thrombocytopenia 5

    […] mL) 4 Small platelet size Absence of other clinical findings of Wiskott-Aldrich syndrome Family history of one or more maternally related males with a WAS-related phenotype[centogene.com] Normal platelet size.[ufrgs.br] platelet size ( 2 SD below the mean) Recurrent bacterial or viral infection Eczema Autoimmune disorder Lymphoma Family history of one or more maternally related males with[centogene.com]

  • Thrombocytopenia-Absent Radius Syndrome

    […] mL) 4 Small platelet size Absence of other clinical findings of Wiskott-Aldrich syndrome Family history of one or more maternally related males with a WAS-related phenotype[centogene.com] Laboratory investigations in addition to thrombocytopenia reveal very small sized platelets, not in clumps in peripheral smear, and have impaired aggregation to ADP, epinephrine[pediatriconcall.com] platelet size ( 2 SD below the mean) Recurrent bacterial or viral infection Eczema Autoimmune disorder Lymphoma Family history of one or more maternally related males with[centogene.com]

  • Recurrent Infection due to Specific Granule Deficiency

    Thrombocytopenia and small platelet size is characteristic of WAS. [18] It is important to include electrolytes, glucose, urine analysis, renal, and liver function tests in[jfcmonline.com]

  • Hyperlipoproteinemia

    Despite the small sample size, the beneficial effect of n-3 PUFA on platelet function, triglycerides and HDL-C is clearly highlighted.[ncbi.nlm.nih.gov]

  • Bleeding Disorder Platelet Type 15

    In addition to being decreased in number, the platelets themselves are small and dysfunctional, less than half the size of normal platelets.[primaryimmune.org] Trapped platelets The spleen is a small organ about the size of your fist located just below your rib cage on the left side of your abdomen.[mayoclinic.org] The characteristic platelet abnormalities including low numbers and small platelet size are almost always present, even in the cord blood of newborns.[primaryimmune.org]

  • Immune Defect due to Absence of Thymus

    In addition to being decreased in number, the platelets themselves are small and dysfunctional, less than half the size of normal platelets.[primaryimmune.org] Pathophysiology - Thrombocytopenia Most common symptom and occurs irrespective of the mutation severity in WASP Platelets are also often small in size main cause still largely[slideshare.net] The characteristic platelet abnormalities including low numbers and small platelet size are almost always present, even in the cord blood of newborns.[primaryimmune.org]

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